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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32421

FusionGeneSummary for RUSC1_TYK2

check button Fusion gene summary
Fusion gene informationFusion gene name: RUSC1_TYK2
Fusion gene ID: 32421
HgeneTgene
Gene symbol

RUSC1

TYK2

Gene ID

23623

7297

Gene nameRUN and SH3 domain containing 1tyrosine kinase 2
SynonymsNESCAIMD35|JTK1
Cytomap

1q22

19p13.2

Type of geneprotein-codingprotein-coding
DescriptionRUN and SH3 domain-containing protein 1new molecule containing SH3 at the carboxy-terminusnon-receptor tyrosine-protein kinase TYK2
Modification date2018051920180522
UniProtAcc

Q9BVN2

P29597

Ensembl transtripts involved in fusion geneENST00000368354, ENST00000368352, 
ENST00000368347, ENST00000462780, 
ENST00000368349, ENST00000292254, 
ENST00000264818, ENST00000524462, 
ENST00000525621, ENST00000529370, 
ENST00000529422, 
Fusion gene scores* DoF score2 X 2 X 2=842 X 7 X 17=4998
# samples 243
** MAII scorelog2(2/8*10)=1.32192809488736log2(43/4998*10)=-3.53894233649724
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RUSC1 [Title/Abstract] AND TYK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRUSC1

GO:0000209

protein polyubiquitination

19365808


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVTHCATCGA-EM-A3O6-01ARUSC1chr1

155300903

+TYK2chr19

10491352

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000368354ENST00000264818RUSC1chr1

155300903

+TYK2chr19

10491352

-
5CDS-intronENST00000368354ENST00000524462RUSC1chr1

155300903

+TYK2chr19

10491352

-
5CDS-intronENST00000368354ENST00000525621RUSC1chr1

155300903

+TYK2chr19

10491352

-
5CDS-intronENST00000368354ENST00000529370RUSC1chr1

155300903

+TYK2chr19

10491352

-
5CDS-intronENST00000368354ENST00000529422RUSC1chr1

155300903

+TYK2chr19

10491352

-
5CDS-intronENST00000368352ENST00000264818RUSC1chr1

155300903

+TYK2chr19

10491352

-
5CDS-intronENST00000368352ENST00000524462RUSC1chr1

155300903

+TYK2chr19

10491352

-
5CDS-intronENST00000368352ENST00000525621RUSC1chr1

155300903

+TYK2chr19

10491352

-
5CDS-intronENST00000368352ENST00000529370RUSC1chr1

155300903

+TYK2chr19

10491352

-
5CDS-intronENST00000368352ENST00000529422RUSC1chr1

155300903

+TYK2chr19

10491352

-
5CDS-intronENST00000368347ENST00000264818RUSC1chr1

155300903

+TYK2chr19

10491352

-
5CDS-intronENST00000368347ENST00000524462RUSC1chr1

155300903

+TYK2chr19

10491352

-
5CDS-intronENST00000368347ENST00000525621RUSC1chr1

155300903

+TYK2chr19

10491352

-
5CDS-intronENST00000368347ENST00000529370RUSC1chr1

155300903

+TYK2chr19

10491352

-
5CDS-intronENST00000368347ENST00000529422RUSC1chr1

155300903

+TYK2chr19

10491352

-
intron-intronENST00000462780ENST00000264818RUSC1chr1

155300903

+TYK2chr19

10491352

-
intron-intronENST00000462780ENST00000524462RUSC1chr1

155300903

+TYK2chr19

10491352

-
intron-intronENST00000462780ENST00000525621RUSC1chr1

155300903

+TYK2chr19

10491352

-
intron-intronENST00000462780ENST00000529370RUSC1chr1

155300903

+TYK2chr19

10491352

-
intron-intronENST00000462780ENST00000529422RUSC1chr1

155300903

+TYK2chr19

10491352

-
5CDS-intronENST00000368349ENST00000264818RUSC1chr1

155300903

+TYK2chr19

10491352

-
5CDS-intronENST00000368349ENST00000524462RUSC1chr1

155300903

+TYK2chr19

10491352

-
5CDS-intronENST00000368349ENST00000525621RUSC1chr1

155300903

+TYK2chr19

10491352

-
5CDS-intronENST00000368349ENST00000529370RUSC1chr1

155300903

+TYK2chr19

10491352

-
5CDS-intronENST00000368349ENST00000529422RUSC1chr1

155300903

+TYK2chr19

10491352

-
5CDS-intronENST00000292254ENST00000264818RUSC1chr1

155300903

+TYK2chr19

10491352

-
5CDS-intronENST00000292254ENST00000524462RUSC1chr1

155300903

+TYK2chr19

10491352

-
5CDS-intronENST00000292254ENST00000525621RUSC1chr1

155300903

+TYK2chr19

10491352

-
5CDS-intronENST00000292254ENST00000529370RUSC1chr1

155300903

+TYK2chr19

10491352

-
5CDS-intronENST00000292254ENST00000529422RUSC1chr1

155300903

+TYK2chr19

10491352

-

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FusionProtFeatures for RUSC1_TYK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RUSC1

Q9BVN2

TYK2

P29597

Putative signaling adapter which may play a role inneuronal differentiation. May be involved in regulation of NGF-dependent neurite outgrowth. Proposed to play a role in neuronalvesicular trafficking, specifically involving pre-synapticmembrane proteins. Seems to be involved in signaling pathways thatare regulated by the prolonged activation of MAPK. Can regulatethe polyubiquitination of IKBKG and thus may be involved inregulation of the NF-kappa-B pathway.{ECO:0000269|PubMed:19365808}. Probably involved in intracellular signal transductionby being involved in the initiation of type I IFN signaling.Phosphorylates the interferon-alpha/beta receptor alpha chain.{ECO:0000269|PubMed:7526154}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RUSC1_TYK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RUSC1_TYK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RUSC1IKBKG, TRAF6, APP, PNMA1, STUB1, RBPMS, WWP2, FAM9B, DVL2, HNRNPH2, UBE2S, FAM83HTYK2GNB2L1, STAT1, PRMT5, XRCC5, VAV1, IFNAR1, CRKL, JAK1, TYK2, ELP2, IL13RA1, LYN, CBL, PTPN6, PLAUR, IL6ST, FYN, PTPN1, STAM2, GHR, IRS2, DNM2, TK1, SOCS1, KLF10, LNX1, PTAFR, EIF2AK2, HSP90AA1, JAK3, COPS5, FHL3, HNRNPK, TRAF4, KRT40, KHDRBS2, SIVA1, SHMT2, MOV10, NXF1, BAG2, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8, DDX5, HNRNPH1, HSPB1, CEP170B, RAN, RUVBL1, RUVBL2, SLC2A1, TCP1, ALYREF, TRIM28, TUBA4A, WDR20, EFNB2, PIH1D1, TGFBR2, LRRC46, LPAR6, RNF13, ZNF333, MIER2, SIAH2, UBE2L6, LRP8, IFT43, PMEL, TNFRSF19, GMNN, IL4R, TMCO3, GPR156, CDH8, CD79A, TNFRSF13B, HAVCR2, PROSER2, LGALS3BP, C16orf71, MAS1, NLGN3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RUSC1_TYK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneTYK2P29597DB08895TofacitinibNon-receptor tyrosine-protein kinase TYK2small moleculeapproved|investigational

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RelatedDiseases for RUSC1_TYK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTYK2C0003873Rheumatoid Arthritis1CTD_human
TgeneTYK2C0010346Crohn Disease1CTD_human
TgeneTYK2C0023892Biliary cirrhosis1CTD_human
TgeneTYK2C0026769Multiple Sclerosis1CTD_human
TgeneTYK2C0033860Psoriasis1CTD_human
TgeneTYK2C0041696Unipolar Depression1PSYGENET
TgeneTYK2C0236736Cocaine-Related Disorders1CTD_human
TgeneTYK2C0344315Depressed mood1PSYGENET
TgeneTYK2C1269683Major Depressive Disorder1PSYGENET
TgeneTYK2C1456784Paranoia1CTD_human