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Fusion gene ID: 32420 |
FusionGeneSummary for RUSC1_MT1X |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RUSC1_MT1X | Fusion gene ID: 32420 | Hgene | Tgene | Gene symbol | RUSC1 | MT1X | Gene ID | 23623 | 4501 |
| Gene name | RUN and SH3 domain containing 1 | metallothionein 1X | |
| Synonyms | NESCA | MT-1l|MT1 | |
| Cytomap | 1q22 | 16q13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RUN and SH3 domain-containing protein 1new molecule containing SH3 at the carboxy-terminus | metallothionein-1XMT-1XMT-IXmetallothionein-IXtesticular tissue protein Li 124 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9BVN2 | P80297 | |
| Ensembl transtripts involved in fusion gene | ENST00000368354, ENST00000368352, ENST00000368347, ENST00000462780, ENST00000368349, ENST00000292254, | ENST00000394485, ENST00000562939, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 1=4 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: RUSC1 [Title/Abstract] AND MT1X [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RUSC1 | GO:0000209 | protein polyubiquitination | 19365808 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF752844 | RUSC1 | chr1 | 155296463 | + | MT1X | chr16 | 56717870 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000368354 | ENST00000394485 | RUSC1 | chr1 | 155296463 | + | MT1X | chr16 | 56717870 | + |
| intron-intron | ENST00000368354 | ENST00000562939 | RUSC1 | chr1 | 155296463 | + | MT1X | chr16 | 56717870 | + |
| Frame-shift | ENST00000368352 | ENST00000394485 | RUSC1 | chr1 | 155296463 | + | MT1X | chr16 | 56717870 | + |
| 5CDS-intron | ENST00000368352 | ENST00000562939 | RUSC1 | chr1 | 155296463 | + | MT1X | chr16 | 56717870 | + |
| Frame-shift | ENST00000368347 | ENST00000394485 | RUSC1 | chr1 | 155296463 | + | MT1X | chr16 | 56717870 | + |
| 5CDS-intron | ENST00000368347 | ENST00000562939 | RUSC1 | chr1 | 155296463 | + | MT1X | chr16 | 56717870 | + |
| 3UTR-3CDS | ENST00000462780 | ENST00000394485 | RUSC1 | chr1 | 155296463 | + | MT1X | chr16 | 56717870 | + |
| 3UTR-intron | ENST00000462780 | ENST00000562939 | RUSC1 | chr1 | 155296463 | + | MT1X | chr16 | 56717870 | + |
| Frame-shift | ENST00000368349 | ENST00000394485 | RUSC1 | chr1 | 155296463 | + | MT1X | chr16 | 56717870 | + |
| 5CDS-intron | ENST00000368349 | ENST00000562939 | RUSC1 | chr1 | 155296463 | + | MT1X | chr16 | 56717870 | + |
| Frame-shift | ENST00000292254 | ENST00000394485 | RUSC1 | chr1 | 155296463 | + | MT1X | chr16 | 56717870 | + |
| 5CDS-intron | ENST00000292254 | ENST00000562939 | RUSC1 | chr1 | 155296463 | + | MT1X | chr16 | 56717870 | + |
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FusionProtFeatures for RUSC1_MT1X |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RUSC1 | MT1X |
| Putative signaling adapter which may play a role inneuronal differentiation. May be involved in regulation of NGF-dependent neurite outgrowth. Proposed to play a role in neuronalvesicular trafficking, specifically involving pre-synapticmembrane proteins. Seems to be involved in signaling pathways thatare regulated by the prolonged activation of MAPK. Can regulatethe polyubiquitination of IKBKG and thus may be involved inregulation of the NF-kappa-B pathway.{ECO:0000269|PubMed:19365808}. | Metallothioneins have a high content of cysteineresidues that bind various heavy metals; these proteins aretranscriptionally regulated by both heavy metals andglucocorticoids. May be involved in FAM168A anti-apoptoticsignaling (PubMed:23251525). {ECO:0000269|PubMed:23251525}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RUSC1_MT1X |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RUSC1_MT1X |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RUSC1_MT1X |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RUSC1_MT1X |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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