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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32420

FusionGeneSummary for RUSC1_MT1X

check button Fusion gene summary
Fusion gene informationFusion gene name: RUSC1_MT1X
Fusion gene ID: 32420
HgeneTgene
Gene symbol

RUSC1

MT1X

Gene ID

23623

4501

Gene nameRUN and SH3 domain containing 1metallothionein 1X
SynonymsNESCAMT-1l|MT1
Cytomap

1q22

16q13

Type of geneprotein-codingprotein-coding
DescriptionRUN and SH3 domain-containing protein 1new molecule containing SH3 at the carboxy-terminusmetallothionein-1XMT-1XMT-IXmetallothionein-IXtesticular tissue protein Li 124
Modification date2018051920180523
UniProtAcc

Q9BVN2

P80297

Ensembl transtripts involved in fusion geneENST00000368354, ENST00000368352, 
ENST00000368347, ENST00000462780, 
ENST00000368349, ENST00000292254, 
ENST00000394485, ENST00000562939, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 1=4
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: RUSC1 [Title/Abstract] AND MT1X [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRUSC1

GO:0000209

protein polyubiquitination

19365808


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF752844RUSC1chr1

155296463

+MT1Xchr16

56717870

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000368354ENST00000394485RUSC1chr1

155296463

+MT1Xchr16

56717870

+
intron-intronENST00000368354ENST00000562939RUSC1chr1

155296463

+MT1Xchr16

56717870

+
Frame-shitENST00000368352ENST00000394485RUSC1chr1

155296463

+MT1Xchr16

56717870

+
5CDS-intronENST00000368352ENST00000562939RUSC1chr1

155296463

+MT1Xchr16

56717870

+
Frame-shitENST00000368347ENST00000394485RUSC1chr1

155296463

+MT1Xchr16

56717870

+
5CDS-intronENST00000368347ENST00000562939RUSC1chr1

155296463

+MT1Xchr16

56717870

+
3UTR-3CDSENST00000462780ENST00000394485RUSC1chr1

155296463

+MT1Xchr16

56717870

+
3UTR-intronENST00000462780ENST00000562939RUSC1chr1

155296463

+MT1Xchr16

56717870

+
Frame-shitENST00000368349ENST00000394485RUSC1chr1

155296463

+MT1Xchr16

56717870

+
5CDS-intronENST00000368349ENST00000562939RUSC1chr1

155296463

+MT1Xchr16

56717870

+
Frame-shitENST00000292254ENST00000394485RUSC1chr1

155296463

+MT1Xchr16

56717870

+
5CDS-intronENST00000292254ENST00000562939RUSC1chr1

155296463

+MT1Xchr16

56717870

+

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FusionProtFeatures for RUSC1_MT1X


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RUSC1

Q9BVN2

MT1X

P80297

Putative signaling adapter which may play a role inneuronal differentiation. May be involved in regulation of NGF-dependent neurite outgrowth. Proposed to play a role in neuronalvesicular trafficking, specifically involving pre-synapticmembrane proteins. Seems to be involved in signaling pathways thatare regulated by the prolonged activation of MAPK. Can regulatethe polyubiquitination of IKBKG and thus may be involved inregulation of the NF-kappa-B pathway.{ECO:0000269|PubMed:19365808}. Metallothioneins have a high content of cysteineresidues that bind various heavy metals; these proteins aretranscriptionally regulated by both heavy metals andglucocorticoids. May be involved in FAM168A anti-apoptoticsignaling (PubMed:23251525). {ECO:0000269|PubMed:23251525}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RUSC1_MT1X


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RUSC1_MT1X


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RUSC1_MT1X


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RUSC1_MT1X


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource