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Fusion gene ID: 32404 |
FusionGeneSummary for RUNX1_PROS1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RUNX1_PROS1 | Fusion gene ID: 32404 | Hgene | Tgene | Gene symbol | RUNX1 | PROS1 | Gene ID | 861 | 5627 |
| Gene name | runt related transcription factor 1 | protein S | |
| Synonyms | AML1|AML1-EVI-1|AMLCR1|CBF2alpha|CBFA2|EVI-1|PEBP2aB|PEBP2alpha | PROS|PS21|PS22|PS23|PS24|PS25|PSA|THPH5|THPH6 | |
| Cytomap | 21q22.12 | 3q11.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | runt-related transcription factor 1AML1-EVI-1 fusion proteinPEA2-alpha BPEBP2-alpha BSL3-3 enhancer factor 1 alpha B subunitSL3/AKV core-binding factor alpha B subunitacute myeloid leukemia 1 proteincore-binding factor, runt domain, alpha subunit 2 | vitamin K-dependent protein Sprotein S (alpha)protein Savitamin K-dependent plasma protein S | |
| Modification date | 20180527 | 20180522 | |
| UniProtAcc | Q01196 | P07225 | |
| Ensembl transtripts involved in fusion gene | ENST00000344691, ENST00000325074, ENST00000437180, ENST00000300305, ENST00000399240, ENST00000486278, ENST00000494829, ENST00000358356, | ENST00000394236, ENST00000407433, | |
| Fusion gene scores | * DoF score | 23 X 25 X 7=4025 | 3 X 2 X 3=18 |
| # samples | 53 | 3 | |
| ** MAII score | log2(53/4025*10)=-2.92492451843878 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: RUNX1 [Title/Abstract] AND PROS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RUNX1 | GO:0030097 | hemopoiesis | 21873977 |
| Hgene | RUNX1 | GO:0045893 | positive regulation of transcription, DNA-templated | 10207087|14970218 |
| Hgene | RUNX1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9199349|10207087|14970218|21873977 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | COAD | TCGA-A6-6654-01A | RUNX1 | chr21 | 36206707 | - | PROS1 | chr3 | 93646251 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000344691 | ENST00000394236 | RUNX1 | chr21 | 36206707 | - | PROS1 | chr3 | 93646251 | - |
| 5CDS-5UTR | ENST00000344691 | ENST00000407433 | RUNX1 | chr21 | 36206707 | - | PROS1 | chr3 | 93646251 | - |
| In-frame | ENST00000325074 | ENST00000394236 | RUNX1 | chr21 | 36206707 | - | PROS1 | chr3 | 93646251 | - |
| 5CDS-5UTR | ENST00000325074 | ENST00000407433 | RUNX1 | chr21 | 36206707 | - | PROS1 | chr3 | 93646251 | - |
| Frame-shit | ENST00000437180 | ENST00000394236 | RUNX1 | chr21 | 36206707 | - | PROS1 | chr3 | 93646251 | - |
| 5CDS-5UTR | ENST00000437180 | ENST00000407433 | RUNX1 | chr21 | 36206707 | - | PROS1 | chr3 | 93646251 | - |
| In-frame | ENST00000300305 | ENST00000394236 | RUNX1 | chr21 | 36206707 | - | PROS1 | chr3 | 93646251 | - |
| 5CDS-5UTR | ENST00000300305 | ENST00000407433 | RUNX1 | chr21 | 36206707 | - | PROS1 | chr3 | 93646251 | - |
| intron-3CDS | ENST00000399240 | ENST00000394236 | RUNX1 | chr21 | 36206707 | - | PROS1 | chr3 | 93646251 | - |
| intron-5UTR | ENST00000399240 | ENST00000407433 | RUNX1 | chr21 | 36206707 | - | PROS1 | chr3 | 93646251 | - |
| intron-3CDS | ENST00000486278 | ENST00000394236 | RUNX1 | chr21 | 36206707 | - | PROS1 | chr3 | 93646251 | - |
| intron-5UTR | ENST00000486278 | ENST00000407433 | RUNX1 | chr21 | 36206707 | - | PROS1 | chr3 | 93646251 | - |
| intron-3CDS | ENST00000494829 | ENST00000394236 | RUNX1 | chr21 | 36206707 | - | PROS1 | chr3 | 93646251 | - |
| intron-5UTR | ENST00000494829 | ENST00000407433 | RUNX1 | chr21 | 36206707 | - | PROS1 | chr3 | 93646251 | - |
| In-frame | ENST00000358356 | ENST00000394236 | RUNX1 | chr21 | 36206707 | - | PROS1 | chr3 | 93646251 | - |
| 5CDS-5UTR | ENST00000358356 | ENST00000407433 | RUNX1 | chr21 | 36206707 | - | PROS1 | chr3 | 93646251 | - |
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FusionProtFeatures for RUNX1_PROS1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RUNX1 | PROS1 |
| Anticoagulant plasma protein; it is a cofactor toactivated protein C in the degradation of coagulation factors Vaand VIIIa. It helps to prevent coagulation and stimulatingfibrinolysis. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000300305 | - | 6 | 8 | 50_178 | 268 | 481 | Domain | Runt |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000325074 | - | 5 | 7 | 50_178 | 256 | 469 | Domain | Runt |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000344691 | - | 4 | 6 | 50_178 | 241 | 454 | Domain | Runt |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000358356 | - | 4 | 5 | 50_178 | 241 | 251 | Domain | Runt |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000437180 | - | 7 | 9 | 50_178 | 268 | 481 | Domain | Runt |
| Tgene | >PROS1 | chr21:36206707 | chr3:93646251 | ENST00000394236 | - | 0 | 15 | 117_155 | 25 | 677 | Domain | EGF-like 1 |
| Tgene | >PROS1 | chr21:36206707 | chr3:93646251 | ENST00000394236 | - | 0 | 15 | 157_200 | 25 | 677 | Domain | EGF-like 2%3B calcium-binding |
| Tgene | >PROS1 | chr21:36206707 | chr3:93646251 | ENST00000394236 | - | 0 | 15 | 201_242 | 25 | 677 | Domain | EGF-like 3%3B calcium-binding |
| Tgene | >PROS1 | chr21:36206707 | chr3:93646251 | ENST00000394236 | - | 0 | 15 | 243_283 | 25 | 677 | Domain | EGF-like 4%3B calcium-binding |
| Tgene | >PROS1 | chr21:36206707 | chr3:93646251 | ENST00000394236 | - | 0 | 15 | 299_475 | 25 | 677 | Domain | Laminin G-like 1 |
| Tgene | >PROS1 | chr21:36206707 | chr3:93646251 | ENST00000394236 | - | 0 | 15 | 42_87 | 25 | 677 | Domain | Gla |
| Tgene | >PROS1 | chr21:36206707 | chr3:93646251 | ENST00000394236 | - | 0 | 15 | 484_666 | 25 | 677 | Domain | Laminin G-like 2 |
| Tgene | >PROS1 | chr21:36206707 | chr3:93646251 | ENST00000394236 | - | 0 | 15 | 88_116 | 25 | 677 | Region | Note=Thrombin-sensitive |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000300305 | - | 6 | 8 | 187_453 | 268 | 481 | Compositional bias | Note=Pro/Ser/Thr-rich |
| Hgene | >RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000325074 | - | 5 | 7 | 187_453 | 256 | 469 | Compositional bias | Note=Pro/Ser/Thr-rich |
| Hgene | >RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000344691 | - | 4 | 6 | 187_453 | 241 | 454 | Compositional bias | Note=Pro/Ser/Thr-rich |
| Hgene | >RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000358356 | - | 4 | 5 | 187_453 | 241 | 251 | Compositional bias | Note=Pro/Ser/Thr-rich |
| Hgene | >RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000437180 | - | 7 | 9 | 187_453 | 268 | 481 | Compositional bias | Note=Pro/Ser/Thr-rich |
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FusionGeneSequence for RUNX1_PROS1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RUNX1_ENST00000344691_chr21_36206707_-_PROS1_ENST00000394236_chr3_93646251_-_893aa MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFK VVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHR QKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQVLSKQQASQVLVRKRRANSLLEETKQGNL ERECIEELCNKEEAREVFENDPETDTFTPKYLVCLRSFQTGLFTAARQSTNATPDLRSCVNAIPDQCSPLPCNEDGTMSCKDGKASFTCT CKPGWQGEKCEFDINECKDPSNINGGCSQICDNTPGSYHCSCKNGFVMLSNKKDCKDVDECSLKPSICGTAVCKNIPGDFECECPEGYRT NLKSKSCEDIDECSENMCAQLCVNYPGGYTCTCDGKKGFKLAQDQKSCEVVSVCLPLNLDTKTELLYLAEQFAGVVLTLKFRLPEISRFS AEFDFRTTDSEGVILYAESIDHSAWLLIALRGGKIEVQLKNEHTSKITTGGDVINNGLWNMVSVEELEHSISIKIAKEAVMDINKPGPLF KPENGLLETKVYFAGFPRKVESELIKPINPRLDGCIRSWNLMKQGASGIKEIIQEKQNKHCLVTVEKGSYTPGSGIAQFHIDTNNVSSAE GWHVNVTLNIRPSTGTGVMLALVSGNNTVPFAVSLVDSTSEKSQDILLSVENTVITRIQALSLCSDQQSHLEFRVNRNNLELSTPLKIET >In-frame_RUNX1_ENST00000325074_chr21_36206707_-_PROS1_ENST00000394236_chr3_93646251_-_908aa MPAAPRGPAQGEAAARTRSRDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVL PTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRA IKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQVLSKQQASQVLVRK RRANSLLEETKQGNLERECIEELCNKEEAREVFENDPETDTFTPKYLVCLRSFQTGLFTAARQSTNATPDLRSCVNAIPDQCSPLPCNED GTMSCKDGKASFTCTCKPGWQGEKCEFDINECKDPSNINGGCSQICDNTPGSYHCSCKNGFVMLSNKKDCKDVDECSLKPSICGTAVCKN IPGDFECECPEGYRTNLKSKSCEDIDECSENMCAQLCVNYPGGYTCTCDGKKGFKLAQDQKSCEVVSVCLPLNLDTKTELLYLAEQFAGV VLTLKFRLPEISRFSAEFDFRTTDSEGVILYAESIDHSAWLLIALRGGKIEVQLKNEHTSKITTGGDVINNGLWNMVSVEELEHSISIKI AKEAVMDINKPGPLFKPENGLLETKVYFAGFPRKVESELIKPINPRLDGCIRSWNLMKQGASGIKEIIQEKQNKHCLVTVEKGSYTPGSG IAQFHIDTNNVSSAEGWHVNVTLNIRPSTGTGVMLALVSGNNTVPFAVSLVDSTSEKSQDILLSVENTVITRIQALSLCSDQQSHLEFRV NRNNLELSTPLKIETISHEDLQRQLAVLDKAMKAKVATYLGGLPDVPFSATPVNAFTNGCMEVNINGVQLDLDEAISKHNDIRAHSCPSV >In-frame_RUNX1_ENST00000300305_chr21_36206707_-_PROS1_ENST00000394236_chr3_93646251_-_920aa MASDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELV RTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVF TNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQVL SKQQASQVLVRKRRANSLLEETKQGNLERECIEELCNKEEAREVFENDPETDTFTPKYLVCLRSFQTGLFTAARQSTNATPDLRSCVNAI PDQCSPLPCNEDGTMSCKDGKASFTCTCKPGWQGEKCEFDINECKDPSNINGGCSQICDNTPGSYHCSCKNGFVMLSNKKDCKDVDECSL KPSICGTAVCKNIPGDFECECPEGYRTNLKSKSCEDIDECSENMCAQLCVNYPGGYTCTCDGKKGFKLAQDQKSCEVVSVCLPLNLDTKT ELLYLAEQFAGVVLTLKFRLPEISRFSAEFDFRTTDSEGVILYAESIDHSAWLLIALRGGKIEVQLKNEHTSKITTGGDVINNGLWNMVS VEELEHSISIKIAKEAVMDINKPGPLFKPENGLLETKVYFAGFPRKVESELIKPINPRLDGCIRSWNLMKQGASGIKEIIQEKQNKHCLV TVEKGSYTPGSGIAQFHIDTNNVSSAEGWHVNVTLNIRPSTGTGVMLALVSGNNTVPFAVSLVDSTSEKSQDILLSVENTVITRIQALSL CSDQQSHLEFRVNRNNLELSTPLKIETISHEDLQRQLAVLDKAMKAKVATYLGGLPDVPFSATPVNAFTNGCMEVNINGVQLDLDEAISK >In-frame_RUNX1_ENST00000358356_chr21_36206707_-_PROS1_ENST00000394236_chr3_93646251_-_893aa MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFK VVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHR QKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQVLSKQQASQVLVRKRRANSLLEETKQGNL ERECIEELCNKEEAREVFENDPETDTFTPKYLVCLRSFQTGLFTAARQSTNATPDLRSCVNAIPDQCSPLPCNEDGTMSCKDGKASFTCT CKPGWQGEKCEFDINECKDPSNINGGCSQICDNTPGSYHCSCKNGFVMLSNKKDCKDVDECSLKPSICGTAVCKNIPGDFECECPEGYRT NLKSKSCEDIDECSENMCAQLCVNYPGGYTCTCDGKKGFKLAQDQKSCEVVSVCLPLNLDTKTELLYLAEQFAGVVLTLKFRLPEISRFS AEFDFRTTDSEGVILYAESIDHSAWLLIALRGGKIEVQLKNEHTSKITTGGDVINNGLWNMVSVEELEHSISIKIAKEAVMDINKPGPLF KPENGLLETKVYFAGFPRKVESELIKPINPRLDGCIRSWNLMKQGASGIKEIIQEKQNKHCLVTVEKGSYTPGSGIAQFHIDTNNVSSAE GWHVNVTLNIRPSTGTGVMLALVSGNNTVPFAVSLVDSTSEKSQDILLSVENTVITRIQALSLCSDQQSHLEFRVNRNNLELSTPLKIET |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RUNX1_ENST00000344691_chr21_36206707_-_PROS1_ENST00000394236_chr3_93646251_-_2679nt ATGCGTATCCCCGTAGATGCCAGCACGAGCCGCCGCTTCACGCCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCG CTGGGCGCCCCGGACGCCGGCGCTGCCCTGGCCGGCAAGCTGAGGAGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGC GAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTGCTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAG GTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACTGTGATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCT ACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTCAGGTTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATC ACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGAGCCATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAAGACATCGG CAGAAACTAGATGATCAGACCAAGCCCGGGAGCTTGTCCTTTTCCGAGCGGCTCAGTGAACTGGAGCAGCTGCGGCGCACAGCCATGAGG GTCAGCCCACACCACCCAGCCCCCACGCCCAACCCTCGTGCCTCCCTGAACCACTCCACTGCCTTTAACCCTCAGCCTCAGAGTCAGATG CAGGTTTTGTCAAAGCAACAGGCTTCACAAGTCCTGGTTAGGAAGCGTCGTGCAAATTCTTTACTTGAAGAAACCAAACAGGGTAATCTT GAAAGAGAATGCATCGAAGAACTGTGCAATAAAGAAGAAGCCAGGGAGGTCTTTGAAAATGACCCGGAAACGGATTATTTTTATCCAAAA TACTTAGTTTGTCTTCGCTCTTTTCAAACTGGGTTATTCACTGCTGCACGTCAGTCAACTAATGCTTATCCTGACCTAAGAAGCTGTGTC AATGCCATTCCAGACCAGTGTAGTCCTCTGCCATGCAATGAAGATGGATATATGAGCTGCAAAGATGGAAAAGCTTCTTTTACTTGCACT TGTAAACCAGGTTGGCAAGGAGAAAAGTGTGAATTTGACATAAATGAATGCAAAGATCCCTCAAATATAAATGGAGGTTGCAGTCAAATT TGTGATAATACACCTGGAAGTTACCACTGTTCCTGTAAAAATGGTTTTGTTATGCTTTCAAATAAGAAAGATTGTAAAGATGTGGATGAA TGCTCTTTGAAGCCAAGCATTTGTGGCACAGCTGTGTGCAAGAACATCCCAGGAGATTTTGAATGTGAATGCCCCGAAGGCTACAGATAT AATCTCAAATCAAAGTCTTGTGAAGATATAGATGAATGCTCTGAGAACATGTGTGCTCAGCTTTGTGTCAATTACCCTGGAGGTTACACT TGCTATTGTGATGGGAAGAAAGGATTCAAACTTGCCCAAGATCAGAAGAGTTGTGAGGTTGTTTCAGTGTGCCTTCCCTTGAACCTTGAC ACAAAGTATGAATTACTTTACTTGGCGGAGCAGTTTGCAGGGGTTGTTTTATATTTAAAATTTCGTTTGCCAGAAATCAGCAGATTTTCA GCAGAATTTGATTTCCGGACATATGATTCAGAAGGCGTGATACTGTACGCAGAATCTATCGATCACTCAGCGTGGCTCCTGATTGCACTT CGTGGTGGAAAGATTGAAGTTCAGCTTAAGAATGAACATACATCCAAAATCACAACTGGAGGTGATGTTATTAATAATGGTCTATGGAAT ATGGTGTCTGTGGAAGAATTAGAACATAGTATTAGCATTAAAATAGCTAAAGAAGCTGTGATGGATATAAATAAACCTGGACCCCTTTTT AAGCCGGAAAATGGATTGCTGGAAACCAAAGTATACTTTGCAGGATTCCCTCGGAAAGTGGAAAGTGAACTCATTAAACCGATTAACCCT CGTCTAGATGGATGTATACGAAGCTGGAATTTGATGAAGCAAGGAGCTTCTGGAATAAAGGAAATTATTCAAGAAAAACAAAATAAGCAT TGCCTGGTTACTGTGGAGAAGGGCTCCTACTATCCTGGTTCTGGAATTGCTCAATTTCACATAGATTATAATAATGTATCCAGTGCTGAG GGTTGGCATGTAAATGTGACCTTGAATATTCGTCCATCCACGGGCACTGGTGTTATGCTTGCCTTGGTTTCTGGTAACAACACAGTGCCC TTTGCTGTGTCCTTGGTGGACTCCACCTCTGAAAAATCACAGGATATTCTGTTATCTGTTGAAAATACTGTAATATATCGGATACAGGCC CTAAGTCTATGTTCCGATCAACAATCTCATCTGGAATTTAGAGTCAACAGAAACAATCTGGAGTTGTCGACACCACTTAAAATAGAAACC ATCTCCCATGAAGACCTTCAAAGACAACTTGCCGTCTTGGACAAAGCAATGAAAGCAAAAGTGGCCACATACCTGGGTGGCCTTCCAGAT GTTCCATTCAGTGCCACACCAGTGAATGCCTTTTATAATGGCTGCATGGAAGTGAATATTAATGGTGTACAGTTGGATCTGGATGAAGCC >In-frame_RUNX1_ENST00000325074_chr21_36206707_-_PROS1_ENST00000394236_chr3_93646251_-_2724nt ATGCCCGCAGCACCGCGGGGACCGGCGCAGGGGGAAGCGGCCGCCCGCACGCGAAGCCGGGATGCCAGCACGAGCCGCCGCTTCACGCCG CCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCGGCGCTGCCCTGGCCGGCAAGCTGAGG AGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTGCTG CCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACTGTG ATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTCAGG TTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGAGCC ATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAAGACATCGGCAGAAACTAGATGATCAGACCAAGCCCGGGAGCTTGTCCTTTTCC GAGCGGCTCAGTGAACTGGAGCAGCTGCGGCGCACAGCCATGAGGGTCAGCCCACACCACCCAGCCCCCACGCCCAACCCTCGTGCCTCC CTGAACCACTCCACTGCCTTTAACCCTCAGCCTCAGAGTCAGATGCAGGTTTTGTCAAAGCAACAGGCTTCACAAGTCCTGGTTAGGAAG CGTCGTGCAAATTCTTTACTTGAAGAAACCAAACAGGGTAATCTTGAAAGAGAATGCATCGAAGAACTGTGCAATAAAGAAGAAGCCAGG GAGGTCTTTGAAAATGACCCGGAAACGGATTATTTTTATCCAAAATACTTAGTTTGTCTTCGCTCTTTTCAAACTGGGTTATTCACTGCT GCACGTCAGTCAACTAATGCTTATCCTGACCTAAGAAGCTGTGTCAATGCCATTCCAGACCAGTGTAGTCCTCTGCCATGCAATGAAGAT GGATATATGAGCTGCAAAGATGGAAAAGCTTCTTTTACTTGCACTTGTAAACCAGGTTGGCAAGGAGAAAAGTGTGAATTTGACATAAAT GAATGCAAAGATCCCTCAAATATAAATGGAGGTTGCAGTCAAATTTGTGATAATACACCTGGAAGTTACCACTGTTCCTGTAAAAATGGT TTTGTTATGCTTTCAAATAAGAAAGATTGTAAAGATGTGGATGAATGCTCTTTGAAGCCAAGCATTTGTGGCACAGCTGTGTGCAAGAAC ATCCCAGGAGATTTTGAATGTGAATGCCCCGAAGGCTACAGATATAATCTCAAATCAAAGTCTTGTGAAGATATAGATGAATGCTCTGAG AACATGTGTGCTCAGCTTTGTGTCAATTACCCTGGAGGTTACACTTGCTATTGTGATGGGAAGAAAGGATTCAAACTTGCCCAAGATCAG AAGAGTTGTGAGGTTGTTTCAGTGTGCCTTCCCTTGAACCTTGACACAAAGTATGAATTACTTTACTTGGCGGAGCAGTTTGCAGGGGTT GTTTTATATTTAAAATTTCGTTTGCCAGAAATCAGCAGATTTTCAGCAGAATTTGATTTCCGGACATATGATTCAGAAGGCGTGATACTG TACGCAGAATCTATCGATCACTCAGCGTGGCTCCTGATTGCACTTCGTGGTGGAAAGATTGAAGTTCAGCTTAAGAATGAACATACATCC AAAATCACAACTGGAGGTGATGTTATTAATAATGGTCTATGGAATATGGTGTCTGTGGAAGAATTAGAACATAGTATTAGCATTAAAATA GCTAAAGAAGCTGTGATGGATATAAATAAACCTGGACCCCTTTTTAAGCCGGAAAATGGATTGCTGGAAACCAAAGTATACTTTGCAGGA TTCCCTCGGAAAGTGGAAAGTGAACTCATTAAACCGATTAACCCTCGTCTAGATGGATGTATACGAAGCTGGAATTTGATGAAGCAAGGA GCTTCTGGAATAAAGGAAATTATTCAAGAAAAACAAAATAAGCATTGCCTGGTTACTGTGGAGAAGGGCTCCTACTATCCTGGTTCTGGA ATTGCTCAATTTCACATAGATTATAATAATGTATCCAGTGCTGAGGGTTGGCATGTAAATGTGACCTTGAATATTCGTCCATCCACGGGC ACTGGTGTTATGCTTGCCTTGGTTTCTGGTAACAACACAGTGCCCTTTGCTGTGTCCTTGGTGGACTCCACCTCTGAAAAATCACAGGAT ATTCTGTTATCTGTTGAAAATACTGTAATATATCGGATACAGGCCCTAAGTCTATGTTCCGATCAACAATCTCATCTGGAATTTAGAGTC AACAGAAACAATCTGGAGTTGTCGACACCACTTAAAATAGAAACCATCTCCCATGAAGACCTTCAAAGACAACTTGCCGTCTTGGACAAA GCAATGAAAGCAAAAGTGGCCACATACCTGGGTGGCCTTCCAGATGTTCCATTCAGTGCCACACCAGTGAATGCCTTTTATAATGGCTGC ATGGAAGTGAATATTAATGGTGTACAGTTGGATCTGGATGAAGCCATTTCTAAACATAATGATATTAGAGCTCACTCATGTCCATCAGTT >In-frame_RUNX1_ENST00000300305_chr21_36206707_-_PROS1_ENST00000394236_chr3_93646251_-_2760nt ATGGCTTCAGACAGCATATTTGAGTCATTTCCTTCGTACCCACAGTGCTTCATGAGAGAATGCATACTTGGAATGAATCCTTCTAGAGAC GTCCACGATGCCAGCACGAGCCGCCGCTTCACGCCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCC CCGGACGCCGGCGCTGCCCTGGCCGGCAAGCTGAGGAGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTG CGCACCGACAGCCCCAACTTCCTCTGCTCCGTGCTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCC CTAGGGGATGTTCCAGATGGCACTCTGGTCACTGTGATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCC ATGAAGAACCAGGTTGCAAGATTTAATGACCTCAGGTTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTC ACAAACCCACCGCAAGTCGCCACCTACCACAGAGCCATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAAGACATCGGCAGAAACTA GATGATCAGACCAAGCCCGGGAGCTTGTCCTTTTCCGAGCGGCTCAGTGAACTGGAGCAGCTGCGGCGCACAGCCATGAGGGTCAGCCCA CACCACCCAGCCCCCACGCCCAACCCTCGTGCCTCCCTGAACCACTCCACTGCCTTTAACCCTCAGCCTCAGAGTCAGATGCAGGTTTTG TCAAAGCAACAGGCTTCACAAGTCCTGGTTAGGAAGCGTCGTGCAAATTCTTTACTTGAAGAAACCAAACAGGGTAATCTTGAAAGAGAA TGCATCGAAGAACTGTGCAATAAAGAAGAAGCCAGGGAGGTCTTTGAAAATGACCCGGAAACGGATTATTTTTATCCAAAATACTTAGTT TGTCTTCGCTCTTTTCAAACTGGGTTATTCACTGCTGCACGTCAGTCAACTAATGCTTATCCTGACCTAAGAAGCTGTGTCAATGCCATT CCAGACCAGTGTAGTCCTCTGCCATGCAATGAAGATGGATATATGAGCTGCAAAGATGGAAAAGCTTCTTTTACTTGCACTTGTAAACCA GGTTGGCAAGGAGAAAAGTGTGAATTTGACATAAATGAATGCAAAGATCCCTCAAATATAAATGGAGGTTGCAGTCAAATTTGTGATAAT ACACCTGGAAGTTACCACTGTTCCTGTAAAAATGGTTTTGTTATGCTTTCAAATAAGAAAGATTGTAAAGATGTGGATGAATGCTCTTTG AAGCCAAGCATTTGTGGCACAGCTGTGTGCAAGAACATCCCAGGAGATTTTGAATGTGAATGCCCCGAAGGCTACAGATATAATCTCAAA TCAAAGTCTTGTGAAGATATAGATGAATGCTCTGAGAACATGTGTGCTCAGCTTTGTGTCAATTACCCTGGAGGTTACACTTGCTATTGT GATGGGAAGAAAGGATTCAAACTTGCCCAAGATCAGAAGAGTTGTGAGGTTGTTTCAGTGTGCCTTCCCTTGAACCTTGACACAAAGTAT GAATTACTTTACTTGGCGGAGCAGTTTGCAGGGGTTGTTTTATATTTAAAATTTCGTTTGCCAGAAATCAGCAGATTTTCAGCAGAATTT GATTTCCGGACATATGATTCAGAAGGCGTGATACTGTACGCAGAATCTATCGATCACTCAGCGTGGCTCCTGATTGCACTTCGTGGTGGA AAGATTGAAGTTCAGCTTAAGAATGAACATACATCCAAAATCACAACTGGAGGTGATGTTATTAATAATGGTCTATGGAATATGGTGTCT GTGGAAGAATTAGAACATAGTATTAGCATTAAAATAGCTAAAGAAGCTGTGATGGATATAAATAAACCTGGACCCCTTTTTAAGCCGGAA AATGGATTGCTGGAAACCAAAGTATACTTTGCAGGATTCCCTCGGAAAGTGGAAAGTGAACTCATTAAACCGATTAACCCTCGTCTAGAT GGATGTATACGAAGCTGGAATTTGATGAAGCAAGGAGCTTCTGGAATAAAGGAAATTATTCAAGAAAAACAAAATAAGCATTGCCTGGTT ACTGTGGAGAAGGGCTCCTACTATCCTGGTTCTGGAATTGCTCAATTTCACATAGATTATAATAATGTATCCAGTGCTGAGGGTTGGCAT GTAAATGTGACCTTGAATATTCGTCCATCCACGGGCACTGGTGTTATGCTTGCCTTGGTTTCTGGTAACAACACAGTGCCCTTTGCTGTG TCCTTGGTGGACTCCACCTCTGAAAAATCACAGGATATTCTGTTATCTGTTGAAAATACTGTAATATATCGGATACAGGCCCTAAGTCTA TGTTCCGATCAACAATCTCATCTGGAATTTAGAGTCAACAGAAACAATCTGGAGTTGTCGACACCACTTAAAATAGAAACCATCTCCCAT GAAGACCTTCAAAGACAACTTGCCGTCTTGGACAAAGCAATGAAAGCAAAAGTGGCCACATACCTGGGTGGCCTTCCAGATGTTCCATTC AGTGCCACACCAGTGAATGCCTTTTATAATGGCTGCATGGAAGTGAATATTAATGGTGTACAGTTGGATCTGGATGAAGCCATTTCTAAA >In-frame_RUNX1_ENST00000358356_chr21_36206707_-_PROS1_ENST00000394236_chr3_93646251_-_2679nt ATGCGTATCCCCGTAGATGCCAGCACGAGCCGCCGCTTCACGCCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCG CTGGGCGCCCCGGACGCCGGCGCTGCCCTGGCCGGCAAGCTGAGGAGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGC GAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTGCTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAG GTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACTGTGATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCT ACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTCAGGTTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATC ACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGAGCCATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAAGACATCGG CAGAAACTAGATGATCAGACCAAGCCCGGGAGCTTGTCCTTTTCCGAGCGGCTCAGTGAACTGGAGCAGCTGCGGCGCACAGCCATGAGG GTCAGCCCACACCACCCAGCCCCCACGCCCAACCCTCGTGCCTCCCTGAACCACTCCACTGCCTTTAACCCTCAGCCTCAGAGTCAGATG CAGGTTTTGTCAAAGCAACAGGCTTCACAAGTCCTGGTTAGGAAGCGTCGTGCAAATTCTTTACTTGAAGAAACCAAACAGGGTAATCTT GAAAGAGAATGCATCGAAGAACTGTGCAATAAAGAAGAAGCCAGGGAGGTCTTTGAAAATGACCCGGAAACGGATTATTTTTATCCAAAA TACTTAGTTTGTCTTCGCTCTTTTCAAACTGGGTTATTCACTGCTGCACGTCAGTCAACTAATGCTTATCCTGACCTAAGAAGCTGTGTC AATGCCATTCCAGACCAGTGTAGTCCTCTGCCATGCAATGAAGATGGATATATGAGCTGCAAAGATGGAAAAGCTTCTTTTACTTGCACT TGTAAACCAGGTTGGCAAGGAGAAAAGTGTGAATTTGACATAAATGAATGCAAAGATCCCTCAAATATAAATGGAGGTTGCAGTCAAATT TGTGATAATACACCTGGAAGTTACCACTGTTCCTGTAAAAATGGTTTTGTTATGCTTTCAAATAAGAAAGATTGTAAAGATGTGGATGAA TGCTCTTTGAAGCCAAGCATTTGTGGCACAGCTGTGTGCAAGAACATCCCAGGAGATTTTGAATGTGAATGCCCCGAAGGCTACAGATAT AATCTCAAATCAAAGTCTTGTGAAGATATAGATGAATGCTCTGAGAACATGTGTGCTCAGCTTTGTGTCAATTACCCTGGAGGTTACACT TGCTATTGTGATGGGAAGAAAGGATTCAAACTTGCCCAAGATCAGAAGAGTTGTGAGGTTGTTTCAGTGTGCCTTCCCTTGAACCTTGAC ACAAAGTATGAATTACTTTACTTGGCGGAGCAGTTTGCAGGGGTTGTTTTATATTTAAAATTTCGTTTGCCAGAAATCAGCAGATTTTCA GCAGAATTTGATTTCCGGACATATGATTCAGAAGGCGTGATACTGTACGCAGAATCTATCGATCACTCAGCGTGGCTCCTGATTGCACTT CGTGGTGGAAAGATTGAAGTTCAGCTTAAGAATGAACATACATCCAAAATCACAACTGGAGGTGATGTTATTAATAATGGTCTATGGAAT ATGGTGTCTGTGGAAGAATTAGAACATAGTATTAGCATTAAAATAGCTAAAGAAGCTGTGATGGATATAAATAAACCTGGACCCCTTTTT AAGCCGGAAAATGGATTGCTGGAAACCAAAGTATACTTTGCAGGATTCCCTCGGAAAGTGGAAAGTGAACTCATTAAACCGATTAACCCT CGTCTAGATGGATGTATACGAAGCTGGAATTTGATGAAGCAAGGAGCTTCTGGAATAAAGGAAATTATTCAAGAAAAACAAAATAAGCAT TGCCTGGTTACTGTGGAGAAGGGCTCCTACTATCCTGGTTCTGGAATTGCTCAATTTCACATAGATTATAATAATGTATCCAGTGCTGAG GGTTGGCATGTAAATGTGACCTTGAATATTCGTCCATCCACGGGCACTGGTGTTATGCTTGCCTTGGTTTCTGGTAACAACACAGTGCCC TTTGCTGTGTCCTTGGTGGACTCCACCTCTGAAAAATCACAGGATATTCTGTTATCTGTTGAAAATACTGTAATATATCGGATACAGGCC CTAAGTCTATGTTCCGATCAACAATCTCATCTGGAATTTAGAGTCAACAGAAACAATCTGGAGTTGTCGACACCACTTAAAATAGAAACC ATCTCCCATGAAGACCTTCAAAGACAACTTGCCGTCTTGGACAAAGCAATGAAAGCAAAAGTGGCCACATACCTGGGTGGCCTTCCAGAT GTTCCATTCAGTGCCACACCAGTGAATGCCTTTTATAATGGCTGCATGGAAGTGAATATTAATGGTGTACAGTTGGATCTGGATGAAGCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RUNX1_ENST00000344691_chr21_36206707_-_PROS1_ENST00000394236_chr3_93646251_-_5465nt CATAGAGCCAGCGGGCGCGGGCGGGACGGGCGCCCCGCGGCCGGACCCAGCCAGGGCACCACGCTGCCCGGCCCTGCGCCGCCAGGCACT TCTTTCCGGGGCTCCTAGGGACGCCAGAAGGAAGTCAACCTCTGCTGCTTCTCCTTGGCCTGCGTTGGACCTTCCTTTTTTTGTTGTTTT TTTTTGTTTTTCCCCTTTCTTCCTTTTGAATTAACTGGCTTCTTGGCTGGATGTTTTCAACTTCTTTCCTGGCTGCGAACTTTTCCCCAA TTGTTTTCCTTTTACAACAGGGGGAGAAAGTGCTCTGTGGTCCGAGGCGAGCCGTGAAGTTGCGTGTGCGTGGCAGTGTGCGTGGCAGGA TGTGCGTGCGTGTGTAACCCGAGCCGCCCGATCTGTTTCGATCTGCGCCGCGGAGCCCTCCCTCAAGGCCCGCTCCACCTGCTGCGGTTA CGCGGCGCTCGTGGGTGTTCGTGCCTCGGAGCAGCTAACCGGCGGGTGCTGGGCGACGGTGGAGGAGTATCGTCTCGCTGCTGCCCGAGT CAGGGCTGAGTCACCCAGCTGATGTAGACAGTGGCTGCCTTCCGAAGAGTGCGTGTTTGCATGTGTGTGACTCTGCGGCTGCTCAACTCC CAACAAACCAGAGGACCAGCCACAAACTTAACCAACATCCCCAAACCCGAGTTCACAGATGTGGGAGAGCTGTAGAACCCTGAGTGTCAT CGACTGGGCCTTCTTATGATTGTTGTTTTAAGATTAGCTGAAGATCTCTGAAACGCTGAATTTTCTGCACTGAGCGTTTTGACAGAATTC ATTGAGAGAACAGAGAACATGACAAGTACTTCTAGCTCAGCACTGCTCCAACTACTGAAGCTGATTTTCAAGGCTACTTAAAAAAATCTG CAGCGTACATTAATGGATTTCTGTTGTGTTTAAATTCTCCACAGATTGTATTGTAAATATTTTATGAAGTAGAGCATATGTATATATTTA TATATACGTGCACATACATTAGTAGCACTACCTTTGGAAGTCTCAGCTCTTGCTTTTCGGGACTGAAGCCAGTTTTGCATGATAAAAGTG GCCTTGTTACGGGAGATAATTGTGTTCTGTTGGGACTTTAGACAAAACTCACCTGCAAAAAACTGACAGGCATTAACTACTGGAACTTCC AAATAATGTGTTTGCTGATCGTTTTACTCTTCGCATAAATATTTTAGGAAGTGTATGAGAATTTTGCCTTCAGGAACTTTTCTAACAGCC AAAGACAGAACTTAACCTCTGCAAGCAAGATTCGTGGAAGATAGTCTCCACTTTTTAATGCACTAAGCAATCGGTTGCTAGGAGCCCATC CTGGGTCAGAGGCCGATCCGCAGAACCAGAACGTTTTCCCCTCCTGGACTGTTAGTAACTTAGTCTCCCTCCTCCCCTAACCACCCCCGC CCCCCCCCACCCCCCGCAGTAATAAAGGCCCCTGAACGTGTATGTTGGTCTCCCGGGAGCTGCTTGCTGAAGATCCGCGCCCCTGTCGCC GTCTGGTAGGAGCTGTTTGCAGGGTCCTAACTCAATCGGCTTGTTGTGATGCGTATCCCCGTAGATGCCAGCACGAGCCGCCGCTTCACG CCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCGGCGCTGCCCTGGCCGGCAAGCTG AGGAGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTG CTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACT GTGATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTC AGGTTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGA GCCATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAAGACATCGGCAGAAACTAGATGATCAGACCAAGCCCGGGAGCTTGTCCTTT TCCGAGCGGCTCAGTGAACTGGAGCAGCTGCGGCGCACAGCCATGAGGGTCAGCCCACACCACCCAGCCCCCACGCCCAACCCTCGTGCC TCCCTGAACCACTCCACTGCCTTTAACCCTCAGCCTCAGAGTCAGATGCAGGTTTTGTCAAAGCAACAGGCTTCACAAGTCCTGGTTAGG AAGCGTCGTGCAAATTCTTTACTTGAAGAAACCAAACAGGGTAATCTTGAAAGAGAATGCATCGAAGAACTGTGCAATAAAGAAGAAGCC AGGGAGGTCTTTGAAAATGACCCGGAAACGGATTATTTTTATCCAAAATACTTAGTTTGTCTTCGCTCTTTTCAAACTGGGTTATTCACT GCTGCACGTCAGTCAACTAATGCTTATCCTGACCTAAGAAGCTGTGTCAATGCCATTCCAGACCAGTGTAGTCCTCTGCCATGCAATGAA GATGGATATATGAGCTGCAAAGATGGAAAAGCTTCTTTTACTTGCACTTGTAAACCAGGTTGGCAAGGAGAAAAGTGTGAATTTGACATA AATGAATGCAAAGATCCCTCAAATATAAATGGAGGTTGCAGTCAAATTTGTGATAATACACCTGGAAGTTACCACTGTTCCTGTAAAAAT GGTTTTGTTATGCTTTCAAATAAGAAAGATTGTAAAGATGTGGATGAATGCTCTTTGAAGCCAAGCATTTGTGGCACAGCTGTGTGCAAG AACATCCCAGGAGATTTTGAATGTGAATGCCCCGAAGGCTACAGATATAATCTCAAATCAAAGTCTTGTGAAGATATAGATGAATGCTCT GAGAACATGTGTGCTCAGCTTTGTGTCAATTACCCTGGAGGTTACACTTGCTATTGTGATGGGAAGAAAGGATTCAAACTTGCCCAAGAT CAGAAGAGTTGTGAGGTTGTTTCAGTGTGCCTTCCCTTGAACCTTGACACAAAGTATGAATTACTTTACTTGGCGGAGCAGTTTGCAGGG GTTGTTTTATATTTAAAATTTCGTTTGCCAGAAATCAGCAGATTTTCAGCAGAATTTGATTTCCGGACATATGATTCAGAAGGCGTGATA CTGTACGCAGAATCTATCGATCACTCAGCGTGGCTCCTGATTGCACTTCGTGGTGGAAAGATTGAAGTTCAGCTTAAGAATGAACATACA TCCAAAATCACAACTGGAGGTGATGTTATTAATAATGGTCTATGGAATATGGTGTCTGTGGAAGAATTAGAACATAGTATTAGCATTAAA ATAGCTAAAGAAGCTGTGATGGATATAAATAAACCTGGACCCCTTTTTAAGCCGGAAAATGGATTGCTGGAAACCAAAGTATACTTTGCA GGATTCCCTCGGAAAGTGGAAAGTGAACTCATTAAACCGATTAACCCTCGTCTAGATGGATGTATACGAAGCTGGAATTTGATGAAGCAA GGAGCTTCTGGAATAAAGGAAATTATTCAAGAAAAACAAAATAAGCATTGCCTGGTTACTGTGGAGAAGGGCTCCTACTATCCTGGTTCT GGAATTGCTCAATTTCACATAGATTATAATAATGTATCCAGTGCTGAGGGTTGGCATGTAAATGTGACCTTGAATATTCGTCCATCCACG GGCACTGGTGTTATGCTTGCCTTGGTTTCTGGTAACAACACAGTGCCCTTTGCTGTGTCCTTGGTGGACTCCACCTCTGAAAAATCACAG GATATTCTGTTATCTGTTGAAAATACTGTAATATATCGGATACAGGCCCTAAGTCTATGTTCCGATCAACAATCTCATCTGGAATTTAGA GTCAACAGAAACAATCTGGAGTTGTCGACACCACTTAAAATAGAAACCATCTCCCATGAAGACCTTCAAAGACAACTTGCCGTCTTGGAC AAAGCAATGAAAGCAAAAGTGGCCACATACCTGGGTGGCCTTCCAGATGTTCCATTCAGTGCCACACCAGTGAATGCCTTTTATAATGGC TGCATGGAAGTGAATATTAATGGTGTACAGTTGGATCTGGATGAAGCCATTTCTAAACATAATGATATTAGAGCTCACTCATGTCCATCA GTTTGGAAAAAGACAAAGAATTCTTAAGGCATCTTTTCTCTGCTTATAATACCTTTTCCTTGTGTGTAATTATACTTATGTTTCAATAAC AGCTGAAGGGTTTTATTTACAATGTGCAGTCTTTGATTATTTTGTGGTCCTTTCCTGGGATTTTTAAAAGGTCCTTTGTCAAGGAAAAAA ATTCTGTTGTGATATAAATCACAGTAAAGAAATTCTTACTTCTCTTGCTATCTAAGAATAGTGAAAAATAACAATTTTAAATTTGAATTT TTTTCCTACAAATGACAGTTTCAATTTTTGTTTGTAAAACTAAATTTTAATTTTATCATCATGAACTAGTGTCTAAATACCTATGTTTTT TTCAGAAAGCAAGGAAGTAAACTCAAACAAAAGTGCGTGTAATTAAATACTATTAATCATAGGCAGATACTATTTTGTTTATGTTTTTGT TTTTTTCCTGATGAAGGCAGAAGAGATGGTGGTCTATTAAATATGAATTGAATGGAGGGTCCTAATGCCTTATTTCAAAACAATTCCTCA GGGGGAACAGCTTTGGCTTCATCTTTCTCTTGTGTGGCTTCACATTTAAACCAGTATCTTTATTGAATTAGAAAACAAGTGGGACATATT TTCCTGAGAGCAGCACAGGAATCTTCTTCTTGGCAGCTGCAGTCTGTCAGGATGAGATATCAGATTAGGTTGGATAGGTGGGGAAATCTG AAGTGGGTACATTTTTTAAATTTTGCTGTGTGGGTCACACAAGGTCTACATTACAAAAGACAGAATTCAGGGATGGAAAGGAGAATGAAC AAATGTGGGAGTTCATAGTTTTCCTTGAATCCAACTTTTAATTACCAGAGTAAGTTGCCAAAATGTGATTGTTGAAGTACAAAAGGAACT ATGAAAACCAGAACAAATTTTAACAAAAGGACAACCACAGAGGGATATAGTGAATATCGTATCATTGTAATCAAAGAAGTAAGGAGGTAA GATTGCCACGTGCCTGCTGGTACTGTGATGCATTTCAAGTGGCAGTTTTATCACGTTTGAATCTACCATTCATAGCCAGATGTGTATCAG ATGTTTCACTGACAGTTTTTAACAATAAATTCTTTTCACTGTATTTTATATCACTTATAATAAATCGGTGTATAATTTTAAAATGCATGT >In-frame_RUNX1_ENST00000325074_chr21_36206707_-_PROS1_ENST00000394236_chr3_93646251_-_3932nt ATGCCCGCAGCACCGCGGGGACCGGCGCAGGGGGAAGCGGCCGCCCGCACGCGAAGCCGGGATGCCAGCACGAGCCGCCGCTTCACGCCG CCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCGGCGCTGCCCTGGCCGGCAAGCTGAGG AGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTGCTG CCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACTGTG ATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTCAGG TTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGAGCC ATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAAGACATCGGCAGAAACTAGATGATCAGACCAAGCCCGGGAGCTTGTCCTTTTCC GAGCGGCTCAGTGAACTGGAGCAGCTGCGGCGCACAGCCATGAGGGTCAGCCCACACCACCCAGCCCCCACGCCCAACCCTCGTGCCTCC CTGAACCACTCCACTGCCTTTAACCCTCAGCCTCAGAGTCAGATGCAGGTTTTGTCAAAGCAACAGGCTTCACAAGTCCTGGTTAGGAAG CGTCGTGCAAATTCTTTACTTGAAGAAACCAAACAGGGTAATCTTGAAAGAGAATGCATCGAAGAACTGTGCAATAAAGAAGAAGCCAGG GAGGTCTTTGAAAATGACCCGGAAACGGATTATTTTTATCCAAAATACTTAGTTTGTCTTCGCTCTTTTCAAACTGGGTTATTCACTGCT GCACGTCAGTCAACTAATGCTTATCCTGACCTAAGAAGCTGTGTCAATGCCATTCCAGACCAGTGTAGTCCTCTGCCATGCAATGAAGAT GGATATATGAGCTGCAAAGATGGAAAAGCTTCTTTTACTTGCACTTGTAAACCAGGTTGGCAAGGAGAAAAGTGTGAATTTGACATAAAT GAATGCAAAGATCCCTCAAATATAAATGGAGGTTGCAGTCAAATTTGTGATAATACACCTGGAAGTTACCACTGTTCCTGTAAAAATGGT TTTGTTATGCTTTCAAATAAGAAAGATTGTAAAGATGTGGATGAATGCTCTTTGAAGCCAAGCATTTGTGGCACAGCTGTGTGCAAGAAC ATCCCAGGAGATTTTGAATGTGAATGCCCCGAAGGCTACAGATATAATCTCAAATCAAAGTCTTGTGAAGATATAGATGAATGCTCTGAG AACATGTGTGCTCAGCTTTGTGTCAATTACCCTGGAGGTTACACTTGCTATTGTGATGGGAAGAAAGGATTCAAACTTGCCCAAGATCAG AAGAGTTGTGAGGTTGTTTCAGTGTGCCTTCCCTTGAACCTTGACACAAAGTATGAATTACTTTACTTGGCGGAGCAGTTTGCAGGGGTT GTTTTATATTTAAAATTTCGTTTGCCAGAAATCAGCAGATTTTCAGCAGAATTTGATTTCCGGACATATGATTCAGAAGGCGTGATACTG TACGCAGAATCTATCGATCACTCAGCGTGGCTCCTGATTGCACTTCGTGGTGGAAAGATTGAAGTTCAGCTTAAGAATGAACATACATCC AAAATCACAACTGGAGGTGATGTTATTAATAATGGTCTATGGAATATGGTGTCTGTGGAAGAATTAGAACATAGTATTAGCATTAAAATA GCTAAAGAAGCTGTGATGGATATAAATAAACCTGGACCCCTTTTTAAGCCGGAAAATGGATTGCTGGAAACCAAAGTATACTTTGCAGGA TTCCCTCGGAAAGTGGAAAGTGAACTCATTAAACCGATTAACCCTCGTCTAGATGGATGTATACGAAGCTGGAATTTGATGAAGCAAGGA GCTTCTGGAATAAAGGAAATTATTCAAGAAAAACAAAATAAGCATTGCCTGGTTACTGTGGAGAAGGGCTCCTACTATCCTGGTTCTGGA ATTGCTCAATTTCACATAGATTATAATAATGTATCCAGTGCTGAGGGTTGGCATGTAAATGTGACCTTGAATATTCGTCCATCCACGGGC ACTGGTGTTATGCTTGCCTTGGTTTCTGGTAACAACACAGTGCCCTTTGCTGTGTCCTTGGTGGACTCCACCTCTGAAAAATCACAGGAT ATTCTGTTATCTGTTGAAAATACTGTAATATATCGGATACAGGCCCTAAGTCTATGTTCCGATCAACAATCTCATCTGGAATTTAGAGTC AACAGAAACAATCTGGAGTTGTCGACACCACTTAAAATAGAAACCATCTCCCATGAAGACCTTCAAAGACAACTTGCCGTCTTGGACAAA GCAATGAAAGCAAAAGTGGCCACATACCTGGGTGGCCTTCCAGATGTTCCATTCAGTGCCACACCAGTGAATGCCTTTTATAATGGCTGC ATGGAAGTGAATATTAATGGTGTACAGTTGGATCTGGATGAAGCCATTTCTAAACATAATGATATTAGAGCTCACTCATGTCCATCAGTT TGGAAAAAGACAAAGAATTCTTAAGGCATCTTTTCTCTGCTTATAATACCTTTTCCTTGTGTGTAATTATACTTATGTTTCAATAACAGC TGAAGGGTTTTATTTACAATGTGCAGTCTTTGATTATTTTGTGGTCCTTTCCTGGGATTTTTAAAAGGTCCTTTGTCAAGGAAAAAAATT CTGTTGTGATATAAATCACAGTAAAGAAATTCTTACTTCTCTTGCTATCTAAGAATAGTGAAAAATAACAATTTTAAATTTGAATTTTTT TCCTACAAATGACAGTTTCAATTTTTGTTTGTAAAACTAAATTTTAATTTTATCATCATGAACTAGTGTCTAAATACCTATGTTTTTTTC AGAAAGCAAGGAAGTAAACTCAAACAAAAGTGCGTGTAATTAAATACTATTAATCATAGGCAGATACTATTTTGTTTATGTTTTTGTTTT TTTCCTGATGAAGGCAGAAGAGATGGTGGTCTATTAAATATGAATTGAATGGAGGGTCCTAATGCCTTATTTCAAAACAATTCCTCAGGG GGAACAGCTTTGGCTTCATCTTTCTCTTGTGTGGCTTCACATTTAAACCAGTATCTTTATTGAATTAGAAAACAAGTGGGACATATTTTC CTGAGAGCAGCACAGGAATCTTCTTCTTGGCAGCTGCAGTCTGTCAGGATGAGATATCAGATTAGGTTGGATAGGTGGGGAAATCTGAAG TGGGTACATTTTTTAAATTTTGCTGTGTGGGTCACACAAGGTCTACATTACAAAAGACAGAATTCAGGGATGGAAAGGAGAATGAACAAA TGTGGGAGTTCATAGTTTTCCTTGAATCCAACTTTTAATTACCAGAGTAAGTTGCCAAAATGTGATTGTTGAAGTACAAAAGGAACTATG AAAACCAGAACAAATTTTAACAAAAGGACAACCACAGAGGGATATAGTGAATATCGTATCATTGTAATCAAAGAAGTAAGGAGGTAAGAT TGCCACGTGCCTGCTGGTACTGTGATGCATTTCAAGTGGCAGTTTTATCACGTTTGAATCTACCATTCATAGCCAGATGTGTATCAGATG TTTCACTGACAGTTTTTAACAATAAATTCTTTTCACTGTATTTTATATCACTTATAATAAATCGGTGTATAATTTTAAAATGCATGTGAA >In-frame_RUNX1_ENST00000300305_chr21_36206707_-_PROS1_ENST00000394236_chr3_93646251_-_4413nt GGAAAGGGGAACAGTTAAATTTGTAATTTGGGTTGTGTGAAAACTTCTTTGGGCCTCATAAACAACCACAGAACCACAAGTTGGGTAGCC TGGCAGTGTCAGAAGTCTGAACCCAGCATAGTGGTCAGCAGGCAGGACGAATCACACTGAATGCAAACCACAGGGTTTCGCAGCGTGGTG AGCATCACCAACCCACAGCCAAGGCGGCGCTGGCTTTTTTTTTTTTTTTAATCTTTAACAATTTGAATATTTGTTTTTACAAAGGTGCAT TTTTTAATAGGGCTTGGGGAGTCCCAGAGGTATCCAGCAGAGGGGAGAAGAAAGAGAGATGTAGGGCTAGAGGGGTGAGGCTGAAACAGT GACCTGTCTTGGTTTTCGCTCCGAAGGTAAAAGAAATCATTGAGTCCCCCGCCTTCAGAAGAGGGTGCATTTTCAGGAGGAAGCGATGGC TTCAGACAGCATATTTGAGTCATTTCCTTCGTACCCACAGTGCTTCATGAGAGAATGCATACTTGGAATGAATCCTTCTAGAGACGTCCA CGATGCCAGCACGAGCCGCCGCTTCACGCCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGA CGCCGGCGCTGCCCTGGCCGGCAAGCTGAGGAGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCAC CGACAGCCCCAACTTCCTCTGCTCCGTGCTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGG GGATGTTCCAGATGGCACTCTGGTCACTGTGATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAA GAACCAGGTTGCAAGATTTAATGACCTCAGGTTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAA CCCACCGCAAGTCGCCACCTACCACAGAGCCATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAAGACATCGGCAGAAACTAGATGA TCAGACCAAGCCCGGGAGCTTGTCCTTTTCCGAGCGGCTCAGTGAACTGGAGCAGCTGCGGCGCACAGCCATGAGGGTCAGCCCACACCA CCCAGCCCCCACGCCCAACCCTCGTGCCTCCCTGAACCACTCCACTGCCTTTAACCCTCAGCCTCAGAGTCAGATGCAGGTTTTGTCAAA GCAACAGGCTTCACAAGTCCTGGTTAGGAAGCGTCGTGCAAATTCTTTACTTGAAGAAACCAAACAGGGTAATCTTGAAAGAGAATGCAT CGAAGAACTGTGCAATAAAGAAGAAGCCAGGGAGGTCTTTGAAAATGACCCGGAAACGGATTATTTTTATCCAAAATACTTAGTTTGTCT TCGCTCTTTTCAAACTGGGTTATTCACTGCTGCACGTCAGTCAACTAATGCTTATCCTGACCTAAGAAGCTGTGTCAATGCCATTCCAGA CCAGTGTAGTCCTCTGCCATGCAATGAAGATGGATATATGAGCTGCAAAGATGGAAAAGCTTCTTTTACTTGCACTTGTAAACCAGGTTG GCAAGGAGAAAAGTGTGAATTTGACATAAATGAATGCAAAGATCCCTCAAATATAAATGGAGGTTGCAGTCAAATTTGTGATAATACACC TGGAAGTTACCACTGTTCCTGTAAAAATGGTTTTGTTATGCTTTCAAATAAGAAAGATTGTAAAGATGTGGATGAATGCTCTTTGAAGCC AAGCATTTGTGGCACAGCTGTGTGCAAGAACATCCCAGGAGATTTTGAATGTGAATGCCCCGAAGGCTACAGATATAATCTCAAATCAAA GTCTTGTGAAGATATAGATGAATGCTCTGAGAACATGTGTGCTCAGCTTTGTGTCAATTACCCTGGAGGTTACACTTGCTATTGTGATGG GAAGAAAGGATTCAAACTTGCCCAAGATCAGAAGAGTTGTGAGGTTGTTTCAGTGTGCCTTCCCTTGAACCTTGACACAAAGTATGAATT ACTTTACTTGGCGGAGCAGTTTGCAGGGGTTGTTTTATATTTAAAATTTCGTTTGCCAGAAATCAGCAGATTTTCAGCAGAATTTGATTT CCGGACATATGATTCAGAAGGCGTGATACTGTACGCAGAATCTATCGATCACTCAGCGTGGCTCCTGATTGCACTTCGTGGTGGAAAGAT TGAAGTTCAGCTTAAGAATGAACATACATCCAAAATCACAACTGGAGGTGATGTTATTAATAATGGTCTATGGAATATGGTGTCTGTGGA AGAATTAGAACATAGTATTAGCATTAAAATAGCTAAAGAAGCTGTGATGGATATAAATAAACCTGGACCCCTTTTTAAGCCGGAAAATGG ATTGCTGGAAACCAAAGTATACTTTGCAGGATTCCCTCGGAAAGTGGAAAGTGAACTCATTAAACCGATTAACCCTCGTCTAGATGGATG TATACGAAGCTGGAATTTGATGAAGCAAGGAGCTTCTGGAATAAAGGAAATTATTCAAGAAAAACAAAATAAGCATTGCCTGGTTACTGT GGAGAAGGGCTCCTACTATCCTGGTTCTGGAATTGCTCAATTTCACATAGATTATAATAATGTATCCAGTGCTGAGGGTTGGCATGTAAA TGTGACCTTGAATATTCGTCCATCCACGGGCACTGGTGTTATGCTTGCCTTGGTTTCTGGTAACAACACAGTGCCCTTTGCTGTGTCCTT GGTGGACTCCACCTCTGAAAAATCACAGGATATTCTGTTATCTGTTGAAAATACTGTAATATATCGGATACAGGCCCTAAGTCTATGTTC CGATCAACAATCTCATCTGGAATTTAGAGTCAACAGAAACAATCTGGAGTTGTCGACACCACTTAAAATAGAAACCATCTCCCATGAAGA CCTTCAAAGACAACTTGCCGTCTTGGACAAAGCAATGAAAGCAAAAGTGGCCACATACCTGGGTGGCCTTCCAGATGTTCCATTCAGTGC CACACCAGTGAATGCCTTTTATAATGGCTGCATGGAAGTGAATATTAATGGTGTACAGTTGGATCTGGATGAAGCCATTTCTAAACATAA TGATATTAGAGCTCACTCATGTCCATCAGTTTGGAAAAAGACAAAGAATTCTTAAGGCATCTTTTCTCTGCTTATAATACCTTTTCCTTG TGTGTAATTATACTTATGTTTCAATAACAGCTGAAGGGTTTTATTTACAATGTGCAGTCTTTGATTATTTTGTGGTCCTTTCCTGGGATT TTTAAAAGGTCCTTTGTCAAGGAAAAAAATTCTGTTGTGATATAAATCACAGTAAAGAAATTCTTACTTCTCTTGCTATCTAAGAATAGT GAAAAATAACAATTTTAAATTTGAATTTTTTTCCTACAAATGACAGTTTCAATTTTTGTTTGTAAAACTAAATTTTAATTTTATCATCAT GAACTAGTGTCTAAATACCTATGTTTTTTTCAGAAAGCAAGGAAGTAAACTCAAACAAAAGTGCGTGTAATTAAATACTATTAATCATAG GCAGATACTATTTTGTTTATGTTTTTGTTTTTTTCCTGATGAAGGCAGAAGAGATGGTGGTCTATTAAATATGAATTGAATGGAGGGTCC TAATGCCTTATTTCAAAACAATTCCTCAGGGGGAACAGCTTTGGCTTCATCTTTCTCTTGTGTGGCTTCACATTTAAACCAGTATCTTTA TTGAATTAGAAAACAAGTGGGACATATTTTCCTGAGAGCAGCACAGGAATCTTCTTCTTGGCAGCTGCAGTCTGTCAGGATGAGATATCA GATTAGGTTGGATAGGTGGGGAAATCTGAAGTGGGTACATTTTTTAAATTTTGCTGTGTGGGTCACACAAGGTCTACATTACAAAAGACA GAATTCAGGGATGGAAAGGAGAATGAACAAATGTGGGAGTTCATAGTTTTCCTTGAATCCAACTTTTAATTACCAGAGTAAGTTGCCAAA ATGTGATTGTTGAAGTACAAAAGGAACTATGAAAACCAGAACAAATTTTAACAAAAGGACAACCACAGAGGGATATAGTGAATATCGTAT CATTGTAATCAAAGAAGTAAGGAGGTAAGATTGCCACGTGCCTGCTGGTACTGTGATGCATTTCAAGTGGCAGTTTTATCACGTTTGAAT CTACCATTCATAGCCAGATGTGTATCAGATGTTTCACTGACAGTTTTTAACAATAAATTCTTTTCACTGTATTTTATATCACTTATAATA AATCGGTGTATAATTTTAAAATGCATGTGAATATCTTTATTATATCAACTGTTTGAATAAAACAAAATTACATAATAGACATTTAACTCT >In-frame_RUNX1_ENST00000358356_chr21_36206707_-_PROS1_ENST00000394236_chr3_93646251_-_5465nt CATAGAGCCAGCGGGCGCGGGCGGGACGGGCGCCCCGCGGCCGGACCCAGCCAGGGCACCACGCTGCCCGGCCCTGCGCCGCCAGGCACT TCTTTCCGGGGCTCCTAGGGACGCCAGAAGGAAGTCAACCTCTGCTGCTTCTCCTTGGCCTGCGTTGGACCTTCCTTTTTTTGTTGTTTT TTTTTGTTTTTCCCCTTTCTTCCTTTTGAATTAACTGGCTTCTTGGCTGGATGTTTTCAACTTCTTTCCTGGCTGCGAACTTTTCCCCAA TTGTTTTCCTTTTACAACAGGGGGAGAAAGTGCTCTGTGGTCCGAGGCGAGCCGTGAAGTTGCGTGTGCGTGGCAGTGTGCGTGGCAGGA TGTGCGTGCGTGTGTAACCCGAGCCGCCCGATCTGTTTCGATCTGCGCCGCGGAGCCCTCCCTCAAGGCCCGCTCCACCTGCTGCGGTTA CGCGGCGCTCGTGGGTGTTCGTGCCTCGGAGCAGCTAACCGGCGGGTGCTGGGCGACGGTGGAGGAGTATCGTCTCGCTGCTGCCCGAGT CAGGGCTGAGTCACCCAGCTGATGTAGACAGTGGCTGCCTTCCGAAGAGTGCGTGTTTGCATGTGTGTGACTCTGCGGCTGCTCAACTCC CAACAAACCAGAGGACCAGCCACAAACTTAACCAACATCCCCAAACCCGAGTTCACAGATGTGGGAGAGCTGTAGAACCCTGAGTGTCAT CGACTGGGCCTTCTTATGATTGTTGTTTTAAGATTAGCTGAAGATCTCTGAAACGCTGAATTTTCTGCACTGAGCGTTTTGACAGAATTC ATTGAGAGAACAGAGAACATGACAAGTACTTCTAGCTCAGCACTGCTCCAACTACTGAAGCTGATTTTCAAGGCTACTTAAAAAAATCTG CAGCGTACATTAATGGATTTCTGTTGTGTTTAAATTCTCCACAGATTGTATTGTAAATATTTTATGAAGTAGAGCATATGTATATATTTA TATATACGTGCACATACATTAGTAGCACTACCTTTGGAAGTCTCAGCTCTTGCTTTTCGGGACTGAAGCCAGTTTTGCATGATAAAAGTG GCCTTGTTACGGGAGATAATTGTGTTCTGTTGGGACTTTAGACAAAACTCACCTGCAAAAAACTGACAGGCATTAACTACTGGAACTTCC AAATAATGTGTTTGCTGATCGTTTTACTCTTCGCATAAATATTTTAGGAAGTGTATGAGAATTTTGCCTTCAGGAACTTTTCTAACAGCC AAAGACAGAACTTAACCTCTGCAAGCAAGATTCGTGGAAGATAGTCTCCACTTTTTAATGCACTAAGCAATCGGTTGCTAGGAGCCCATC CTGGGTCAGAGGCCGATCCGCAGAACCAGAACGTTTTCCCCTCCTGGACTGTTAGTAACTTAGTCTCCCTCCTCCCCTAACCACCCCCGC CCCCCCCCACCCCCCGCAGTAATAAAGGCCCCTGAACGTGTATGTTGGTCTCCCGGGAGCTGCTTGCTGAAGATCCGCGCCCCTGTCGCC GTCTGGTAGGAGCTGTTTGCAGGGTCCTAACTCAATCGGCTTGTTGTGATGCGTATCCCCGTAGATGCCAGCACGAGCCGCCGCTTCACG CCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCGGCGCTGCCCTGGCCGGCAAGCTG AGGAGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTG CTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACT GTGATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTC AGGTTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGA GCCATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAAGACATCGGCAGAAACTAGATGATCAGACCAAGCCCGGGAGCTTGTCCTTT TCCGAGCGGCTCAGTGAACTGGAGCAGCTGCGGCGCACAGCCATGAGGGTCAGCCCACACCACCCAGCCCCCACGCCCAACCCTCGTGCC TCCCTGAACCACTCCACTGCCTTTAACCCTCAGCCTCAGAGTCAGATGCAGGTTTTGTCAAAGCAACAGGCTTCACAAGTCCTGGTTAGG AAGCGTCGTGCAAATTCTTTACTTGAAGAAACCAAACAGGGTAATCTTGAAAGAGAATGCATCGAAGAACTGTGCAATAAAGAAGAAGCC AGGGAGGTCTTTGAAAATGACCCGGAAACGGATTATTTTTATCCAAAATACTTAGTTTGTCTTCGCTCTTTTCAAACTGGGTTATTCACT GCTGCACGTCAGTCAACTAATGCTTATCCTGACCTAAGAAGCTGTGTCAATGCCATTCCAGACCAGTGTAGTCCTCTGCCATGCAATGAA GATGGATATATGAGCTGCAAAGATGGAAAAGCTTCTTTTACTTGCACTTGTAAACCAGGTTGGCAAGGAGAAAAGTGTGAATTTGACATA AATGAATGCAAAGATCCCTCAAATATAAATGGAGGTTGCAGTCAAATTTGTGATAATACACCTGGAAGTTACCACTGTTCCTGTAAAAAT GGTTTTGTTATGCTTTCAAATAAGAAAGATTGTAAAGATGTGGATGAATGCTCTTTGAAGCCAAGCATTTGTGGCACAGCTGTGTGCAAG AACATCCCAGGAGATTTTGAATGTGAATGCCCCGAAGGCTACAGATATAATCTCAAATCAAAGTCTTGTGAAGATATAGATGAATGCTCT GAGAACATGTGTGCTCAGCTTTGTGTCAATTACCCTGGAGGTTACACTTGCTATTGTGATGGGAAGAAAGGATTCAAACTTGCCCAAGAT CAGAAGAGTTGTGAGGTTGTTTCAGTGTGCCTTCCCTTGAACCTTGACACAAAGTATGAATTACTTTACTTGGCGGAGCAGTTTGCAGGG GTTGTTTTATATTTAAAATTTCGTTTGCCAGAAATCAGCAGATTTTCAGCAGAATTTGATTTCCGGACATATGATTCAGAAGGCGTGATA CTGTACGCAGAATCTATCGATCACTCAGCGTGGCTCCTGATTGCACTTCGTGGTGGAAAGATTGAAGTTCAGCTTAAGAATGAACATACA TCCAAAATCACAACTGGAGGTGATGTTATTAATAATGGTCTATGGAATATGGTGTCTGTGGAAGAATTAGAACATAGTATTAGCATTAAA ATAGCTAAAGAAGCTGTGATGGATATAAATAAACCTGGACCCCTTTTTAAGCCGGAAAATGGATTGCTGGAAACCAAAGTATACTTTGCA GGATTCCCTCGGAAAGTGGAAAGTGAACTCATTAAACCGATTAACCCTCGTCTAGATGGATGTATACGAAGCTGGAATTTGATGAAGCAA GGAGCTTCTGGAATAAAGGAAATTATTCAAGAAAAACAAAATAAGCATTGCCTGGTTACTGTGGAGAAGGGCTCCTACTATCCTGGTTCT GGAATTGCTCAATTTCACATAGATTATAATAATGTATCCAGTGCTGAGGGTTGGCATGTAAATGTGACCTTGAATATTCGTCCATCCACG GGCACTGGTGTTATGCTTGCCTTGGTTTCTGGTAACAACACAGTGCCCTTTGCTGTGTCCTTGGTGGACTCCACCTCTGAAAAATCACAG GATATTCTGTTATCTGTTGAAAATACTGTAATATATCGGATACAGGCCCTAAGTCTATGTTCCGATCAACAATCTCATCTGGAATTTAGA GTCAACAGAAACAATCTGGAGTTGTCGACACCACTTAAAATAGAAACCATCTCCCATGAAGACCTTCAAAGACAACTTGCCGTCTTGGAC AAAGCAATGAAAGCAAAAGTGGCCACATACCTGGGTGGCCTTCCAGATGTTCCATTCAGTGCCACACCAGTGAATGCCTTTTATAATGGC TGCATGGAAGTGAATATTAATGGTGTACAGTTGGATCTGGATGAAGCCATTTCTAAACATAATGATATTAGAGCTCACTCATGTCCATCA GTTTGGAAAAAGACAAAGAATTCTTAAGGCATCTTTTCTCTGCTTATAATACCTTTTCCTTGTGTGTAATTATACTTATGTTTCAATAAC AGCTGAAGGGTTTTATTTACAATGTGCAGTCTTTGATTATTTTGTGGTCCTTTCCTGGGATTTTTAAAAGGTCCTTTGTCAAGGAAAAAA ATTCTGTTGTGATATAAATCACAGTAAAGAAATTCTTACTTCTCTTGCTATCTAAGAATAGTGAAAAATAACAATTTTAAATTTGAATTT TTTTCCTACAAATGACAGTTTCAATTTTTGTTTGTAAAACTAAATTTTAATTTTATCATCATGAACTAGTGTCTAAATACCTATGTTTTT TTCAGAAAGCAAGGAAGTAAACTCAAACAAAAGTGCGTGTAATTAAATACTATTAATCATAGGCAGATACTATTTTGTTTATGTTTTTGT TTTTTTCCTGATGAAGGCAGAAGAGATGGTGGTCTATTAAATATGAATTGAATGGAGGGTCCTAATGCCTTATTTCAAAACAATTCCTCA GGGGGAACAGCTTTGGCTTCATCTTTCTCTTGTGTGGCTTCACATTTAAACCAGTATCTTTATTGAATTAGAAAACAAGTGGGACATATT TTCCTGAGAGCAGCACAGGAATCTTCTTCTTGGCAGCTGCAGTCTGTCAGGATGAGATATCAGATTAGGTTGGATAGGTGGGGAAATCTG AAGTGGGTACATTTTTTAAATTTTGCTGTGTGGGTCACACAAGGTCTACATTACAAAAGACAGAATTCAGGGATGGAAAGGAGAATGAAC AAATGTGGGAGTTCATAGTTTTCCTTGAATCCAACTTTTAATTACCAGAGTAAGTTGCCAAAATGTGATTGTTGAAGTACAAAAGGAACT ATGAAAACCAGAACAAATTTTAACAAAAGGACAACCACAGAGGGATATAGTGAATATCGTATCATTGTAATCAAAGAAGTAAGGAGGTAA GATTGCCACGTGCCTGCTGGTACTGTGATGCATTTCAAGTGGCAGTTTTATCACGTTTGAATCTACCATTCATAGCCAGATGTGTATCAG ATGTTTCACTGACAGTTTTTAACAATAAATTCTTTTCACTGTATTTTATATCACTTATAATAAATCGGTGTATAATTTTAAAATGCATGT |
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FusionGenePPI for RUNX1_PROS1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RUNX1 | SUV39H1, KAT6B, CBFB, AES, PAX5, YAP1, JUN, FOS, SMAD3, SMAD1, SMAD2, SMAD5, VDR, ELF4, ELF2, CEBPB, TLE1, CBFA2T2, TRAF6, FHL2, MYOD1, HIPK2, EP300, HDAC1, HDAC3, KAT6A, TCF12, TCF3, RUNX1T1, NCOR1, SIAH1, UBE2L6, RUNX1, PML, RARA, HDAC2, SIN3A, NR4A2, TRIM33, STUB1, SMARCA4, SMARCB1, SMARCC1, CDK1, TAL1, COPRS, KMT2A, RBM14, SPEN, DNMT1, ELAVL1, CBFA2T3, PRMT1, HLA-DMA, CREBBP, UXT, CTBP2, NOTCH1, MYC, NCOR2, FOXP3, SOX2, CTBP1, HDAC11, RAG1, SPI1, ELF1, CDK6, KLF6, NFATC1, NFATC2, ZNF131, BRCA1, CDK9, FANCD2 | PROS1 | F8, F5, NPM1, RPSA, TBK1, FBXO6, C4BPB, ZPBP2, LYZL2, TCTN2, PROC, BMP4 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000300305 | - | 6 | 8 | 135_143 | 268 | 481 | DNA |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000300305 | - | 6 | 8 | 168_177 | 268 | 481 | DNA |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000300305 | - | 6 | 8 | 80_84 | 268 | 481 | DNA |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000325074 | - | 5 | 7 | 135_143 | 256 | 469 | DNA |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000325074 | - | 5 | 7 | 168_177 | 256 | 469 | DNA |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000325074 | - | 5 | 7 | 80_84 | 256 | 469 | DNA |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000344691 | - | 4 | 6 | 135_143 | 241 | 454 | DNA |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000344691 | - | 4 | 6 | 168_177 | 241 | 454 | DNA |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000344691 | - | 4 | 6 | 80_84 | 241 | 454 | DNA |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000358356 | - | 4 | 5 | 135_143 | 241 | 251 | DNA |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000358356 | - | 4 | 5 | 168_177 | 241 | 251 | DNA |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000358356 | - | 4 | 5 | 80_84 | 241 | 251 | DNA |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000437180 | - | 7 | 9 | 135_143 | 268 | 481 | DNA |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000437180 | - | 7 | 9 | 168_177 | 268 | 481 | DNA |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000437180 | - | 7 | 9 | 80_84 | 268 | 481 | DNA |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000300305 | - | 6 | 8 | 362_402 | 268 | 481 | FOXP3 |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000325074 | - | 5 | 7 | 362_402 | 256 | 469 | FOXP3 |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000344691 | - | 4 | 6 | 362_402 | 241 | 454 | FOXP3 |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000358356 | - | 4 | 5 | 362_402 | 241 | 251 | FOXP3 |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000437180 | - | 7 | 9 | 362_402 | 268 | 481 | FOXP3 |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000300305 | - | 6 | 8 | 291_371 | 268 | 481 | KAT6A |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000325074 | - | 5 | 7 | 291_371 | 256 | 469 | KAT6A |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000344691 | - | 4 | 6 | 291_371 | 241 | 454 | KAT6A |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000358356 | - | 4 | 5 | 291_371 | 241 | 251 | KAT6A |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000437180 | - | 7 | 9 | 291_371 | 268 | 481 | KAT6A |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000300305 | - | 6 | 8 | 307_400 | 268 | 481 | KAT6B |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000325074 | - | 5 | 7 | 307_400 | 256 | 469 | KAT6B |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000344691 | - | 4 | 6 | 307_400 | 241 | 454 | KAT6B |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000358356 | - | 4 | 5 | 307_400 | 241 | 251 | KAT6B |
| Hgene | RUNX1 | chr21:36206707 | chr3:93646251 | ENST00000437180 | - | 7 | 9 | 307_400 | 268 | 481 | KAT6B |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RUNX1_PROS1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | PROS1 | P07225 | DB00464 | Sodium Tetradecyl Sulfate | Vitamin K-dependent protein S | small molecule | approved|investigational |
| Tgene | PROS1 | P07225 | DB00055 | Drotrecogin alfa | Vitamin K-dependent protein S | biotech | approved|investigational|withdrawn |
| Tgene | PROS1 | P07225 | DB00170 | Menadione | Vitamin K-dependent protein S | small molecule | approved|nutraceutical |
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RelatedDiseases for RUNX1_PROS1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RUNX1 | C0023467 | Leukemia, Myelocytic, Acute | 2 | CTD_human;HPO |
| Hgene | RUNX1 | C0023485 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 2 | CTD_human |
| Hgene | RUNX1 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| Hgene | RUNX1 | C0017636 | Glioblastoma | 1 | CTD_human |
| Hgene | RUNX1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | RUNX1 | C0349639 | Juvenile Myelomonocytic Leukemia | 1 | CTD_human |
| Hgene | RUNX1 | C1832388 | Platelet Disorder, Familial, with Associated Myeloid Malignancy | 1 | CTD_human;ORPHANET;UNIPROT |
| Hgene | RUNX1 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
| Tgene | PROS1 | C3278211 | THROMBOPHILIA DUE TO PROTEIN S DEFICIENCY, AUTOSOMAL DOMINANT | 26 | CTD_human;UNIPROT |
| Tgene | PROS1 | C0035222 | Respiratory Distress Syndrome, Adult | 1 | CTD_human |
| Tgene | PROS1 | C0040038 | Thromboembolism | 1 | CTD_human |
| Tgene | PROS1 | C0040053 | Thrombosis | 1 | CTD_human |
| Tgene | PROS1 | C0338575 | Sagittal Sinus Thrombosis | 1 | CTD_human |
| Tgene | PROS1 | C0600433 | Activated Protein C Resistance | 1 | CTD_human |
| Tgene | PROS1 | C3281092 | THROMBOPHILIA DUE TO PROTEIN S DEFICIENCY, AUTOSOMAL RECESSIVE | 1 | UNIPROT |
| Tgene | PROS1 | C3495559 | Juvenile arthritis | 1 | CTD_human |
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