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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32394

FusionGeneSummary for RUNX1_CBFA2T2

check button Fusion gene summary
Fusion gene informationFusion gene name: RUNX1_CBFA2T2
Fusion gene ID: 32394
HgeneTgene
Gene symbol

RUNX1

CBFA2T2

Gene ID

861

9139

Gene namerunt related transcription factor 1CBFA2/RUNX1 translocation partner 2
SynonymsAML1|AML1-EVI-1|AMLCR1|CBF2alpha|CBFA2|EVI-1|PEBP2aB|PEBP2alphaEHT|MTGR1|ZMYND3|p85
Cytomap

21q22.12

20q11.21-q11.22

Type of geneprotein-codingprotein-coding
Descriptionrunt-related transcription factor 1AML1-EVI-1 fusion proteinPEA2-alpha BPEBP2-alpha BSL3-3 enhancer factor 1 alpha B subunitSL3/AKV core-binding factor alpha B subunitacute myeloid leukemia 1 proteincore-binding factor, runt domain, alpha subunit 2protein CBFA2T2ETO homolog on chromosome 20ETO homologous on chromosome 20MTG8-like proteinMTG8-related protein 1core-binding factor, runt domain, alpha subunit 2; translocated to, 2myeloid translocation gene-related protein 1myeloid translocation-
Modification date2018052720180523
UniProtAcc

Q01196

O43439

Ensembl transtripts involved in fusion geneENST00000344691, ENST00000325074, 
ENST00000437180, ENST00000300305, 
ENST00000399240, ENST00000486278, 
ENST00000494829, ENST00000358356, 
ENST00000342704, ENST00000375279, 
ENST00000344201, ENST00000397798, 
ENST00000346541, ENST00000397800, 
ENST00000492345, ENST00000359606, 
ENST00000491618, ENST00000543126, 
Fusion gene scores* DoF score23 X 25 X 7=402511 X 10 X 8=880
# samples 5315
** MAII scorelog2(53/4025*10)=-2.92492451843878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/880*10)=-2.55254102302878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RUNX1 [Title/Abstract] AND CBFA2T2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Transcription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRUNX1

GO:0030097

hemopoiesis

21873977

HgeneRUNX1

GO:0045893

positive regulation of transcription, DNA-templated

10207087|14970218

HgeneRUNX1

GO:0045944

positive regulation of transcription by RNA polymerase II

9199349|10207087|14970218|21873977

TgeneCBFA2T2

GO:0010976

positive regulation of neuron projection development

19026687

TgeneCBFA2T2

GO:0045892

negative regulation of transcription, DNA-templated

23251453


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1GU070940RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
ChiTaRS3.1GU086368RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000344691ENST00000342704RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
In-frameENST00000344691ENST00000375279RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000344691ENST00000344201RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000344691ENST00000397798RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000344691ENST00000346541RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000344691ENST00000397800RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000344691ENST00000492345RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000344691ENST00000359606RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000344691ENST00000491618RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000344691ENST00000543126RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
In-frameENST00000325074ENST00000342704RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
In-frameENST00000325074ENST00000375279RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000325074ENST00000344201RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000325074ENST00000397798RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000325074ENST00000346541RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000325074ENST00000397800RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000325074ENST00000492345RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000325074ENST00000359606RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000325074ENST00000491618RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000325074ENST00000543126RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
Frame-shitENST00000437180ENST00000342704RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
Frame-shitENST00000437180ENST00000375279RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000437180ENST00000344201RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000437180ENST00000397798RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000437180ENST00000346541RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000437180ENST00000397800RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000437180ENST00000492345RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000437180ENST00000359606RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000437180ENST00000491618RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000437180ENST00000543126RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
In-frameENST00000300305ENST00000342704RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
In-frameENST00000300305ENST00000375279RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000300305ENST00000344201RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000300305ENST00000397798RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000300305ENST00000346541RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000300305ENST00000397800RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000300305ENST00000492345RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000300305ENST00000359606RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000300305ENST00000491618RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000300305ENST00000543126RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
In-frameENST00000399240ENST00000342704RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
In-frameENST00000399240ENST00000375279RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000399240ENST00000344201RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000399240ENST00000397798RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000399240ENST00000346541RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000399240ENST00000397800RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000399240ENST00000492345RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000399240ENST00000359606RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000399240ENST00000491618RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000399240ENST00000543126RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
In-frameENST00000486278ENST00000342704RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
In-frameENST00000486278ENST00000375279RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000486278ENST00000344201RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000486278ENST00000397798RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000486278ENST00000346541RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000486278ENST00000397800RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000486278ENST00000492345RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000486278ENST00000359606RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000486278ENST00000491618RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000486278ENST00000543126RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
intron-3CDSENST00000494829ENST00000342704RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
intron-3CDSENST00000494829ENST00000375279RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
intron-5UTRENST00000494829ENST00000344201RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
intron-5UTRENST00000494829ENST00000397798RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
intron-5UTRENST00000494829ENST00000346541RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
intron-5UTRENST00000494829ENST00000397800RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
intron-5UTRENST00000494829ENST00000492345RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
intron-5UTRENST00000494829ENST00000359606RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
intron-intronENST00000494829ENST00000491618RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
intron-intronENST00000494829ENST00000543126RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
In-frameENST00000358356ENST00000342704RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
In-frameENST00000358356ENST00000375279RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000358356ENST00000344201RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000358356ENST00000397798RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000358356ENST00000346541RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000358356ENST00000397800RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000358356ENST00000492345RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-5UTRENST00000358356ENST00000359606RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000358356ENST00000491618RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000358356ENST00000543126RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
5CDS-intronENST00000344691ENST00000342704RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-5UTRENST00000344691ENST00000375279RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000344691ENST00000344201RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-5UTRENST00000344691ENST00000397798RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-5UTRENST00000344691ENST00000346541RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000344691ENST00000397800RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-5UTRENST00000344691ENST00000492345RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000344691ENST00000359606RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000344691ENST00000491618RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000344691ENST00000543126RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000325074ENST00000342704RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-5UTRENST00000325074ENST00000375279RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000325074ENST00000344201RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-5UTRENST00000325074ENST00000397798RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-5UTRENST00000325074ENST00000346541RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000325074ENST00000397800RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-5UTRENST00000325074ENST00000492345RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000325074ENST00000359606RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000325074ENST00000491618RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000325074ENST00000543126RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000437180ENST00000342704RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-5UTRENST00000437180ENST00000375279RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000437180ENST00000344201RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-5UTRENST00000437180ENST00000397798RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-5UTRENST00000437180ENST00000346541RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000437180ENST00000397800RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-5UTRENST00000437180ENST00000492345RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000437180ENST00000359606RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000437180ENST00000491618RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000437180ENST00000543126RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000300305ENST00000342704RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-5UTRENST00000300305ENST00000375279RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000300305ENST00000344201RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-5UTRENST00000300305ENST00000397798RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-5UTRENST00000300305ENST00000346541RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000300305ENST00000397800RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-5UTRENST00000300305ENST00000492345RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000300305ENST00000359606RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000300305ENST00000491618RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000300305ENST00000543126RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-intronENST00000399240ENST00000342704RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000399240ENST00000375279RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-intronENST00000399240ENST00000344201RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000399240ENST00000397798RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000399240ENST00000346541RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-intronENST00000399240ENST00000397800RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000399240ENST00000492345RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-intronENST00000399240ENST00000359606RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-intronENST00000399240ENST00000491618RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-intronENST00000399240ENST00000543126RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-intronENST00000486278ENST00000342704RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000486278ENST00000375279RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-intronENST00000486278ENST00000344201RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000486278ENST00000397798RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000486278ENST00000346541RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-intronENST00000486278ENST00000397800RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000486278ENST00000492345RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-intronENST00000486278ENST00000359606RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-intronENST00000486278ENST00000491618RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-intronENST00000486278ENST00000543126RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-intronENST00000494829ENST00000342704RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000494829ENST00000375279RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-intronENST00000494829ENST00000344201RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000494829ENST00000397798RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000494829ENST00000346541RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-intronENST00000494829ENST00000397800RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-5UTRENST00000494829ENST00000492345RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-intronENST00000494829ENST00000359606RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-intronENST00000494829ENST00000491618RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
intron-intronENST00000494829ENST00000543126RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000358356ENST00000342704RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-5UTRENST00000358356ENST00000375279RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000358356ENST00000344201RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-5UTRENST00000358356ENST00000397798RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-5UTRENST00000358356ENST00000346541RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000358356ENST00000397800RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-5UTRENST00000358356ENST00000492345RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000358356ENST00000359606RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000358356ENST00000491618RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+
5CDS-intronENST00000358356ENST00000543126RUNX1chr21

36206707

-CBFA2T2chr20

32161779

+

Top

FusionProtFeatures for RUNX1_CBFA2T2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RUNX1

Q01196

CBFA2T2

O43439


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRUNX1chr21:36231771chr20:32194762ENST00000300305-5850_178204481DomainRunt
HgeneRUNX1chr21:36231771chr20:32194762ENST00000325074-4750_178192469DomainRunt
HgeneRUNX1chr21:36231771chr20:32194762ENST00000344691-3650_178177454DomainRunt
HgeneRUNX1chr21:36231771chr20:32194762ENST00000358356-3550_178177251DomainRunt
HgeneRUNX1chr21:36231771chr20:32194762ENST00000437180-6950_178204481DomainRunt
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000342704+011451_49111596Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000344201+06451_491-9264Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000346541+112451_49120605Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000359606+011451_49130615Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000375279+112451_49120605Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000397798+17451_491-9264Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000397800+011451_491-9576Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000492345+213451_491-9576Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000342704+01133_9711596Compositional biasNote=Pro-rich
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000344201+0633_97-9264Compositional biasNote=Pro-rich
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000346541+11233_9720605Compositional biasNote=Pro-rich
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000359606+01133_9730615Compositional biasNote=Pro-rich
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000375279+11233_9720605Compositional biasNote=Pro-rich
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000397798+1733_97-9264Compositional biasNote=Pro-rich
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000397800+01133_97-9576Compositional biasNote=Pro-rich
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000492345+21333_97-9576Compositional biasNote=Pro-rich
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000342704+011113_20811596DomainTAFH
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000344201+06113_208-9264DomainTAFH
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000346541+112113_20820605DomainTAFH
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000359606+011113_20830615DomainTAFH
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000375279+112113_20820605DomainTAFH
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000397798+17113_208-9264DomainTAFH
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000397800+011113_208-9576DomainTAFH
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000492345+213113_208-9576DomainTAFH
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000342704+011331_37711596RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000342704+011435_48411596RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000344201+06331_377-9264RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000344201+06435_484-9264RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000346541+112331_37720605RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000346541+112435_48420605RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000359606+011331_37730615RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000359606+011435_48430615RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000375279+112331_37720605RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000375279+112435_48420605RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000397798+17331_377-9264RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000397798+17435_484-9264RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000397800+011331_377-9576RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000397800+011435_484-9576RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000492345+213331_377-9576RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000492345+213435_484-9576RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000342704+011517_55311596Zinc fingerMYND-type
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000344201+06517_553-9264Zinc fingerMYND-type
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000346541+112517_55320605Zinc fingerMYND-type
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000359606+011517_55330615Zinc fingerMYND-type
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000375279+112517_55320605Zinc fingerMYND-type
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000397798+17517_553-9264Zinc fingerMYND-type
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000397800+011517_553-9576Zinc fingerMYND-type
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000492345+213517_553-9576Zinc fingerMYND-type

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRUNX1chr21:36231771chr20:32194762ENST00000300305-58187_453204481Compositional biasNote=Pro/Ser/Thr-rich
HgeneRUNX1chr21:36231771chr20:32194762ENST00000325074-47187_453192469Compositional biasNote=Pro/Ser/Thr-rich
HgeneRUNX1chr21:36231771chr20:32194762ENST00000344691-36187_453177454Compositional biasNote=Pro/Ser/Thr-rich
HgeneRUNX1chr21:36231771chr20:32194762ENST00000358356-35187_453177251Compositional biasNote=Pro/Ser/Thr-rich
HgeneRUNX1chr21:36231771chr20:32194762ENST00000437180-69187_453204481Compositional biasNote=Pro/Ser/Thr-rich


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FusionGeneSequence for RUNX1_CBFA2T2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RUNX1_ENST00000486278_chr21_36231771_-_CBFA2T2_ENST00000342704_chr20_32194762_+_628aa
MASTGKRNH_VPRLQKRVHFQEEAMASDSIFESFPSYPQCFMRVGPEKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPT
ALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEE
FHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFD
RDTIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQHYTLEDIATSHLTREPNKMLEHREVRDRHHSLGLNGGTQDELVDH
RLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREELNYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSR
PGTGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASET

>In-frame_RUNX1_ENST00000486278_chr21_36231771_-_CBFA2T2_ENST00000375279_chr20_32194762_+_628aa
MASTGKRNH_VPRLQKRVHFQEEAMASDSIFESFPSYPQCFMRVGPEKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPT
ALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEE
FHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFD
RDTIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQHYTLEDIATSHLTREPNKMLEHREVRDRHHSLGLNGGTQDELVDH
RLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREELNYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSR
PGTGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASET


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RUNX1_ENST00000486278_chr21_36231771_-_CBFA2T2_ENST00000342704_chr20_32194762_+_1884nt
ATGGCGTCCACGGGTAAAAGAAATCATTGAGTCCCCCGCCTTCAGAAGAGGGTGCATTTTCAGGAGGAAGCGATGGCTTCAGACAGCATA
TTTGAGTCATTTCCTTCGTACCCACAGTGCTTCATGAGAGTTGGTCCTGAGAAAAGGGTGCCAGCGATGCCTGGATCGCCTGTGGAAGTG
AAGATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGGACCGAGGCCAGTGTCCTTCACTCCTACT
GCATTAAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACAGAGATTCAGCAATGGTCCTGCCTCCTCC
ACATCATCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAAGTTGAAACGCTTTCTTACCACTCTGCAA
CAGTTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACTGGTGAACTCAACAGTGACAATTGAGGAA
TTCCACTGTAAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCTCAAGGCCAACCTGCCCCTGCTGCAGCGG
GAACTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGAACACCTTCTGCTCAACACAAGCATTGCA
TCGCCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCCAGAGAGGAGAGAAGAGAATAGTTTTGAT
AGAGACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCGGCACAGTCCTGCTCTCACTGTGCCCCTC
ATGAATCCCGGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGATATTGCAACTTCTCACCTGTATCGGGAA
CCCAACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGGAGGCTATCAAGATGAGTTGGTAGATCAT
CGTTTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCATTATGGAAATGGTAGAGAAAACAAGGCGC
TCTATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAGACGGTACAATGAAAACACAGAGCTGAGG
AAAACGGGGACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAATGATTCTCAGAGAGAGTTCAACAGCAGG
CCAGGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGTGAAAATTCAGGCCATGTCAGAAGTACAG
AAGGCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAATGGAGCAAACCATAGCGGATGTCAAGCGG
CAGGCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTGGAACTGTGGCCGCAAAGCCAGCGAGACA
TGCAGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACCACCGCCTCTGTGGTCAGAACCTG
CATGGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGGTCCGCCGACTGCAGCGTGCCCAGC

>In-frame_RUNX1_ENST00000486278_chr21_36231771_-_CBFA2T2_ENST00000375279_chr20_32194762_+_1884nt
ATGGCGTCCACGGGTAAAAGAAATCATTGAGTCCCCCGCCTTCAGAAGAGGGTGCATTTTCAGGAGGAAGCGATGGCTTCAGACAGCATA
TTTGAGTCATTTCCTTCGTACCCACAGTGCTTCATGAGAGTTGGTCCTGAGAAAAGGGTGCCAGCGATGCCTGGATCGCCTGTGGAAGTG
AAGATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGGACCGAGGCCAGTGTCCTTCACTCCTACT
GCATTAAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACAGAGATTCAGCAATGGTCCTGCCTCCTCC
ACATCATCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAAGTTGAAACGCTTTCTTACCACTCTGCAA
CAGTTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACTGGTGAACTCAACAGTGACAATTGAGGAA
TTCCACTGTAAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCTCAAGGCCAACCTGCCCCTGCTGCAGCGG
GAACTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGAACACCTTCTGCTCAACACAAGCATTGCA
TCGCCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCCAGAGAGGAGAGAAGAGAATAGTTTTGAT
AGAGACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCGGCACAGTCCTGCTCTCACTGTGCCCCTC
ATGAATCCCGGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGATATTGCAACTTCTCACCTGTATCGGGAA
CCCAACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGGAGGCTATCAAGATGAGTTGGTAGATCAT
CGTTTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCATTATGGAAATGGTAGAGAAAACAAGGCGC
TCTATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAGACGGTACAATGAAAACACAGAGCTGAGG
AAAACGGGGACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAATGATTCTCAGAGAGAGTTCAACAGCAGG
CCAGGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGTGAAAATTCAGGCCATGTCAGAAGTACAG
AAGGCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAATGGAGCAAACCATAGCGGATGTCAAGCGG
CAGGCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTGGAACTGTGGCCGCAAAGCCAGCGAGACA
TGCAGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACCACCGCCTCTGTGGTCAGAACCTG
CATGGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGGTCCGCCGACTGCAGCGTGCCCAGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_RUNX1_ENST00000344691_chr21_36231771_-_CBFA2T2_ENST00000342704_chr20_32194762_+_4759nt
CATAGAGCCAGCGGGCGCGGGCGGGACGGGCGCCCCGCGGCCGGACCCAGCCAGGGCACCACGCTGCCCGGCCCTGCGCCGCCAGGCACT
TCTTTCCGGGGCTCCTAGGGACGCCAGAAGGAAGTCAACCTCTGCTGCTTCTCCTTGGCCTGCGTTGGACCTTCCTTTTTTTGTTGTTTT
TTTTTGTTTTTCCCCTTTCTTCCTTTTGAATTAACTGGCTTCTTGGCTGGATGTTTTCAACTTCTTTCCTGGCTGCGAACTTTTCCCCAA
TTGTTTTCCTTTTACAACAGGGGGAGAAAGTGCTCTGTGGTCCGAGGCGAGCCGTGAAGTTGCGTGTGCGTGGCAGTGTGCGTGGCAGGA
TGTGCGTGCGTGTGTAACCCGAGCCGCCCGATCTGTTTCGATCTGCGCCGCGGAGCCCTCCCTCAAGGCCCGCTCCACCTGCTGCGGTTA
CGCGGCGCTCGTGGGTGTTCGTGCCTCGGAGCAGCTAACCGGCGGGTGCTGGGCGACGGTGGAGGAGTATCGTCTCGCTGCTGCCCGAGT
CAGGGCTGAGTCACCCAGCTGATGTAGACAGTGGCTGCCTTCCGAAGAGTGCGTGTTTGCATGTGTGTGACTCTGCGGCTGCTCAACTCC
CAACAAACCAGAGGACCAGCCACAAACTTAACCAACATCCCCAAACCCGAGTTCACAGATGTGGGAGAGCTGTAGAACCCTGAGTGTCAT
CGACTGGGCCTTCTTATGATTGTTGTTTTAAGATTAGCTGAAGATCTCTGAAACGCTGAATTTTCTGCACTGAGCGTTTTGACAGAATTC
ATTGAGAGAACAGAGAACATGACAAGTACTTCTAGCTCAGCACTGCTCCAACTACTGAAGCTGATTTTCAAGGCTACTTAAAAAAATCTG
CAGCGTACATTAATGGATTTCTGTTGTGTTTAAATTCTCCACAGATTGTATTGTAAATATTTTATGAAGTAGAGCATATGTATATATTTA
TATATACGTGCACATACATTAGTAGCACTACCTTTGGAAGTCTCAGCTCTTGCTTTTCGGGACTGAAGCCAGTTTTGCATGATAAAAGTG
GCCTTGTTACGGGAGATAATTGTGTTCTGTTGGGACTTTAGACAAAACTCACCTGCAAAAAACTGACAGGCATTAACTACTGGAACTTCC
AAATAATGTGTTTGCTGATCGTTTTACTCTTCGCATAAATATTTTAGGAAGTGTATGAGAATTTTGCCTTCAGGAACTTTTCTAACAGCC
AAAGACAGAACTTAACCTCTGCAAGCAAGATTCGTGGAAGATAGTCTCCACTTTTTAATGCACTAAGCAATCGGTTGCTAGGAGCCCATC
CTGGGTCAGAGGCCGATCCGCAGAACCAGAACGTTTTCCCCTCCTGGACTGTTAGTAACTTAGTCTCCCTCCTCCCCTAACCACCCCCGC
CCCCCCCCACCCCCCGCAGTAATAAAGGCCCCTGAACGTGTATGTTGGTCTCCCGGGAGCTGCTTGCTGAAGATCCGCGCCCCTGTCGCC
GTCTGGTAGGAGCTGTTTGCAGGGTCCTAACTCAATCGGCTTGTTGTGATGCGTATCCCCGTAGATGCCAGCACGAGCCGCCGCTTCACG
CCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCGGCGCTGCCCTGGCCGGCAAGCTG
AGGAGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTG
CTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACT
GTGATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTC
AGGTTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGA
GCCATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAATTGGTCCTGAGAAAAGGGTGCCAGCGATGCCTGGATCGCCTGTGGAAGTG
AAGATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGGACCGAGGCCAGTGTCCTTCACTCCTACT
GCATTAAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACAGAGATTCAGCAATGGTCCTGCCTCCTCC
ACATCATCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAAGTTGAAACGCTTTCTTACCACTCTGCAA
CAGTTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACTGGTGAACTCAACAGTGACAATTGAGGAA
TTCCACTGTAAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCTCAAGGCCAACCTGCCCCTGCTGCAGCGG
GAACTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGAACACCTTCTGCTCAACACAAGCATTGCA
TCGCCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCCAGAGAGGAGAGAAGAGAATAGTTTTGAT
AGAGACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCGGCACAGTCCTGCTCTCACTGTGCCCCTC
ATGAATCCCGGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGATATTGCAACTTCTCACCTGTATCGGGAA
CCCAACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGGAGGCTATCAAGATGAGTTGGTAGATCAT
CGTTTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCATTATGGAAATGGTAGAGAAAACAAGGCGC
TCTATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAGACGGTACAATGAAAACACAGAGCTGAGG
AAAACGGGGACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAATGATTCTCAGAGAGAGTTCAACAGCAGG
CCAGGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGTGAAAATTCAGGCCATGTCAGAAGTACAG
AAGGCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAATGGAGCAAACCATAGCGGATGTCAAGCGG
CAGGCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTGGAACTGTGGCCGCAAAGCCAGCGAGACA
TGCAGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACCACCGCCTCTGTGGTCAGAACCTG
CATGGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGGTCCGCCGACTGCAGCGTGCCCAGC
CCAGCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGCTATCGACACCAACGGACTCTGAGCCCCG
GACTCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGCTTGGGCTGAGGGACTGACTGTTGGAACCCGTGCATGTAGCTGCCGGGTC
ATCAGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCTGAATAATAACACCCCACAGCCTCTCTGTGCACTTGCTGTCTGCGGAGCC
AGTGTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGTTTGTTCCTCTCTCCACTGAAGCTGACTT
AGCCGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACTGTCCAATGTGCTCAGCCAGGCTGGAGGC
GGCAGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACCCCTGAATAGCTCCTTCGGCCCCATCTCC
ATCCTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGGGTAAGCAACAGGCGGCATTCAGGACTCTTCTCAACCCTGCTGTTCAGAC
TTGATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTGCAATAAAAGCACCCGTAGTAGCAAAAACATAAAACAAATAAAACTTCCC
CCACATCACAGATGATTTTGGACAAGATTTTCCAACCTTGCTGGCTACTTTAGTTTGGGACCTGTTTTTTTTCTCATTTGATTTTGCTTG
TGCAGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAGAATGAGGCTCAGTTGTGGATAGTCTGTTTTCTCTGAGCATGTTGGCCAA

>In-frame_RUNX1_ENST00000344691_chr21_36231771_-_CBFA2T2_ENST00000375279_chr20_32194762_+_9254nt
CATAGAGCCAGCGGGCGCGGGCGGGACGGGCGCCCCGCGGCCGGACCCAGCCAGGGCACCACGCTGCCCGGCCCTGCGCCGCCAGGCACT
TCTTTCCGGGGCTCCTAGGGACGCCAGAAGGAAGTCAACCTCTGCTGCTTCTCCTTGGCCTGCGTTGGACCTTCCTTTTTTTGTTGTTTT
TTTTTGTTTTTCCCCTTTCTTCCTTTTGAATTAACTGGCTTCTTGGCTGGATGTTTTCAACTTCTTTCCTGGCTGCGAACTTTTCCCCAA
TTGTTTTCCTTTTACAACAGGGGGAGAAAGTGCTCTGTGGTCCGAGGCGAGCCGTGAAGTTGCGTGTGCGTGGCAGTGTGCGTGGCAGGA
TGTGCGTGCGTGTGTAACCCGAGCCGCCCGATCTGTTTCGATCTGCGCCGCGGAGCCCTCCCTCAAGGCCCGCTCCACCTGCTGCGGTTA
CGCGGCGCTCGTGGGTGTTCGTGCCTCGGAGCAGCTAACCGGCGGGTGCTGGGCGACGGTGGAGGAGTATCGTCTCGCTGCTGCCCGAGT
CAGGGCTGAGTCACCCAGCTGATGTAGACAGTGGCTGCCTTCCGAAGAGTGCGTGTTTGCATGTGTGTGACTCTGCGGCTGCTCAACTCC
CAACAAACCAGAGGACCAGCCACAAACTTAACCAACATCCCCAAACCCGAGTTCACAGATGTGGGAGAGCTGTAGAACCCTGAGTGTCAT
CGACTGGGCCTTCTTATGATTGTTGTTTTAAGATTAGCTGAAGATCTCTGAAACGCTGAATTTTCTGCACTGAGCGTTTTGACAGAATTC
ATTGAGAGAACAGAGAACATGACAAGTACTTCTAGCTCAGCACTGCTCCAACTACTGAAGCTGATTTTCAAGGCTACTTAAAAAAATCTG
CAGCGTACATTAATGGATTTCTGTTGTGTTTAAATTCTCCACAGATTGTATTGTAAATATTTTATGAAGTAGAGCATATGTATATATTTA
TATATACGTGCACATACATTAGTAGCACTACCTTTGGAAGTCTCAGCTCTTGCTTTTCGGGACTGAAGCCAGTTTTGCATGATAAAAGTG
GCCTTGTTACGGGAGATAATTGTGTTCTGTTGGGACTTTAGACAAAACTCACCTGCAAAAAACTGACAGGCATTAACTACTGGAACTTCC
AAATAATGTGTTTGCTGATCGTTTTACTCTTCGCATAAATATTTTAGGAAGTGTATGAGAATTTTGCCTTCAGGAACTTTTCTAACAGCC
AAAGACAGAACTTAACCTCTGCAAGCAAGATTCGTGGAAGATAGTCTCCACTTTTTAATGCACTAAGCAATCGGTTGCTAGGAGCCCATC
CTGGGTCAGAGGCCGATCCGCAGAACCAGAACGTTTTCCCCTCCTGGACTGTTAGTAACTTAGTCTCCCTCCTCCCCTAACCACCCCCGC
CCCCCCCCACCCCCCGCAGTAATAAAGGCCCCTGAACGTGTATGTTGGTCTCCCGGGAGCTGCTTGCTGAAGATCCGCGCCCCTGTCGCC
GTCTGGTAGGAGCTGTTTGCAGGGTCCTAACTCAATCGGCTTGTTGTGATGCGTATCCCCGTAGATGCCAGCACGAGCCGCCGCTTCACG
CCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCGGCGCTGCCCTGGCCGGCAAGCTG
AGGAGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTG
CTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACT
GTGATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTC
AGGTTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGA
GCCATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAATTGGTCCTGAGAAAAGGGTGCCAGCGATGCCTGGATCGCCTGTGGAAGTG
AAGATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGGACCGAGGCCAGTGTCCTTCACTCCTACT
GCATTAAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACAGAGATTCAGCAATGGTCCTGCCTCCTCC
ACATCATCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAAGTTGAAACGCTTTCTTACCACTCTGCAA
CAGTTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACTGGTGAACTCAACAGTGACAATTGAGGAA
TTCCACTGTAAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCTCAAGGCCAACCTGCCCCTGCTGCAGCGG
GAACTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGAACACCTTCTGCTCAACACAAGCATTGCA
TCGCCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCCAGAGAGGAGAGAAGAGAATAGTTTTGAT
AGAGACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCGGCACAGTCCTGCTCTCACTGTGCCCCTC
ATGAATCCCGGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGATATTGCAACTTCTCACCTGTATCGGGAA
CCCAACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGGAGGCTATCAAGATGAGTTGGTAGATCAT
CGTTTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCATTATGGAAATGGTAGAGAAAACAAGGCGC
TCTATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAGACGGTACAATGAAAACACAGAGCTGAGG
AAAACGGGGACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAATGATTCTCAGAGAGAGTTCAACAGCAGG
CCAGGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGTGAAAATTCAGGCCATGTCAGAAGTACAG
AAGGCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAATGGAGCAAACCATAGCGGATGTCAAGCGG
CAGGCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTGGAACTGTGGCCGCAAAGCCAGCGAGACA
TGCAGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACCACCGCCTCTGTGGTCAGAACCTG
CATGGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGGTCCGCCGACTGCAGCGTGCCCAGC
CCAGCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGCTATCGACACCAACGGACTCTGAGCCCCG
GACTCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGCTTGGGCTGAGGGACTGACTGTTGGAACCCGTGCATGTAGCTGCCGGGTC
ATCAGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCTGAATAATAACACCCCACAGCCTCTCTGTGCACTTGCTGTCTGCGGAGCC
AGTGTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGTTTGTTCCTCTCTCCACTGAAGCTGACTT
AGCCGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACTGTCCAATGTGCTCAGCCAGGCTGGAGGC
GGCAGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACCCCTGAATAGCTCCTTCGGCCCCATCTCC
ATCCTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGGGTAAGCAACAGGCGGCATTCAGGACTCTTCTCAACCCTGCTGTTCAGAC
TTGATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTGCAATAAAAGCACCCGTAGTAGCAAAAACATAAAACAAATAAAACTTCCC
CCACATCACAGATGATTTTGGACAAGATTTTCCAACCTTGCTGGCTACTTTAGTTTGGGACCTGTTTTTTTTCTCATTTGATTTTGCTTG
TGCAGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAGAATGAGGCTCAGTTGTGGATAGTCTGTTTTCTCTGAGCATGTTGGCCAA
CTAGTATCGTCAAATTATTGAGTGGATCATCTCTTGGAAATGCAGAACTTCTGCCACCACTTGGCTATTTGCACAGTCATCTTGTTCTGT
GTCCTTTTATCTCTCAGACCACACACATCTGGAACGCTGTGGGCATCTTCTGCCCATGGGCTCCATTTGGCACCTGCTGAGCCACAGTTG
TCCTGCTGGATGTGCTGTGCAGGTTGGTAGGACTTGCCCCCACTGTCAAGGCCTGGTCTCATCTGAAAAGCCCTCCTGGACCTCAAAGAA
TTCTTCAGACCTCATAGTTACAGGTCATTATATCTACTATGTTGATTTATCATCAGGCACACAACTTCTGTTTCCTTCTCTTGTGTTATC
TGATAGCGTCCCTCCTTGAGCTCATCAGAAAGGTTTTATGAAATGTGAACCATTTTGGGAAAAGCTGATCAATTTTTCTTCCTAGCTTCC
CATTTTCAAATGGGACATCACTCATATCCCTTTCAGAATGTTAGGAACTGCCTCCCACATTCTTCCCTGTCTTTTTGGGTTTTGTTTTTT
GTTGTTGTGGTGGTTTTTTAACACAAAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTTGGCTCACTGCAACCTCTGCC
TTCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGAGATTACAGGCGCCCACCACCACGCCCAGCTAATTTTTGTATTTT
TAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGATCTCGAACTCCTGACCTCAGGTGACCTGCCTTGGCCTCCCAAAGTGCAGGGAT
TACAAGCGTGAGCCACCATGCCCGGCCTGTCTTTTTGGTTTTGATGGGAGTCTGAGGACCCCGACCCCTCCTGCTCTCCATCTTTGAGCC
TCTGGCATCCTCTCACACCCAGAAATCAGTTGGAGTAAGTTTAATTGGCCCTGCTCCAGCTGGCCTTTGAAGCACAAGTTTAAATCTCCA
CCTTCTGTGCACTGACCAGAGTCTAAAATAAAAGTTGTCAGTACCATAAAGGAAAAGGGATCCACACAGGTAGCCTTCTCCTTGGATACA
GGTACATCTTACTGTAAGAATTTCAAGTCCTGGCTGGGCGCAGTGGCTCACTCCTGTAATCCCAGCACTTTGAGAGACCGAGGCAGGCAG
ATCACTTGAGGTCAGGAATTCAAGACCAACCTGGCCAACATGGTGAAACCCTGTCTCTAATAAAAAAAAAATAGAAAAATCAGCCGGGTG
TGGTGGCACACACCTGTAATCCTAGCTACTCAGGAGGCTGAGGCAAGAGAATCTCTTGAACCTGTGAGCCAGAGGTTGCAGTGAGCCGAG
ATTCCACCACTGCACTCCAGCCTGGGCAACAGAGCAAAACTCTGTCTCAAAAAAAAAAAAAAAAAGGCAAAATTAAAGAATTTCAAGTCC
CTAATTTACTCTAACCAAGCATTTTCAGTCTTACAAAGAAATCTAGTGCACGACACCTTTAAAATGCCTAGATTTCCATTGCCTAAAGTA
AGGTGTGACCAGTGAAACAACAGCAGAGAATCATGTTCCTTTGCTGTGGAACACATAAGCCCCACAGTTTTCCAGTCAGCCTAATACATG
GGTATCCCCCGACCCCATCTGCCTCCTTAAGCCACAGTCCTTGGTGGGGAACTCTAAGGGGGACGGAGTCAGTACCCCGGACAGGGCCAC
ATTTGCATGAGACATGGCTGTCTCACAGGTCACAGAGCCATTACAACAGCTTACTAGTTTTTCATGGATTTGTTGGATTAACACCTTAAG
CAGGTTTTTTATTGTTATTTTGTTTGTTTGTTTGTTTTGAGACGGGAGTTTCTCTCTTGTCTCCCAGGCTGGAGTGCAATCGCGCAATCT
CGGCTCACGGTAACCTCTGCCTCCCAGGTTCAAGCGAGTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGATTACAGGCATGCGCCACCACG
CCCAACTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCCTTGTTGGTCAGGCTGGTCTCAAACCCCGGACCTCAGGTGATCCCCCCAC
CTTGGCCTCCCAAAGTGCCAGGATTACAGGCATGAGCCACTGTGTCCGGTCTTGAGCAGGTTTTTAAAATCTCCAGTGGCCATAAAACTA
GCCAGGGTAGCTCATGCTTTTACTGGTTGGAATAAGGAGCCAAAACCAACAAAATAATATTTATTAGGGCTCGATGCCCATTTCTGTGGC
TAAGGCTTAGGTTTGGTGTGCAGAGCCTGGCCTGCTCTTGTGGGCTGTGGTTGCTGTGACAGTTTCGTTTTCTGAATCTTTGTAATGCTC
TTCCACCCTGCTCGTGCTGCCCAGAGGCTGATCTGCAAACCTGGGCAGTATTCCACACTGAAGCTCAGTTTGCAAACCTTCTGCTGTGTT
AATTCTGGTCAGTTTCACACAGAAGTCACGAGGGCCTCTGCCCAGGACCTTCTATTCACATTTCAAGAATCCCTTTCTGAAATTCTCCAA
CTCTCTGGTCAGGAGGAGGAGCACCATTGGGGCGGGGTAGGCAGCTAGAGGCGCAGGAGCGAATCCAGGTTCCTTGCGTGGTTCCCAGCC
TCTGCTGACAGCACCTCAGCTACCAGGTGGGGAGTGGAAATTCAGCCTGCTTAGAGGACTGACCTCTACAGTTCATATTTGCAGTGACAT
AAAAGGCAAAGAGGAGCTGGCATGGTGGTACAGAAGGTATCAGTCAAGCGCAGGCTCTTCAGAAACCTAGAAACTAAAAAGAGATGCAAC
ATGTGACTGGCCATCAGCCAGACATGTCTAGGGTGAGACCAGTGCTCAGCACCACCCGCCAAGGAACACTGATGAGTTGTGGGACATTAT
GGTCGGCCAAGTGAGGAATGATTGCAGGGACCAGAGAAGACCAAAGATGCCAGATGTCCCCAGAGTTTCTTGAGGGCTGGGTTTCACGTC
TTTGCTTGTCCTTTTTGTCCCCACTTGCCTGCACCGTGCCTGACTCATCCAGTGGGGAAGGTGACTCAAGAAGTTGTTTAAGCCTAGGCC
TAGGCAGTCCACTTCGGGAGGTGGGGGCACTCCACACTGGGGGGCCCTGCAGCTCCAGGGCTGGTGCTCTAGCAGATCCGCTCAGGCACG
GTTGGGTGACCGTGGGGTCACCGATTGCGTAGATTATTTCTAGGGCAGTGCTGGGTTAGAAATGTCTGTCTGGAAACAGGACACATCTTG
CCACCACAAGTCCACACCTGGCCTTGGCTGCTGCCCGCTCTCTGCAGCGTGGATTTCCTTTGCCCATTTGGGCCAGAAGGTCACCAGGAG
TTCATCACTGCTTAGTGTCAACTTGACATCTTCAGCTTCCAGACAGAAAACCCATGCTTTACTTTGTACAGCCCTGTCCCAGAGTTAGTA
AGCCTCGGCTTGTCACCTGCTTGCAAAGGGTATAGACATCATTCTGGGTAGTTCTAGAGGATATCGCAACAAGTGCGTTTGAAGGTTCAG
CACAGCTGGAATTGTACGGTAGTGAGCTCTTCAAAATGAAAACAGAATGACCGGATGGCCATCTGTCCTGGAAACTGTAGAATTGAATAA
ATCACTGAAAATAGAACACTTCTTGGAGGCTTTCTTCAGAACTGAACTAGAAACAAGGTTTCCAGGCTCCCAGGTCAGTAGACCAAACCA
ACTTCCTTAGATTTTTTTTTTTAAGCTGTTTGCAGAAAACTGGGTGGTAGCGTGTCTGAACCAAACGGAAGAATAGCCAGCGGAGCATGG
ACTGTTCCAGCACGGGCCAGATGGCCAGCTGTCGAGAGCAGCCCTGCCCAGATTGCGGTGGGGGCTGTGCCAGCGGCTCCGCAGGGCCCT
TCCAACTCTGGAGTGTCTGTAGTTCTTGTGAAACCAAAACGTTGACTACCTGCCTCTTTCCTCGGGCATCGACGTGCTCATTTCCAAAGA
TGATGGTGCAGGTGACCTTTTCCATCGTGAGCTAAGAGAAGGTTAGGAGGCCTGAGGGGCGGGCCTTGTGTCCCCTCCTCCCCCTCCACA
GCCCCTGAGGTGGAGCTTCCCTCACAGACCCCATCTGGTCGAGCCTACGGCTGCCCAGTGTACACTCAGTGATGCTTATACCAAATAGGG
CATGTGCGCTGGTGTCTGTTGGGGACAGCCCCATCCCTACCTTGGAGTCGGCAGAGAAGCAGCAATAAGCATTAGGCGAATGATTGAAAG
GGCTGCTGCGCCAAGAGGCCTTCAGTCCCCTTAACGTGGCTTTCCAACTTCCTGACGAGGCTACAAAGGCTCCGCTCACAAAAGAAAGCC
AATAATGTAAATAAATAGAAAACGAAGCCTCCACGCGTGGTTTTTAAAGGGGGATGATGAATGTGACACCACCCACAGAATGCATTAGAA
TCTGGTTTTTCTGTGCTTTGTCATTTTACTCTGATAGGAATTTTTGTTACCTAACTCTGTGCATAACTTATTTAATGTACTGTATAAATG

>In-frame_RUNX1_ENST00000325074_chr21_36231771_-_CBFA2T2_ENST00000342704_chr20_32194762_+_3226nt
ATGCCCGCAGCACCGCGGGGACCGGCGCAGGGGGAAGCGGCCGCCCGCACGCGAAGCCGGGATGCCAGCACGAGCCGCCGCTTCACGCCG
CCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCGGCGCTGCCCTGGCCGGCAAGCTGAGG
AGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTGCTG
CCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACTGTG
ATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTCAGG
TTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGAGCC
ATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAATTGGTCCTGAGAAAAGGGTGCCAGCGATGCCTGGATCGCCTGTGGAAGTGAAG
ATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGGACCGAGGCCAGTGTCCTTCACTCCTACTGCA
TTAAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACAGAGATTCAGCAATGGTCCTGCCTCCTCCACA
TCATCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAAGTTGAAACGCTTTCTTACCACTCTGCAACAG
TTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACTGGTGAACTCAACAGTGACAATTGAGGAATTC
CACTGTAAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCTCAAGGCCAACCTGCCCCTGCTGCAGCGGGAA
CTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGAACACCTTCTGCTCAACACAAGCATTGCATCG
CCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCCAGAGAGGAGAGAAGAGAATAGTTTTGATAGA
GACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCGGCACAGTCCTGCTCTCACTGTGCCCCTCATG
AATCCCGGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGATATTGCAACTTCTCACCTGTATCGGGAACCC
AACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGGAGGCTATCAAGATGAGTTGGTAGATCATCGT
TTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCATTATGGAAATGGTAGAGAAAACAAGGCGCTCT
ATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAGACGGTACAATGAAAACACAGAGCTGAGGAAA
ACGGGGACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAATGATTCTCAGAGAGAGTTCAACAGCAGGCCA
GGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGTGAAAATTCAGGCCATGTCAGAAGTACAGAAG
GCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAATGGAGCAAACCATAGCGGATGTCAAGCGGCAG
GCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTGGAACTGTGGCCGCAAAGCCAGCGAGACATGC
AGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACCACCGCCTCTGTGGTCAGAACCTGCAT
GGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGGTCCGCCGACTGCAGCGTGCCCAGCCCA
GCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGCTATCGACACCAACGGACTCTGAGCCCCGGAC
TCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGCTTGGGCTGAGGGACTGACTGTTGGAACCCGTGCATGTAGCTGCCGGGTCATC
AGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCTGAATAATAACACCCCACAGCCTCTCTGTGCACTTGCTGTCTGCGGAGCCAGT
GTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGTTTGTTCCTCTCTCCACTGAAGCTGACTTAGC
CGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACTGTCCAATGTGCTCAGCCAGGCTGGAGGCGGC
AGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACCCCTGAATAGCTCCTTCGGCCCCATCTCCATC
CTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGGGTAAGCAACAGGCGGCATTCAGGACTCTTCTCAACCCTGCTGTTCAGACTTG
ATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTGCAATAAAAGCACCCGTAGTAGCAAAAACATAAAACAAATAAAACTTCCCCCA
CATCACAGATGATTTTGGACAAGATTTTCCAACCTTGCTGGCTACTTTAGTTTGGGACCTGTTTTTTTTCTCATTTGATTTTGCTTGTGC
AGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAGAATGAGGCTCAGTTGTGGATAGTCTGTTTTCTCTGAGCATGTTGGCCAACTA

>In-frame_RUNX1_ENST00000325074_chr21_36231771_-_CBFA2T2_ENST00000375279_chr20_32194762_+_7721nt
ATGCCCGCAGCACCGCGGGGACCGGCGCAGGGGGAAGCGGCCGCCCGCACGCGAAGCCGGGATGCCAGCACGAGCCGCCGCTTCACGCCG
CCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCGGCGCTGCCCTGGCCGGCAAGCTGAGG
AGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTGCTG
CCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACTGTG
ATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTCAGG
TTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGAGCC
ATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAATTGGTCCTGAGAAAAGGGTGCCAGCGATGCCTGGATCGCCTGTGGAAGTGAAG
ATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGGACCGAGGCCAGTGTCCTTCACTCCTACTGCA
TTAAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACAGAGATTCAGCAATGGTCCTGCCTCCTCCACA
TCATCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAAGTTGAAACGCTTTCTTACCACTCTGCAACAG
TTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACTGGTGAACTCAACAGTGACAATTGAGGAATTC
CACTGTAAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCTCAAGGCCAACCTGCCCCTGCTGCAGCGGGAA
CTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGAACACCTTCTGCTCAACACAAGCATTGCATCG
CCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCCAGAGAGGAGAGAAGAGAATAGTTTTGATAGA
GACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCGGCACAGTCCTGCTCTCACTGTGCCCCTCATG
AATCCCGGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGATATTGCAACTTCTCACCTGTATCGGGAACCC
AACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGGAGGCTATCAAGATGAGTTGGTAGATCATCGT
TTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCATTATGGAAATGGTAGAGAAAACAAGGCGCTCT
ATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAGACGGTACAATGAAAACACAGAGCTGAGGAAA
ACGGGGACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAATGATTCTCAGAGAGAGTTCAACAGCAGGCCA
GGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGTGAAAATTCAGGCCATGTCAGAAGTACAGAAG
GCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAATGGAGCAAACCATAGCGGATGTCAAGCGGCAG
GCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTGGAACTGTGGCCGCAAAGCCAGCGAGACATGC
AGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACCACCGCCTCTGTGGTCAGAACCTGCAT
GGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGGTCCGCCGACTGCAGCGTGCCCAGCCCA
GCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGCTATCGACACCAACGGACTCTGAGCCCCGGAC
TCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGCTTGGGCTGAGGGACTGACTGTTGGAACCCGTGCATGTAGCTGCCGGGTCATC
AGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCTGAATAATAACACCCCACAGCCTCTCTGTGCACTTGCTGTCTGCGGAGCCAGT
GTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGTTTGTTCCTCTCTCCACTGAAGCTGACTTAGC
CGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACTGTCCAATGTGCTCAGCCAGGCTGGAGGCGGC
AGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACCCCTGAATAGCTCCTTCGGCCCCATCTCCATC
CTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGGGTAAGCAACAGGCGGCATTCAGGACTCTTCTCAACCCTGCTGTTCAGACTTG
ATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTGCAATAAAAGCACCCGTAGTAGCAAAAACATAAAACAAATAAAACTTCCCCCA
CATCACAGATGATTTTGGACAAGATTTTCCAACCTTGCTGGCTACTTTAGTTTGGGACCTGTTTTTTTTCTCATTTGATTTTGCTTGTGC
AGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAGAATGAGGCTCAGTTGTGGATAGTCTGTTTTCTCTGAGCATGTTGGCCAACTA
GTATCGTCAAATTATTGAGTGGATCATCTCTTGGAAATGCAGAACTTCTGCCACCACTTGGCTATTTGCACAGTCATCTTGTTCTGTGTC
CTTTTATCTCTCAGACCACACACATCTGGAACGCTGTGGGCATCTTCTGCCCATGGGCTCCATTTGGCACCTGCTGAGCCACAGTTGTCC
TGCTGGATGTGCTGTGCAGGTTGGTAGGACTTGCCCCCACTGTCAAGGCCTGGTCTCATCTGAAAAGCCCTCCTGGACCTCAAAGAATTC
TTCAGACCTCATAGTTACAGGTCATTATATCTACTATGTTGATTTATCATCAGGCACACAACTTCTGTTTCCTTCTCTTGTGTTATCTGA
TAGCGTCCCTCCTTGAGCTCATCAGAAAGGTTTTATGAAATGTGAACCATTTTGGGAAAAGCTGATCAATTTTTCTTCCTAGCTTCCCAT
TTTCAAATGGGACATCACTCATATCCCTTTCAGAATGTTAGGAACTGCCTCCCACATTCTTCCCTGTCTTTTTGGGTTTTGTTTTTTGTT
GTTGTGGTGGTTTTTTAACACAAAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTTGGCTCACTGCAACCTCTGCCTTC
CAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGAGATTACAGGCGCCCACCACCACGCCCAGCTAATTTTTGTATTTTTAG
TAGAGACAGGGTTTCACCATGTTGGCCAGGCTGATCTCGAACTCCTGACCTCAGGTGACCTGCCTTGGCCTCCCAAAGTGCAGGGATTAC
AAGCGTGAGCCACCATGCCCGGCCTGTCTTTTTGGTTTTGATGGGAGTCTGAGGACCCCGACCCCTCCTGCTCTCCATCTTTGAGCCTCT
GGCATCCTCTCACACCCAGAAATCAGTTGGAGTAAGTTTAATTGGCCCTGCTCCAGCTGGCCTTTGAAGCACAAGTTTAAATCTCCACCT
TCTGTGCACTGACCAGAGTCTAAAATAAAAGTTGTCAGTACCATAAAGGAAAAGGGATCCACACAGGTAGCCTTCTCCTTGGATACAGGT
ACATCTTACTGTAAGAATTTCAAGTCCTGGCTGGGCGCAGTGGCTCACTCCTGTAATCCCAGCACTTTGAGAGACCGAGGCAGGCAGATC
ACTTGAGGTCAGGAATTCAAGACCAACCTGGCCAACATGGTGAAACCCTGTCTCTAATAAAAAAAAAATAGAAAAATCAGCCGGGTGTGG
TGGCACACACCTGTAATCCTAGCTACTCAGGAGGCTGAGGCAAGAGAATCTCTTGAACCTGTGAGCCAGAGGTTGCAGTGAGCCGAGATT
CCACCACTGCACTCCAGCCTGGGCAACAGAGCAAAACTCTGTCTCAAAAAAAAAAAAAAAAAGGCAAAATTAAAGAATTTCAAGTCCCTA
ATTTACTCTAACCAAGCATTTTCAGTCTTACAAAGAAATCTAGTGCACGACACCTTTAAAATGCCTAGATTTCCATTGCCTAAAGTAAGG
TGTGACCAGTGAAACAACAGCAGAGAATCATGTTCCTTTGCTGTGGAACACATAAGCCCCACAGTTTTCCAGTCAGCCTAATACATGGGT
ATCCCCCGACCCCATCTGCCTCCTTAAGCCACAGTCCTTGGTGGGGAACTCTAAGGGGGACGGAGTCAGTACCCCGGACAGGGCCACATT
TGCATGAGACATGGCTGTCTCACAGGTCACAGAGCCATTACAACAGCTTACTAGTTTTTCATGGATTTGTTGGATTAACACCTTAAGCAG
GTTTTTTATTGTTATTTTGTTTGTTTGTTTGTTTTGAGACGGGAGTTTCTCTCTTGTCTCCCAGGCTGGAGTGCAATCGCGCAATCTCGG
CTCACGGTAACCTCTGCCTCCCAGGTTCAAGCGAGTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGATTACAGGCATGCGCCACCACGCCC
AACTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCCTTGTTGGTCAGGCTGGTCTCAAACCCCGGACCTCAGGTGATCCCCCCACCTT
GGCCTCCCAAAGTGCCAGGATTACAGGCATGAGCCACTGTGTCCGGTCTTGAGCAGGTTTTTAAAATCTCCAGTGGCCATAAAACTAGCC
AGGGTAGCTCATGCTTTTACTGGTTGGAATAAGGAGCCAAAACCAACAAAATAATATTTATTAGGGCTCGATGCCCATTTCTGTGGCTAA
GGCTTAGGTTTGGTGTGCAGAGCCTGGCCTGCTCTTGTGGGCTGTGGTTGCTGTGACAGTTTCGTTTTCTGAATCTTTGTAATGCTCTTC
CACCCTGCTCGTGCTGCCCAGAGGCTGATCTGCAAACCTGGGCAGTATTCCACACTGAAGCTCAGTTTGCAAACCTTCTGCTGTGTTAAT
TCTGGTCAGTTTCACACAGAAGTCACGAGGGCCTCTGCCCAGGACCTTCTATTCACATTTCAAGAATCCCTTTCTGAAATTCTCCAACTC
TCTGGTCAGGAGGAGGAGCACCATTGGGGCGGGGTAGGCAGCTAGAGGCGCAGGAGCGAATCCAGGTTCCTTGCGTGGTTCCCAGCCTCT
GCTGACAGCACCTCAGCTACCAGGTGGGGAGTGGAAATTCAGCCTGCTTAGAGGACTGACCTCTACAGTTCATATTTGCAGTGACATAAA
AGGCAAAGAGGAGCTGGCATGGTGGTACAGAAGGTATCAGTCAAGCGCAGGCTCTTCAGAAACCTAGAAACTAAAAAGAGATGCAACATG
TGACTGGCCATCAGCCAGACATGTCTAGGGTGAGACCAGTGCTCAGCACCACCCGCCAAGGAACACTGATGAGTTGTGGGACATTATGGT
CGGCCAAGTGAGGAATGATTGCAGGGACCAGAGAAGACCAAAGATGCCAGATGTCCCCAGAGTTTCTTGAGGGCTGGGTTTCACGTCTTT
GCTTGTCCTTTTTGTCCCCACTTGCCTGCACCGTGCCTGACTCATCCAGTGGGGAAGGTGACTCAAGAAGTTGTTTAAGCCTAGGCCTAG
GCAGTCCACTTCGGGAGGTGGGGGCACTCCACACTGGGGGGCCCTGCAGCTCCAGGGCTGGTGCTCTAGCAGATCCGCTCAGGCACGGTT
GGGTGACCGTGGGGTCACCGATTGCGTAGATTATTTCTAGGGCAGTGCTGGGTTAGAAATGTCTGTCTGGAAACAGGACACATCTTGCCA
CCACAAGTCCACACCTGGCCTTGGCTGCTGCCCGCTCTCTGCAGCGTGGATTTCCTTTGCCCATTTGGGCCAGAAGGTCACCAGGAGTTC
ATCACTGCTTAGTGTCAACTTGACATCTTCAGCTTCCAGACAGAAAACCCATGCTTTACTTTGTACAGCCCTGTCCCAGAGTTAGTAAGC
CTCGGCTTGTCACCTGCTTGCAAAGGGTATAGACATCATTCTGGGTAGTTCTAGAGGATATCGCAACAAGTGCGTTTGAAGGTTCAGCAC
AGCTGGAATTGTACGGTAGTGAGCTCTTCAAAATGAAAACAGAATGACCGGATGGCCATCTGTCCTGGAAACTGTAGAATTGAATAAATC
ACTGAAAATAGAACACTTCTTGGAGGCTTTCTTCAGAACTGAACTAGAAACAAGGTTTCCAGGCTCCCAGGTCAGTAGACCAAACCAACT
TCCTTAGATTTTTTTTTTTAAGCTGTTTGCAGAAAACTGGGTGGTAGCGTGTCTGAACCAAACGGAAGAATAGCCAGCGGAGCATGGACT
GTTCCAGCACGGGCCAGATGGCCAGCTGTCGAGAGCAGCCCTGCCCAGATTGCGGTGGGGGCTGTGCCAGCGGCTCCGCAGGGCCCTTCC
AACTCTGGAGTGTCTGTAGTTCTTGTGAAACCAAAACGTTGACTACCTGCCTCTTTCCTCGGGCATCGACGTGCTCATTTCCAAAGATGA
TGGTGCAGGTGACCTTTTCCATCGTGAGCTAAGAGAAGGTTAGGAGGCCTGAGGGGCGGGCCTTGTGTCCCCTCCTCCCCCTCCACAGCC
CCTGAGGTGGAGCTTCCCTCACAGACCCCATCTGGTCGAGCCTACGGCTGCCCAGTGTACACTCAGTGATGCTTATACCAAATAGGGCAT
GTGCGCTGGTGTCTGTTGGGGACAGCCCCATCCCTACCTTGGAGTCGGCAGAGAAGCAGCAATAAGCATTAGGCGAATGATTGAAAGGGC
TGCTGCGCCAAGAGGCCTTCAGTCCCCTTAACGTGGCTTTCCAACTTCCTGACGAGGCTACAAAGGCTCCGCTCACAAAAGAAAGCCAAT
AATGTAAATAAATAGAAAACGAAGCCTCCACGCGTGGTTTTTAAAGGGGGATGATGAATGTGACACCACCCACAGAATGCATTAGAATCT
GGTTTTTCTGTGCTTTGTCATTTTACTCTGATAGGAATTTTTGTTACCTAACTCTGTGCATAACTTATTTAATGTACTGTATAAATGAAC

>In-frame_RUNX1_ENST00000300305_chr21_36231771_-_CBFA2T2_ENST00000342704_chr20_32194762_+_3707nt
GGAAAGGGGAACAGTTAAATTTGTAATTTGGGTTGTGTGAAAACTTCTTTGGGCCTCATAAACAACCACAGAACCACAAGTTGGGTAGCC
TGGCAGTGTCAGAAGTCTGAACCCAGCATAGTGGTCAGCAGGCAGGACGAATCACACTGAATGCAAACCACAGGGTTTCGCAGCGTGGTG
AGCATCACCAACCCACAGCCAAGGCGGCGCTGGCTTTTTTTTTTTTTTTAATCTTTAACAATTTGAATATTTGTTTTTACAAAGGTGCAT
TTTTTAATAGGGCTTGGGGAGTCCCAGAGGTATCCAGCAGAGGGGAGAAGAAAGAGAGATGTAGGGCTAGAGGGGTGAGGCTGAAACAGT
GACCTGTCTTGGTTTTCGCTCCGAAGGTAAAAGAAATCATTGAGTCCCCCGCCTTCAGAAGAGGGTGCATTTTCAGGAGGAAGCGATGGC
TTCAGACAGCATATTTGAGTCATTTCCTTCGTACCCACAGTGCTTCATGAGAGAATGCATACTTGGAATGAATCCTTCTAGAGACGTCCA
CGATGCCAGCACGAGCCGCCGCTTCACGCCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGA
CGCCGGCGCTGCCCTGGCCGGCAAGCTGAGGAGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCAC
CGACAGCCCCAACTTCCTCTGCTCCGTGCTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGG
GGATGTTCCAGATGGCACTCTGGTCACTGTGATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAA
GAACCAGGTTGCAAGATTTAATGACCTCAGGTTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAA
CCCACCGCAAGTCGCCACCTACCACAGAGCCATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAATTGGTCCTGAGAAAAGGGTGCC
AGCGATGCCTGGATCGCCTGTGGAAGTGAAGATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGG
ACCGAGGCCAGTGTCCTTCACTCCTACTGCATTAAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACA
GAGATTCAGCAATGGTCCTGCCTCCTCCACATCATCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAA
GTTGAAACGCTTTCTTACCACTCTGCAACAGTTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACT
GGTGAACTCAACAGTGACAATTGAGGAATTCCACTGTAAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCT
CAAGGCCAACCTGCCCCTGCTGCAGCGGGAACTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGA
ACACCTTCTGCTCAACACAAGCATTGCATCGCCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCC
AGAGAGGAGAGAAGAGAATAGTTTTGATAGAGACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCG
GCACAGTCCTGCTCTCACTGTGCCCCTCATGAATCCCGGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGA
TATTGCAACTTCTCACCTGTATCGGGAACCCAACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGG
AGGCTATCAAGATGAGTTGGTAGATCATCGTTTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCAT
TATGGAAATGGTAGAGAAAACAAGGCGCTCTATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAG
ACGGTACAATGAAAACACAGAGCTGAGGAAAACGGGGACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAA
TGATTCTCAGAGAGAGTTCAACAGCAGGCCAGGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGT
GAAAATTCAGGCCATGTCAGAAGTACAGAAGGCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAAT
GGAGCAAACCATAGCGGATGTCAAGCGGCAGGCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTG
GAACTGTGGCCGCAAAGCCAGCGAGACATGCAGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCG
GCACCACCGCCTCTGTGGTCAGAACCTGCATGGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGC
CAGGTCCGCCGACTGCAGCGTGCCCAGCCCAGCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGC
TATCGACACCAACGGACTCTGAGCCCCGGACTCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGCTTGGGCTGAGGGACTGACTGT
TGGAACCCGTGCATGTAGCTGCCGGGTCATCAGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCTGAATAATAACACCCCACAGCC
TCTCTGTGCACTTGCTGTCTGCGGAGCCAGTGTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGT
TTGTTCCTCTCTCCACTGAAGCTGACTTAGCCGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACT
GTCCAATGTGCTCAGCCAGGCTGGAGGCGGCAGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACC
CCTGAATAGCTCCTTCGGCCCCATCTCCATCCTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGGGTAAGCAACAGGCGGCATTCA
GGACTCTTCTCAACCCTGCTGTTCAGACTTGATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTGCAATAAAAGCACCCGTAGTAG
CAAAAACATAAAACAAATAAAACTTCCCCCACATCACAGATGATTTTGGACAAGATTTTCCAACCTTGCTGGCTACTTTAGTTTGGGACC
TGTTTTTTTTCTCATTTGATTTTGCTTGTGCAGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAGAATGAGGCTCAGTTGTGGATA
GTCTGTTTTCTCTGAGCATGTTGGCCAACTAGTATCGTCAAATTATTGAGTGGATCATCTCTTGGAAATGCAGAACTTCTGCCACCACTT

>In-frame_RUNX1_ENST00000300305_chr21_36231771_-_CBFA2T2_ENST00000375279_chr20_32194762_+_8202nt
GGAAAGGGGAACAGTTAAATTTGTAATTTGGGTTGTGTGAAAACTTCTTTGGGCCTCATAAACAACCACAGAACCACAAGTTGGGTAGCC
TGGCAGTGTCAGAAGTCTGAACCCAGCATAGTGGTCAGCAGGCAGGACGAATCACACTGAATGCAAACCACAGGGTTTCGCAGCGTGGTG
AGCATCACCAACCCACAGCCAAGGCGGCGCTGGCTTTTTTTTTTTTTTTAATCTTTAACAATTTGAATATTTGTTTTTACAAAGGTGCAT
TTTTTAATAGGGCTTGGGGAGTCCCAGAGGTATCCAGCAGAGGGGAGAAGAAAGAGAGATGTAGGGCTAGAGGGGTGAGGCTGAAACAGT
GACCTGTCTTGGTTTTCGCTCCGAAGGTAAAAGAAATCATTGAGTCCCCCGCCTTCAGAAGAGGGTGCATTTTCAGGAGGAAGCGATGGC
TTCAGACAGCATATTTGAGTCATTTCCTTCGTACCCACAGTGCTTCATGAGAGAATGCATACTTGGAATGAATCCTTCTAGAGACGTCCA
CGATGCCAGCACGAGCCGCCGCTTCACGCCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGA
CGCCGGCGCTGCCCTGGCCGGCAAGCTGAGGAGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCAC
CGACAGCCCCAACTTCCTCTGCTCCGTGCTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGG
GGATGTTCCAGATGGCACTCTGGTCACTGTGATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAA
GAACCAGGTTGCAAGATTTAATGACCTCAGGTTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAA
CCCACCGCAAGTCGCCACCTACCACAGAGCCATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAATTGGTCCTGAGAAAAGGGTGCC
AGCGATGCCTGGATCGCCTGTGGAAGTGAAGATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGG
ACCGAGGCCAGTGTCCTTCACTCCTACTGCATTAAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACA
GAGATTCAGCAATGGTCCTGCCTCCTCCACATCATCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAA
GTTGAAACGCTTTCTTACCACTCTGCAACAGTTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACT
GGTGAACTCAACAGTGACAATTGAGGAATTCCACTGTAAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCT
CAAGGCCAACCTGCCCCTGCTGCAGCGGGAACTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGA
ACACCTTCTGCTCAACACAAGCATTGCATCGCCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCC
AGAGAGGAGAGAAGAGAATAGTTTTGATAGAGACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCG
GCACAGTCCTGCTCTCACTGTGCCCCTCATGAATCCCGGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGA
TATTGCAACTTCTCACCTGTATCGGGAACCCAACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGG
AGGCTATCAAGATGAGTTGGTAGATCATCGTTTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCAT
TATGGAAATGGTAGAGAAAACAAGGCGCTCTATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAG
ACGGTACAATGAAAACACAGAGCTGAGGAAAACGGGGACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAA
TGATTCTCAGAGAGAGTTCAACAGCAGGCCAGGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGT
GAAAATTCAGGCCATGTCAGAAGTACAGAAGGCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAAT
GGAGCAAACCATAGCGGATGTCAAGCGGCAGGCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTG
GAACTGTGGCCGCAAAGCCAGCGAGACATGCAGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCG
GCACCACCGCCTCTGTGGTCAGAACCTGCATGGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGC
CAGGTCCGCCGACTGCAGCGTGCCCAGCCCAGCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGC
TATCGACACCAACGGACTCTGAGCCCCGGACTCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGCTTGGGCTGAGGGACTGACTGT
TGGAACCCGTGCATGTAGCTGCCGGGTCATCAGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCTGAATAATAACACCCCACAGCC
TCTCTGTGCACTTGCTGTCTGCGGAGCCAGTGTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGT
TTGTTCCTCTCTCCACTGAAGCTGACTTAGCCGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACT
GTCCAATGTGCTCAGCCAGGCTGGAGGCGGCAGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACC
CCTGAATAGCTCCTTCGGCCCCATCTCCATCCTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGGGTAAGCAACAGGCGGCATTCA
GGACTCTTCTCAACCCTGCTGTTCAGACTTGATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTGCAATAAAAGCACCCGTAGTAG
CAAAAACATAAAACAAATAAAACTTCCCCCACATCACAGATGATTTTGGACAAGATTTTCCAACCTTGCTGGCTACTTTAGTTTGGGACC
TGTTTTTTTTCTCATTTGATTTTGCTTGTGCAGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAGAATGAGGCTCAGTTGTGGATA
GTCTGTTTTCTCTGAGCATGTTGGCCAACTAGTATCGTCAAATTATTGAGTGGATCATCTCTTGGAAATGCAGAACTTCTGCCACCACTT
GGCTATTTGCACAGTCATCTTGTTCTGTGTCCTTTTATCTCTCAGACCACACACATCTGGAACGCTGTGGGCATCTTCTGCCCATGGGCT
CCATTTGGCACCTGCTGAGCCACAGTTGTCCTGCTGGATGTGCTGTGCAGGTTGGTAGGACTTGCCCCCACTGTCAAGGCCTGGTCTCAT
CTGAAAAGCCCTCCTGGACCTCAAAGAATTCTTCAGACCTCATAGTTACAGGTCATTATATCTACTATGTTGATTTATCATCAGGCACAC
AACTTCTGTTTCCTTCTCTTGTGTTATCTGATAGCGTCCCTCCTTGAGCTCATCAGAAAGGTTTTATGAAATGTGAACCATTTTGGGAAA
AGCTGATCAATTTTTCTTCCTAGCTTCCCATTTTCAAATGGGACATCACTCATATCCCTTTCAGAATGTTAGGAACTGCCTCCCACATTC
TTCCCTGTCTTTTTGGGTTTTGTTTTTTGTTGTTGTGGTGGTTTTTTAACACAAAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGC
ATGATCTTGGCTCACTGCAACCTCTGCCTTCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGAGATTACAGGCGCCCAC
CACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGATCTCGAACTCCTGACCTCAGGTGAC
CTGCCTTGGCCTCCCAAAGTGCAGGGATTACAAGCGTGAGCCACCATGCCCGGCCTGTCTTTTTGGTTTTGATGGGAGTCTGAGGACCCC
GACCCCTCCTGCTCTCCATCTTTGAGCCTCTGGCATCCTCTCACACCCAGAAATCAGTTGGAGTAAGTTTAATTGGCCCTGCTCCAGCTG
GCCTTTGAAGCACAAGTTTAAATCTCCACCTTCTGTGCACTGACCAGAGTCTAAAATAAAAGTTGTCAGTACCATAAAGGAAAAGGGATC
CACACAGGTAGCCTTCTCCTTGGATACAGGTACATCTTACTGTAAGAATTTCAAGTCCTGGCTGGGCGCAGTGGCTCACTCCTGTAATCC
CAGCACTTTGAGAGACCGAGGCAGGCAGATCACTTGAGGTCAGGAATTCAAGACCAACCTGGCCAACATGGTGAAACCCTGTCTCTAATA
AAAAAAAAATAGAAAAATCAGCCGGGTGTGGTGGCACACACCTGTAATCCTAGCTACTCAGGAGGCTGAGGCAAGAGAATCTCTTGAACC
TGTGAGCCAGAGGTTGCAGTGAGCCGAGATTCCACCACTGCACTCCAGCCTGGGCAACAGAGCAAAACTCTGTCTCAAAAAAAAAAAAAA
AAAGGCAAAATTAAAGAATTTCAAGTCCCTAATTTACTCTAACCAAGCATTTTCAGTCTTACAAAGAAATCTAGTGCACGACACCTTTAA
AATGCCTAGATTTCCATTGCCTAAAGTAAGGTGTGACCAGTGAAACAACAGCAGAGAATCATGTTCCTTTGCTGTGGAACACATAAGCCC
CACAGTTTTCCAGTCAGCCTAATACATGGGTATCCCCCGACCCCATCTGCCTCCTTAAGCCACAGTCCTTGGTGGGGAACTCTAAGGGGG
ACGGAGTCAGTACCCCGGACAGGGCCACATTTGCATGAGACATGGCTGTCTCACAGGTCACAGAGCCATTACAACAGCTTACTAGTTTTT
CATGGATTTGTTGGATTAACACCTTAAGCAGGTTTTTTATTGTTATTTTGTTTGTTTGTTTGTTTTGAGACGGGAGTTTCTCTCTTGTCT
CCCAGGCTGGAGTGCAATCGCGCAATCTCGGCTCACGGTAACCTCTGCCTCCCAGGTTCAAGCGAGTCTCCTGCCTCAGCCTTCTGAGTA
GCTGGGATTACAGGCATGCGCCACCACGCCCAACTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCCTTGTTGGTCAGGCTGGTCTCA
AACCCCGGACCTCAGGTGATCCCCCCACCTTGGCCTCCCAAAGTGCCAGGATTACAGGCATGAGCCACTGTGTCCGGTCTTGAGCAGGTT
TTTAAAATCTCCAGTGGCCATAAAACTAGCCAGGGTAGCTCATGCTTTTACTGGTTGGAATAAGGAGCCAAAACCAACAAAATAATATTT
ATTAGGGCTCGATGCCCATTTCTGTGGCTAAGGCTTAGGTTTGGTGTGCAGAGCCTGGCCTGCTCTTGTGGGCTGTGGTTGCTGTGACAG
TTTCGTTTTCTGAATCTTTGTAATGCTCTTCCACCCTGCTCGTGCTGCCCAGAGGCTGATCTGCAAACCTGGGCAGTATTCCACACTGAA
GCTCAGTTTGCAAACCTTCTGCTGTGTTAATTCTGGTCAGTTTCACACAGAAGTCACGAGGGCCTCTGCCCAGGACCTTCTATTCACATT
TCAAGAATCCCTTTCTGAAATTCTCCAACTCTCTGGTCAGGAGGAGGAGCACCATTGGGGCGGGGTAGGCAGCTAGAGGCGCAGGAGCGA
ATCCAGGTTCCTTGCGTGGTTCCCAGCCTCTGCTGACAGCACCTCAGCTACCAGGTGGGGAGTGGAAATTCAGCCTGCTTAGAGGACTGA
CCTCTACAGTTCATATTTGCAGTGACATAAAAGGCAAAGAGGAGCTGGCATGGTGGTACAGAAGGTATCAGTCAAGCGCAGGCTCTTCAG
AAACCTAGAAACTAAAAAGAGATGCAACATGTGACTGGCCATCAGCCAGACATGTCTAGGGTGAGACCAGTGCTCAGCACCACCCGCCAA
GGAACACTGATGAGTTGTGGGACATTATGGTCGGCCAAGTGAGGAATGATTGCAGGGACCAGAGAAGACCAAAGATGCCAGATGTCCCCA
GAGTTTCTTGAGGGCTGGGTTTCACGTCTTTGCTTGTCCTTTTTGTCCCCACTTGCCTGCACCGTGCCTGACTCATCCAGTGGGGAAGGT
GACTCAAGAAGTTGTTTAAGCCTAGGCCTAGGCAGTCCACTTCGGGAGGTGGGGGCACTCCACACTGGGGGGCCCTGCAGCTCCAGGGCT
GGTGCTCTAGCAGATCCGCTCAGGCACGGTTGGGTGACCGTGGGGTCACCGATTGCGTAGATTATTTCTAGGGCAGTGCTGGGTTAGAAA
TGTCTGTCTGGAAACAGGACACATCTTGCCACCACAAGTCCACACCTGGCCTTGGCTGCTGCCCGCTCTCTGCAGCGTGGATTTCCTTTG
CCCATTTGGGCCAGAAGGTCACCAGGAGTTCATCACTGCTTAGTGTCAACTTGACATCTTCAGCTTCCAGACAGAAAACCCATGCTTTAC
TTTGTACAGCCCTGTCCCAGAGTTAGTAAGCCTCGGCTTGTCACCTGCTTGCAAAGGGTATAGACATCATTCTGGGTAGTTCTAGAGGAT
ATCGCAACAAGTGCGTTTGAAGGTTCAGCACAGCTGGAATTGTACGGTAGTGAGCTCTTCAAAATGAAAACAGAATGACCGGATGGCCAT
CTGTCCTGGAAACTGTAGAATTGAATAAATCACTGAAAATAGAACACTTCTTGGAGGCTTTCTTCAGAACTGAACTAGAAACAAGGTTTC
CAGGCTCCCAGGTCAGTAGACCAAACCAACTTCCTTAGATTTTTTTTTTTAAGCTGTTTGCAGAAAACTGGGTGGTAGCGTGTCTGAACC
AAACGGAAGAATAGCCAGCGGAGCATGGACTGTTCCAGCACGGGCCAGATGGCCAGCTGTCGAGAGCAGCCCTGCCCAGATTGCGGTGGG
GGCTGTGCCAGCGGCTCCGCAGGGCCCTTCCAACTCTGGAGTGTCTGTAGTTCTTGTGAAACCAAAACGTTGACTACCTGCCTCTTTCCT
CGGGCATCGACGTGCTCATTTCCAAAGATGATGGTGCAGGTGACCTTTTCCATCGTGAGCTAAGAGAAGGTTAGGAGGCCTGAGGGGCGG
GCCTTGTGTCCCCTCCTCCCCCTCCACAGCCCCTGAGGTGGAGCTTCCCTCACAGACCCCATCTGGTCGAGCCTACGGCTGCCCAGTGTA
CACTCAGTGATGCTTATACCAAATAGGGCATGTGCGCTGGTGTCTGTTGGGGACAGCCCCATCCCTACCTTGGAGTCGGCAGAGAAGCAG
CAATAAGCATTAGGCGAATGATTGAAAGGGCTGCTGCGCCAAGAGGCCTTCAGTCCCCTTAACGTGGCTTTCCAACTTCCTGACGAGGCT
ACAAAGGCTCCGCTCACAAAAGAAAGCCAATAATGTAAATAAATAGAAAACGAAGCCTCCACGCGTGGTTTTTAAAGGGGGATGATGAAT
GTGACACCACCCACAGAATGCATTAGAATCTGGTTTTTCTGTGCTTTGTCATTTTACTCTGATAGGAATTTTTGTTACCTAACTCTGTGC
ATAACTTATTTAATGTACTGTATAAATGAACCAAAACTGTTAAATATGTATTTAGTTTGTTCTACTTAAAGTAGTCAATAAAAAGGCTAT

>In-frame_RUNX1_ENST00000399240_chr21_36231771_-_CBFA2T2_ENST00000342704_chr20_32194762_+_3252nt
TGAAGATCCGCGCCCCTGTCGCCGTCTGGTAGGAGCTGTTTGCAGGGTCCTAACTCAATCGGCTTGTTGTGATGCGTATCCCCGTAGATG
CCAGCACGAGCCGCCGCTTCACGCCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCG
GCGCTGCCCTGGCCGGCAAGCTGAGGAGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACA
GCCCCAACTTCCTCTGCTCCGTGCTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATG
TTCCAGATGGCACTCTGGTCACTGTGATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACC
AGGTTGCAAGATTTAATGACCTCAGGTTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCAC
CGCAAGTCGCCACCTACCACAGAGCCATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAATTGGTCCTGAGAAAAGGGTGCCAGCGA
TGCCTGGATCGCCTGTGGAAGTGAAGATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGGACCGA
GGCCAGTGTCCTTCACTCCTACTGCATTAAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACAGAGAT
TCAGCAATGGTCCTGCCTCCTCCACATCATCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAAGTTGA
AACGCTTTCTTACCACTCTGCAACAGTTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACTGGTGA
ACTCAACAGTGACAATTGAGGAATTCCACTGTAAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCTCAAGG
CCAACCTGCCCCTGCTGCAGCGGGAACTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGAACACC
TTCTGCTCAACACAAGCATTGCATCGCCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCCAGAGA
GGAGAGAAGAGAATAGTTTTGATAGAGACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCGGCACA
GTCCTGCTCTCACTGTGCCCCTCATGAATCCCGGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGATATTG
CAACTTCTCACCTGTATCGGGAACCCAACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGGAGGCT
ATCAAGATGAGTTGGTAGATCATCGTTTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCATTATGG
AAATGGTAGAGAAAACAAGGCGCTCTATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAGACGGT
ACAATGAAAACACAGAGCTGAGGAAAACGGGGACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAATGATT
CTCAGAGAGAGTTCAACAGCAGGCCAGGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGTGAAAA
TTCAGGCCATGTCAGAAGTACAGAAGGCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAATGGAGC
AAACCATAGCGGATGTCAAGCGGCAGGCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTGGAACT
GTGGCCGCAAAGCCAGCGAGACATGCAGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACC
ACCGCCTCTGTGGTCAGAACCTGCATGGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGGT
CCGCCGACTGCAGCGTGCCCAGCCCAGCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGCTATCG
ACACCAACGGACTCTGAGCCCCGGACTCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGCTTGGGCTGAGGGACTGACTGTTGGAA
CCCGTGCATGTAGCTGCCGGGTCATCAGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCTGAATAATAACACCCCACAGCCTCTCT
GTGCACTTGCTGTCTGCGGAGCCAGTGTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGTTTGTT
CCTCTCTCCACTGAAGCTGACTTAGCCGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACTGTCCA
ATGTGCTCAGCCAGGCTGGAGGCGGCAGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACCCCTGA
ATAGCTCCTTCGGCCCCATCTCCATCCTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGGGTAAGCAACAGGCGGCATTCAGGACT
CTTCTCAACCCTGCTGTTCAGACTTGATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTGCAATAAAAGCACCCGTAGTAGCAAAA
ACATAAAACAAATAAAACTTCCCCCACATCACAGATGATTTTGGACAAGATTTTCCAACCTTGCTGGCTACTTTAGTTTGGGACCTGTTT
TTTTTCTCATTTGATTTTGCTTGTGCAGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAGAATGAGGCTCAGTTGTGGATAGTCTG
TTTTCTCTGAGCATGTTGGCCAACTAGTATCGTCAAATTATTGAGTGGATCATCTCTTGGAAATGCAGAACTTCTGCCACCACTTGGCTA

>In-frame_RUNX1_ENST00000399240_chr21_36231771_-_CBFA2T2_ENST00000375279_chr20_32194762_+_7747nt
TGAAGATCCGCGCCCCTGTCGCCGTCTGGTAGGAGCTGTTTGCAGGGTCCTAACTCAATCGGCTTGTTGTGATGCGTATCCCCGTAGATG
CCAGCACGAGCCGCCGCTTCACGCCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCG
GCGCTGCCCTGGCCGGCAAGCTGAGGAGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACA
GCCCCAACTTCCTCTGCTCCGTGCTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATG
TTCCAGATGGCACTCTGGTCACTGTGATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACC
AGGTTGCAAGATTTAATGACCTCAGGTTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCAC
CGCAAGTCGCCACCTACCACAGAGCCATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAATTGGTCCTGAGAAAAGGGTGCCAGCGA
TGCCTGGATCGCCTGTGGAAGTGAAGATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGGACCGA
GGCCAGTGTCCTTCACTCCTACTGCATTAAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACAGAGAT
TCAGCAATGGTCCTGCCTCCTCCACATCATCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAAGTTGA
AACGCTTTCTTACCACTCTGCAACAGTTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACTGGTGA
ACTCAACAGTGACAATTGAGGAATTCCACTGTAAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCTCAAGG
CCAACCTGCCCCTGCTGCAGCGGGAACTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGAACACC
TTCTGCTCAACACAAGCATTGCATCGCCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCCAGAGA
GGAGAGAAGAGAATAGTTTTGATAGAGACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCGGCACA
GTCCTGCTCTCACTGTGCCCCTCATGAATCCCGGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGATATTG
CAACTTCTCACCTGTATCGGGAACCCAACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGGAGGCT
ATCAAGATGAGTTGGTAGATCATCGTTTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCATTATGG
AAATGGTAGAGAAAACAAGGCGCTCTATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAGACGGT
ACAATGAAAACACAGAGCTGAGGAAAACGGGGACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAATGATT
CTCAGAGAGAGTTCAACAGCAGGCCAGGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGTGAAAA
TTCAGGCCATGTCAGAAGTACAGAAGGCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAATGGAGC
AAACCATAGCGGATGTCAAGCGGCAGGCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTGGAACT
GTGGCCGCAAAGCCAGCGAGACATGCAGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACC
ACCGCCTCTGTGGTCAGAACCTGCATGGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGGT
CCGCCGACTGCAGCGTGCCCAGCCCAGCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGCTATCG
ACACCAACGGACTCTGAGCCCCGGACTCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGCTTGGGCTGAGGGACTGACTGTTGGAA
CCCGTGCATGTAGCTGCCGGGTCATCAGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCTGAATAATAACACCCCACAGCCTCTCT
GTGCACTTGCTGTCTGCGGAGCCAGTGTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGTTTGTT
CCTCTCTCCACTGAAGCTGACTTAGCCGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACTGTCCA
ATGTGCTCAGCCAGGCTGGAGGCGGCAGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACCCCTGA
ATAGCTCCTTCGGCCCCATCTCCATCCTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGGGTAAGCAACAGGCGGCATTCAGGACT
CTTCTCAACCCTGCTGTTCAGACTTGATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTGCAATAAAAGCACCCGTAGTAGCAAAA
ACATAAAACAAATAAAACTTCCCCCACATCACAGATGATTTTGGACAAGATTTTCCAACCTTGCTGGCTACTTTAGTTTGGGACCTGTTT
TTTTTCTCATTTGATTTTGCTTGTGCAGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAGAATGAGGCTCAGTTGTGGATAGTCTG
TTTTCTCTGAGCATGTTGGCCAACTAGTATCGTCAAATTATTGAGTGGATCATCTCTTGGAAATGCAGAACTTCTGCCACCACTTGGCTA
TTTGCACAGTCATCTTGTTCTGTGTCCTTTTATCTCTCAGACCACACACATCTGGAACGCTGTGGGCATCTTCTGCCCATGGGCTCCATT
TGGCACCTGCTGAGCCACAGTTGTCCTGCTGGATGTGCTGTGCAGGTTGGTAGGACTTGCCCCCACTGTCAAGGCCTGGTCTCATCTGAA
AAGCCCTCCTGGACCTCAAAGAATTCTTCAGACCTCATAGTTACAGGTCATTATATCTACTATGTTGATTTATCATCAGGCACACAACTT
CTGTTTCCTTCTCTTGTGTTATCTGATAGCGTCCCTCCTTGAGCTCATCAGAAAGGTTTTATGAAATGTGAACCATTTTGGGAAAAGCTG
ATCAATTTTTCTTCCTAGCTTCCCATTTTCAAATGGGACATCACTCATATCCCTTTCAGAATGTTAGGAACTGCCTCCCACATTCTTCCC
TGTCTTTTTGGGTTTTGTTTTTTGTTGTTGTGGTGGTTTTTTAACACAAAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGAT
CTTGGCTCACTGCAACCTCTGCCTTCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGAGATTACAGGCGCCCACCACCA
CGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGATCTCGAACTCCTGACCTCAGGTGACCTGCC
TTGGCCTCCCAAAGTGCAGGGATTACAAGCGTGAGCCACCATGCCCGGCCTGTCTTTTTGGTTTTGATGGGAGTCTGAGGACCCCGACCC
CTCCTGCTCTCCATCTTTGAGCCTCTGGCATCCTCTCACACCCAGAAATCAGTTGGAGTAAGTTTAATTGGCCCTGCTCCAGCTGGCCTT
TGAAGCACAAGTTTAAATCTCCACCTTCTGTGCACTGACCAGAGTCTAAAATAAAAGTTGTCAGTACCATAAAGGAAAAGGGATCCACAC
AGGTAGCCTTCTCCTTGGATACAGGTACATCTTACTGTAAGAATTTCAAGTCCTGGCTGGGCGCAGTGGCTCACTCCTGTAATCCCAGCA
CTTTGAGAGACCGAGGCAGGCAGATCACTTGAGGTCAGGAATTCAAGACCAACCTGGCCAACATGGTGAAACCCTGTCTCTAATAAAAAA
AAAATAGAAAAATCAGCCGGGTGTGGTGGCACACACCTGTAATCCTAGCTACTCAGGAGGCTGAGGCAAGAGAATCTCTTGAACCTGTGA
GCCAGAGGTTGCAGTGAGCCGAGATTCCACCACTGCACTCCAGCCTGGGCAACAGAGCAAAACTCTGTCTCAAAAAAAAAAAAAAAAAGG
CAAAATTAAAGAATTTCAAGTCCCTAATTTACTCTAACCAAGCATTTTCAGTCTTACAAAGAAATCTAGTGCACGACACCTTTAAAATGC
CTAGATTTCCATTGCCTAAAGTAAGGTGTGACCAGTGAAACAACAGCAGAGAATCATGTTCCTTTGCTGTGGAACACATAAGCCCCACAG
TTTTCCAGTCAGCCTAATACATGGGTATCCCCCGACCCCATCTGCCTCCTTAAGCCACAGTCCTTGGTGGGGAACTCTAAGGGGGACGGA
GTCAGTACCCCGGACAGGGCCACATTTGCATGAGACATGGCTGTCTCACAGGTCACAGAGCCATTACAACAGCTTACTAGTTTTTCATGG
ATTTGTTGGATTAACACCTTAAGCAGGTTTTTTATTGTTATTTTGTTTGTTTGTTTGTTTTGAGACGGGAGTTTCTCTCTTGTCTCCCAG
GCTGGAGTGCAATCGCGCAATCTCGGCTCACGGTAACCTCTGCCTCCCAGGTTCAAGCGAGTCTCCTGCCTCAGCCTTCTGAGTAGCTGG
GATTACAGGCATGCGCCACCACGCCCAACTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCCTTGTTGGTCAGGCTGGTCTCAAACCC
CGGACCTCAGGTGATCCCCCCACCTTGGCCTCCCAAAGTGCCAGGATTACAGGCATGAGCCACTGTGTCCGGTCTTGAGCAGGTTTTTAA
AATCTCCAGTGGCCATAAAACTAGCCAGGGTAGCTCATGCTTTTACTGGTTGGAATAAGGAGCCAAAACCAACAAAATAATATTTATTAG
GGCTCGATGCCCATTTCTGTGGCTAAGGCTTAGGTTTGGTGTGCAGAGCCTGGCCTGCTCTTGTGGGCTGTGGTTGCTGTGACAGTTTCG
TTTTCTGAATCTTTGTAATGCTCTTCCACCCTGCTCGTGCTGCCCAGAGGCTGATCTGCAAACCTGGGCAGTATTCCACACTGAAGCTCA
GTTTGCAAACCTTCTGCTGTGTTAATTCTGGTCAGTTTCACACAGAAGTCACGAGGGCCTCTGCCCAGGACCTTCTATTCACATTTCAAG
AATCCCTTTCTGAAATTCTCCAACTCTCTGGTCAGGAGGAGGAGCACCATTGGGGCGGGGTAGGCAGCTAGAGGCGCAGGAGCGAATCCA
GGTTCCTTGCGTGGTTCCCAGCCTCTGCTGACAGCACCTCAGCTACCAGGTGGGGAGTGGAAATTCAGCCTGCTTAGAGGACTGACCTCT
ACAGTTCATATTTGCAGTGACATAAAAGGCAAAGAGGAGCTGGCATGGTGGTACAGAAGGTATCAGTCAAGCGCAGGCTCTTCAGAAACC
TAGAAACTAAAAAGAGATGCAACATGTGACTGGCCATCAGCCAGACATGTCTAGGGTGAGACCAGTGCTCAGCACCACCCGCCAAGGAAC
ACTGATGAGTTGTGGGACATTATGGTCGGCCAAGTGAGGAATGATTGCAGGGACCAGAGAAGACCAAAGATGCCAGATGTCCCCAGAGTT
TCTTGAGGGCTGGGTTTCACGTCTTTGCTTGTCCTTTTTGTCCCCACTTGCCTGCACCGTGCCTGACTCATCCAGTGGGGAAGGTGACTC
AAGAAGTTGTTTAAGCCTAGGCCTAGGCAGTCCACTTCGGGAGGTGGGGGCACTCCACACTGGGGGGCCCTGCAGCTCCAGGGCTGGTGC
TCTAGCAGATCCGCTCAGGCACGGTTGGGTGACCGTGGGGTCACCGATTGCGTAGATTATTTCTAGGGCAGTGCTGGGTTAGAAATGTCT
GTCTGGAAACAGGACACATCTTGCCACCACAAGTCCACACCTGGCCTTGGCTGCTGCCCGCTCTCTGCAGCGTGGATTTCCTTTGCCCAT
TTGGGCCAGAAGGTCACCAGGAGTTCATCACTGCTTAGTGTCAACTTGACATCTTCAGCTTCCAGACAGAAAACCCATGCTTTACTTTGT
ACAGCCCTGTCCCAGAGTTAGTAAGCCTCGGCTTGTCACCTGCTTGCAAAGGGTATAGACATCATTCTGGGTAGTTCTAGAGGATATCGC
AACAAGTGCGTTTGAAGGTTCAGCACAGCTGGAATTGTACGGTAGTGAGCTCTTCAAAATGAAAACAGAATGACCGGATGGCCATCTGTC
CTGGAAACTGTAGAATTGAATAAATCACTGAAAATAGAACACTTCTTGGAGGCTTTCTTCAGAACTGAACTAGAAACAAGGTTTCCAGGC
TCCCAGGTCAGTAGACCAAACCAACTTCCTTAGATTTTTTTTTTTAAGCTGTTTGCAGAAAACTGGGTGGTAGCGTGTCTGAACCAAACG
GAAGAATAGCCAGCGGAGCATGGACTGTTCCAGCACGGGCCAGATGGCCAGCTGTCGAGAGCAGCCCTGCCCAGATTGCGGTGGGGGCTG
TGCCAGCGGCTCCGCAGGGCCCTTCCAACTCTGGAGTGTCTGTAGTTCTTGTGAAACCAAAACGTTGACTACCTGCCTCTTTCCTCGGGC
ATCGACGTGCTCATTTCCAAAGATGATGGTGCAGGTGACCTTTTCCATCGTGAGCTAAGAGAAGGTTAGGAGGCCTGAGGGGCGGGCCTT
GTGTCCCCTCCTCCCCCTCCACAGCCCCTGAGGTGGAGCTTCCCTCACAGACCCCATCTGGTCGAGCCTACGGCTGCCCAGTGTACACTC
AGTGATGCTTATACCAAATAGGGCATGTGCGCTGGTGTCTGTTGGGGACAGCCCCATCCCTACCTTGGAGTCGGCAGAGAAGCAGCAATA
AGCATTAGGCGAATGATTGAAAGGGCTGCTGCGCCAAGAGGCCTTCAGTCCCCTTAACGTGGCTTTCCAACTTCCTGACGAGGCTACAAA
GGCTCCGCTCACAAAAGAAAGCCAATAATGTAAATAAATAGAAAACGAAGCCTCCACGCGTGGTTTTTAAAGGGGGATGATGAATGTGAC
ACCACCCACAGAATGCATTAGAATCTGGTTTTTCTGTGCTTTGTCATTTTACTCTGATAGGAATTTTTGTTACCTAACTCTGTGCATAAC
TTATTTAATGTACTGTATAAATGAACCAAAACTGTTAAATATGTATTTAGTTTGTTCTACTTAAAGTAGTCAATAAAAAGGCTATATTCC

>In-frame_RUNX1_ENST00000486278_chr21_36231771_-_CBFA2T2_ENST00000342704_chr20_32194762_+_3406nt
GAGCATCACCAACCCACAGCCAAGGCGGCGCTGGCTTTTTTTTTTTTTTTAATCTTTAACAATTTGAATATTTGTTTTTACAAAGGTAAA
AGAAATCATTGAGTCCCCCGCCTTCAGAAGAGGGTGCATTTTCAGGAGGAAGCGATGGCTTCAGACAGCATATTTGAGTCATTTCCTTCG
TACCCACAGTGCTTCATGAGAGAATGCATACTTGGAATGAATCCTTCTAGAGACGTCCACGATGCCAGCACGAGCCGCCGCTTCACGCCG
CCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCGGCGCTGCCCTGGCCGGCAAGCTGAGG
AGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTGCTG
CCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACTGTG
ATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTCAGG
TTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGAGCC
ATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAATTGGTCCTGAGAAAAGGGTGCCAGCGATGCCTGGATCGCCTGTGGAAGTGAAG
ATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGGACCGAGGCCAGTGTCCTTCACTCCTACTGCA
TTAAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACAGAGATTCAGCAATGGTCCTGCCTCCTCCACA
TCATCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAAGTTGAAACGCTTTCTTACCACTCTGCAACAG
TTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACTGGTGAACTCAACAGTGACAATTGAGGAATTC
CACTGTAAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCTCAAGGCCAACCTGCCCCTGCTGCAGCGGGAA
CTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGAACACCTTCTGCTCAACACAAGCATTGCATCG
CCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCCAGAGAGGAGAGAAGAGAATAGTTTTGATAGA
GACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCGGCACAGTCCTGCTCTCACTGTGCCCCTCATG
AATCCCGGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGATATTGCAACTTCTCACCTGTATCGGGAACCC
AACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGGAGGCTATCAAGATGAGTTGGTAGATCATCGT
TTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCATTATGGAAATGGTAGAGAAAACAAGGCGCTCT
ATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAGACGGTACAATGAAAACACAGAGCTGAGGAAA
ACGGGGACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAATGATTCTCAGAGAGAGTTCAACAGCAGGCCA
GGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGTGAAAATTCAGGCCATGTCAGAAGTACAGAAG
GCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAATGGAGCAAACCATAGCGGATGTCAAGCGGCAG
GCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTGGAACTGTGGCCGCAAAGCCAGCGAGACATGC
AGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACCACCGCCTCTGTGGTCAGAACCTGCAT
GGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGGTCCGCCGACTGCAGCGTGCCCAGCCCA
GCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGCTATCGACACCAACGGACTCTGAGCCCCGGAC
TCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGCTTGGGCTGAGGGACTGACTGTTGGAACCCGTGCATGTAGCTGCCGGGTCATC
AGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCTGAATAATAACACCCCACAGCCTCTCTGTGCACTTGCTGTCTGCGGAGCCAGT
GTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGTTTGTTCCTCTCTCCACTGAAGCTGACTTAGC
CGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACTGTCCAATGTGCTCAGCCAGGCTGGAGGCGGC
AGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACCCCTGAATAGCTCCTTCGGCCCCATCTCCATC
CTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGGGTAAGCAACAGGCGGCATTCAGGACTCTTCTCAACCCTGCTGTTCAGACTTG
ATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTGCAATAAAAGCACCCGTAGTAGCAAAAACATAAAACAAATAAAACTTCCCCCA
CATCACAGATGATTTTGGACAAGATTTTCCAACCTTGCTGGCTACTTTAGTTTGGGACCTGTTTTTTTTCTCATTTGATTTTGCTTGTGC
AGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAGAATGAGGCTCAGTTGTGGATAGTCTGTTTTCTCTGAGCATGTTGGCCAACTA

>In-frame_RUNX1_ENST00000486278_chr21_36231771_-_CBFA2T2_ENST00000375279_chr20_32194762_+_7901nt
GAGCATCACCAACCCACAGCCAAGGCGGCGCTGGCTTTTTTTTTTTTTTTAATCTTTAACAATTTGAATATTTGTTTTTACAAAGGTAAA
AGAAATCATTGAGTCCCCCGCCTTCAGAAGAGGGTGCATTTTCAGGAGGAAGCGATGGCTTCAGACAGCATATTTGAGTCATTTCCTTCG
TACCCACAGTGCTTCATGAGAGAATGCATACTTGGAATGAATCCTTCTAGAGACGTCCACGATGCCAGCACGAGCCGCCGCTTCACGCCG
CCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCGGCGCTGCCCTGGCCGGCAAGCTGAGG
AGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTGCTG
CCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACTGTG
ATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTCAGG
TTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGAGCC
ATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAATTGGTCCTGAGAAAAGGGTGCCAGCGATGCCTGGATCGCCTGTGGAAGTGAAG
ATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGGACCGAGGCCAGTGTCCTTCACTCCTACTGCA
TTAAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACAGAGATTCAGCAATGGTCCTGCCTCCTCCACA
TCATCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAAGTTGAAACGCTTTCTTACCACTCTGCAACAG
TTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACTGGTGAACTCAACAGTGACAATTGAGGAATTC
CACTGTAAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCTCAAGGCCAACCTGCCCCTGCTGCAGCGGGAA
CTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGAACACCTTCTGCTCAACACAAGCATTGCATCG
CCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCCAGAGAGGAGAGAAGAGAATAGTTTTGATAGA
GACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCGGCACAGTCCTGCTCTCACTGTGCCCCTCATG
AATCCCGGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGATATTGCAACTTCTCACCTGTATCGGGAACCC
AACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGGAGGCTATCAAGATGAGTTGGTAGATCATCGT
TTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCATTATGGAAATGGTAGAGAAAACAAGGCGCTCT
ATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAGACGGTACAATGAAAACACAGAGCTGAGGAAA
ACGGGGACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAATGATTCTCAGAGAGAGTTCAACAGCAGGCCA
GGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGTGAAAATTCAGGCCATGTCAGAAGTACAGAAG
GCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAATGGAGCAAACCATAGCGGATGTCAAGCGGCAG
GCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTGGAACTGTGGCCGCAAAGCCAGCGAGACATGC
AGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACCACCGCCTCTGTGGTCAGAACCTGCAT
GGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGGTCCGCCGACTGCAGCGTGCCCAGCCCA
GCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGCTATCGACACCAACGGACTCTGAGCCCCGGAC
TCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGCTTGGGCTGAGGGACTGACTGTTGGAACCCGTGCATGTAGCTGCCGGGTCATC
AGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCTGAATAATAACACCCCACAGCCTCTCTGTGCACTTGCTGTCTGCGGAGCCAGT
GTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGTTTGTTCCTCTCTCCACTGAAGCTGACTTAGC
CGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACTGTCCAATGTGCTCAGCCAGGCTGGAGGCGGC
AGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACCCCTGAATAGCTCCTTCGGCCCCATCTCCATC
CTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGGGTAAGCAACAGGCGGCATTCAGGACTCTTCTCAACCCTGCTGTTCAGACTTG
ATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTGCAATAAAAGCACCCGTAGTAGCAAAAACATAAAACAAATAAAACTTCCCCCA
CATCACAGATGATTTTGGACAAGATTTTCCAACCTTGCTGGCTACTTTAGTTTGGGACCTGTTTTTTTTCTCATTTGATTTTGCTTGTGC
AGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAGAATGAGGCTCAGTTGTGGATAGTCTGTTTTCTCTGAGCATGTTGGCCAACTA
GTATCGTCAAATTATTGAGTGGATCATCTCTTGGAAATGCAGAACTTCTGCCACCACTTGGCTATTTGCACAGTCATCTTGTTCTGTGTC
CTTTTATCTCTCAGACCACACACATCTGGAACGCTGTGGGCATCTTCTGCCCATGGGCTCCATTTGGCACCTGCTGAGCCACAGTTGTCC
TGCTGGATGTGCTGTGCAGGTTGGTAGGACTTGCCCCCACTGTCAAGGCCTGGTCTCATCTGAAAAGCCCTCCTGGACCTCAAAGAATTC
TTCAGACCTCATAGTTACAGGTCATTATATCTACTATGTTGATTTATCATCAGGCACACAACTTCTGTTTCCTTCTCTTGTGTTATCTGA
TAGCGTCCCTCCTTGAGCTCATCAGAAAGGTTTTATGAAATGTGAACCATTTTGGGAAAAGCTGATCAATTTTTCTTCCTAGCTTCCCAT
TTTCAAATGGGACATCACTCATATCCCTTTCAGAATGTTAGGAACTGCCTCCCACATTCTTCCCTGTCTTTTTGGGTTTTGTTTTTTGTT
GTTGTGGTGGTTTTTTAACACAAAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTTGGCTCACTGCAACCTCTGCCTTC
CAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGAGATTACAGGCGCCCACCACCACGCCCAGCTAATTTTTGTATTTTTAG
TAGAGACAGGGTTTCACCATGTTGGCCAGGCTGATCTCGAACTCCTGACCTCAGGTGACCTGCCTTGGCCTCCCAAAGTGCAGGGATTAC
AAGCGTGAGCCACCATGCCCGGCCTGTCTTTTTGGTTTTGATGGGAGTCTGAGGACCCCGACCCCTCCTGCTCTCCATCTTTGAGCCTCT
GGCATCCTCTCACACCCAGAAATCAGTTGGAGTAAGTTTAATTGGCCCTGCTCCAGCTGGCCTTTGAAGCACAAGTTTAAATCTCCACCT
TCTGTGCACTGACCAGAGTCTAAAATAAAAGTTGTCAGTACCATAAAGGAAAAGGGATCCACACAGGTAGCCTTCTCCTTGGATACAGGT
ACATCTTACTGTAAGAATTTCAAGTCCTGGCTGGGCGCAGTGGCTCACTCCTGTAATCCCAGCACTTTGAGAGACCGAGGCAGGCAGATC
ACTTGAGGTCAGGAATTCAAGACCAACCTGGCCAACATGGTGAAACCCTGTCTCTAATAAAAAAAAAATAGAAAAATCAGCCGGGTGTGG
TGGCACACACCTGTAATCCTAGCTACTCAGGAGGCTGAGGCAAGAGAATCTCTTGAACCTGTGAGCCAGAGGTTGCAGTGAGCCGAGATT
CCACCACTGCACTCCAGCCTGGGCAACAGAGCAAAACTCTGTCTCAAAAAAAAAAAAAAAAAGGCAAAATTAAAGAATTTCAAGTCCCTA
ATTTACTCTAACCAAGCATTTTCAGTCTTACAAAGAAATCTAGTGCACGACACCTTTAAAATGCCTAGATTTCCATTGCCTAAAGTAAGG
TGTGACCAGTGAAACAACAGCAGAGAATCATGTTCCTTTGCTGTGGAACACATAAGCCCCACAGTTTTCCAGTCAGCCTAATACATGGGT
ATCCCCCGACCCCATCTGCCTCCTTAAGCCACAGTCCTTGGTGGGGAACTCTAAGGGGGACGGAGTCAGTACCCCGGACAGGGCCACATT
TGCATGAGACATGGCTGTCTCACAGGTCACAGAGCCATTACAACAGCTTACTAGTTTTTCATGGATTTGTTGGATTAACACCTTAAGCAG
GTTTTTTATTGTTATTTTGTTTGTTTGTTTGTTTTGAGACGGGAGTTTCTCTCTTGTCTCCCAGGCTGGAGTGCAATCGCGCAATCTCGG
CTCACGGTAACCTCTGCCTCCCAGGTTCAAGCGAGTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGATTACAGGCATGCGCCACCACGCCC
AACTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCCTTGTTGGTCAGGCTGGTCTCAAACCCCGGACCTCAGGTGATCCCCCCACCTT
GGCCTCCCAAAGTGCCAGGATTACAGGCATGAGCCACTGTGTCCGGTCTTGAGCAGGTTTTTAAAATCTCCAGTGGCCATAAAACTAGCC
AGGGTAGCTCATGCTTTTACTGGTTGGAATAAGGAGCCAAAACCAACAAAATAATATTTATTAGGGCTCGATGCCCATTTCTGTGGCTAA
GGCTTAGGTTTGGTGTGCAGAGCCTGGCCTGCTCTTGTGGGCTGTGGTTGCTGTGACAGTTTCGTTTTCTGAATCTTTGTAATGCTCTTC
CACCCTGCTCGTGCTGCCCAGAGGCTGATCTGCAAACCTGGGCAGTATTCCACACTGAAGCTCAGTTTGCAAACCTTCTGCTGTGTTAAT
TCTGGTCAGTTTCACACAGAAGTCACGAGGGCCTCTGCCCAGGACCTTCTATTCACATTTCAAGAATCCCTTTCTGAAATTCTCCAACTC
TCTGGTCAGGAGGAGGAGCACCATTGGGGCGGGGTAGGCAGCTAGAGGCGCAGGAGCGAATCCAGGTTCCTTGCGTGGTTCCCAGCCTCT
GCTGACAGCACCTCAGCTACCAGGTGGGGAGTGGAAATTCAGCCTGCTTAGAGGACTGACCTCTACAGTTCATATTTGCAGTGACATAAA
AGGCAAAGAGGAGCTGGCATGGTGGTACAGAAGGTATCAGTCAAGCGCAGGCTCTTCAGAAACCTAGAAACTAAAAAGAGATGCAACATG
TGACTGGCCATCAGCCAGACATGTCTAGGGTGAGACCAGTGCTCAGCACCACCCGCCAAGGAACACTGATGAGTTGTGGGACATTATGGT
CGGCCAAGTGAGGAATGATTGCAGGGACCAGAGAAGACCAAAGATGCCAGATGTCCCCAGAGTTTCTTGAGGGCTGGGTTTCACGTCTTT
GCTTGTCCTTTTTGTCCCCACTTGCCTGCACCGTGCCTGACTCATCCAGTGGGGAAGGTGACTCAAGAAGTTGTTTAAGCCTAGGCCTAG
GCAGTCCACTTCGGGAGGTGGGGGCACTCCACACTGGGGGGCCCTGCAGCTCCAGGGCTGGTGCTCTAGCAGATCCGCTCAGGCACGGTT
GGGTGACCGTGGGGTCACCGATTGCGTAGATTATTTCTAGGGCAGTGCTGGGTTAGAAATGTCTGTCTGGAAACAGGACACATCTTGCCA
CCACAAGTCCACACCTGGCCTTGGCTGCTGCCCGCTCTCTGCAGCGTGGATTTCCTTTGCCCATTTGGGCCAGAAGGTCACCAGGAGTTC
ATCACTGCTTAGTGTCAACTTGACATCTTCAGCTTCCAGACAGAAAACCCATGCTTTACTTTGTACAGCCCTGTCCCAGAGTTAGTAAGC
CTCGGCTTGTCACCTGCTTGCAAAGGGTATAGACATCATTCTGGGTAGTTCTAGAGGATATCGCAACAAGTGCGTTTGAAGGTTCAGCAC
AGCTGGAATTGTACGGTAGTGAGCTCTTCAAAATGAAAACAGAATGACCGGATGGCCATCTGTCCTGGAAACTGTAGAATTGAATAAATC
ACTGAAAATAGAACACTTCTTGGAGGCTTTCTTCAGAACTGAACTAGAAACAAGGTTTCCAGGCTCCCAGGTCAGTAGACCAAACCAACT
TCCTTAGATTTTTTTTTTTAAGCTGTTTGCAGAAAACTGGGTGGTAGCGTGTCTGAACCAAACGGAAGAATAGCCAGCGGAGCATGGACT
GTTCCAGCACGGGCCAGATGGCCAGCTGTCGAGAGCAGCCCTGCCCAGATTGCGGTGGGGGCTGTGCCAGCGGCTCCGCAGGGCCCTTCC
AACTCTGGAGTGTCTGTAGTTCTTGTGAAACCAAAACGTTGACTACCTGCCTCTTTCCTCGGGCATCGACGTGCTCATTTCCAAAGATGA
TGGTGCAGGTGACCTTTTCCATCGTGAGCTAAGAGAAGGTTAGGAGGCCTGAGGGGCGGGCCTTGTGTCCCCTCCTCCCCCTCCACAGCC
CCTGAGGTGGAGCTTCCCTCACAGACCCCATCTGGTCGAGCCTACGGCTGCCCAGTGTACACTCAGTGATGCTTATACCAAATAGGGCAT
GTGCGCTGGTGTCTGTTGGGGACAGCCCCATCCCTACCTTGGAGTCGGCAGAGAAGCAGCAATAAGCATTAGGCGAATGATTGAAAGGGC
TGCTGCGCCAAGAGGCCTTCAGTCCCCTTAACGTGGCTTTCCAACTTCCTGACGAGGCTACAAAGGCTCCGCTCACAAAAGAAAGCCAAT
AATGTAAATAAATAGAAAACGAAGCCTCCACGCGTGGTTTTTAAAGGGGGATGATGAATGTGACACCACCCACAGAATGCATTAGAATCT
GGTTTTTCTGTGCTTTGTCATTTTACTCTGATAGGAATTTTTGTTACCTAACTCTGTGCATAACTTATTTAATGTACTGTATAAATGAAC

>In-frame_RUNX1_ENST00000358356_chr21_36231771_-_CBFA2T2_ENST00000342704_chr20_32194762_+_4759nt
CATAGAGCCAGCGGGCGCGGGCGGGACGGGCGCCCCGCGGCCGGACCCAGCCAGGGCACCACGCTGCCCGGCCCTGCGCCGCCAGGCACT
TCTTTCCGGGGCTCCTAGGGACGCCAGAAGGAAGTCAACCTCTGCTGCTTCTCCTTGGCCTGCGTTGGACCTTCCTTTTTTTGTTGTTTT
TTTTTGTTTTTCCCCTTTCTTCCTTTTGAATTAACTGGCTTCTTGGCTGGATGTTTTCAACTTCTTTCCTGGCTGCGAACTTTTCCCCAA
TTGTTTTCCTTTTACAACAGGGGGAGAAAGTGCTCTGTGGTCCGAGGCGAGCCGTGAAGTTGCGTGTGCGTGGCAGTGTGCGTGGCAGGA
TGTGCGTGCGTGTGTAACCCGAGCCGCCCGATCTGTTTCGATCTGCGCCGCGGAGCCCTCCCTCAAGGCCCGCTCCACCTGCTGCGGTTA
CGCGGCGCTCGTGGGTGTTCGTGCCTCGGAGCAGCTAACCGGCGGGTGCTGGGCGACGGTGGAGGAGTATCGTCTCGCTGCTGCCCGAGT
CAGGGCTGAGTCACCCAGCTGATGTAGACAGTGGCTGCCTTCCGAAGAGTGCGTGTTTGCATGTGTGTGACTCTGCGGCTGCTCAACTCC
CAACAAACCAGAGGACCAGCCACAAACTTAACCAACATCCCCAAACCCGAGTTCACAGATGTGGGAGAGCTGTAGAACCCTGAGTGTCAT
CGACTGGGCCTTCTTATGATTGTTGTTTTAAGATTAGCTGAAGATCTCTGAAACGCTGAATTTTCTGCACTGAGCGTTTTGACAGAATTC
ATTGAGAGAACAGAGAACATGACAAGTACTTCTAGCTCAGCACTGCTCCAACTACTGAAGCTGATTTTCAAGGCTACTTAAAAAAATCTG
CAGCGTACATTAATGGATTTCTGTTGTGTTTAAATTCTCCACAGATTGTATTGTAAATATTTTATGAAGTAGAGCATATGTATATATTTA
TATATACGTGCACATACATTAGTAGCACTACCTTTGGAAGTCTCAGCTCTTGCTTTTCGGGACTGAAGCCAGTTTTGCATGATAAAAGTG
GCCTTGTTACGGGAGATAATTGTGTTCTGTTGGGACTTTAGACAAAACTCACCTGCAAAAAACTGACAGGCATTAACTACTGGAACTTCC
AAATAATGTGTTTGCTGATCGTTTTACTCTTCGCATAAATATTTTAGGAAGTGTATGAGAATTTTGCCTTCAGGAACTTTTCTAACAGCC
AAAGACAGAACTTAACCTCTGCAAGCAAGATTCGTGGAAGATAGTCTCCACTTTTTAATGCACTAAGCAATCGGTTGCTAGGAGCCCATC
CTGGGTCAGAGGCCGATCCGCAGAACCAGAACGTTTTCCCCTCCTGGACTGTTAGTAACTTAGTCTCCCTCCTCCCCTAACCACCCCCGC
CCCCCCCCACCCCCCGCAGTAATAAAGGCCCCTGAACGTGTATGTTGGTCTCCCGGGAGCTGCTTGCTGAAGATCCGCGCCCCTGTCGCC
GTCTGGTAGGAGCTGTTTGCAGGGTCCTAACTCAATCGGCTTGTTGTGATGCGTATCCCCGTAGATGCCAGCACGAGCCGCCGCTTCACG
CCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCGGCGCTGCCCTGGCCGGCAAGCTG
AGGAGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTG
CTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACT
GTGATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTC
AGGTTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGA
GCCATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAATTGGTCCTGAGAAAAGGGTGCCAGCGATGCCTGGATCGCCTGTGGAAGTG
AAGATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGGACCGAGGCCAGTGTCCTTCACTCCTACT
GCATTAAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACAGAGATTCAGCAATGGTCCTGCCTCCTCC
ACATCATCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAAGTTGAAACGCTTTCTTACCACTCTGCAA
CAGTTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACTGGTGAACTCAACAGTGACAATTGAGGAA
TTCCACTGTAAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCTCAAGGCCAACCTGCCCCTGCTGCAGCGG
GAACTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGAACACCTTCTGCTCAACACAAGCATTGCA
TCGCCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCCAGAGAGGAGAGAAGAGAATAGTTTTGAT
AGAGACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCGGCACAGTCCTGCTCTCACTGTGCCCCTC
ATGAATCCCGGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGATATTGCAACTTCTCACCTGTATCGGGAA
CCCAACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGGAGGCTATCAAGATGAGTTGGTAGATCAT
CGTTTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCATTATGGAAATGGTAGAGAAAACAAGGCGC
TCTATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAGACGGTACAATGAAAACACAGAGCTGAGG
AAAACGGGGACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAATGATTCTCAGAGAGAGTTCAACAGCAGG
CCAGGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGTGAAAATTCAGGCCATGTCAGAAGTACAG
AAGGCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAATGGAGCAAACCATAGCGGATGTCAAGCGG
CAGGCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTGGAACTGTGGCCGCAAAGCCAGCGAGACA
TGCAGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACCACCGCCTCTGTGGTCAGAACCTG
CATGGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGGTCCGCCGACTGCAGCGTGCCCAGC
CCAGCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGCTATCGACACCAACGGACTCTGAGCCCCG
GACTCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGCTTGGGCTGAGGGACTGACTGTTGGAACCCGTGCATGTAGCTGCCGGGTC
ATCAGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCTGAATAATAACACCCCACAGCCTCTCTGTGCACTTGCTGTCTGCGGAGCC
AGTGTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGTTTGTTCCTCTCTCCACTGAAGCTGACTT
AGCCGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACTGTCCAATGTGCTCAGCCAGGCTGGAGGC
GGCAGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACCCCTGAATAGCTCCTTCGGCCCCATCTCC
ATCCTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGGGTAAGCAACAGGCGGCATTCAGGACTCTTCTCAACCCTGCTGTTCAGAC
TTGATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTGCAATAAAAGCACCCGTAGTAGCAAAAACATAAAACAAATAAAACTTCCC
CCACATCACAGATGATTTTGGACAAGATTTTCCAACCTTGCTGGCTACTTTAGTTTGGGACCTGTTTTTTTTCTCATTTGATTTTGCTTG
TGCAGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAGAATGAGGCTCAGTTGTGGATAGTCTGTTTTCTCTGAGCATGTTGGCCAA

>In-frame_RUNX1_ENST00000358356_chr21_36231771_-_CBFA2T2_ENST00000375279_chr20_32194762_+_9254nt
CATAGAGCCAGCGGGCGCGGGCGGGACGGGCGCCCCGCGGCCGGACCCAGCCAGGGCACCACGCTGCCCGGCCCTGCGCCGCCAGGCACT
TCTTTCCGGGGCTCCTAGGGACGCCAGAAGGAAGTCAACCTCTGCTGCTTCTCCTTGGCCTGCGTTGGACCTTCCTTTTTTTGTTGTTTT
TTTTTGTTTTTCCCCTTTCTTCCTTTTGAATTAACTGGCTTCTTGGCTGGATGTTTTCAACTTCTTTCCTGGCTGCGAACTTTTCCCCAA
TTGTTTTCCTTTTACAACAGGGGGAGAAAGTGCTCTGTGGTCCGAGGCGAGCCGTGAAGTTGCGTGTGCGTGGCAGTGTGCGTGGCAGGA
TGTGCGTGCGTGTGTAACCCGAGCCGCCCGATCTGTTTCGATCTGCGCCGCGGAGCCCTCCCTCAAGGCCCGCTCCACCTGCTGCGGTTA
CGCGGCGCTCGTGGGTGTTCGTGCCTCGGAGCAGCTAACCGGCGGGTGCTGGGCGACGGTGGAGGAGTATCGTCTCGCTGCTGCCCGAGT
CAGGGCTGAGTCACCCAGCTGATGTAGACAGTGGCTGCCTTCCGAAGAGTGCGTGTTTGCATGTGTGTGACTCTGCGGCTGCTCAACTCC
CAACAAACCAGAGGACCAGCCACAAACTTAACCAACATCCCCAAACCCGAGTTCACAGATGTGGGAGAGCTGTAGAACCCTGAGTGTCAT
CGACTGGGCCTTCTTATGATTGTTGTTTTAAGATTAGCTGAAGATCTCTGAAACGCTGAATTTTCTGCACTGAGCGTTTTGACAGAATTC
ATTGAGAGAACAGAGAACATGACAAGTACTTCTAGCTCAGCACTGCTCCAACTACTGAAGCTGATTTTCAAGGCTACTTAAAAAAATCTG
CAGCGTACATTAATGGATTTCTGTTGTGTTTAAATTCTCCACAGATTGTATTGTAAATATTTTATGAAGTAGAGCATATGTATATATTTA
TATATACGTGCACATACATTAGTAGCACTACCTTTGGAAGTCTCAGCTCTTGCTTTTCGGGACTGAAGCCAGTTTTGCATGATAAAAGTG
GCCTTGTTACGGGAGATAATTGTGTTCTGTTGGGACTTTAGACAAAACTCACCTGCAAAAAACTGACAGGCATTAACTACTGGAACTTCC
AAATAATGTGTTTGCTGATCGTTTTACTCTTCGCATAAATATTTTAGGAAGTGTATGAGAATTTTGCCTTCAGGAACTTTTCTAACAGCC
AAAGACAGAACTTAACCTCTGCAAGCAAGATTCGTGGAAGATAGTCTCCACTTTTTAATGCACTAAGCAATCGGTTGCTAGGAGCCCATC
CTGGGTCAGAGGCCGATCCGCAGAACCAGAACGTTTTCCCCTCCTGGACTGTTAGTAACTTAGTCTCCCTCCTCCCCTAACCACCCCCGC
CCCCCCCCACCCCCCGCAGTAATAAAGGCCCCTGAACGTGTATGTTGGTCTCCCGGGAGCTGCTTGCTGAAGATCCGCGCCCCTGTCGCC
GTCTGGTAGGAGCTGTTTGCAGGGTCCTAACTCAATCGGCTTGTTGTGATGCGTATCCCCGTAGATGCCAGCACGAGCCGCCGCTTCACG
CCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCGGACGCCGGCGCTGCCCTGGCCGGCAAGCTG
AGGAGCGGCGACCGCAGCATGGTGGAGGTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTG
CTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACT
GTGATGGCTGGCAATGATGAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTC
AGGTTTGTCGGTCGAAGTGGAAGAGGGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGA
GCCATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAATTGGTCCTGAGAAAAGGGTGCCAGCGATGCCTGGATCGCCTGTGGAAGTG
AAGATACAGTCCAGATCCTCACCTCCCACCATGCCACCCCTCCCACCAATAAATCCTGGAGGACCGAGGCCAGTGTCCTTCACTCCTACT
GCATTAAGCAATGGCATCAACCATTCTCCTCCTACCCTGAATGGTGCCCCATCACCGCCACAGAGATTCAGCAATGGTCCTGCCTCCTCC
ACATCATCTGCACTCACAAATCAGCAATTGCCAGCCACTTGTGGTGCTCGACAACTCAGCAAGTTGAAACGCTTTCTTACCACTCTGCAA
CAGTTTGGCAATGACATCTCCCCTGAGATTGGGGAGAAGGTGCGGACTCTTGTTCTTGCACTGGTGAACTCAACAGTGACAATTGAGGAA
TTCCACTGTAAGCTCCAAGAAGCCACAAACTTTCCCCTTCGTCCTTTTGTGATTCCATTTCTCAAGGCCAACCTGCCCCTGCTGCAGCGG
GAACTGCTGCACTGCGCTCGGGCGGCCAAGCAGACCCCATCCCAGTACCTGGCTCAGCACGAACACCTTCTGCTCAACACAAGCATTGCA
TCGCCTGCTGACTCGTCAGAGTTGCTCATGGAGGTGCACGGAAATGGGAAGAGGCCCAGTCCAGAGAGGAGAGAAGAGAATAGTTTTGAT
AGAGACACAATTGCTCCTGAGCCTCCTGCCAAGAGAGTATGTACCATCAGCCCTGCTCCTCGGCACAGTCCTGCTCTCACTGTGCCCCTC
ATGAATCCCGGGGGCCAATTCCATCCTACCCCTCCACCTCTTCAGCATTACACCTTAGAGGATATTGCAACTTCTCACCTGTATCGGGAA
CCCAACAAGATGCTAGAGCATCGAGAAGTTCGTGATAGACACCACAGTCTTGGTCTAAATGGAGGCTATCAAGATGAGTTGGTAGATCAT
CGTTTGACAGAAAGGGAATGGGCTGATGAATGGAAACATCTTGACCATGCGCTGAATTGCATTATGGAAATGGTAGAGAAAACAAGGCGC
TCTATGGCAGTTCTGCGGCGCTGTCAGGAATCAGATCGTGAAGAACTCAACTACTGGAAAAGACGGTACAATGAAAACACAGAGCTGAGG
AAAACGGGGACCGAGTTGGTCTCCAGGCAGCACAGCCCTGGGAGTGCAGATTCTCTCAGCAATGATTCTCAGAGAGAGTTCAACAGCAGG
CCAGGTACAGGATACGTACCTGTGGAGTTTTGGAAAAAAACAGAAGAAGCTGTGAATAAGGTGAAAATTCAGGCCATGTCAGAAGTACAG
AAGGCCGTCGCTGAGGCAGAGCAGAAAGCCTTTGAAGTGATTGCAACAGAGAGAGCACGAATGGAGCAAACCATAGCGGATGTCAAGCGG
CAGGCCGCAGAGGATGCTTTCCTCGTCATCAATGAGCAAGAGGAGTCCACGGAGAACTGCTGGAACTGTGGCCGCAAAGCCAGCGAGACA
TGCAGTGGCTGCAATATCGCGCGATACTGTGGCTCTTTCTGCCAGCACAAGGACTGGGAGCGGCACCACCGCCTCTGTGGTCAGAACCTG
CATGGCCAGAGCCCCCACGGCCAGGGCCGGCCGCTGCTTCCTGTAGGCAGGGGCTCCTCTGCCAGGTCCGCCGACTGCAGCGTGCCCAGC
CCAGCCCTCGACAAGACCTCGGCAACCACATCGCGTTCCTCAACACCTGCTTCTGTGACAGCTATCGACACCAACGGACTCTGAGCCCCG
GACTCTGCTTACCCTGATGGCTGCTCAGCACCACAGAGTGCTTGGGCTGAGGGACTGACTGTTGGAACCCGTGCATGTAGCTGCCGGGTC
ATCAGCAAGAAATGAATTGGAGGCAGGAAGAGTCCAAGCCTGAATAATAACACCCCACAGCCTCTCTGTGCACTTGCTGTCTGCGGAGCC
AGTGTGCCATTCTCTGCACATGGGCAGCCAGCCTGAGCTGCCTCCTCCATGGCTTTCCTGGTTTGTTCCTCTCTCCACTGAAGCTGACTT
AGCCGGCCCCTTTTCAGTGTAGACCACCAGCTCCCCTCCCCATCTCCTTGAGTCAGCAGACTGTCCAATGTGCTCAGCCAGGCTGGAGGC
GGCAGGCGGCAGGCAGCAGGCTGTGGAGGAGGCCCCTCGGTCAGGGAGCGGCCTGCCTCACCCCTGAATAGCTCCTTCGGCCCCATCTCC
ATCCTCAGCAGATGACACTGATTGGCCTCACGGGGACTTGGGTAAGCAACAGGCGGCATTCAGGACTCTTCTCAACCCTGCTGTTCAGAC
TTGATAAGATCTCAGAGTCCACAGGAAAGAAGTCACTGTTGCAATAAAAGCACCCGTAGTAGCAAAAACATAAAACAAATAAAACTTCCC
CCACATCACAGATGATTTTGGACAAGATTTTCCAACCTTGCTGGCTACTTTAGTTTGGGACCTGTTTTTTTTCTCATTTGATTTTGCTTG
TGCAGAAAATAGTTTCCAGCACATGGATTGATCTGAGAGAGAATGAGGCTCAGTTGTGGATAGTCTGTTTTCTCTGAGCATGTTGGCCAA
CTAGTATCGTCAAATTATTGAGTGGATCATCTCTTGGAAATGCAGAACTTCTGCCACCACTTGGCTATTTGCACAGTCATCTTGTTCTGT
GTCCTTTTATCTCTCAGACCACACACATCTGGAACGCTGTGGGCATCTTCTGCCCATGGGCTCCATTTGGCACCTGCTGAGCCACAGTTG
TCCTGCTGGATGTGCTGTGCAGGTTGGTAGGACTTGCCCCCACTGTCAAGGCCTGGTCTCATCTGAAAAGCCCTCCTGGACCTCAAAGAA
TTCTTCAGACCTCATAGTTACAGGTCATTATATCTACTATGTTGATTTATCATCAGGCACACAACTTCTGTTTCCTTCTCTTGTGTTATC
TGATAGCGTCCCTCCTTGAGCTCATCAGAAAGGTTTTATGAAATGTGAACCATTTTGGGAAAAGCTGATCAATTTTTCTTCCTAGCTTCC
CATTTTCAAATGGGACATCACTCATATCCCTTTCAGAATGTTAGGAACTGCCTCCCACATTCTTCCCTGTCTTTTTGGGTTTTGTTTTTT
GTTGTTGTGGTGGTTTTTTAACACAAAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTTGGCTCACTGCAACCTCTGCC
TTCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGAGATTACAGGCGCCCACCACCACGCCCAGCTAATTTTTGTATTTT
TAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGATCTCGAACTCCTGACCTCAGGTGACCTGCCTTGGCCTCCCAAAGTGCAGGGAT
TACAAGCGTGAGCCACCATGCCCGGCCTGTCTTTTTGGTTTTGATGGGAGTCTGAGGACCCCGACCCCTCCTGCTCTCCATCTTTGAGCC
TCTGGCATCCTCTCACACCCAGAAATCAGTTGGAGTAAGTTTAATTGGCCCTGCTCCAGCTGGCCTTTGAAGCACAAGTTTAAATCTCCA
CCTTCTGTGCACTGACCAGAGTCTAAAATAAAAGTTGTCAGTACCATAAAGGAAAAGGGATCCACACAGGTAGCCTTCTCCTTGGATACA
GGTACATCTTACTGTAAGAATTTCAAGTCCTGGCTGGGCGCAGTGGCTCACTCCTGTAATCCCAGCACTTTGAGAGACCGAGGCAGGCAG
ATCACTTGAGGTCAGGAATTCAAGACCAACCTGGCCAACATGGTGAAACCCTGTCTCTAATAAAAAAAAAATAGAAAAATCAGCCGGGTG
TGGTGGCACACACCTGTAATCCTAGCTACTCAGGAGGCTGAGGCAAGAGAATCTCTTGAACCTGTGAGCCAGAGGTTGCAGTGAGCCGAG
ATTCCACCACTGCACTCCAGCCTGGGCAACAGAGCAAAACTCTGTCTCAAAAAAAAAAAAAAAAAGGCAAAATTAAAGAATTTCAAGTCC
CTAATTTACTCTAACCAAGCATTTTCAGTCTTACAAAGAAATCTAGTGCACGACACCTTTAAAATGCCTAGATTTCCATTGCCTAAAGTA
AGGTGTGACCAGTGAAACAACAGCAGAGAATCATGTTCCTTTGCTGTGGAACACATAAGCCCCACAGTTTTCCAGTCAGCCTAATACATG
GGTATCCCCCGACCCCATCTGCCTCCTTAAGCCACAGTCCTTGGTGGGGAACTCTAAGGGGGACGGAGTCAGTACCCCGGACAGGGCCAC
ATTTGCATGAGACATGGCTGTCTCACAGGTCACAGAGCCATTACAACAGCTTACTAGTTTTTCATGGATTTGTTGGATTAACACCTTAAG
CAGGTTTTTTATTGTTATTTTGTTTGTTTGTTTGTTTTGAGACGGGAGTTTCTCTCTTGTCTCCCAGGCTGGAGTGCAATCGCGCAATCT
CGGCTCACGGTAACCTCTGCCTCCCAGGTTCAAGCGAGTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGATTACAGGCATGCGCCACCACG
CCCAACTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCCTTGTTGGTCAGGCTGGTCTCAAACCCCGGACCTCAGGTGATCCCCCCAC
CTTGGCCTCCCAAAGTGCCAGGATTACAGGCATGAGCCACTGTGTCCGGTCTTGAGCAGGTTTTTAAAATCTCCAGTGGCCATAAAACTA
GCCAGGGTAGCTCATGCTTTTACTGGTTGGAATAAGGAGCCAAAACCAACAAAATAATATTTATTAGGGCTCGATGCCCATTTCTGTGGC
TAAGGCTTAGGTTTGGTGTGCAGAGCCTGGCCTGCTCTTGTGGGCTGTGGTTGCTGTGACAGTTTCGTTTTCTGAATCTTTGTAATGCTC
TTCCACCCTGCTCGTGCTGCCCAGAGGCTGATCTGCAAACCTGGGCAGTATTCCACACTGAAGCTCAGTTTGCAAACCTTCTGCTGTGTT
AATTCTGGTCAGTTTCACACAGAAGTCACGAGGGCCTCTGCCCAGGACCTTCTATTCACATTTCAAGAATCCCTTTCTGAAATTCTCCAA
CTCTCTGGTCAGGAGGAGGAGCACCATTGGGGCGGGGTAGGCAGCTAGAGGCGCAGGAGCGAATCCAGGTTCCTTGCGTGGTTCCCAGCC
TCTGCTGACAGCACCTCAGCTACCAGGTGGGGAGTGGAAATTCAGCCTGCTTAGAGGACTGACCTCTACAGTTCATATTTGCAGTGACAT
AAAAGGCAAAGAGGAGCTGGCATGGTGGTACAGAAGGTATCAGTCAAGCGCAGGCTCTTCAGAAACCTAGAAACTAAAAAGAGATGCAAC
ATGTGACTGGCCATCAGCCAGACATGTCTAGGGTGAGACCAGTGCTCAGCACCACCCGCCAAGGAACACTGATGAGTTGTGGGACATTAT
GGTCGGCCAAGTGAGGAATGATTGCAGGGACCAGAGAAGACCAAAGATGCCAGATGTCCCCAGAGTTTCTTGAGGGCTGGGTTTCACGTC
TTTGCTTGTCCTTTTTGTCCCCACTTGCCTGCACCGTGCCTGACTCATCCAGTGGGGAAGGTGACTCAAGAAGTTGTTTAAGCCTAGGCC
TAGGCAGTCCACTTCGGGAGGTGGGGGCACTCCACACTGGGGGGCCCTGCAGCTCCAGGGCTGGTGCTCTAGCAGATCCGCTCAGGCACG
GTTGGGTGACCGTGGGGTCACCGATTGCGTAGATTATTTCTAGGGCAGTGCTGGGTTAGAAATGTCTGTCTGGAAACAGGACACATCTTG
CCACCACAAGTCCACACCTGGCCTTGGCTGCTGCCCGCTCTCTGCAGCGTGGATTTCCTTTGCCCATTTGGGCCAGAAGGTCACCAGGAG
TTCATCACTGCTTAGTGTCAACTTGACATCTTCAGCTTCCAGACAGAAAACCCATGCTTTACTTTGTACAGCCCTGTCCCAGAGTTAGTA
AGCCTCGGCTTGTCACCTGCTTGCAAAGGGTATAGACATCATTCTGGGTAGTTCTAGAGGATATCGCAACAAGTGCGTTTGAAGGTTCAG
CACAGCTGGAATTGTACGGTAGTGAGCTCTTCAAAATGAAAACAGAATGACCGGATGGCCATCTGTCCTGGAAACTGTAGAATTGAATAA
ATCACTGAAAATAGAACACTTCTTGGAGGCTTTCTTCAGAACTGAACTAGAAACAAGGTTTCCAGGCTCCCAGGTCAGTAGACCAAACCA
ACTTCCTTAGATTTTTTTTTTTAAGCTGTTTGCAGAAAACTGGGTGGTAGCGTGTCTGAACCAAACGGAAGAATAGCCAGCGGAGCATGG
ACTGTTCCAGCACGGGCCAGATGGCCAGCTGTCGAGAGCAGCCCTGCCCAGATTGCGGTGGGGGCTGTGCCAGCGGCTCCGCAGGGCCCT
TCCAACTCTGGAGTGTCTGTAGTTCTTGTGAAACCAAAACGTTGACTACCTGCCTCTTTCCTCGGGCATCGACGTGCTCATTTCCAAAGA
TGATGGTGCAGGTGACCTTTTCCATCGTGAGCTAAGAGAAGGTTAGGAGGCCTGAGGGGCGGGCCTTGTGTCCCCTCCTCCCCCTCCACA
GCCCCTGAGGTGGAGCTTCCCTCACAGACCCCATCTGGTCGAGCCTACGGCTGCCCAGTGTACACTCAGTGATGCTTATACCAAATAGGG
CATGTGCGCTGGTGTCTGTTGGGGACAGCCCCATCCCTACCTTGGAGTCGGCAGAGAAGCAGCAATAAGCATTAGGCGAATGATTGAAAG
GGCTGCTGCGCCAAGAGGCCTTCAGTCCCCTTAACGTGGCTTTCCAACTTCCTGACGAGGCTACAAAGGCTCCGCTCACAAAAGAAAGCC
AATAATGTAAATAAATAGAAAACGAAGCCTCCACGCGTGGTTTTTAAAGGGGGATGATGAATGTGACACCACCCACAGAATGCATTAGAA
TCTGGTTTTTCTGTGCTTTGTCATTTTACTCTGATAGGAATTTTTGTTACCTAACTCTGTGCATAACTTATTTAATGTACTGTATAAATG


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FusionGenePPI for RUNX1_CBFA2T2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RUNX1SUV39H1, KAT6B, CBFB, AES, PAX5, YAP1, JUN, FOS, SMAD3, SMAD1, SMAD2, SMAD5, VDR, ELF4, ELF2, CEBPB, TLE1, CBFA2T2, TRAF6, FHL2, MYOD1, HIPK2, EP300, HDAC1, HDAC3, KAT6A, TCF12, TCF3, RUNX1T1, NCOR1, SIAH1, UBE2L6, RUNX1, PML, RARA, HDAC2, SIN3A, NR4A2, TRIM33, STUB1, SMARCA4, SMARCB1, SMARCC1, CDK1, TAL1, COPRS, KMT2A, RBM14, SPEN, DNMT1, ELAVL1, CBFA2T3, PRMT1, HLA-DMA, CREBBP, UXT, CTBP2, NOTCH1, MYC, NCOR2, FOXP3, SOX2, CTBP1, HDAC11, RAG1, SPI1, ELF1, CDK6, KLF6, NFATC1, NFATC2, ZNF131, BRCA1, CDK9, FANCD2CBFA2T2WDYHV1, MDFI, RUNX1T1, CBFA2T3, TAL1, RUNX1, GTF2E1, ID3, NEUROG1, TAL2, FBXL19, PRDM14, SIN3A, NCOR1, HDAC3, ATN1, ATXN1L, RERE, APP, LBP, TCP1, CBFA2T2, PDP1, NOTCH3, PRDM6, TCF4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneRUNX1chr21:36231771chr20:32194762ENST00000300305-58135_143204481DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000300305-58168_177204481DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000300305-5880_84204481DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000325074-47135_143192469DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000325074-47168_177192469DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000325074-4780_84192469DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000344691-36135_143177454DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000344691-36168_177177454DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000344691-3680_84177454DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000358356-35135_143177251DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000358356-35168_177177251DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000358356-3580_84177251DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000437180-69135_143204481DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000437180-69168_177204481DNA
HgeneRUNX1chr21:36231771chr20:32194762ENST00000437180-6980_84204481DNA
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000342704+011107_21511596PRDM14
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000344201+06107_215-9264PRDM14
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000346541+112107_21520605PRDM14
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000359606+011107_21530615PRDM14
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000375279+112107_21520605PRDM14
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000397798+17107_215-9264PRDM14
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000397800+011107_215-9576PRDM14
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000492345+213107_215-9576PRDM14


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRUNX1chr21:36231771chr20:32194762ENST00000300305-58362_402204481FOXP3
HgeneRUNX1chr21:36231771chr20:32194762ENST00000325074-47362_402192469FOXP3
HgeneRUNX1chr21:36231771chr20:32194762ENST00000344691-36362_402177454FOXP3
HgeneRUNX1chr21:36231771chr20:32194762ENST00000358356-35362_402177251FOXP3
HgeneRUNX1chr21:36231771chr20:32194762ENST00000437180-69362_402204481FOXP3
HgeneRUNX1chr21:36231771chr20:32194762ENST00000300305-58291_371204481KAT6A
HgeneRUNX1chr21:36231771chr20:32194762ENST00000325074-47291_371192469KAT6A
HgeneRUNX1chr21:36231771chr20:32194762ENST00000344691-36291_371177454KAT6A
HgeneRUNX1chr21:36231771chr20:32194762ENST00000358356-35291_371177251KAT6A
HgeneRUNX1chr21:36231771chr20:32194762ENST00000437180-69291_371204481KAT6A
HgeneRUNX1chr21:36231771chr20:32194762ENST00000300305-58307_400204481KAT6B
HgeneRUNX1chr21:36231771chr20:32194762ENST00000325074-47307_400192469KAT6B
HgeneRUNX1chr21:36231771chr20:32194762ENST00000344691-36307_400177454KAT6B
HgeneRUNX1chr21:36231771chr20:32194762ENST00000358356-35307_400177251KAT6B
HgeneRUNX1chr21:36231771chr20:32194762ENST00000437180-69307_400204481KAT6B


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RUNX1_CBFA2T2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RUNX1_CBFA2T2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRUNX1C0023467Leukemia, Myelocytic, Acute2CTD_human;HPO
HgeneRUNX1C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma2CTD_human
HgeneRUNX1C0003873Rheumatoid Arthritis1CTD_human
HgeneRUNX1C0017636Glioblastoma1CTD_human
HgeneRUNX1C0033578Prostatic Neoplasms1CTD_human
HgeneRUNX1C0349639Juvenile Myelomonocytic Leukemia1CTD_human
HgeneRUNX1C1832388Platelet Disorder, Familial, with Associated Myeloid Malignancy1CTD_human;ORPHANET;UNIPROT
HgeneRUNX1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human