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Fusion gene ID: 32379 |
FusionGeneSummary for RUFY3_ZNF462 |
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Fusion gene information | Fusion gene name: RUFY3_ZNF462 | Fusion gene ID: 32379 | Hgene | Tgene | Gene symbol | RUFY3 | ZNF462 | Gene ID | 79443 | 58499 |
Gene name | FYVE and coiled-coil domain containing 1 | zinc finger protein 462 | |
Synonyms | CATC2|CTRCT18|RUFY3|ZFYVE7 | Zfp462 | |
Cytomap | 3p21.31 | 9q31.2 | |
Type of gene | protein-coding | protein-coding | |
Description | FYVE and coiled-coil domain-containing protein 1RUN and FYVE domain containing 3zinc finger FYVE domain-containing protein 7 | zinc finger protein 462 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q7L099 | Q96JM2 | |
Ensembl transtripts involved in fusion gene | ENST00000417478, ENST00000381006, ENST00000226328, ENST00000536664, ENST00000502653, ENST00000512331, | ENST00000457913, ENST00000277225, ENST00000441147, ENST00000542028, ENST00000497489, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 5 X 3=90 |
# samples | 2 | 7 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(7/90*10)=-0.362570079384708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RUFY3 [Title/Abstract] AND ZNF462 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | M78270 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000417478 | ENST00000457913 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
intron-3CDS | ENST00000417478 | ENST00000277225 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
intron-3CDS | ENST00000417478 | ENST00000441147 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
intron-intron | ENST00000417478 | ENST00000542028 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
intron-intron | ENST00000417478 | ENST00000497489 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
5UTR-3CDS | ENST00000381006 | ENST00000457913 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
5UTR-3CDS | ENST00000381006 | ENST00000277225 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
5UTR-3CDS | ENST00000381006 | ENST00000441147 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
5UTR-intron | ENST00000381006 | ENST00000542028 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
5UTR-intron | ENST00000381006 | ENST00000497489 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
5UTR-3CDS | ENST00000226328 | ENST00000457913 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
5UTR-3CDS | ENST00000226328 | ENST00000277225 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
5UTR-3CDS | ENST00000226328 | ENST00000441147 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
5UTR-intron | ENST00000226328 | ENST00000542028 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
5UTR-intron | ENST00000226328 | ENST00000497489 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
intron-3CDS | ENST00000536664 | ENST00000457913 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
intron-3CDS | ENST00000536664 | ENST00000277225 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
intron-3CDS | ENST00000536664 | ENST00000441147 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
intron-intron | ENST00000536664 | ENST00000542028 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
intron-intron | ENST00000536664 | ENST00000497489 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
intron-3CDS | ENST00000502653 | ENST00000457913 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
intron-3CDS | ENST00000502653 | ENST00000277225 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
intron-3CDS | ENST00000502653 | ENST00000441147 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
intron-intron | ENST00000502653 | ENST00000542028 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
intron-intron | ENST00000502653 | ENST00000497489 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
intron-3CDS | ENST00000512331 | ENST00000457913 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
intron-3CDS | ENST00000512331 | ENST00000277225 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
intron-3CDS | ENST00000512331 | ENST00000441147 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
intron-intron | ENST00000512331 | ENST00000542028 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
intron-intron | ENST00000512331 | ENST00000497489 | RUFY3 | chr4 | 71587988 | + | ZNF462 | chr9 | 109691565 | - |
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FusionProtFeatures for RUFY3_ZNF462 |
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Hgene | Tgene |
RUFY3 | ZNF462 |
Plays a role in the generation of neuronal polarityformation and axon growth (By similarity). Implicated in theformation of a single axon by developing neurons (By similarity).May inhibit the formation of additional axons by inhibition ofPI3K in minor neuronal processes (By similarity). Plays a role inthe formation of F-actin-enriched protrusive structures at thecell periphery (PubMed:25766321). Plays a role in cytoskeletalorganization by regulating the subcellular localization of FSCN1and DBN1 at axonal growth cones (By similarity). Promotes gastriccancer cell migration and invasion in a PAK1-dependent manner(PubMed:25766321). {ECO:0000250|UniProtKB:Q5FVJ0,ECO:0000250|UniProtKB:Q9D394, ECO:0000269|PubMed:25766321}. | May be involved in transcriptional regulation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RUFY3_ZNF462 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RUFY3_ZNF462 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RUFY3_ZNF462 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RUFY3_ZNF462 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RUFY3 | C0037274 | Dermatologic disorders | 1 | CTD_human |
Hgene | RUFY3 | C0311375 | Arsenic Poisoning | 1 | CTD_human |