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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32379

FusionGeneSummary for RUFY3_ZNF462

check button Fusion gene summary
Fusion gene informationFusion gene name: RUFY3_ZNF462
Fusion gene ID: 32379
HgeneTgene
Gene symbol

RUFY3

ZNF462

Gene ID

79443

58499

Gene nameFYVE and coiled-coil domain containing 1zinc finger protein 462
SynonymsCATC2|CTRCT18|RUFY3|ZFYVE7Zfp462
Cytomap

3p21.31

9q31.2

Type of geneprotein-codingprotein-coding
DescriptionFYVE and coiled-coil domain-containing protein 1RUN and FYVE domain containing 3zinc finger FYVE domain-containing protein 7zinc finger protein 462
Modification date2018052320180523
UniProtAcc

Q7L099

Q96JM2

Ensembl transtripts involved in fusion geneENST00000417478, ENST00000381006, 
ENST00000226328, ENST00000536664, 
ENST00000502653, ENST00000512331, 
ENST00000457913, ENST00000277225, 
ENST00000441147, ENST00000542028, 
ENST00000497489, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 5 X 3=90
# samples 27
** MAII scorelog2(2/8*10)=1.32192809488736log2(7/90*10)=-0.362570079384708
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RUFY3 [Title/Abstract] AND ZNF462 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1M78270RUFY3chr4

71587988

+ZNF462chr9

109691565

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000417478ENST00000457913RUFY3chr4

71587988

+ZNF462chr9

109691565

-
intron-3CDSENST00000417478ENST00000277225RUFY3chr4

71587988

+ZNF462chr9

109691565

-
intron-3CDSENST00000417478ENST00000441147RUFY3chr4

71587988

+ZNF462chr9

109691565

-
intron-intronENST00000417478ENST00000542028RUFY3chr4

71587988

+ZNF462chr9

109691565

-
intron-intronENST00000417478ENST00000497489RUFY3chr4

71587988

+ZNF462chr9

109691565

-
5UTR-3CDSENST00000381006ENST00000457913RUFY3chr4

71587988

+ZNF462chr9

109691565

-
5UTR-3CDSENST00000381006ENST00000277225RUFY3chr4

71587988

+ZNF462chr9

109691565

-
5UTR-3CDSENST00000381006ENST00000441147RUFY3chr4

71587988

+ZNF462chr9

109691565

-
5UTR-intronENST00000381006ENST00000542028RUFY3chr4

71587988

+ZNF462chr9

109691565

-
5UTR-intronENST00000381006ENST00000497489RUFY3chr4

71587988

+ZNF462chr9

109691565

-
5UTR-3CDSENST00000226328ENST00000457913RUFY3chr4

71587988

+ZNF462chr9

109691565

-
5UTR-3CDSENST00000226328ENST00000277225RUFY3chr4

71587988

+ZNF462chr9

109691565

-
5UTR-3CDSENST00000226328ENST00000441147RUFY3chr4

71587988

+ZNF462chr9

109691565

-
5UTR-intronENST00000226328ENST00000542028RUFY3chr4

71587988

+ZNF462chr9

109691565

-
5UTR-intronENST00000226328ENST00000497489RUFY3chr4

71587988

+ZNF462chr9

109691565

-
intron-3CDSENST00000536664ENST00000457913RUFY3chr4

71587988

+ZNF462chr9

109691565

-
intron-3CDSENST00000536664ENST00000277225RUFY3chr4

71587988

+ZNF462chr9

109691565

-
intron-3CDSENST00000536664ENST00000441147RUFY3chr4

71587988

+ZNF462chr9

109691565

-
intron-intronENST00000536664ENST00000542028RUFY3chr4

71587988

+ZNF462chr9

109691565

-
intron-intronENST00000536664ENST00000497489RUFY3chr4

71587988

+ZNF462chr9

109691565

-
intron-3CDSENST00000502653ENST00000457913RUFY3chr4

71587988

+ZNF462chr9

109691565

-
intron-3CDSENST00000502653ENST00000277225RUFY3chr4

71587988

+ZNF462chr9

109691565

-
intron-3CDSENST00000502653ENST00000441147RUFY3chr4

71587988

+ZNF462chr9

109691565

-
intron-intronENST00000502653ENST00000542028RUFY3chr4

71587988

+ZNF462chr9

109691565

-
intron-intronENST00000502653ENST00000497489RUFY3chr4

71587988

+ZNF462chr9

109691565

-
intron-3CDSENST00000512331ENST00000457913RUFY3chr4

71587988

+ZNF462chr9

109691565

-
intron-3CDSENST00000512331ENST00000277225RUFY3chr4

71587988

+ZNF462chr9

109691565

-
intron-3CDSENST00000512331ENST00000441147RUFY3chr4

71587988

+ZNF462chr9

109691565

-
intron-intronENST00000512331ENST00000542028RUFY3chr4

71587988

+ZNF462chr9

109691565

-
intron-intronENST00000512331ENST00000497489RUFY3chr4

71587988

+ZNF462chr9

109691565

-

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FusionProtFeatures for RUFY3_ZNF462


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RUFY3

Q7L099

ZNF462

Q96JM2

Plays a role in the generation of neuronal polarityformation and axon growth (By similarity). Implicated in theformation of a single axon by developing neurons (By similarity).May inhibit the formation of additional axons by inhibition ofPI3K in minor neuronal processes (By similarity). Plays a role inthe formation of F-actin-enriched protrusive structures at thecell periphery (PubMed:25766321). Plays a role in cytoskeletalorganization by regulating the subcellular localization of FSCN1and DBN1 at axonal growth cones (By similarity). Promotes gastriccancer cell migration and invasion in a PAK1-dependent manner(PubMed:25766321). {ECO:0000250|UniProtKB:Q5FVJ0,ECO:0000250|UniProtKB:Q9D394, ECO:0000269|PubMed:25766321}. May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RUFY3_ZNF462


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RUFY3_ZNF462


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RUFY3_ZNF462


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RUFY3_ZNF462


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRUFY3C0037274Dermatologic disorders1CTD_human
HgeneRUFY3C0311375Arsenic Poisoning1CTD_human