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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32364

FusionGeneSummary for RTN4_ANAPC4

check button Fusion gene summary
Fusion gene informationFusion gene name: RTN4_ANAPC4
Fusion gene ID: 32364
HgeneTgene
Gene symbol

RTN4

ANAPC4

Gene ID

57142

29945

Gene namereticulon 4anaphase promoting complex subunit 4
SynonymsASY|NI220/250|NOGO|NSP|NSP-CL|Nbla00271|Nbla10545|RTN-X|RTN4-A|RTN4-B1|RTN4-B2|RTN4-CAPC4
Cytomap

2p16.1

4p15.2

Type of geneprotein-codingprotein-coding
Descriptionreticulon-4Human NogoAMy043 proteinfoocenneurite growth inhibitor 220neurite outgrowth inhibitorneuroendocrine-specific protein C homologreticulon 5anaphase-promoting complex subunit 4cyclosome subunit 4
Modification date2018052320180523
UniProtAcc

Q9NQC3

Q9UJX5

Ensembl transtripts involved in fusion geneENST00000394609, ENST00000405240, 
ENST00000357376, ENST00000317610, 
ENST00000357732, ENST00000337526, 
ENST00000394611, ENST00000404909, 
ENST00000486085, ENST00000354474, 
ENST00000402434, 		ENST00000315368, 
ENST00000510092, 
Fusion gene scores* DoF score8 X 15 X 4=4802 X 2 X 2=8
# samples 182
** MAII scorelog2(18/480*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: RTN4 [Title/Abstract] AND ANAPC4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRTN4

GO:0030517

negative regulation of axon extension

10667797

HgeneRTN4

GO:0071787

endoplasmic reticulum tubular network formation

24262037|25612671

HgeneRTN4

GO:1905552

positive regulation of protein localization to endoplasmic reticulum

27353365

TgeneANAPC4

GO:0070979

protein K11-linked ubiquitination

18485873


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1W68781RTN4chr2

55209717

-ANAPC4chr4

25419961

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000394609ENST00000315368RTN4chr2

55209717

-ANAPC4chr4

25419961

+
intron-3CDSENST00000394609ENST00000510092RTN4chr2

55209717

-ANAPC4chr4

25419961

+
intron-3CDSENST00000405240ENST00000315368RTN4chr2

55209717

-ANAPC4chr4

25419961

+
intron-3CDSENST00000405240ENST00000510092RTN4chr2

55209717

-ANAPC4chr4

25419961

+
intron-3CDSENST00000357376ENST00000315368RTN4chr2

55209717

-ANAPC4chr4

25419961

+
intron-3CDSENST00000357376ENST00000510092RTN4chr2

55209717

-ANAPC4chr4

25419961

+
intron-3CDSENST00000317610ENST00000315368RTN4chr2

55209717

-ANAPC4chr4

25419961

+
intron-3CDSENST00000317610ENST00000510092RTN4chr2

55209717

-ANAPC4chr4

25419961

+
intron-3CDSENST00000357732ENST00000315368RTN4chr2

55209717

-ANAPC4chr4

25419961

+
intron-3CDSENST00000357732ENST00000510092RTN4chr2

55209717

-ANAPC4chr4

25419961

+
intron-3CDSENST00000337526ENST00000315368RTN4chr2

55209717

-ANAPC4chr4

25419961

+
intron-3CDSENST00000337526ENST00000510092RTN4chr2

55209717

-ANAPC4chr4

25419961

+
intron-3CDSENST00000394611ENST00000315368RTN4chr2

55209717

-ANAPC4chr4

25419961

+
intron-3CDSENST00000394611ENST00000510092RTN4chr2

55209717

-ANAPC4chr4

25419961

+
intron-3CDSENST00000404909ENST00000315368RTN4chr2

55209717

-ANAPC4chr4

25419961

+
intron-3CDSENST00000404909ENST00000510092RTN4chr2

55209717

-ANAPC4chr4

25419961

+
intron-3CDSENST00000486085ENST00000315368RTN4chr2

55209717

-ANAPC4chr4

25419961

+
intron-3CDSENST00000486085ENST00000510092RTN4chr2

55209717

-ANAPC4chr4

25419961

+
intron-3CDSENST00000354474ENST00000315368RTN4chr2

55209717

-ANAPC4chr4

25419961

+
intron-3CDSENST00000354474ENST00000510092RTN4chr2

55209717

-ANAPC4chr4

25419961

+
intron-3CDSENST00000402434ENST00000315368RTN4chr2

55209717

-ANAPC4chr4

25419961

+
intron-3CDSENST00000402434ENST00000510092RTN4chr2

55209717

-ANAPC4chr4

25419961

+

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FusionProtFeatures for RTN4_ANAPC4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RTN4

Q9NQC3

ANAPC4

Q9UJX5

Component of the anaphase promoting complex/cyclosome(APC/C), a cell cycle-regulated E3 ubiquitin ligase that controlsprogression through mitosis and the G1 phase of the cell cycle.The APC/C complex acts by mediating ubiquitination and subsequentdegradation of target proteins: it mainly mediates the formationof 'Lys-11'-linked polyubiquitin chains and, to a lower extent,the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitinchains. {ECO:0000269|PubMed:18485873}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RTN4_ANAPC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RTN4_ANAPC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RTN4_ANAPC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RTN4_ANAPC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRTN4C0005586Bipolar Disorder1PSYGENET
HgeneRTN4C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneRTN4C0036341Schizophrenia1CTD_human