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Fusion gene ID: 32364 |
FusionGeneSummary for RTN4_ANAPC4 |
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Fusion gene information | Fusion gene name: RTN4_ANAPC4 | Fusion gene ID: 32364 | Hgene | Tgene | Gene symbol | RTN4 | ANAPC4 | Gene ID | 57142 | 29945 |
Gene name | reticulon 4 | anaphase promoting complex subunit 4 | |
Synonyms | ASY|NI220/250|NOGO|NSP|NSP-CL|Nbla00271|Nbla10545|RTN-X|RTN4-A|RTN4-B1|RTN4-B2|RTN4-C | APC4 | |
Cytomap | 2p16.1 | 4p15.2 | |
Type of gene | protein-coding | protein-coding | |
Description | reticulon-4Human NogoAMy043 proteinfoocenneurite growth inhibitor 220neurite outgrowth inhibitorneuroendocrine-specific protein C homologreticulon 5 | anaphase-promoting complex subunit 4cyclosome subunit 4 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9NQC3 | Q9UJX5 | |
Ensembl transtripts involved in fusion gene | ENST00000394609, ENST00000405240, ENST00000357376, ENST00000317610, ENST00000357732, ENST00000337526, ENST00000394611, ENST00000404909, ENST00000486085, ENST00000354474, ENST00000402434, | ENST00000315368, ENST00000510092, | |
Fusion gene scores | * DoF score | 8 X 15 X 4=480 | 2 X 2 X 2=8 |
# samples | 18 | 2 | |
** MAII score | log2(18/480*10)=-1.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: RTN4 [Title/Abstract] AND ANAPC4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RTN4 | GO:0030517 | negative regulation of axon extension | 10667797 |
Hgene | RTN4 | GO:0071787 | endoplasmic reticulum tubular network formation | 24262037|25612671 |
Hgene | RTN4 | GO:1905552 | positive regulation of protein localization to endoplasmic reticulum | 27353365 |
Tgene | ANAPC4 | GO:0070979 | protein K11-linked ubiquitination | 18485873 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | W68781 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000394609 | ENST00000315368 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
intron-3CDS | ENST00000394609 | ENST00000510092 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
intron-3CDS | ENST00000405240 | ENST00000315368 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
intron-3CDS | ENST00000405240 | ENST00000510092 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
intron-3CDS | ENST00000357376 | ENST00000315368 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
intron-3CDS | ENST00000357376 | ENST00000510092 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
intron-3CDS | ENST00000317610 | ENST00000315368 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
intron-3CDS | ENST00000317610 | ENST00000510092 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
intron-3CDS | ENST00000357732 | ENST00000315368 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
intron-3CDS | ENST00000357732 | ENST00000510092 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
intron-3CDS | ENST00000337526 | ENST00000315368 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
intron-3CDS | ENST00000337526 | ENST00000510092 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
intron-3CDS | ENST00000394611 | ENST00000315368 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
intron-3CDS | ENST00000394611 | ENST00000510092 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
intron-3CDS | ENST00000404909 | ENST00000315368 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
intron-3CDS | ENST00000404909 | ENST00000510092 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
intron-3CDS | ENST00000486085 | ENST00000315368 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
intron-3CDS | ENST00000486085 | ENST00000510092 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
intron-3CDS | ENST00000354474 | ENST00000315368 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
intron-3CDS | ENST00000354474 | ENST00000510092 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
intron-3CDS | ENST00000402434 | ENST00000315368 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
intron-3CDS | ENST00000402434 | ENST00000510092 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
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FusionProtFeatures for RTN4_ANAPC4 |
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Hgene | Tgene |
RTN4 | ANAPC4 |
Component of the anaphase promoting complex/cyclosome(APC/C), a cell cycle-regulated E3 ubiquitin ligase that controlsprogression through mitosis and the G1 phase of the cell cycle.The APC/C complex acts by mediating ubiquitination and subsequentdegradation of target proteins: it mainly mediates the formationof 'Lys-11'-linked polyubiquitin chains and, to a lower extent,the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitinchains. {ECO:0000269|PubMed:18485873}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RTN4_ANAPC4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RTN4_ANAPC4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RTN4_ANAPC4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RTN4_ANAPC4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RTN4 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | RTN4 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | RTN4 | C0036341 | Schizophrenia | 1 | CTD_human |