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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32329

FusionGeneSummary for RTF1_EHD4

check button Fusion gene summary
Fusion gene informationFusion gene name: RTF1_EHD4
Fusion gene ID: 32329
HgeneTgene
Gene symbol

RTF1

EHD4

Gene ID

23168

30844

Gene nameRTF1 homolog, Paf1/RNA polymerase II complex componentEH domain containing 4
SynonymsGTL7|KIAA0252PAST4
Cytomap

15q15.1

15q15.1

Type of geneprotein-codingprotein-coding
DescriptionRNA polymerase-associated protein RTF1 homologRtf1, Paf1/RNA polymerase II complex component, homologortholog of mouse gene trap locus 7EH domain-containing protein 4PAST homolog 4hepatocellular carcinoma-associated protein 10/11hepatocellular carcinoma-associated protein HCA11ortholog of rat pincher
Modification date2018052320180522
UniProtAcc

Q92541

Q9H223

Ensembl transtripts involved in fusion geneENST00000389629, ENST00000462276, 
ENST00000220325, 
Fusion gene scores* DoF score7 X 7 X 6=2945 X 5 X 5=125
# samples 96
** MAII scorelog2(9/294*10)=-1.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/125*10)=-1.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RTF1 [Title/Abstract] AND EHD4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRTF1

GO:0019827

stem cell population maintenance

19345177

HgeneRTF1

GO:0032968

positive regulation of transcription elongation from RNA polymerase II promoter

20178742

HgeneRTF1

GO:0045944

positive regulation of transcription by RNA polymerase II

20178742


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-CH-5739-01ARTF1chr15

41750074

+EHD4chr15

42246138

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000389629ENST00000220325RTF1chr15

41750074

+EHD4chr15

42246138

-
intron-3CDSENST00000462276ENST00000220325RTF1chr15

41750074

+EHD4chr15

42246138

-

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FusionProtFeatures for RTF1_EHD4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RTF1

Q92541

EHD4

Q9H223

Component of the PAF1 complex (PAF1C) which has multiplefunctions during transcription by RNA polymerase II and isimplicated in regulation of development and maintenance ofembryonic stem cell pluripotency. PAF1C associates with RNApolymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms andis involved in transcriptional elongation, acting bothindepentently and synergistically with TCEA1 and in cooperationwith the DSIF complex and HTATSF1. PAF1C is required fortranscription of Hox and Wnt target genes. PAF1C is involved inhematopoiesis and stimulates transcriptional activity ofKMT2A/MLL1; it promotes leukemogenesis through association withKMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histonemodifications such as ubiquitination of histone H2B andmethylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits theRNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzymeUBE2A or UBE2B to chromatin which mediate monoubiquitination of'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2Bubiquitination is proposed to be coupled to transcription. PAF1Cis involved in mRNA 3' end formation probably through associationwith cleavage and poly(A) factors. In case of infection byinfluenza A strain H3N2, PAF1C associates with viral NS1 protein,thereby regulating gene transcription. Binds single-stranded DNA.Required for maximal induction of heat-shock genes. Required forthe trimethylation of histone H3 'Lys-4' (H3K4me3) on genesinvolved in stem cell pluripotency; this function is synergisticwith CXXC1 indicative for an involvement of a SET1 complex (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:19345177,ECO:0000269|PubMed:20178742}. ATP- and membrane-binding protein that probably controlsmembrane reorganization/tubulation upon ATP hydrolysis. Plays arole in early endosomal transport. {ECO:0000269|PubMed:17233914,ECO:0000269|PubMed:18331452}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRTF1chr15:41750074chr15:42246138ENST00000389629+41810_18220711Compositional biasNote=Poly-Ala
HgeneRTF1chr15:41750074chr15:42246138ENST00000389629+418135_173220711Compositional biasNote=Ser-rich
TgeneEHD4chr15:41750074chr15:42246138ENST00000220325-06492_50378542Calcium bindingOntology_term=ECO:0000250,ECO:0000255
TgeneEHD4chr15:41750074chr15:42246138ENST00000220325-06447_53578542DomainEH
TgeneEHD4chr15:41750074chr15:42246138ENST00000220325-06479_51478542DomainEF-hand
TgeneEHD4chr15:41750074chr15:42246138ENST00000220325-06156_15978542RegionG3 motif
TgeneEHD4chr15:41750074chr15:42246138ENST00000220325-06222_22578542RegionG4 motif
TgeneEHD4chr15:41750074chr15:42246138ENST00000220325-06246_24678542RegionG5 motif
TgeneEHD4chr15:41750074chr15:42246138ENST00000220325-0694_9578542RegionG2 motif

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRTF1chr15:41750074chr15:42246138ENST00000389629+418526_560220711Coiled coilOntology_term=ECO:0000255
HgeneRTF1chr15:41750074chr15:42246138ENST00000389629+418174_345220711Compositional biasNote=Glu-rich
HgeneRTF1chr15:41750074chr15:42246138ENST00000389629+418214_307220711Compositional biasNote=Lys-rich
HgeneRTF1chr15:41750074chr15:42246138ENST00000389629+418353_484220711DomainPlus3
TgeneEHD4chr15:41750074chr15:42246138ENST00000220325-0658_28978542DomainDynamin-type G
TgeneEHD4chr15:41750074chr15:42246138ENST00000220325-0668_7578542RegionG1 motif


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FusionGeneSequence for RTF1_EHD4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RTF1_ENST00000389629_chr15_41750074_+_EHD4_ENST00000220325_chr15_42246138_-_684aa
MRGRLCVGRAAAAAAAVAVPLAGGQEGSPGGGRRGSRGTTMVKKRKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPA
ASSDSETSDSDDEWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSDSDSSSEDEEFHD
GYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKRRYLLEQDFPGMRIGPEPTTDSFIAVMYGETEGSTPGNALVVDPKKPFRKL
SRFGNAFLNRFMCSQLPNQVLKSISVIDSPGILSGEKQRISRGYDFCQVLQWFAERVDRIILLFDAHKLDISDEFSEAIKAFRGQDDKIR
VVLNKADQVDTQQLMRVYGALMWSLGKVINTPEVLRVYIGSFWAQPLQNTDNRRLFEAEAQDLFRDIQSLPQKAAVRKLNDLIKRARLAK
VHAYIISYLKKEMPSVFGKENKKRELISRLPEIYIQLQREYQISAGDFPEVKAMQEQLENYDFTKFHSLKPKLIEAVDNMLSNKISPLMN
LISQEETSTPTQLVQGGAFDGTTEGPFNQGYGEGAKEGADEEEWVVAKDKPVYDELFYTLSPINGKISGVNAKKEMVTSKLPNSVLGKIW


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RTF1_ENST00000389629_chr15_41750074_+_EHD4_ENST00000220325_chr15_42246138_-_2052nt
ATGCGCGGTCGCCTTTGTGTGGGTCGAGCAGCGGCGGCGGCGGCGGCAGTGGCGGTCCCACTGGCAGGCGGGCAAGAGGGGAGTCCGGGC
GGCGGCCGGCGTGGGAGCCGGGGGACCACCATGGTAAAGAAGCGGAAAGGCCGCGTCGTGATCGACTCGGACACAGAGGACAGCGGCAGC
GACGAGAACCTGGATCAGGAGCTCTTGTCCCTGGCAAAGCGAAAGCGCAGTGACTCTGAGGAGAAGGAGCCGCCTGTGAGTCAGCCTGCA
GCCTCGTCAGACTCGGAGACGTCTGACAGTGACGATGAGTGGACATTTGGGAGCAATAAAAATAAGAAGAAAGGAAAAGCCAGAAAAATA
GAGAAGAAAGGAACCATGAAGAAACAGGCCAACAAAACTGCCTCCTCAGGCAGTTCAGACAAAGACAGTTCAGCTGAGAGCTCAGCCCCT
GAGGAAGGTGAAGTGTCAGACTCTGACAGCAACAGCTCCTCTTCCAGTTCAGATTCAGACTCTTCCTCAGAAGATGAAGAGTTCCATGAT
GGCTATGGAGAAGACCTCATGGGAGATGAGGAAGACAGGGCCCGTCTGGAACAGATGACAGAGAAAGAGAGAGAGCAAGAACTGTTCAAT
CGCATAGAGAAGAGGGAGGTGTTGAAAAGAAGATACCTACTGGAGCAGGATTTCCCAGGCATGAGGATTGGTCCGGAGCCCACCACAGAC
TCCTTCATCGCCGTGATGTATGGAGAGACTGAGGGCAGCACCCCAGGGAATGCTTTAGTCGTGGACCCCAAAAAGCCGTTTAGAAAGCTC
AGTCGCTTTGGAAACGCTTTCCTGAATCGATTCATGTGCTCACAGCTCCCCAATCAGGTCCTGAAGAGCATCAGCGTCATCGACAGCCCC
GGCATCCTTTCTGGGGAGAAGCAGCGCATCAGCCGAGGCTATGACTTCTGCCAGGTCCTGCAGTGGTTTGCCGAGAGGGTGGACAGGATC
ATCCTGCTCTTTGACGCTCACAAGCTGGACATCTCAGATGAATTCTCAGAGGCCATCAAGGCCTTCCGGGGCCAGGACGACAAGATCCGT
GTCGTGCTGAACAAGGCCGACCAAGTGGACACGCAGCAGCTGATGCGGGTCTACGGGGCCCTCATGTGGTCCCTAGGCAAGGTCATCAAC
ACGCCCGAGGTACTGCGCGTCTACATTGGCTCCTTCTGGGCGCAGCCCCTGCAGAACACGGACAACCGCCGGCTCTTCGAGGCTGAGGCC
CAGGACCTCTTTAGAGACATCCAGAGCCTCCCCCAGAAGGCAGCGGTGCGCAAGCTCAACGACCTCATCAAGCGAGCGAGGCTGGCCAAG
GTGCATGCCTACATCATCAGCTACCTGAAGAAGGAGATGCCAAGTGTATTTGGAAAGGAAAACAAGAAGAGAGAGCTTATCAGCAGGCTA
CCGGAAATCTACATTCAGCTACAGCGAGAATACCAGATTTCTGCAGGGGACTTCCCTGAGGTCAAGGCTATGCAGGAACAGCTTGAGAAC
TATGACTTCACCAAATTCCACTCGCTGAAGCCCAAGCTGATCGAGGCAGTGGACAACATGCTGAGCAACAAGATCTCGCCCCTCATGAAC
CTCATCAGCCAGGAGGAGACGAGCACGCCCACGCAGCTGGTGCAGGGCGGCGCCTTCGATGGCACCACCGAGGGCCCCTTCAACCAGGGC
TACGGGGAGGGTGCCAAGGAGGGCGCCGACGAGGAGGAGTGGGTCGTGGCCAAAGACAAGCCCGTCTACGACGAGCTCTTCTACACTCTG
TCGCCCATCAATGGCAAGATATCAGGTGTCAACGCCAAGAAGGAGATGGTGACCTCCAAGCTGCCCAACAGCGTCCTGGGCAAGATCTGG
AAGCTGGCCGACTGCGACTGCGACGGCATGCTTGATGAGGAGGAGTTCGCGCTGGCCAAGCACCTCATCAAGATCAAGCTCGACGGCTAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_RTF1_ENST00000389629_chr15_41750074_+_EHD4_ENST00000220325_chr15_42246138_-_3957nt
AGCGGAGCGCGCATGCGCGGTCGCCTTTGTGTGGGTCGAGCAGCGGCGGCGGCGGCGGCAGTGGCGGTCCCACTGGCAGGCGGGCAAGAG
GGGAGTCCGGGCGGCGGCCGGCGTGGGAGCCGGGGGACCACCATGGTAAAGAAGCGGAAAGGCCGCGTCGTGATCGACTCGGACACAGAG
GACAGCGGCAGCGACGAGAACCTGGATCAGGAGCTCTTGTCCCTGGCAAAGCGAAAGCGCAGTGACTCTGAGGAGAAGGAGCCGCCTGTG
AGTCAGCCTGCAGCCTCGTCAGACTCGGAGACGTCTGACAGTGACGATGAGTGGACATTTGGGAGCAATAAAAATAAGAAGAAAGGAAAA
GCCAGAAAAATAGAGAAGAAAGGAACCATGAAGAAACAGGCCAACAAAACTGCCTCCTCAGGCAGTTCAGACAAAGACAGTTCAGCTGAG
AGCTCAGCCCCTGAGGAAGGTGAAGTGTCAGACTCTGACAGCAACAGCTCCTCTTCCAGTTCAGATTCAGACTCTTCCTCAGAAGATGAA
GAGTTCCATGATGGCTATGGAGAAGACCTCATGGGAGATGAGGAAGACAGGGCCCGTCTGGAACAGATGACAGAGAAAGAGAGAGAGCAA
GAACTGTTCAATCGCATAGAGAAGAGGGAGGTGTTGAAAAGAAGATACCTACTGGAGCAGGATTTCCCAGGCATGAGGATTGGTCCGGAG
CCCACCACAGACTCCTTCATCGCCGTGATGTATGGAGAGACTGAGGGCAGCACCCCAGGGAATGCTTTAGTCGTGGACCCCAAAAAGCCG
TTTAGAAAGCTCAGTCGCTTTGGAAACGCTTTCCTGAATCGATTCATGTGCTCACAGCTCCCCAATCAGGTCCTGAAGAGCATCAGCGTC
ATCGACAGCCCCGGCATCCTTTCTGGGGAGAAGCAGCGCATCAGCCGAGGCTATGACTTCTGCCAGGTCCTGCAGTGGTTTGCCGAGAGG
GTGGACAGGATCATCCTGCTCTTTGACGCTCACAAGCTGGACATCTCAGATGAATTCTCAGAGGCCATCAAGGCCTTCCGGGGCCAGGAC
GACAAGATCCGTGTCGTGCTGAACAAGGCCGACCAAGTGGACACGCAGCAGCTGATGCGGGTCTACGGGGCCCTCATGTGGTCCCTAGGC
AAGGTCATCAACACGCCCGAGGTACTGCGCGTCTACATTGGCTCCTTCTGGGCGCAGCCCCTGCAGAACACGGACAACCGCCGGCTCTTC
GAGGCTGAGGCCCAGGACCTCTTTAGAGACATCCAGAGCCTCCCCCAGAAGGCAGCGGTGCGCAAGCTCAACGACCTCATCAAGCGAGCG
AGGCTGGCCAAGGTGCATGCCTACATCATCAGCTACCTGAAGAAGGAGATGCCAAGTGTATTTGGAAAGGAAAACAAGAAGAGAGAGCTT
ATCAGCAGGCTACCGGAAATCTACATTCAGCTACAGCGAGAATACCAGATTTCTGCAGGGGACTTCCCTGAGGTCAAGGCTATGCAGGAA
CAGCTTGAGAACTATGACTTCACCAAATTCCACTCGCTGAAGCCCAAGCTGATCGAGGCAGTGGACAACATGCTGAGCAACAAGATCTCG
CCCCTCATGAACCTCATCAGCCAGGAGGAGACGAGCACGCCCACGCAGCTGGTGCAGGGCGGCGCCTTCGATGGCACCACCGAGGGCCCC
TTCAACCAGGGCTACGGGGAGGGTGCCAAGGAGGGCGCCGACGAGGAGGAGTGGGTCGTGGCCAAAGACAAGCCCGTCTACGACGAGCTC
TTCTACACTCTGTCGCCCATCAATGGCAAGATATCAGGTGTCAACGCCAAGAAGGAGATGGTGACCTCCAAGCTGCCCAACAGCGTCCTG
GGCAAGATCTGGAAGCTGGCCGACTGCGACTGCGACGGCATGCTTGATGAGGAGGAGTTCGCGCTGGCCAAGCACCTCATCAAGATCAAG
CTCGACGGCTACGAGCTGCCCAGCAGCCTGCCCCCCCACCTCGTGCCCCCCTCGCACAGGAAGTCCCTGCCCAAGGCCGACTGAGGGGTG
GGCTGCAGAACGGGGTGGGAACTGGGGGACCTGGGCCTCAGGCCTGCTCCACCACTGACTCACCGAATGACCTTGGGCAAGGCACTGCCC
TCTCTGTGCCTTGGTTTCCCCATCTGTAGAATGGGGAGGGTGGACACTGGAAACTAGATGACTTCTTTCACCTCCAAAATTCCCTTAGTT
TCTATGAAAATATTGGGGGTAGGGGGGTGGATTAGGAGATTGAAGGGTTGAGAAGAAAGAGAAATTGTCCAAAGAGTCCTCAGAACCTGC
CTGGAGAAATGCGCATGGGGGTGGGCCTGGTAAGTCCCAGGAACCACAGGAAGTGAGCTAAGGCTCACCCAGAGCAGCTGGGTCTCCAGG
CTGCCTGGGCTTTTTGTCCTCATGAACAACTCTGGAGCAGCTGTCTGTCCCTCAGAGGGCACCTGGAGGCAGCAAAGATTATCTTATTTA
TTTTATTTTGTTTTCTGCTATATTTAGAGTGGCAAAAAAATAGAGCAGAGGGTTTCTGCTGTCTCCAGACTGTCTACCAAAGAGAAGGCG
ACAGATGCCTCCTGGGTTTGGAAGGGGGATGCACTGTGGATCTGCCATCCATTCTGCAGTCTCCAGCAGAGCAGGCAGTCAGGCCCCAGC
GTGCCTCCATCCCAGTGCCCCGATGACCATCTGGTCAGCCCTCCCAACCTCCCTTCCAGGGGGCTTACCAGCAAAGCCATATTCGGCTAG
GAATTTGGAATTCACAACCTTTATTAACCCCTGGCAAAACTTCCCGTTTGCATGTCAAATCACATTGAAGCCTGAAAATTAGCTTTTCTT
ACTGGTTTTTCCAATAAGTAATAGCAAAGCCCACTTATCATACTTAAACTACAGTAAAGAAAAGAGGTGGTTCTCTGCAGTGATCGTTTA
GTGTGGCCCTCAAACATTAAATATCCCGAGGTCTCCTTGGTGGGTGGCAGGATTTAAATTCAATCAAATCCTGTCCTAGTGTGTGCAGTG
TCTTCGGCCCTGTGGACACAGGTGAATGAGGGACCAGCCCTGCCCTGGGCTGTTGAGAAGAGATCAGTCCACCCAGAGTTAGACATTGTT
TTTGTAGAAAACAGGCATTTATTATGTCTAGGGTTTTGTGTTTTTTTTTTTTCCTTACAGGATAAAAGCCTTTATACAGAAACAAAATGG
AACCTTTCATATAAAACCTTTTCTTTAAAGGCTGTGTGGTTCGTATCATGAATGCCCATCACGAGGCAGGATTCGGGCACATACCTGTAC
TTCTGCTCCAGAGTGTGCGCTCCCCAAATCCCCTGAGTAAACCTCTCTGGACTGCTGCTCAGACACCTGCGTCAGGTGGAGGTGCCTCCC
CCTCTGTGGGCACCAGCTTGGGGAGGTAGGTGACTTTTCCTTGCAAATCTCCCTGCCTCATCTCCAGAAAATTGCATACCTGCATGGCCT
CTCTGCATTATTTATGCAGGAAGAGACACGAAACAGCAATGGCCACATGGTATGGGGGCCTGCTGGCACCAGAAGTGAATGAAATCAGAA
CCGTCCCACTGAGTCTTCCAAAAGGCACATAATTTTTTTTTTCTGTCACCTGCCTTTGGTGACAGGGTCAAAGGCACAGATTGAAGAGAA
AATCTTGATTTGGGAGAAGCATTTATATCCAGATGCCTACCCTTACACTCCCTAGCTTACTTTCTACATAATTTAGTTTTAAGAGCAGGA
AATGCATAACATGGTTTTTAGTCTTAACAAGCACTTAAATTCATTAGACGCATAGAAAAGAACCATTTATTATTTTATTATTTTTATTTT


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FusionGenePPI for RTF1_EHD4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RTF1ARRB1, PAF1, CTR9, LEO1, TCEA1, CDC73, WDR61, NEDD4, HADHA, HADHB, PTPN11, APP, SUPT16H, CSNK2A1, SSRP1, TRPM8, CD81, DNMT3B, DNMT3A, SRPK2, ETF1, GSPT1, SNX6, YAP1, STAT1, DENND2D, CHD1, RPL37, BRD4, NUMA1, RPL35A, UBTF, ZC3H18, SRRM2, SUPT5H, NTRK1, PIP4K2A, ARRB2EHD4STYXL1, DGKQ, EHD1, RASGRF1, AFP, ADSL, SZRD1, CTPS2, AASDHPPT, GTF3C4, HIST1H2AB, NOL3, PLCG1, PSMG1, RPL38, ZC3HC1, LRSAM1, MTMR2, NT5C2, UBA2, CCDC8, EGFR, TGFBR2, FSD1, DDX19B, HEPACAM2, C19orf54, DDOST, STX7, UQCRC2, WARS, NTRK1, CLTC, MCM2, SNW1, CDC5L, CDH1, PTPRM, RBSN, EXOC8, VWA5A, IQCF1, TNFRSF13B, OLFM3, TPCN2, TRIM11, NTRK3, PCDHB16, TMEM52B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RTF1_EHD4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RTF1_EHD4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource