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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3231

FusionGeneSummary for ATMIN_EIF4E2

check button Fusion gene summary
Fusion gene informationFusion gene name: ATMIN_EIF4E2
Fusion gene ID: 3231
HgeneTgene
Gene symbol

ATMIN

EIF4E2

Gene ID

23300

9470

Gene nameATM interactoreukaryotic translation initiation factor 4E family member 2
SynonymsASCIZ|ZNF8224E-LP|4EHP|EIF4EL3|IF4e|h4EHP
Cytomap

16q23.2

2q37.1

Type of geneprotein-codingprotein-coding
DescriptionATM interactorATM INteracting proteinATM/ATR-Substrate Chk2-Interacting Zn++-finger proteinATM/ATR-substrate CHEK2-interacting zinc finger proteinATM/ATR-substrate CHK2-interacting zinc finger proteinzinc finger protein 822eukaryotic translation initiation factor 4E type 2eIF-4E type 2eIF4E-like cap-binding proteineIF4E-like protein 4E-LPeukaryotic translation initiation factor 4E homologous proteineukaryotic translation initiation factor 4E-like 3mRNA cap-binding pro
Modification date2018052220180520
UniProtAcc

O43313

O60573

Ensembl transtripts involved in fusion geneENST00000299575, ENST00000539819, 
ENST00000564241, ENST00000566488, 
ENST00000409514, ENST00000409098, 
ENST00000409394, ENST00000258416, 
ENST00000409495, ENST00000409167, 
ENST00000409322, ENST00000479834, 
Fusion gene scores* DoF score4 X 4 X 2=324 X 5 X 3=60
# samples 45
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATMIN [Title/Abstract] AND EIF4E2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATMIN

GO:0045893

positive regulation of transcription, DNA-templated

22167198


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI004991ATMINchr16

81080140

+EIF4E2chr2

233448154

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000299575ENST00000409514ATMINchr16

81080140

+EIF4E2chr2

233448154

+
3UTR-3UTRENST00000299575ENST00000409098ATMINchr16

81080140

+EIF4E2chr2

233448154

+
3UTR-intronENST00000299575ENST00000409394ATMINchr16

81080140

+EIF4E2chr2

233448154

+
3UTR-intronENST00000299575ENST00000258416ATMINchr16

81080140

+EIF4E2chr2

233448154

+
3UTR-intronENST00000299575ENST00000409495ATMINchr16

81080140

+EIF4E2chr2

233448154

+
3UTR-intronENST00000299575ENST00000409167ATMINchr16

81080140

+EIF4E2chr2

233448154

+
3UTR-intronENST00000299575ENST00000409322ATMINchr16

81080140

+EIF4E2chr2

233448154

+
3UTR-intronENST00000299575ENST00000479834ATMINchr16

81080140

+EIF4E2chr2

233448154

+
intron-3UTRENST00000539819ENST00000409514ATMINchr16

81080140

+EIF4E2chr2

233448154

+
intron-3UTRENST00000539819ENST00000409098ATMINchr16

81080140

+EIF4E2chr2

233448154

+
intron-intronENST00000539819ENST00000409394ATMINchr16

81080140

+EIF4E2chr2

233448154

+
intron-intronENST00000539819ENST00000258416ATMINchr16

81080140

+EIF4E2chr2

233448154

+
intron-intronENST00000539819ENST00000409495ATMINchr16

81080140

+EIF4E2chr2

233448154

+
intron-intronENST00000539819ENST00000409167ATMINchr16

81080140

+EIF4E2chr2

233448154

+
intron-intronENST00000539819ENST00000409322ATMINchr16

81080140

+EIF4E2chr2

233448154

+
intron-intronENST00000539819ENST00000479834ATMINchr16

81080140

+EIF4E2chr2

233448154

+
3UTR-3UTRENST00000564241ENST00000409514ATMINchr16

81080140

+EIF4E2chr2

233448154

+
3UTR-3UTRENST00000564241ENST00000409098ATMINchr16

81080140

+EIF4E2chr2

233448154

+
3UTR-intronENST00000564241ENST00000409394ATMINchr16

81080140

+EIF4E2chr2

233448154

+
3UTR-intronENST00000564241ENST00000258416ATMINchr16

81080140

+EIF4E2chr2

233448154

+
3UTR-intronENST00000564241ENST00000409495ATMINchr16

81080140

+EIF4E2chr2

233448154

+
3UTR-intronENST00000564241ENST00000409167ATMINchr16

81080140

+EIF4E2chr2

233448154

+
3UTR-intronENST00000564241ENST00000409322ATMINchr16

81080140

+EIF4E2chr2

233448154

+
3UTR-intronENST00000564241ENST00000479834ATMINchr16

81080140

+EIF4E2chr2

233448154

+
3UTR-3UTRENST00000566488ENST00000409514ATMINchr16

81080140

+EIF4E2chr2

233448154

+
3UTR-3UTRENST00000566488ENST00000409098ATMINchr16

81080140

+EIF4E2chr2

233448154

+
3UTR-intronENST00000566488ENST00000409394ATMINchr16

81080140

+EIF4E2chr2

233448154

+
3UTR-intronENST00000566488ENST00000258416ATMINchr16

81080140

+EIF4E2chr2

233448154

+
3UTR-intronENST00000566488ENST00000409495ATMINchr16

81080140

+EIF4E2chr2

233448154

+
3UTR-intronENST00000566488ENST00000409167ATMINchr16

81080140

+EIF4E2chr2

233448154

+
3UTR-intronENST00000566488ENST00000409322ATMINchr16

81080140

+EIF4E2chr2

233448154

+
3UTR-intronENST00000566488ENST00000479834ATMINchr16

81080140

+EIF4E2chr2

233448154

+

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FusionProtFeatures for ATMIN_EIF4E2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATMIN

O43313

EIF4E2

O60573

Transcription factor. Plays a crucial role in cellsurvival and RAD51 foci formation in response to methylating DNAdamage. Involved in regulating the activity of ATM in the absenceof DNA damage. May play a role in stabilizing ATM. Binds to theDYNLL1 promoter and activates its transcription.{ECO:0000269|PubMed:15933716, ECO:0000269|PubMed:17525732,ECO:0000269|PubMed:22167198}. Recognizes and binds the 7-methylguanosine-containingmRNA cap during an early step in the initiation (PubMed:9582349,PubMed:17368478, PubMed:25624349). Acts as a repressor oftranslation initiation (PubMed:22751931). In contrast to EIF4E, itis unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggestingthat it acts by competing with EIF4E and block assembly of eIF4Fat the cap (By similarity). {ECO:0000250|UniProtKB:Q8BMB3,ECO:0000269|PubMed:17368478, ECO:0000269|PubMed:22751931,ECO:0000269|PubMed:25624349, ECO:0000269|PubMed:9582349}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATMIN_EIF4E2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATMIN_EIF4E2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATMIN_EIF4E2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATMIN_EIF4E2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource