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Fusion gene ID: 3231 |
FusionGeneSummary for ATMIN_EIF4E2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: ATMIN_EIF4E2 | Fusion gene ID: 3231 | Hgene | Tgene | Gene symbol | ATMIN | EIF4E2 | Gene ID | 23300 | 9470 |
Gene name | ATM interactor | eukaryotic translation initiation factor 4E family member 2 | |
Synonyms | ASCIZ|ZNF822 | 4E-LP|4EHP|EIF4EL3|IF4e|h4EHP | |
Cytomap | 16q23.2 | 2q37.1 | |
Type of gene | protein-coding | protein-coding | |
Description | ATM interactorATM INteracting proteinATM/ATR-Substrate Chk2-Interacting Zn++-finger proteinATM/ATR-substrate CHEK2-interacting zinc finger proteinATM/ATR-substrate CHK2-interacting zinc finger proteinzinc finger protein 822 | eukaryotic translation initiation factor 4E type 2eIF-4E type 2eIF4E-like cap-binding proteineIF4E-like protein 4E-LPeukaryotic translation initiation factor 4E homologous proteineukaryotic translation initiation factor 4E-like 3mRNA cap-binding pro | |
Modification date | 20180522 | 20180520 | |
UniProtAcc | O43313 | O60573 | |
Ensembl transtripts involved in fusion gene | ENST00000299575, ENST00000539819, ENST00000564241, ENST00000566488, | ENST00000409514, ENST00000409098, ENST00000409394, ENST00000258416, ENST00000409495, ENST00000409167, ENST00000409322, ENST00000479834, | |
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 4 X 5 X 3=60 |
# samples | 4 | 5 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ATMIN [Title/Abstract] AND EIF4E2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ATMIN | GO:0045893 | positive regulation of transcription, DNA-templated | 22167198 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI004991 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000299575 | ENST00000409514 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
3UTR-3UTR | ENST00000299575 | ENST00000409098 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
3UTR-intron | ENST00000299575 | ENST00000409394 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
3UTR-intron | ENST00000299575 | ENST00000258416 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
3UTR-intron | ENST00000299575 | ENST00000409495 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
3UTR-intron | ENST00000299575 | ENST00000409167 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
3UTR-intron | ENST00000299575 | ENST00000409322 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
3UTR-intron | ENST00000299575 | ENST00000479834 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
intron-3UTR | ENST00000539819 | ENST00000409514 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
intron-3UTR | ENST00000539819 | ENST00000409098 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
intron-intron | ENST00000539819 | ENST00000409394 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
intron-intron | ENST00000539819 | ENST00000258416 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
intron-intron | ENST00000539819 | ENST00000409495 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
intron-intron | ENST00000539819 | ENST00000409167 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
intron-intron | ENST00000539819 | ENST00000409322 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
intron-intron | ENST00000539819 | ENST00000479834 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
3UTR-3UTR | ENST00000564241 | ENST00000409514 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
3UTR-3UTR | ENST00000564241 | ENST00000409098 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
3UTR-intron | ENST00000564241 | ENST00000409394 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
3UTR-intron | ENST00000564241 | ENST00000258416 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
3UTR-intron | ENST00000564241 | ENST00000409495 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
3UTR-intron | ENST00000564241 | ENST00000409167 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
3UTR-intron | ENST00000564241 | ENST00000409322 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
3UTR-intron | ENST00000564241 | ENST00000479834 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
3UTR-3UTR | ENST00000566488 | ENST00000409514 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
3UTR-3UTR | ENST00000566488 | ENST00000409098 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
3UTR-intron | ENST00000566488 | ENST00000409394 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
3UTR-intron | ENST00000566488 | ENST00000258416 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
3UTR-intron | ENST00000566488 | ENST00000409495 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
3UTR-intron | ENST00000566488 | ENST00000409167 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
3UTR-intron | ENST00000566488 | ENST00000409322 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
3UTR-intron | ENST00000566488 | ENST00000479834 | ATMIN | chr16 | 81080140 | + | EIF4E2 | chr2 | 233448154 | + |
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FusionProtFeatures for ATMIN_EIF4E2 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ATMIN | EIF4E2 |
Transcription factor. Plays a crucial role in cellsurvival and RAD51 foci formation in response to methylating DNAdamage. Involved in regulating the activity of ATM in the absenceof DNA damage. May play a role in stabilizing ATM. Binds to theDYNLL1 promoter and activates its transcription.{ECO:0000269|PubMed:15933716, ECO:0000269|PubMed:17525732,ECO:0000269|PubMed:22167198}. | Recognizes and binds the 7-methylguanosine-containingmRNA cap during an early step in the initiation (PubMed:9582349,PubMed:17368478, PubMed:25624349). Acts as a repressor oftranslation initiation (PubMed:22751931). In contrast to EIF4E, itis unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggestingthat it acts by competing with EIF4E and block assembly of eIF4Fat the cap (By similarity). {ECO:0000250|UniProtKB:Q8BMB3,ECO:0000269|PubMed:17368478, ECO:0000269|PubMed:22751931,ECO:0000269|PubMed:25624349, ECO:0000269|PubMed:9582349}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ATMIN_EIF4E2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ATMIN_EIF4E2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ATMIN_EIF4E2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ATMIN_EIF4E2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |