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Fusion gene ID: 32283 |
FusionGeneSummary for RSF1_HSPA13 |
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Fusion gene information | Fusion gene name: RSF1_HSPA13 | Fusion gene ID: 32283 | Hgene | Tgene | Gene symbol | RSF1 | HSPA13 | Gene ID | 51773 | 6782 |
Gene name | remodeling and spacing factor 1 | heat shock protein family A (Hsp70) member 13 | |
Synonyms | HBXAP|RSF-1|XAP8|p325 | STCH | |
Cytomap | 11q14.1 | 21q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | remodeling and spacing factor 1HBV pX-associated protein 8hepatitis B virus x-associated proteinp325 subunit of RSF chromatin-remodeling complex | heat shock 70 kDa protein 13heat shock protein 70kDa family, member 13microsomal stress 70 protein ATPase corestress 70 protein chaperone, microsome-associated, 60kDstress 70 protein chaperone, microsome-associated, 60kDastress-70 protein chaperone m | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q96T23 | P48723 | |
Ensembl transtripts involved in fusion gene | ENST00000308488, ENST00000360355, ENST00000480887, ENST00000530604, | ENST00000285667, ENST00000544452, ENST00000478035, | |
Fusion gene scores | * DoF score | 15 X 8 X 9=1080 | 3 X 3 X 2=18 |
# samples | 17 | 3 | |
** MAII score | log2(17/1080*10)=-2.66742466091313 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: RSF1 [Title/Abstract] AND HSPA13 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RSF1 | GO:0006334 | nucleosome assembly | 12972596 |
Hgene | RSF1 | GO:0006338 | chromatin remodeling | 9836642 |
Hgene | RSF1 | GO:0006352 | DNA-templated transcription, initiation | 9836642 |
Hgene | RSF1 | GO:0016584 | nucleosome positioning | 9836642 |
Hgene | RSF1 | GO:0043392 | negative regulation of DNA binding | 12972596 |
Hgene | RSF1 | GO:0045892 | negative regulation of transcription, DNA-templated | 11944984 |
Hgene | RSF1 | GO:0045893 | positive regulation of transcription, DNA-templated | 11788598 |
Hgene | RSF1 | GO:0050434 | positive regulation of viral transcription | 11788598 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-AN-A03X-01A | RSF1 | chr11 | 77531574 | - | HSPA13 | chr21 | 15753864 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000308488 | ENST00000285667 | RSF1 | chr11 | 77531574 | - | HSPA13 | chr21 | 15753864 | - |
5CDS-5UTR | ENST00000308488 | ENST00000544452 | RSF1 | chr11 | 77531574 | - | HSPA13 | chr21 | 15753864 | - |
5CDS-5UTR | ENST00000308488 | ENST00000478035 | RSF1 | chr11 | 77531574 | - | HSPA13 | chr21 | 15753864 | - |
Frame-shift | ENST00000360355 | ENST00000285667 | RSF1 | chr11 | 77531574 | - | HSPA13 | chr21 | 15753864 | - |
5CDS-5UTR | ENST00000360355 | ENST00000544452 | RSF1 | chr11 | 77531574 | - | HSPA13 | chr21 | 15753864 | - |
5CDS-5UTR | ENST00000360355 | ENST00000478035 | RSF1 | chr11 | 77531574 | - | HSPA13 | chr21 | 15753864 | - |
intron-3CDS | ENST00000480887 | ENST00000285667 | RSF1 | chr11 | 77531574 | - | HSPA13 | chr21 | 15753864 | - |
intron-5UTR | ENST00000480887 | ENST00000544452 | RSF1 | chr11 | 77531574 | - | HSPA13 | chr21 | 15753864 | - |
intron-5UTR | ENST00000480887 | ENST00000478035 | RSF1 | chr11 | 77531574 | - | HSPA13 | chr21 | 15753864 | - |
5UTR-3CDS | ENST00000530604 | ENST00000285667 | RSF1 | chr11 | 77531574 | - | HSPA13 | chr21 | 15753864 | - |
5UTR-5UTR | ENST00000530604 | ENST00000544452 | RSF1 | chr11 | 77531574 | - | HSPA13 | chr21 | 15753864 | - |
5UTR-5UTR | ENST00000530604 | ENST00000478035 | RSF1 | chr11 | 77531574 | - | HSPA13 | chr21 | 15753864 | - |
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FusionProtFeatures for RSF1_HSPA13 |
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Hgene | Tgene |
RSF1 | HSPA13 |
Required for assembly of regular nucleosome arrays bythe RSF chromatin-remodeling complex (PubMed:12972596).Facilitates transcription of hepatitis B virus (HBV) genes by thepX transcription activator. In case of infection by HBV, togetherwith pX, it represses TNF-alpha induced NF-kappa-B transcriptionactivation. Represses transcription when artificially recruited tochromatin by fusion to a heterogeneous DNA binding domain(PubMed:11944984, PubMed:11788598). {ECO:0000269|PubMed:11788598,ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596}. | Has peptide-independent ATPase activity. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RSF1_HSPA13 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RSF1_HSPA13 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RSF1 | NFKB1, SMARCA5, CENPA, SIRT7, SP1, COPS6, CSNK2A1, HIST1H2BG, HIST1H3A, EWSR1, MARK2, ATXN3, KAT6A, MCM2 | HSPA13 | UBQLN1, UBQLN2, RMI1, POLE4, SSR1, UBQLN4, BAG6, SGTA, CEACAM21, FBXO6, TNF, DKKL1, B4GALT5, TXNIP |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RSF1_HSPA13 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RSF1_HSPA13 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |