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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32260

FusionGeneSummary for RRP12_PTMA

check button Fusion gene summary
Fusion gene informationFusion gene name: RRP12_PTMA
Fusion gene ID: 32260
HgeneTgene
Gene symbol

RRP12

PTMA

Gene ID

23223

5757

Gene nameribosomal RNA processing 12 homologprothymosin alpha
SynonymsKIAA0690TMSA
Cytomap

10q24.1

2q37.1

Type of geneprotein-codingprotein-coding
DescriptionRRP12-like proteinprothymosin alphagene sequence 28prothymosin alpha proteinprothymosin-I+/-
Modification date2018051920180522
UniProtAcc

Q5JTH9

P06454

Ensembl transtripts involved in fusion geneENST00000479481, ENST00000370992, 
ENST00000536831, ENST00000315563, 
ENST00000414986, 		ENST00000466801, 
ENST00000409321, ENST00000409115, 
ENST00000341369, ENST00000409683, 
ENST00000410064, 
Fusion gene scores* DoF score6 X 6 X 3=10817 X 17 X 2=578
# samples 618
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/578*10)=-1.683072586171
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RRP12 [Title/Abstract] AND PTMA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM473671RRP12chr10

99125871

-PTMAchr2

232576674

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000479481ENST00000466801RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000479481ENST00000409321RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000479481ENST00000409115RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000479481ENST00000341369RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000479481ENST00000409683RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000479481ENST00000410064RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000370992ENST00000466801RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000370992ENST00000409321RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000370992ENST00000409115RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000370992ENST00000341369RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000370992ENST00000409683RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000370992ENST00000410064RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000536831ENST00000466801RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000536831ENST00000409321RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000536831ENST00000409115RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000536831ENST00000341369RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000536831ENST00000409683RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000536831ENST00000410064RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000315563ENST00000466801RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000315563ENST00000409321RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000315563ENST00000409115RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000315563ENST00000341369RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000315563ENST00000409683RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000315563ENST00000410064RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000414986ENST00000466801RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000414986ENST00000409321RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000414986ENST00000409115RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000414986ENST00000341369RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000414986ENST00000409683RRP12chr10

99125871

-PTMAchr2

232576674

+
intron-3UTRENST00000414986ENST00000410064RRP12chr10

99125871

-PTMAchr2

232576674

+

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FusionProtFeatures for RRP12_PTMA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RRP12

Q5JTH9

PTMA

P06454

Prothymosin alpha may mediate immune function byconferring resistance to certain opportunistic infections.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RRP12_PTMA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RRP12_PTMA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RRP12_PTMA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RRP12_PTMA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePTMAC0001430Adenoma1CTD_human
TgenePTMAC0015695Fatty Liver1CTD_human
TgenePTMAC0024121Lung Neoplasms1CTD_human
TgenePTMAC0035412Rhabdomyosarcoma1CTD_human