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Fusion gene ID: 32253 |
FusionGeneSummary for RRN3P2_BANP |
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Fusion gene information | Fusion gene name: RRN3P2_BANP | Fusion gene ID: 32253 | Hgene | Tgene | Gene symbol | RRN3P2 | BANP | Gene ID | 653390 | 54971 |
Gene name | RRN3 homolog, RNA polymerase I transcription factor pseudogene 2 | BTG3 associated nuclear protein | |
Synonyms | - | BEND1|SMAR1|SMARBP1 | |
Cytomap | 16p11.2 | 16q24.2 | |
Type of gene | pseudo | protein-coding | |
Description | RNA polymerase I transcription factor homolog pseudogene 2RRN3 RNA polymerase I transcription factor homolog pseudogeneRRN3-like protein 1 | protein BANPBEN domain-containing protein 1scaffold/matrix-associated region-1-binding protein | |
Modification date | 20180329 | 20180520 | |
UniProtAcc | Q8N9N5 | ||
Ensembl transtripts involved in fusion gene | ENST00000564580, | ENST00000286122, ENST00000355163, ENST00000479780, ENST00000393208, ENST00000355022, ENST00000538234, ENST00000393207, ENST00000481948, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: RRN3P2 [Title/Abstract] AND BANP [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LAML | TCGA-AB-2868-03A | RRN3P2 | chr16 | 29107476 | + | BANP | chr16 | 88014681 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000564580 | ENST00000286122 | RRN3P2 | chr16 | 29107476 | + | BANP | chr16 | 88014681 | + |
3UTR-3CDS | ENST00000564580 | ENST00000355163 | RRN3P2 | chr16 | 29107476 | + | BANP | chr16 | 88014681 | + |
3UTR-3CDS | ENST00000564580 | ENST00000479780 | RRN3P2 | chr16 | 29107476 | + | BANP | chr16 | 88014681 | + |
3UTR-3CDS | ENST00000564580 | ENST00000393208 | RRN3P2 | chr16 | 29107476 | + | BANP | chr16 | 88014681 | + |
3UTR-3CDS | ENST00000564580 | ENST00000355022 | RRN3P2 | chr16 | 29107476 | + | BANP | chr16 | 88014681 | + |
3UTR-3CDS | ENST00000564580 | ENST00000538234 | RRN3P2 | chr16 | 29107476 | + | BANP | chr16 | 88014681 | + |
3UTR-3CDS | ENST00000564580 | ENST00000393207 | RRN3P2 | chr16 | 29107476 | + | BANP | chr16 | 88014681 | + |
3UTR-intron | ENST00000564580 | ENST00000481948 | RRN3P2 | chr16 | 29107476 | + | BANP | chr16 | 88014681 | + |
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FusionProtFeatures for RRN3P2_BANP |
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Hgene | Tgene |
RRN3P2 | BANP |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Controls V(D)J recombination during T-cell developmentby repressing T-cell receptor (TCR) beta enhancer function. Bindsto scaffold/matrix attachment region beta (S/MARbeta), an ATC-richDNA sequence located upstream of the TCR beta enhancer. Repressescyclin D1 transcription by recruiting HDAC1 to its promoter,thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. PromotesTP53 'Ser-15' phosphorylation and nuclear accumulation, whichcauses cell cycle arrest (By similarity). {ECO:0000250,ECO:0000269|PubMed:16166625}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RRN3P2_BANP |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RRN3P2_BANP |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RRN3P2 | BANP | TRAF2, TP53, MDM2, HIF1A, RELA, NFKB1, HDAC1, PML, TERF2IP, TERF2, NPM1, FOXM1, MVP, PRKAB2, RIMS3, PARP1, EP300, ALAS2, CAMK2D, COL10A1, FHL2, LMO2, MAX, NEDD9, PIM1, POLR2L, PPIB, PPIC, PRKCH, MAP2K1, PSMD9, SNRPB, SP2, TNXB, LMO4, ADAM15, SLC16A3, XAGE1E, BAG5, RBM39, TRAF4, TOX4, TROAP, PPIF, MRPL28, RBPMS, POGZ, ISCU, PHF21A, ZNF581, FAM120C, BANP, PRPF39, PID1, FAM90A1, DNAJA4, LMO3, LGALS14, ZNF471, LSM2, LENG1, ZC2HC1C, CEP76, ZMIZ2, NRIP2, POLDIP3, GFM2, L3MBTL3, LINC01547, C1orf94, LINC00152, RAB3IP, ZNF488, HMGB3P1, C22orf39, CCDC26, SPACA6P, DCDC2B, FAM117B, SH3RF2, C6orf165, FAM71C, LACE1, FOXR1, EPHA10, MIR4435-1HG, CCDC101, PDHB, TMEM25, VMAC, CPSF4L, MAPK1, KHDRBS1, HDAC6, MRRF, XRCC6, H2AFX, ATM, JUN, GATAD1, CCDC53, HEXIM2, AHCYL2, FLCN, TRIM11, GDF10, PFDN4, BFSP2, OLFM2, TRIM25, CDC20, MAPK8 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RRN3P2_BANP |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RRN3P2_BANP |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |