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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32245

FusionGeneSummary for RREB1_WRAP53

check button Fusion gene summary
Fusion gene informationFusion gene name: RREB1_WRAP53
Fusion gene ID: 32245
HgeneTgene
Gene symbol

RREB1

WRAP53

Gene ID

6239

55135

Gene nameras responsive element binding protein 1WD repeat containing antisense to TP53
SynonymsFINB|HNT|LZ321|RREB-1|Zep-1DKCB3|TCAB1|WDR79
Cytomap

6p24.3

17p13.1

Type of geneprotein-codingprotein-coding
Descriptionras-responsive element-binding protein 1DNA-binding proteinfinger protein in nuclear bodieshindsight homolograf-responsive zinc finger protein LZ321zinc finger motif enhancer-binding protein 1telomerase Cajal body protein 1WD repeat-containing protein 79WD repeat-containing protein WRAP53WD40 protein Wrap53WD40 repeat-containing protein antisense to TP53WD40 repeat-containing protein encoding RNA antisense to p53
Modification date2018052320180519
UniProtAcc

Q92766

Q9BUR4

Ensembl transtripts involved in fusion geneENST00000379933, ENST00000379938, 
ENST00000334984, ENST00000349384, 
ENST00000431639, ENST00000316024, 
ENST00000457584, ENST00000396463, 
ENST00000534050, 
Fusion gene scores* DoF score11 X 9 X 6=5949 X 4 X 5=180
# samples 119
** MAII scorelog2(11/594*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/180*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RREB1 [Title/Abstract] AND WRAP53 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRREB1

GO:0045944

positive regulation of transcription by RNA polymerase II

8816445

TgeneWRAP53

GO:0007004

telomere maintenance via telomerase

23685356

TgeneWRAP53

GO:0051973

positive regulation of telomerase activity

19179534|23685356


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-ZG-A9LU-01ARREB1chr6

7108293

+WRAP53chr17

7591966

+
TCGALDPRADTCGA-ZG-A9LU-01ARREB1chr6

7108935

+WRAP53chr17

7591966

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000379933ENST00000431639RREB1chr6

7108293

+WRAP53chr17

7591966

+
intron-5UTRENST00000379933ENST00000316024RREB1chr6

7108293

+WRAP53chr17

7591966

+
intron-5UTRENST00000379933ENST00000457584RREB1chr6

7108293

+WRAP53chr17

7591966

+
intron-5UTRENST00000379933ENST00000396463RREB1chr6

7108293

+WRAP53chr17

7591966

+
intron-5UTRENST00000379933ENST00000534050RREB1chr6

7108293

+WRAP53chr17

7591966

+
5UTR-5UTRENST00000379938ENST00000431639RREB1chr6

7108293

+WRAP53chr17

7591966

+
5UTR-5UTRENST00000379938ENST00000316024RREB1chr6

7108293

+WRAP53chr17

7591966

+
5UTR-5UTRENST00000379938ENST00000457584RREB1chr6

7108293

+WRAP53chr17

7591966

+
5UTR-5UTRENST00000379938ENST00000396463RREB1chr6

7108293

+WRAP53chr17

7591966

+
5UTR-5UTRENST00000379938ENST00000534050RREB1chr6

7108293

+WRAP53chr17

7591966

+
5UTR-5UTRENST00000334984ENST00000431639RREB1chr6

7108293

+WRAP53chr17

7591966

+
5UTR-5UTRENST00000334984ENST00000316024RREB1chr6

7108293

+WRAP53chr17

7591966

+
5UTR-5UTRENST00000334984ENST00000457584RREB1chr6

7108293

+WRAP53chr17

7591966

+
5UTR-5UTRENST00000334984ENST00000396463RREB1chr6

7108293

+WRAP53chr17

7591966

+
5UTR-5UTRENST00000334984ENST00000534050RREB1chr6

7108293

+WRAP53chr17

7591966

+
5UTR-5UTRENST00000349384ENST00000431639RREB1chr6

7108293

+WRAP53chr17

7591966

+
5UTR-5UTRENST00000349384ENST00000316024RREB1chr6

7108293

+WRAP53chr17

7591966

+
5UTR-5UTRENST00000349384ENST00000457584RREB1chr6

7108293

+WRAP53chr17

7591966

+
5UTR-5UTRENST00000349384ENST00000396463RREB1chr6

7108293

+WRAP53chr17

7591966

+
5UTR-5UTRENST00000349384ENST00000534050RREB1chr6

7108293

+WRAP53chr17

7591966

+
intron-5UTRENST00000379933ENST00000431639RREB1chr6

7108935

+WRAP53chr17

7591966

+
intron-5UTRENST00000379933ENST00000316024RREB1chr6

7108935

+WRAP53chr17

7591966

+
intron-5UTRENST00000379933ENST00000457584RREB1chr6

7108935

+WRAP53chr17

7591966

+
intron-5UTRENST00000379933ENST00000396463RREB1chr6

7108935

+WRAP53chr17

7591966

+
intron-5UTRENST00000379933ENST00000534050RREB1chr6

7108935

+WRAP53chr17

7591966

+
intron-5UTRENST00000379938ENST00000431639RREB1chr6

7108935

+WRAP53chr17

7591966

+
intron-5UTRENST00000379938ENST00000316024RREB1chr6

7108935

+WRAP53chr17

7591966

+
intron-5UTRENST00000379938ENST00000457584RREB1chr6

7108935

+WRAP53chr17

7591966

+
intron-5UTRENST00000379938ENST00000396463RREB1chr6

7108935

+WRAP53chr17

7591966

+
intron-5UTRENST00000379938ENST00000534050RREB1chr6

7108935

+WRAP53chr17

7591966

+
intron-5UTRENST00000334984ENST00000431639RREB1chr6

7108935

+WRAP53chr17

7591966

+
intron-5UTRENST00000334984ENST00000316024RREB1chr6

7108935

+WRAP53chr17

7591966

+
intron-5UTRENST00000334984ENST00000457584RREB1chr6

7108935

+WRAP53chr17

7591966

+
intron-5UTRENST00000334984ENST00000396463RREB1chr6

7108935

+WRAP53chr17

7591966

+
intron-5UTRENST00000334984ENST00000534050RREB1chr6

7108935

+WRAP53chr17

7591966

+
intron-5UTRENST00000349384ENST00000431639RREB1chr6

7108935

+WRAP53chr17

7591966

+
intron-5UTRENST00000349384ENST00000316024RREB1chr6

7108935

+WRAP53chr17

7591966

+
intron-5UTRENST00000349384ENST00000457584RREB1chr6

7108935

+WRAP53chr17

7591966

+
intron-5UTRENST00000349384ENST00000396463RREB1chr6

7108935

+WRAP53chr17

7591966

+
intron-5UTRENST00000349384ENST00000534050RREB1chr6

7108935

+WRAP53chr17

7591966

+

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FusionProtFeatures for RREB1_WRAP53


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RREB1

Q92766

WRAP53

Q9BUR4

Essential component of the telomerase holoenzymecomplex, a ribonucleoprotein complex essential for the replicationof chromosome termini that elongates telomeres in most eukaryotes.In the telomerase holoenzyme complex, it controls telomeraselocalization to Cajal body. Required for delivery of TERC totelomeres during S phase and for telomerase activity. Binds smallCajal body RNAs (scaRNAs). The mRNA encoding this protein plays acritical role in the regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basalp53 mRNA levels and in p53 induction upon DNA damage.{ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19250907}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RREB1_WRAP53


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RREB1_WRAP53


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RREB1KDM1A, CTBP1, AR, HIST3H3, HDAC2, HDAC3, HDAC1, BLM, SNCA, SPATA20, ARL6, NEK7, TOR1AIP2, TRIM25WRAP53PRPF4, PTGES3, XPC, WAPAL, SNRPC, USP11, TNPO1, RBBP7, GAR1, FAM43A, MDC1, RNF8, H2AFX, HNRNPU, ZFHX3, CCT6A, DKC1, MYBPH, NDUFV3, TCP1, CCT3, STK24, CCT7, CCT4, CCT2, CCT8, CCT5, PRPF38B, PTPN1, RAP1B, RXRB, POLG2, CNTROB, MRPL14, KIAA1683, LYPD4, CRYL1, ARHGAP25, FAM46A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RREB1_WRAP53


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RREB1_WRAP53


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneWRAP53C3151442DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE, 31UNIPROT