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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32244

FusionGeneSummary for RREB1_TCF12

check button Fusion gene summary
Fusion gene informationFusion gene name: RREB1_TCF12
Fusion gene ID: 32244
HgeneTgene
Gene symbol

RREB1

TCF12

Gene ID

6239

6938

Gene nameras responsive element binding protein 1transcription factor 12
SynonymsFINB|HNT|LZ321|RREB-1|Zep-1CRS3|HEB|HTF4|HsT17266|TCF-12|bHLHb20|p64
Cytomap

6p24.3

15q21.3

Type of geneprotein-codingprotein-coding
Descriptionras-responsive element-binding protein 1DNA-binding proteinfinger protein in nuclear bodieshindsight homolograf-responsive zinc finger protein LZ321zinc finger motif enhancer-binding protein 1transcription factor 12DNA-binding protein HTF4E-box-binding proteinclass B basic helix-loop-helix protein 20helix-loop-helix transcription factor 4transcription factor HTF-4
Modification date2018052320180523
UniProtAcc

Q92766

Q99081

Ensembl transtripts involved in fusion geneENST00000379933, ENST00000379938, 
ENST00000334984, ENST00000349384, 
ENST00000438423, ENST00000267811, 
ENST00000452095, ENST00000333725, 
ENST00000557843, ENST00000560764, 
ENST00000543579, ENST00000537840, 
ENST00000343827, ENST00000559710, 
ENST00000559703, 
Fusion gene scores* DoF score11 X 9 X 6=59410 X 10 X 5=500
# samples 1110
** MAII scorelog2(11/594*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/500*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RREB1 [Title/Abstract] AND TCF12 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRREB1

GO:0045944

positive regulation of transcription by RNA polymerase II

8816445

TgeneTCF12

GO:0045944

positive regulation of transcription by RNA polymerase II

11802795


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE072437RREB1chr6

7212843

-TCF12chr15

57282442

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000379933ENST00000438423RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000379933ENST00000267811RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000379933ENST00000452095RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000379933ENST00000333725RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000379933ENST00000557843RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000379933ENST00000560764RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000379933ENST00000543579RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000379933ENST00000537840RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000379933ENST00000343827RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000379933ENST00000559710RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000379933ENST00000559703RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000379938ENST00000438423RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000379938ENST00000267811RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000379938ENST00000452095RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000379938ENST00000333725RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000379938ENST00000557843RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000379938ENST00000560764RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000379938ENST00000543579RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000379938ENST00000537840RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000379938ENST00000343827RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000379938ENST00000559710RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000379938ENST00000559703RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000334984ENST00000438423RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000334984ENST00000267811RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000334984ENST00000452095RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000334984ENST00000333725RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000334984ENST00000557843RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000334984ENST00000560764RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000334984ENST00000543579RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000334984ENST00000537840RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000334984ENST00000343827RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000334984ENST00000559710RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000334984ENST00000559703RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000349384ENST00000438423RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000349384ENST00000267811RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000349384ENST00000452095RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000349384ENST00000333725RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000349384ENST00000557843RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000349384ENST00000560764RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000349384ENST00000543579RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000349384ENST00000537840RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000349384ENST00000343827RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000349384ENST00000559710RREB1chr6

7212843

-TCF12chr15

57282442

+
intron-intronENST00000349384ENST00000559703RREB1chr6

7212843

-TCF12chr15

57282442

+

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FusionProtFeatures for RREB1_TCF12


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RREB1

Q92766

TCF12

Q99081

Transcriptional regulator. Involved in the initiation ofneuronal differentiation. Activates transcription by binding tothe E box (5'-CANNTG-3').

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RREB1_TCF12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RREB1_TCF12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RREB1_TCF12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RREB1_TCF12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTCF12C3715051CRANIOSYNOSTOSIS 32UNIPROT
TgeneTCF12C0010278Craniosynostosis1CTD_human;HPO