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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32240

FusionGeneSummary for RREB1_KIFAP3

check button Fusion gene summary
Fusion gene informationFusion gene name: RREB1_KIFAP3
Fusion gene ID: 32240
HgeneTgene
Gene symbol

RREB1

KIFAP3

Gene ID

6239

22920

Gene nameras responsive element binding protein 1kinesin associated protein 3
SynonymsFINB|HNT|LZ321|RREB-1|Zep-1FLA3|KAP-1|KAP-3|KAP3|SMAP|Smg-GDS|dJ190I16.1
Cytomap

6p24.3

1q24.2

Type of geneprotein-codingprotein-coding
Descriptionras-responsive element-binding protein 1DNA-binding proteinfinger protein in nuclear bodieshindsight homolograf-responsive zinc finger protein LZ321zinc finger motif enhancer-binding protein 1kinesin-associated protein 3small G protein GDP dissociation stimulatorsmg GDS-associated protein
Modification date2018052320180519
UniProtAcc

Q92766

Q92845

Ensembl transtripts involved in fusion geneENST00000379933, ENST00000379938, 
ENST00000334984, ENST00000349384, 
ENST00000367765, ENST00000367767, 
ENST00000361580, ENST00000538366, 
ENST00000540905, ENST00000490550, 
Fusion gene scores* DoF score11 X 9 X 6=5946 X 6 X 6=216
# samples 116
** MAII scorelog2(11/594*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/216*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RREB1 [Title/Abstract] AND KIFAP3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRREB1

GO:0045944

positive regulation of transcription by RNA polymerase II

8816445


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU679959RREB1chr6

7252147

-KIFAP3chr1

170003513

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000379933ENST00000367765RREB1chr6

7252147

-KIFAP3chr1

170003513

+
intron-intronENST00000379933ENST00000367767RREB1chr6

7252147

-KIFAP3chr1

170003513

+
intron-intronENST00000379933ENST00000361580RREB1chr6

7252147

-KIFAP3chr1

170003513

+
intron-intronENST00000379933ENST00000538366RREB1chr6

7252147

-KIFAP3chr1

170003513

+
intron-intronENST00000379933ENST00000540905RREB1chr6

7252147

-KIFAP3chr1

170003513

+
intron-intronENST00000379933ENST00000490550RREB1chr6

7252147

-KIFAP3chr1

170003513

+
3UTR-intronENST00000379938ENST00000367765RREB1chr6

7252147

-KIFAP3chr1

170003513

+
3UTR-intronENST00000379938ENST00000367767RREB1chr6

7252147

-KIFAP3chr1

170003513

+
3UTR-intronENST00000379938ENST00000361580RREB1chr6

7252147

-KIFAP3chr1

170003513

+
3UTR-intronENST00000379938ENST00000538366RREB1chr6

7252147

-KIFAP3chr1

170003513

+
3UTR-intronENST00000379938ENST00000540905RREB1chr6

7252147

-KIFAP3chr1

170003513

+
3UTR-intronENST00000379938ENST00000490550RREB1chr6

7252147

-KIFAP3chr1

170003513

+
intron-intronENST00000334984ENST00000367765RREB1chr6

7252147

-KIFAP3chr1

170003513

+
intron-intronENST00000334984ENST00000367767RREB1chr6

7252147

-KIFAP3chr1

170003513

+
intron-intronENST00000334984ENST00000361580RREB1chr6

7252147

-KIFAP3chr1

170003513

+
intron-intronENST00000334984ENST00000538366RREB1chr6

7252147

-KIFAP3chr1

170003513

+
intron-intronENST00000334984ENST00000540905RREB1chr6

7252147

-KIFAP3chr1

170003513

+
intron-intronENST00000334984ENST00000490550RREB1chr6

7252147

-KIFAP3chr1

170003513

+
intron-intronENST00000349384ENST00000367765RREB1chr6

7252147

-KIFAP3chr1

170003513

+
intron-intronENST00000349384ENST00000367767RREB1chr6

7252147

-KIFAP3chr1

170003513

+
intron-intronENST00000349384ENST00000361580RREB1chr6

7252147

-KIFAP3chr1

170003513

+
intron-intronENST00000349384ENST00000538366RREB1chr6

7252147

-KIFAP3chr1

170003513

+
intron-intronENST00000349384ENST00000540905RREB1chr6

7252147

-KIFAP3chr1

170003513

+
intron-intronENST00000349384ENST00000490550RREB1chr6

7252147

-KIFAP3chr1

170003513

+

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FusionProtFeatures for RREB1_KIFAP3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RREB1

Q92766

KIFAP3

Q92845

Involved in tethering the chromosomes to the spindlepole and in chromosome movement. Binds to the tail domain of theKIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex andmay regulate the membrane binding of this complex (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RREB1_KIFAP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RREB1_KIFAP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RREB1_KIFAP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RREB1_KIFAP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource