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Fusion gene ID: 32237 |
FusionGeneSummary for RREB1_F13A1 |
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Fusion gene information | Fusion gene name: RREB1_F13A1 | Fusion gene ID: 32237 | Hgene | Tgene | Gene symbol | RREB1 | F13A1 | Gene ID | 6239 | 2162 |
Gene name | ras responsive element binding protein 1 | coagulation factor XIII A chain | |
Synonyms | FINB|HNT|LZ321|RREB-1|Zep-1 | F13A | |
Cytomap | 6p24.3 | 6p25.1 | |
Type of gene | protein-coding | protein-coding | |
Description | ras-responsive element-binding protein 1DNA-binding proteinfinger protein in nuclear bodieshindsight homolograf-responsive zinc finger protein LZ321zinc finger motif enhancer-binding protein 1 | coagulation factor XIII A chainFSF, A subunitTGasebA525O21.1 (coagulation factor XIII, A1 polypeptide)coagulation factor XIII, A polypeptidecoagulation factor XIII, A1 polypeptidecoagulation factor XIIIafactor XIIIafibrin stabilizing factor, A sub | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q92766 | P00488 | |
Ensembl transtripts involved in fusion gene | ENST00000379933, ENST00000379938, ENST00000334984, ENST00000349384, | ENST00000264870, | |
Fusion gene scores | * DoF score | 11 X 9 X 6=594 | 6 X 5 X 4=120 |
# samples | 11 | 6 | |
** MAII score | log2(11/594*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RREB1 [Title/Abstract] AND F13A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RREB1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 8816445 |
Tgene | F13A1 | GO:0018149 | peptide cross-linking | 27363989 |
Tgene | F13A1 | GO:0072378 | blood coagulation, fibrin clot formation | 27363989 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LIHC | TCGA-CC-A3M9-01A | RREB1 | chr6 | 7108293 | + | F13A1 | chr6 | 6318915 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000379933 | ENST00000264870 | RREB1 | chr6 | 7108293 | + | F13A1 | chr6 | 6318915 | - |
5UTR-5UTR | ENST00000379938 | ENST00000264870 | RREB1 | chr6 | 7108293 | + | F13A1 | chr6 | 6318915 | - |
5UTR-5UTR | ENST00000334984 | ENST00000264870 | RREB1 | chr6 | 7108293 | + | F13A1 | chr6 | 6318915 | - |
5UTR-5UTR | ENST00000349384 | ENST00000264870 | RREB1 | chr6 | 7108293 | + | F13A1 | chr6 | 6318915 | - |
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FusionProtFeatures for RREB1_F13A1 |
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Hgene | Tgene |
RREB1 | F13A1 |
Factor XIII is activated by thrombin and calcium ion toa transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizingthe fibrin clot. Also cross-link alpha-2-plasmin inhibitor, orfibronectin, to the alpha chains of fibrin.{ECO:0000269|PubMed:27363989}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RREB1_F13A1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RREB1_F13A1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RREB1 | KDM1A, CTBP1, AR, HIST3H3, HDAC2, HDAC3, HDAC1, BLM, SNCA, SPATA20, ARL6, NEK7, TOR1AIP2, TRIM25 | F13A1 | F13A1, F13B, FN1, FGA, NUDT21, UFD1L, SH3GL2, TK1, PTK2, CDKN1A, ANXA7 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RREB1_F13A1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | F13A1 | P00488 | DB13151 | Anti-inhibitor coagulant complex | Coagulation factor XIII A chain | biotech | approved|investigational |
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RelatedDiseases for RREB1_F13A1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | F13A1 | C2750514 | Factor Xiii, A Subunit, Deficiency Of | 3 | CTD_human;UNIPROT |
Tgene | F13A1 | C0015530 | Factor XIII Deficiency | 1 | CTD_human |
Tgene | F13A1 | C0027051 | Myocardial Infarction | 1 | CTD_human |
Tgene | F13A1 | C0042487 | Venous Thrombosis | 1 | CTD_human |
Tgene | F13A1 | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |