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Fusion gene ID: 32231 |
FusionGeneSummary for RRBP1_SNX5 |
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Fusion gene information | Fusion gene name: RRBP1_SNX5 | Fusion gene ID: 32231 | Hgene | Tgene | Gene symbol | RRBP1 | SNX5 | Gene ID | 6238 | 27131 |
Gene name | ribosome binding protein 1 | sorting nexin 5 | |
Synonyms | ES/130|ES130|RRp|hES | - | |
Cytomap | 20p12.1 | 20p11.23 | |
Type of gene | protein-coding | protein-coding | |
Description | ribosome-binding protein 1180 kDa ribosome receptor homologES/130-related proteinribosome binding protein 1 homolog 180kDa (dog)ribosome receptor protein | sorting nexin-5 | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q9P2E9 | Q9Y5X3 | |
Ensembl transtripts involved in fusion gene | ENST00000470422, ENST00000246043, ENST00000377813, ENST00000377807, ENST00000360807, ENST00000455029, | ENST00000483485, ENST00000377759, ENST00000377768, ENST00000606557, ENST00000606602, ENST00000481323, ENST00000486039, | |
Fusion gene scores | * DoF score | 14 X 12 X 7=1176 | 2 X 2 X 2=8 |
# samples | 17 | 2 | |
** MAII score | log2(17/1176*10)=-2.79028140869866 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: RRBP1 [Title/Abstract] AND SNX5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SNX5 | GO:0006907 | pinocytosis | 18854019 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | STAD | TCGA-CG-4443-01A | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000470422 | ENST00000483485 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
intron-5UTR | ENST00000470422 | ENST00000377759 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
intron-5UTR | ENST00000470422 | ENST00000377768 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
intron-intron | ENST00000470422 | ENST00000606557 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
intron-intron | ENST00000470422 | ENST00000606602 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
intron-intron | ENST00000470422 | ENST00000481323 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
intron-intron | ENST00000470422 | ENST00000486039 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
intron-5UTR | ENST00000246043 | ENST00000483485 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
intron-5UTR | ENST00000246043 | ENST00000377759 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
intron-5UTR | ENST00000246043 | ENST00000377768 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
intron-intron | ENST00000246043 | ENST00000606557 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
intron-intron | ENST00000246043 | ENST00000606602 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
intron-intron | ENST00000246043 | ENST00000481323 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
intron-intron | ENST00000246043 | ENST00000486039 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
5UTR-5UTR | ENST00000377813 | ENST00000483485 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
5UTR-5UTR | ENST00000377813 | ENST00000377759 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
5UTR-5UTR | ENST00000377813 | ENST00000377768 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
5UTR-intron | ENST00000377813 | ENST00000606557 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
5UTR-intron | ENST00000377813 | ENST00000606602 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
5UTR-intron | ENST00000377813 | ENST00000481323 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
5UTR-intron | ENST00000377813 | ENST00000486039 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
5UTR-5UTR | ENST00000377807 | ENST00000483485 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
5UTR-5UTR | ENST00000377807 | ENST00000377759 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
5UTR-5UTR | ENST00000377807 | ENST00000377768 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
5UTR-intron | ENST00000377807 | ENST00000606557 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
5UTR-intron | ENST00000377807 | ENST00000606602 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
5UTR-intron | ENST00000377807 | ENST00000481323 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
5UTR-intron | ENST00000377807 | ENST00000486039 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
intron-5UTR | ENST00000360807 | ENST00000483485 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
intron-5UTR | ENST00000360807 | ENST00000377759 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
intron-5UTR | ENST00000360807 | ENST00000377768 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
intron-intron | ENST00000360807 | ENST00000606557 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
intron-intron | ENST00000360807 | ENST00000606602 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
intron-intron | ENST00000360807 | ENST00000481323 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
intron-intron | ENST00000360807 | ENST00000486039 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
5UTR-5UTR | ENST00000455029 | ENST00000483485 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
5UTR-5UTR | ENST00000455029 | ENST00000377759 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
5UTR-5UTR | ENST00000455029 | ENST00000377768 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
5UTR-intron | ENST00000455029 | ENST00000606557 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
5UTR-intron | ENST00000455029 | ENST00000606602 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
5UTR-intron | ENST00000455029 | ENST00000481323 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
5UTR-intron | ENST00000455029 | ENST00000486039 | RRBP1 | chr20 | 17660644 | - | SNX5 | chr20 | 17937681 | - |
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FusionProtFeatures for RRBP1_SNX5 |
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Hgene | Tgene |
RRBP1 | SNX5 |
Involved in several stages of intracellular trafficking.Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate(PtdIns(3,4)P2) (PubMed:15561769). Acts in part as component ofthe retromer membrane-deforming SNX-BAR subcomplex. The SNX-BARretromer mediates retrograde transport of cargo proteins fromendosomes to the trans-Golgi network (TGN) and is involved inendosome-to-plasma membrane transport for cargo protein recycling.The SNX-BAR subcomplex functions to deform the donor membrane intoa tubular profile called endosome-to-TGN transport carrier (ETC)(Probable). Does not have in vitro vesicle-to-membrane remodelingactivity (PubMed:23085988). Involved in retrograde transport oflysosomal enzyme receptor IGF2R (PubMed:17148574,PubMed:18596235). May function as link between endosomal transportvesicles and dynactin (Probable). Plays a role in theinternalization of EGFR after EGF stimulation (Probable). Involvedin EGFR endosomal sorting and degradation; the function involvesPIP5K1C isoform 3 and is retromer-independent (PubMed:23602387).Together with PIP5K1C isoform 3 facilitates HGS interaction withubiquitinated EGFR, which initiates EGFR sorting to intraluminalvesicles (ILVs) of the multivesicular body for subsequentlysosomal degradation (Probable). Involved in E-cadherin sortingand degradation; inhibits PIP5K1C isoform 3-mediated E-cadherindegradation (PubMed:24610942). Plays a role in macropinocytosis(PubMed:18854019, PubMed:21048941). {ECO:0000269|PubMed:18854019,ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:24610942,ECO:0000303|PubMed:15561769, ECO:0000303|PubMed:19619496,ECO:0000303|PubMed:23085988}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RRBP1_SNX5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RRBP1_SNX5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RRBP1 | DSTN, ZWINT, CUL3, NDUFA7, CDV3, SCP2, RPS19, ILF3, PPIF, HNRNPM, MRPL53, SRPRB, PIN4, RBMS1, KLF5, RAB8A, CHMP2A, PQBP1, RPL38, HSPA1L, HSBP1, IQCB1, SMAD9, PRKD2, MAP1LC3A, KIAA0101, TARDBP, LGR4, VCP, CUL7, NTRK1, MORC2, RBM8A, BUD31, SMNDC1, EWSR1, TMPO, FOXG1, FOXL1, PES1, EMILIN1, EEF1D, KLHL2, TSPYL6, STYX, DLST, PDHA1, TRIM25, YAP1 | SNX5 | CLTCL1, CLTC, ITSN1, FANCA, HMOX2, MESDC2, DNAJB11, CDC37, PRKRA, PFDN1, MIB1, VPS33B, PIP5K1C, HGS, SNX2, STK4, ARFIP2, NUP155, BOP1, ELAC2, SARS, XPO5, APPBP2, LAPTM4B, BIN3, GAS2L1, BLVRA, FAM221A, C11orf42, DNM3, GNAT2, FAM90A1, VAPB, SNX1, SCLT1, CDH1, C1orf87, CCDC102B, TEX28, KLHL10, HCLS1, GTF2E2, MLX, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RRBP1_SNX5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RRBP1_SNX5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SNX5 | C0038356 | Stomach Neoplasms | 1 | CTD_human |