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Fusion gene ID: 32218 |
FusionGeneSummary for RRAGA_SESN2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RRAGA_SESN2 | Fusion gene ID: 32218 | Hgene | Tgene | Gene symbol | RRAGA | SESN2 | Gene ID | 10670 | 83667 |
| Gene name | Ras related GTP binding A | sestrin 2 | |
| Synonyms | FIP-1|FIP1|RAGA | HI95|SES2|SEST2 | |
| Cytomap | 9p22.1 | 1p35.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ras-related GTP-binding protein Aadenovirus E3 14.7 kDa-interacting protein 1adenovirus E3-14.7K interacting protein 1rag A | sestrin-2hypoxia induced gene 95hypoxia-induced | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q7L523 | P58004 | |
| Ensembl transtripts involved in fusion gene | ENST00000380527, | ENST00000253063, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 3 X 3 X 2=18 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: RRAGA [Title/Abstract] AND SESN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RRAGA | GO:0008219 | cell death | 8995684|9394008 |
| Hgene | RRAGA | GO:0019048 | modulation by virus of host morphology or physiology | 8995684 |
| Hgene | RRAGA | GO:0045919 | positive regulation of cytolysis | 8995684 |
| Tgene | SESN2 | GO:0001932 | regulation of protein phosphorylation | 25040165 |
| Tgene | SESN2 | GO:0098869 | cellular oxidant detoxification | 26612684 |
| Tgene | SESN2 | GO:0098869 | cellular oxidant detoxification | 19113821 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW300167 | RRAGA | chr9 | 19050780 | - | SESN2 | chr1 | 28594630 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000380527 | ENST00000253063 | RRAGA | chr9 | 19050780 | - | SESN2 | chr1 | 28594630 | - |
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FusionProtFeatures for RRAGA_SESN2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RRAGA | SESN2 |
| Guanine nucleotide-binding protein that plays a crucialrole in the cellular response to amino acid availability throughregulation of the mTORC1 signaling cascade. Forms heterodimericRag complexes with RRAGC or RRAGD and cycles between an inactiveGDP-bound and an active GTP-bound form. In its active formparticipates in the relocalization of mTORC1 to the lysosomes andits subsequent activation by the GTPase RHEB. Involved in theRCC1/Ran-GTPase pathway. May play a direct role in a TNF-alphasignaling pathway leading to induction of cell death. Mayalternatively act as a cellular target for adenovirus E3-14.7K, aninhibitor of TNF-alpha functions, thereby affecting cell death.{ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:25936802,ECO:0000269|PubMed:8995684, ECO:0000269|PubMed:9394008}. | Functions as an intracellular leucine sensor thatnegatively regulates the TORC1 signaling pathway through the GATORcomplex. In absence of leucine, binds the GATOR subcomplex GATOR2and prevents TORC1 signaling (PubMed:18692468, PubMed:25263562,PubMed:25457612, PubMed:26449471, PubMed:26612684,PubMed:26586190). Binding of leucine to SESN2 disrupts itsinteraction with GATOR2 thereby activating the TORC1 signalingpathway (PubMed:26449471, PubMed:26586190). This stress-induciblemetabolic regulator also plays a role in protection againstoxidative and genotoxic stresses. May negatively regulate proteintranslation in response to endoplasmic reticulum stress, via TORC1(PubMed:24947615). May positively regulate the transcription byNFE2L2 of genes involved in the response to oxidative stress byfacilitating the SQSTM1-mediated autophagic degradation of KEAP1(PubMed:23274085). May also mediate TP53 inhibition of TORC1signaling upon genotoxic stress (PubMed:18692468). Has analkylhydroperoxide reductase activity born by the N-terminaldomain of the protein (PubMed:26612684). Was originally reportedto contribute to oxidative stress resistance by reducing PRDX1(PubMed:15105503). However, this could not be confirmed(PubMed:19113821). {ECO:0000269|PubMed:15105503,ECO:0000269|PubMed:18692468, ECO:0000269|PubMed:19113821,ECO:0000269|PubMed:23274085, ECO:0000269|PubMed:24947615,ECO:0000269|PubMed:25263562, ECO:0000269|PubMed:25457612,ECO:0000269|PubMed:26449471, ECO:0000269|PubMed:26586190,ECO:0000269|PubMed:26612684}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RRAGA_SESN2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RRAGA_SESN2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RRAGA_SESN2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RRAGA_SESN2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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