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Fusion gene ID: 32215 |
FusionGeneSummary for RPUSD2_ZFYVE19 |
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Fusion gene information | Fusion gene name: RPUSD2_ZFYVE19 | Fusion gene ID: 32215 | Hgene | Tgene | Gene symbol | RPUSD2 | ZFYVE19 | Gene ID | 27079 | 84936 |
Gene name | RNA pseudouridylate synthase domain containing 2 | zinc finger FYVE-type containing 19 | |
Synonyms | C15orf19|C18B11 | ANCHR|MPFYVE | |
Cytomap | 15q15.1 | 15q15.1 | |
Type of gene | protein-coding | protein-coding | |
Description | RNA pseudouridylate synthase domain-containing protein 2C18B11 homolog (44.9kD) | abscission/NoCut checkpoint regulatorMLL partner containing FYVE domainzinc finger FYVE domain-containing protein 19zinc finger, FYVE domain containing 19 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8IZ73 | Q96K21 | |
Ensembl transtripts involved in fusion gene | ENST00000315616, ENST00000559271, | ENST00000570108, ENST00000564258, ENST00000355341, ENST00000336455, ENST00000299173, ENST00000563530, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 3=27 |
# samples | 1 | 3 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: RPUSD2 [Title/Abstract] AND ZFYVE19 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | READ | TCGA-AF-5654-01A | RPUSD2 | chr15 | 40862142 | + | ZFYVE19 | chr15 | 41104897 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000315616 | ENST00000570108 | RPUSD2 | chr15 | 40862142 | + | ZFYVE19 | chr15 | 41104897 | + |
Frame-shift | ENST00000315616 | ENST00000564258 | RPUSD2 | chr15 | 40862142 | + | ZFYVE19 | chr15 | 41104897 | + |
Frame-shift | ENST00000315616 | ENST00000355341 | RPUSD2 | chr15 | 40862142 | + | ZFYVE19 | chr15 | 41104897 | + |
Frame-shift | ENST00000315616 | ENST00000336455 | RPUSD2 | chr15 | 40862142 | + | ZFYVE19 | chr15 | 41104897 | + |
5CDS-intron | ENST00000315616 | ENST00000299173 | RPUSD2 | chr15 | 40862142 | + | ZFYVE19 | chr15 | 41104897 | + |
5CDS-intron | ENST00000315616 | ENST00000563530 | RPUSD2 | chr15 | 40862142 | + | ZFYVE19 | chr15 | 41104897 | + |
intron-3CDS | ENST00000559271 | ENST00000570108 | RPUSD2 | chr15 | 40862142 | + | ZFYVE19 | chr15 | 41104897 | + |
intron-3CDS | ENST00000559271 | ENST00000564258 | RPUSD2 | chr15 | 40862142 | + | ZFYVE19 | chr15 | 41104897 | + |
intron-3CDS | ENST00000559271 | ENST00000355341 | RPUSD2 | chr15 | 40862142 | + | ZFYVE19 | chr15 | 41104897 | + |
intron-3CDS | ENST00000559271 | ENST00000336455 | RPUSD2 | chr15 | 40862142 | + | ZFYVE19 | chr15 | 41104897 | + |
intron-intron | ENST00000559271 | ENST00000299173 | RPUSD2 | chr15 | 40862142 | + | ZFYVE19 | chr15 | 41104897 | + |
intron-intron | ENST00000559271 | ENST00000563530 | RPUSD2 | chr15 | 40862142 | + | ZFYVE19 | chr15 | 41104897 | + |
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FusionProtFeatures for RPUSD2_ZFYVE19 |
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Hgene | Tgene |
RPUSD2 | ZFYVE19 |
Key regulator of abscission step in cytokinesis: part ofthe cytokinesis checkpoint, a process required to delay abscissionto prevent both premature resolution of intercellular chromosomebridges and accumulation of DNA damage. Together with CHMP4C,required to retain abscission-competent VPS4 (VPS4A and/or VPS4B)at the midbody ring until abscission checkpoint signaling isterminated at late cytokinesis. Deactivation of AURKB results indephosphorylation of CHMP4C followed by its dissociation fromZFYVE19/ANCHR and VPS4 and subsequent abscission.{ECO:0000269|PubMed:24814515}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RPUSD2_ZFYVE19 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RPUSD2_ZFYVE19 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RPUSD2 | APP, AARSD1, LZTFL1, ME1, ACBD3, EFTUD2, GORASP2, GTF2A1, GTF2E1, HARS, SH3GLB2, TTC1, WDR12, SNF8, TBCD, UGDH, CELA2B, ALDH8A1, CUL3, MCAT, SBDS, PFDN4, GPR156, NEU4, PMPCA, SPATA8 | ZFYVE19 | UCHL3, UNK, UBQLN4, UBA2, UBXN1, UFM1, TYMS, LAGE3, YAP1, UBXN7, USP34, TTC1, UBQLN2, UBE2D1, UBA52, VPS4B, UFC1, UBE2V2, UBE2A, UBE2B, UBE2C, UBE4B, SULT1A1, SEC24C, TTC9C, ATP6V1B2, DSTN, USP9X, IGBP1, AHCYL1, PRDX5, HTT, SFN, G6PD, PAK2, TGM2, YWHAZ, CAPN7, CCHCR1, MITD1, ZDHHC17, VPS4A, PSMD13 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RPUSD2_ZFYVE19 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RPUSD2_ZFYVE19 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |