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Fusion gene ID: 32198 |
FusionGeneSummary for RPSAP52_ELAC2 |
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Fusion gene information | Fusion gene name: RPSAP52_ELAC2 | Fusion gene ID: 32198 | Hgene | Tgene | Gene symbol | RPSAP52 | ELAC2 | Gene ID | 204010 | 60528 |
Gene name | ribosomal protein SA pseudogene 52 | elaC ribonuclease Z 2 | |
Synonyms | RPSA_17_1251 | COXPD17|ELC2|HPC2 | |
Cytomap | 12q14.3 | 17p12 | |
Type of gene | pseudo | protein-coding | |
Description | - | zinc phosphodiesterase ELAC protein 2RNase Z 2elaC homolog 2elaC homolog protein 2elaC-like protein 2heredity prostate cancer protein 2putative prostate cancer susceptibility protein HPC2/ELAC2ribonuclease Z 2tRNA 3 endonuclease 2tRNase Z (long f | |
Modification date | 20180329 | 20180523 | |
UniProtAcc | Q9BQ52 | ||
Ensembl transtripts involved in fusion gene | ENST00000489520, | ENST00000338034, ENST00000395962, ENST00000426905, ENST00000609345, ENST00000578071, | |
Fusion gene scores | * DoF score | 5 X 4 X 2=40 | 2 X 2 X 1=4 |
# samples | 8 | 5 | |
** MAII score | log2(8/40*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/4*10)=3.64385618977473 | |
Context | PubMed: RPSAP52 [Title/Abstract] AND ELAC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BX283235 | RPSAP52 | chr12 | 66221868 | + | ELAC2 | chr17 | 12899297 | - | ||
ChiTaRS3.1 | BQ948076 | RPSAP52 | chr12 | 66221868 | + | ELAC2 | chr17 | 12899297 | - | ||
ChiTaRS3.1 | BC046924 | RPSAP52 | chr12 | 66221868 | + | ELAC2 | chr17 | 12899297 | - | ||
ChiTaRS3.1 | BQ073577 | RPSAP52 | chr12 | 66221868 | + | ELAC2 | chr17 | 12899297 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000489520 | ENST00000338034 | RPSAP52 | chr12 | 66221868 | + | ELAC2 | chr17 | 12899297 | - |
intron-3CDS | ENST00000489520 | ENST00000395962 | RPSAP52 | chr12 | 66221868 | + | ELAC2 | chr17 | 12899297 | - |
intron-3CDS | ENST00000489520 | ENST00000426905 | RPSAP52 | chr12 | 66221868 | + | ELAC2 | chr17 | 12899297 | - |
intron-intron | ENST00000489520 | ENST00000609345 | RPSAP52 | chr12 | 66221868 | + | ELAC2 | chr17 | 12899297 | - |
intron-intron | ENST00000489520 | ENST00000578071 | RPSAP52 | chr12 | 66221868 | + | ELAC2 | chr17 | 12899297 | - |
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FusionProtFeatures for RPSAP52_ELAC2 |
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Hgene | Tgene |
RPSAP52 | ELAC2 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Zinc phosphodiesterase, which displays mitochondrialtRNA 3'-processing endonuclease activity. Involved in tRNAmaturation, by removing a 3'-trailer from precursor tRNA.{ECO:0000269|PubMed:21593607}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RPSAP52_ELAC2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RPSAP52_ELAC2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RPSAP52_ELAC2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RPSAP52_ELAC2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ELAC2 | C3539120 | PROSTATE CANCER, HEREDITARY, 2 | 10 | UNIPROT |
Tgene | ELAC2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | ELAC2 | C3809526 | COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 17 | 1 | ORPHANET;UNIPROT |