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Fusion gene ID: 32194 |
FusionGeneSummary for RPS9_TSEN34 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RPS9_TSEN34 | Fusion gene ID: 32194 | Hgene | Tgene | Gene symbol | RPS9 | TSEN34 | Gene ID | 6203 | 79042 |
| Gene name | ribosomal protein S9 | tRNA splicing endonuclease subunit 34 | |
| Synonyms | S9 | LENG5|PCH2C|SEN34|SEN34L | |
| Cytomap | 19q13.42 | 19q13.42 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 40S ribosomal protein S9small ribosomal subunit protein uS4 | tRNA-splicing endonuclease subunit Sen34CTD-3093M3.1TSEN34 tRNA splicing endonuclease subunithsSen34leukocyte receptor cluster (LRC) member 5leukocyte receptor cluster member 5tRNA-intron endonuclease Sen34 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P46781 | Q9BSV6 | |
| Ensembl transtripts involved in fusion gene | ENST00000302907, ENST00000391752, ENST00000402367, ENST00000391751, ENST00000391753, ENST00000441429, | ENST00000302937, ENST00000429671, ENST00000396383, ENST00000396388, | |
| Fusion gene scores | * DoF score | 6 X 6 X 2=72 | 1 X 1 X 1=1 |
| # samples | 6 | 1 | |
| ** MAII score | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: RPS9 [Title/Abstract] AND TSEN34 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-D8-A1XQ-01A | RPS9 | chr19 | 54705477 | + | TSEN34 | chr19 | 54697030 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000302907 | ENST00000302937 | RPS9 | chr19 | 54705477 | + | TSEN34 | chr19 | 54697030 | + |
| In-frame | ENST00000302907 | ENST00000429671 | RPS9 | chr19 | 54705477 | + | TSEN34 | chr19 | 54697030 | + |
| Frame-shift | ENST00000302907 | ENST00000396383 | RPS9 | chr19 | 54705477 | + | TSEN34 | chr19 | 54697030 | + |
| Frame-shift | ENST00000302907 | ENST00000396388 | RPS9 | chr19 | 54705477 | + | TSEN34 | chr19 | 54697030 | + |
| Frame-shift | ENST00000391752 | ENST00000302937 | RPS9 | chr19 | 54705477 | + | TSEN34 | chr19 | 54697030 | + |
| In-frame | ENST00000391752 | ENST00000429671 | RPS9 | chr19 | 54705477 | + | TSEN34 | chr19 | 54697030 | + |
| Frame-shift | ENST00000391752 | ENST00000396383 | RPS9 | chr19 | 54705477 | + | TSEN34 | chr19 | 54697030 | + |
| Frame-shift | ENST00000391752 | ENST00000396388 | RPS9 | chr19 | 54705477 | + | TSEN34 | chr19 | 54697030 | + |
| Frame-shift | ENST00000402367 | ENST00000302937 | RPS9 | chr19 | 54705477 | + | TSEN34 | chr19 | 54697030 | + |
| In-frame | ENST00000402367 | ENST00000429671 | RPS9 | chr19 | 54705477 | + | TSEN34 | chr19 | 54697030 | + |
| Frame-shift | ENST00000402367 | ENST00000396383 | RPS9 | chr19 | 54705477 | + | TSEN34 | chr19 | 54697030 | + |
| Frame-shift | ENST00000402367 | ENST00000396388 | RPS9 | chr19 | 54705477 | + | TSEN34 | chr19 | 54697030 | + |
| Frame-shift | ENST00000391751 | ENST00000302937 | RPS9 | chr19 | 54705477 | + | TSEN34 | chr19 | 54697030 | + |
| In-frame | ENST00000391751 | ENST00000429671 | RPS9 | chr19 | 54705477 | + | TSEN34 | chr19 | 54697030 | + |
| Frame-shift | ENST00000391751 | ENST00000396383 | RPS9 | chr19 | 54705477 | + | TSEN34 | chr19 | 54697030 | + |
| Frame-shift | ENST00000391751 | ENST00000396388 | RPS9 | chr19 | 54705477 | + | TSEN34 | chr19 | 54697030 | + |
| Frame-shift | ENST00000391753 | ENST00000302937 | RPS9 | chr19 | 54705477 | + | TSEN34 | chr19 | 54697030 | + |
| In-frame | ENST00000391753 | ENST00000429671 | RPS9 | chr19 | 54705477 | + | TSEN34 | chr19 | 54697030 | + |
| Frame-shift | ENST00000391753 | ENST00000396383 | RPS9 | chr19 | 54705477 | + | TSEN34 | chr19 | 54697030 | + |
| Frame-shift | ENST00000391753 | ENST00000396388 | RPS9 | chr19 | 54705477 | + | TSEN34 | chr19 | 54697030 | + |
| Frame-shift | ENST00000441429 | ENST00000302937 | RPS9 | chr19 | 54705477 | + | TSEN34 | chr19 | 54697030 | + |
| In-frame | ENST00000441429 | ENST00000429671 | RPS9 | chr19 | 54705477 | + | TSEN34 | chr19 | 54697030 | + |
| Frame-shift | ENST00000441429 | ENST00000396383 | RPS9 | chr19 | 54705477 | + | TSEN34 | chr19 | 54697030 | + |
| Frame-shift | ENST00000441429 | ENST00000396388 | RPS9 | chr19 | 54705477 | + | TSEN34 | chr19 | 54697030 | + |
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FusionProtFeatures for RPS9_TSEN34 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RPS9 | TSEN34 |
| Constitutes one of the two catalytic subunit of thetRNA-splicing endonuclease complex, a complex responsible foridentification and cleavage of the splice sites in pre-tRNA. Itcleaves pre-tRNA at the 5'- and 3'-splice sites to release theintron. The products are an intron and two tRNA half-moleculesbearing 2',3'-cyclic phosphate and 5'-OH termini. There are noconserved sequences at the splice sites, but the intron isinvariably located at the same site in the gene, placing thesplice sites an invariant distance from the constant structuralfeatures of the tRNA body. It probably carries the active site for3'-splice site cleavage. The tRNA splicing endonuclease is alsoinvolved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNAsplicing and pre-mRNA 3'-end formation, suggesting that theendonuclease subunits function in multiple RNA-processing events.{ECO:0000269|PubMed:15109492}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RPS9_TSEN34 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RPS9_TSEN34 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RPS9 | DDX56, LYAR, EIF1B, MAGEB2, DSTYK, VHL, MEPCE, CHAF1A, ESR1, AGO4, CD4, NOP56, NDRG1, CUL3, CUL5, CUL2, CDK2, CUL1, COPS5, CAND1, RPS4X, APP, RPL10A, RPL7A, RPS3, RPL4, RPL6, RPL21, RPS3A, RPL12, RPL30, RPL8, RPL27, RPS17, RPS6, RPS23, RPS16, RPS2, RPS7, RPS8, RPL18, RPSA, RPL11, RPL19, RPS24, RPL5, RPS19, RPS13, RPS14, RPS28, RPS25, RPL23A, RPS29, FAU, RPL37, CCNT1, PRPF40A, MAGOH, EIF4A3, SMURF1, VCP, FN1, VCAM1, UBL4A, ITGA4, PAN2, CD81, IGSF8, ICAM1, STAT3, FBXO6, TARDBP, LARP1, PNO1, RPS10, RPS12, RPS15A, RPS20, RPS21, RPS26, RPS27, RPS5, DDX3X, EIF3A, EIF3D, EIF3E, EIF3L, EIF3H, GNB2L1, RPS11, RPS15, RPS18, SND1, WIBG, TSR1, RPA1, RPA2, RPA3, ZBTB1, STAU1, CDKN1A, CEP250, CEP76, NEDD1, TP53, TUBG1, TUBGCP3, HUWE1, FUS, CUL7, OBSL1, NTRK1, RNPS1, RPL13A, RPL14, RPL15, RPL17, RPL27A, RPL32, RPL35, RPL35A, RPL37A, RPL38, RPL7, RPLP2, LOC101929876, ATP1B3, BCLAF1, PABPC4, POLR2C, RPL10, RPL13, RPL18A, RPL22, RPL23, RPL24, RPL26, RPL26L1, RPL3, RPL31, RPL34, RPL36, RPL39, RPL3L, RPL9, RPLP0, SFN, PTEN, XPO1, HNRNPU, NPM1, IBTK, GAN, MCM2, SEC61B, ZNF746, RRS1, H2AFX, EBNA1BP2, NCL, CYLD, TRIM25, UBE2A, BRCA1, MTF1 | TSEN34 | TSEN2, TSEN54, CLP1, TSEN15, HNRNPD, ARMCX3, RAB3GAP2, BCAR1, GABPA, GNE, RAB3GAP1, FBXW11, L1TD1, FBXW7, EYA3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RPS9_TSEN34 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | RPS9 | P46781 | DB11638 | Artenimol | 40S ribosomal protein S9 | small molecule | approved|investigational |
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RelatedDiseases for RPS9_TSEN34 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | TSEN34 | C0011168 | Deglutition Disorders | 1 | CTD_human |
| Tgene | TSEN34 | C0025958 | Microcephaly | 1 | CTD_human |
| Tgene | TSEN34 | C0026650 | Movement Disorders | 1 | CTD_human |
| Tgene | TSEN34 | C0042790 | Vision Disorders | 1 | CTD_human |
| Tgene | TSEN34 | C2676465 | Pontocerebellar Hypoplasia Type 2C | 1 | CTD_human;UNIPROT |
| Tgene | TSEN34 | C3714756 | Intellectual Disability | 1 | CTD_human |
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