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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32186

FusionGeneSummary for RPS8_MAP3K7

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS8_MAP3K7
Fusion gene ID: 32186
HgeneTgene
Gene symbol

RPS8

MAP3K7

Gene ID

6202

6885

Gene nameribosomal protein S8mitogen-activated protein kinase kinase kinase 7
SynonymsS8CSCF|FMD2|MEKK7|TAK1|TGF1a
Cytomap

1p34.1

6q15

Type of geneprotein-codingprotein-coding
Description40S ribosomal protein S8OK/SW-cl.83small ribosomal subunit protein eS8mitogen-activated protein kinase kinase kinase 7TGF-beta activated kinase 1transforming growth factor-beta-activated kinase 1
Modification date2018052320180523
UniProtAcc

P62241

O43318

Ensembl transtripts involved in fusion geneENST00000396651, ENST00000372209, 
ENST00000485390, 		ENST00000369325, 
ENST00000369327, ENST00000369332, 
ENST00000369329, ENST00000479630, 
ENST00000369320, 
Fusion gene scores* DoF score6 X 7 X 3=1263 X 4 X 2=24
# samples 79
** MAII scorelog2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/24*10)=1.90689059560852
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RPS8 [Title/Abstract] AND MAP3K7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMAP3K7

GO:0000186

activation of MAPKK activity

8663074|9079627

TgeneMAP3K7

GO:0000187

activation of MAPK activity

9079627

TgeneMAP3K7

GO:0007252

I-kappaB phosphorylation

11460167

TgeneMAP3K7

GO:0007254

JNK cascade

9079627

TgeneMAP3K7

GO:0043507

positive regulation of JUN kinase activity

11460167

TgeneMAP3K7

GO:0043966

histone H3 acetylation

18838386

TgeneMAP3K7

GO:0051403

stress-activated MAPK cascade

9079627


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM682967RPS8chr1

45243774

-MAP3K7chr6

91246054

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000396651ENST00000369325RPS8chr1

45243774

-MAP3K7chr6

91246054

+
5CDS-intronENST00000396651ENST00000369327RPS8chr1

45243774

-MAP3K7chr6

91246054

+
5CDS-intronENST00000396651ENST00000369332RPS8chr1

45243774

-MAP3K7chr6

91246054

+
5CDS-intronENST00000396651ENST00000369329RPS8chr1

45243774

-MAP3K7chr6

91246054

+
5CDS-intronENST00000396651ENST00000479630RPS8chr1

45243774

-MAP3K7chr6

91246054

+
5CDS-intronENST00000396651ENST00000369320RPS8chr1

45243774

-MAP3K7chr6

91246054

+
5CDS-intronENST00000372209ENST00000369325RPS8chr1

45243774

-MAP3K7chr6

91246054

+
5CDS-intronENST00000372209ENST00000369327RPS8chr1

45243774

-MAP3K7chr6

91246054

+
5CDS-intronENST00000372209ENST00000369332RPS8chr1

45243774

-MAP3K7chr6

91246054

+
5CDS-intronENST00000372209ENST00000369329RPS8chr1

45243774

-MAP3K7chr6

91246054

+
5CDS-intronENST00000372209ENST00000479630RPS8chr1

45243774

-MAP3K7chr6

91246054

+
5CDS-intronENST00000372209ENST00000369320RPS8chr1

45243774

-MAP3K7chr6

91246054

+
3UTR-intronENST00000485390ENST00000369325RPS8chr1

45243774

-MAP3K7chr6

91246054

+
3UTR-intronENST00000485390ENST00000369327RPS8chr1

45243774

-MAP3K7chr6

91246054

+
3UTR-intronENST00000485390ENST00000369332RPS8chr1

45243774

-MAP3K7chr6

91246054

+
3UTR-intronENST00000485390ENST00000369329RPS8chr1

45243774

-MAP3K7chr6

91246054

+
3UTR-intronENST00000485390ENST00000479630RPS8chr1

45243774

-MAP3K7chr6

91246054

+
3UTR-intronENST00000485390ENST00000369320RPS8chr1

45243774

-MAP3K7chr6

91246054

+

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FusionProtFeatures for RPS8_MAP3K7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPS8

P62241

MAP3K7

O43318


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPS8_MAP3K7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPS8_MAP3K7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPS8_MAP3K7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneRPS8P62241DB11638Artenimol40S ribosomal protein S8small moleculeapproved|investigational

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RelatedDiseases for RPS8_MAP3K7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRPS8C0030567Parkinson Disease1CTD_human
HgeneRPS8C0043094Weight Gain1CTD_human
HgeneRPS8C1458155Mammary Neoplasms1CTD_human
TgeneMAP3K7C0033578Prostatic Neoplasms1CTD_human
TgeneMAP3K7C1834818Mitral Regurgitation, Conductive Deafness, and Fusion of Cervical Vertebrae and of Carpal and Tarsal Bones1ORPHANET;UNIPROT