FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 32131

FusionGeneSummary for RPS6KA2_PSMG4

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS6KA2_PSMG4
Fusion gene ID: 32131
HgeneTgene
Gene symbol

RPS6KA2

PSMG4

Gene ID

6196

389362

Gene nameribosomal protein S6 kinase A2proteasome assembly chaperone 4
SynonymsHU-2|MAPKAPK1C|RSK|RSK3|S6K-alpha|S6K-alpha2|p90-RSK3|p90RSK2|pp90RSK3C6orf86|PAC4|bA506K6.2
Cytomap

6q27

6p25.2

Type of geneprotein-codingprotein-coding
Descriptionribosomal protein S6 kinase alpha-2MAP kinase-activated protein kinase 1cMAPK-activated protein kinase 1cMAPKAP kinase 1Cmitogen-activated protein kinase-activated protein kinase 1Cribosomal S6 kinase 3ribosomal protein S6 kinase, 90kDa, polypeptideproteasome assembly chaperone 4PAC-4hPAC4proteasome (prosome, macropain) assembly chaperone 4
Modification date2018052320180519
UniProtAcc

Q15349

Q5JS54

Ensembl transtripts involved in fusion geneENST00000265678, ENST00000510118, 
ENST00000503859, ENST00000481261, 
ENST00000405189, ENST00000366863, 
ENST00000509742, 		ENST00000451246, 
ENST00000380306, ENST00000416079, 
ENST00000438998, ENST00000380305, 
ENST00000419065, ENST00000473000, 
Fusion gene scores* DoF score6 X 5 X 4=1201 X 1 X 1=1
# samples 61
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: RPS6KA2 [Title/Abstract] AND PSMG4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPS6KA2

GO:0008285

negative regulation of cell proliferation

16878154

HgeneRPS6KA2

GO:0043065

positive regulation of apoptotic process

16878154

HgeneRPS6KA2

GO:0045786

negative regulation of cell cycle

16878154


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E2-A15D-01ARPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000265678ENST00000451246RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000265678ENST00000380306RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000265678ENST00000416079RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000265678ENST00000438998RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000265678ENST00000380305RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000265678ENST00000419065RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000265678ENST00000473000RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000510118ENST00000451246RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000510118ENST00000380306RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000510118ENST00000416079RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000510118ENST00000438998RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000510118ENST00000380305RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000510118ENST00000419065RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000510118ENST00000473000RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000503859ENST00000451246RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000503859ENST00000380306RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000503859ENST00000416079RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000503859ENST00000438998RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000503859ENST00000380305RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000503859ENST00000419065RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000503859ENST00000473000RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000481261ENST00000451246RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000481261ENST00000380306RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000481261ENST00000416079RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000481261ENST00000438998RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000481261ENST00000380305RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000481261ENST00000419065RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000481261ENST00000473000RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000405189ENST00000451246RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000405189ENST00000380306RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000405189ENST00000416079RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000405189ENST00000438998RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000405189ENST00000380305RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000405189ENST00000419065RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
5CDS-intronENST00000405189ENST00000473000RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
intron-intronENST00000366863ENST00000451246RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
intron-intronENST00000366863ENST00000380306RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
intron-intronENST00000366863ENST00000416079RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
intron-intronENST00000366863ENST00000438998RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
intron-intronENST00000366863ENST00000380305RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
intron-intronENST00000366863ENST00000419065RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
intron-intronENST00000366863ENST00000473000RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
intron-intronENST00000509742ENST00000451246RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
intron-intronENST00000509742ENST00000380306RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
intron-intronENST00000509742ENST00000416079RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
intron-intronENST00000509742ENST00000438998RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
intron-intronENST00000509742ENST00000380305RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
intron-intronENST00000509742ENST00000419065RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+
intron-intronENST00000509742ENST00000473000RPS6KA2chr6

166872937

-PSMG4chr6

3263918

+

Top

FusionProtFeatures for RPS6KA2_PSMG4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPS6KA2

Q15349

PSMG4

Q5JS54

Serine/threonine-protein kinase that acts downstream ofERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenicand stress-induced activation of transcription factors, regulatestranslation, and mediates cellular proliferation, survival, anddifferentiation. May function as tumor suppressor in epithelialovarian cancer cells. {ECO:0000269|PubMed:16878154,ECO:0000269|PubMed:7623830}. Chaperone protein which promotes assembly of the 20Sproteasome.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for RPS6KA2_PSMG4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for RPS6KA2_PSMG4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RPS6KA2MAPK3, MAPK1, CREBBP, RPS6KA2, JUN, FOS, NQO2, STXBP2, HSP90AA1, CSNK2B, FLNC, RPS6KA1, FAT1, GRSF1, SHROOM3, ECE2, ZMYM5, MISP, FYN, IL17RA, TRIM11, FGFR2, STRADB, SPRED2, IRGC, ALOX5, TRIM25PSMG4PSMA1, PSMG2, CA10, PSMB9, GLO1, GMDS, ITPA, NIT1, NIT2, PEPD, TALDO1, WDR1, MRPS34, CCDC69, PSMB3, PPM1E, ZMAT5, FOXD4, DQX1, DCDC2B, SIRT6, IL17RE, AMACR, TRIM41


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RPS6KA2_PSMG4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for RPS6KA2_PSMG4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource