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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32129

FusionGeneSummary for RPS6KA2_KIFC1

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS6KA2_KIFC1
Fusion gene ID: 32129
HgeneTgene
Gene symbol

RPS6KA2

KIFC1

Gene ID

6196

3833

Gene nameribosomal protein S6 kinase A2kinesin family member C1
SynonymsHU-2|MAPKAPK1C|RSK|RSK3|S6K-alpha|S6K-alpha2|p90-RSK3|p90RSK2|pp90RSK3HSET|KNSL2
Cytomap

6q27

6p21.32

Type of geneprotein-codingprotein-coding
Descriptionribosomal protein S6 kinase alpha-2MAP kinase-activated protein kinase 1cMAPK-activated protein kinase 1cMAPKAP kinase 1Cmitogen-activated protein kinase-activated protein kinase 1Cribosomal S6 kinase 3ribosomal protein S6 kinase, 90kDa, polypeptidekinesin-like protein KIFC1kinesin-like 2kinesin-like protein 2kinesin-related protein HSET
Modification date2018052320180523
UniProtAcc

Q15349

Q9BW19

Ensembl transtripts involved in fusion geneENST00000265678, ENST00000510118, 
ENST00000503859, ENST00000481261, 
ENST00000405189, ENST00000366863, 
ENST00000509742, 		ENST00000428849, 
ENST00000486695, ENST00000417146, 
ENST00000374523, ENST00000492999, 
ENST00000448818, ENST00000467671, 
Fusion gene scores* DoF score6 X 5 X 4=1203 X 3 X 2=18
# samples 63
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RPS6KA2 [Title/Abstract] AND KIFC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPS6KA2

GO:0008285

negative regulation of cell proliferation

16878154

HgeneRPS6KA2

GO:0043065

positive regulation of apoptotic process

16878154

HgeneRPS6KA2

GO:0045786

negative regulation of cell cycle

16878154


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-IE-A3OV-01ARPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000265678ENST00000428849RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
5CDS-intronENST00000265678ENST00000486695RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
5CDS-intronENST00000265678ENST00000417146RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
5CDS-intronENST00000265678ENST00000374523RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
5CDS-intronENST00000265678ENST00000492999RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
5CDS-intronENST00000265678ENST00000448818RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
5CDS-intronENST00000265678ENST00000467671RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-3CDSENST00000510118ENST00000428849RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000510118ENST00000486695RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000510118ENST00000417146RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000510118ENST00000374523RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000510118ENST00000492999RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000510118ENST00000448818RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000510118ENST00000467671RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-3CDSENST00000503859ENST00000428849RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000503859ENST00000486695RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000503859ENST00000417146RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000503859ENST00000374523RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000503859ENST00000492999RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000503859ENST00000448818RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000503859ENST00000467671RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-3CDSENST00000481261ENST00000428849RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000481261ENST00000486695RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000481261ENST00000417146RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000481261ENST00000374523RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000481261ENST00000492999RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000481261ENST00000448818RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000481261ENST00000467671RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-3CDSENST00000405189ENST00000428849RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000405189ENST00000486695RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000405189ENST00000417146RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000405189ENST00000374523RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000405189ENST00000492999RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000405189ENST00000448818RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000405189ENST00000467671RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
5UTR-3CDSENST00000366863ENST00000428849RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
5UTR-intronENST00000366863ENST00000486695RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
5UTR-intronENST00000366863ENST00000417146RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
5UTR-intronENST00000366863ENST00000374523RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
5UTR-intronENST00000366863ENST00000492999RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
5UTR-intronENST00000366863ENST00000448818RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
5UTR-intronENST00000366863ENST00000467671RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-3CDSENST00000509742ENST00000428849RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000509742ENST00000486695RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000509742ENST00000417146RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000509742ENST00000374523RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000509742ENST00000492999RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000509742ENST00000448818RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+
intron-intronENST00000509742ENST00000467671RPS6KA2chr6

167040409

-KIFC1chr6

33365806

+

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FusionProtFeatures for RPS6KA2_KIFC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPS6KA2

Q15349

KIFC1

Q9BW19

Serine/threonine-protein kinase that acts downstream ofERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenicand stress-induced activation of transcription factors, regulatestranslation, and mediates cellular proliferation, survival, anddifferentiation. May function as tumor suppressor in epithelialovarian cancer cells. {ECO:0000269|PubMed:16878154,ECO:0000269|PubMed:7623830}. Minus end-directed microtubule-dependent motor requiredfor bipolar spindle formation (PubMed:15843429). May contribute tomovement of early endocytic vesicles (By similarity). Regulatescilium formation and structure (By similarity).{ECO:0000250|UniProtKB:Q9QWT9, ECO:0000269|PubMed:15843429}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKIFC1chr6:167040409chr6:33365806ENST00000374523+011142_306-150674Coiled coilOntology_term=ECO:0000255
TgeneKIFC1chr6:167040409chr6:33365806ENST00000428849+011142_3064674Coiled coilOntology_term=ECO:0000255
TgeneKIFC1chr6:167040409chr6:33365806ENST00000448818+011142_306-150674Coiled coilOntology_term=ECO:0000255
TgeneKIFC1chr6:167040409chr6:33365806ENST00000374523+011310_663-150674DomainKinesin motor
TgeneKIFC1chr6:167040409chr6:33365806ENST00000428849+011310_6634674DomainKinesin motor
TgeneKIFC1chr6:167040409chr6:33365806ENST00000448818+011310_663-150674DomainKinesin motor
TgeneKIFC1chr6:167040409chr6:33365806ENST00000374523+011410_417-150674Nucleotide bindingATP
TgeneKIFC1chr6:167040409chr6:33365806ENST00000428849+011410_4174674Nucleotide bindingATP
TgeneKIFC1chr6:167040409chr6:33365806ENST00000448818+011410_417-150674Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRPS6KA2chr6:167040409chr6:33365806ENST00000265678-121319_38833734DomainNote=AGC-kinase C-terminal
HgeneRPS6KA2chr6:167040409chr6:33365806ENST00000265678-121415_67233734DomainProtein kinase 2
HgeneRPS6KA2chr6:167040409chr6:33365806ENST00000265678-12159_31833734DomainProtein kinase 1
HgeneRPS6KA2chr6:167040409chr6:33365806ENST00000503859-122319_388-127742DomainNote=AGC-kinase C-terminal
HgeneRPS6KA2chr6:167040409chr6:33365806ENST00000503859-122415_672-127742DomainProtein kinase 2
HgeneRPS6KA2chr6:167040409chr6:33365806ENST00000503859-12259_318-127742DomainProtein kinase 1
HgeneRPS6KA2chr6:167040409chr6:33365806ENST00000265678-121421_42933734Nucleotide bindingATP
HgeneRPS6KA2chr6:167040409chr6:33365806ENST00000265678-12165_7333734Nucleotide bindingATP
HgeneRPS6KA2chr6:167040409chr6:33365806ENST00000503859-122421_429-127742Nucleotide bindingATP
HgeneRPS6KA2chr6:167040409chr6:33365806ENST00000503859-12265_73-127742Nucleotide bindingATP


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FusionGeneSequence for RPS6KA2_KIFC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RPS6KA2_ENST00000265678_chr6_167040409_-_KIFC1_ENST00000428849_chr6_33365806_+_703aa
MDLSMKKFAVRRFFSVYLRRKSRSKSSSLSRLERSPLLEVKGNIELKRPLIKAPSQLPLSGSRLKRRPDQMEDGLEPEKKRTRGLGATTK
ITTSHPRVPSLTTVPQTQGQTTAQKVSKKTGPRCSTAIATGLKNQKPVPAVPVQKSGTSGVPPMAGGKKPSKRPAWDLKGQLCDLNAELK
RCRERTQTLDQENQQLQDQLRDAQQQVKALGTERTTLEGHLAKVQAQAEQGQQELKNLRACVLELEERLSTQEGLVQELQKKQVELQEER
RGLMSQLEEKERRLQTSEAALSSSQAEVASLRQETVAQAALLTEREERLHGLEMERRRLHNQLQELKGNIRVFCRVRPVLPGEPTPPPGL
LLFPSGPGGPSDPPTRLSLSRSDERRGTLSGAPAPPTRHDFSFDRVFPPGSGQDEVFEEIAMLVQSALDGYPVCIFAYGQTGSGKTFTME
GGPGGDPQLEGLIPRALRHLFSVAQELSGQGWTYSFVASYVEIYNETVRDLLATGTRKGQGGECEIRRAGPGSEELTVTNARYVPVSCEK
EVDALLHLARQNRAVARTAQNERSSRSHSVFQLQISGEHSSRGLQCGAPLSLVDLAGSERLDPGLALGPGERERLRETQAINSSLSTLGL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RPS6KA2_ENST00000265678_chr6_167040409_-_KIFC1_ENST00000428849_chr6_33365806_+_2109nt
ATGGACCTGAGCATGAAGAAGTTCGCCGTGCGCAGGTTCTTCTCTGTGTACCTGCGCAGGAAGTCGCGCTCCAAGAGCTCCAGCCTGAGC
CGGCTCGAGAGGTCCCCCCTATTGGAAGTAAAGGGGAACATAGAACTGAAGAGACCTCTGATTAAGGCCCCTTCCCAGCTGCCTCTCTCA
GGAAGCAGACTCAAGAGGAGGCCTGACCAGATGGAAGATGGCCTGGAGCCTGAGAAGAAACGGACAAGAGGCCTGGGTGCAACGACCAAA
ATTACCACATCCCACCCAAGAGTTCCATCCCTCACTACAGTGCCACAGACACAAGGCCAGACCACAGCTCAAAAAGTTTCCAAGAAGACA
GGACCCCGGTGTTCCACAGCTATTGCCACAGGGTTGAAGAACCAGAAGCCAGTTCCTGCTGTTCCTGTCCAGAAGTCTGGCACATCAGGT
GTTCCTCCCATGGCAGGAGGGAAGAAACCCAGCAAACGTCCAGCCTGGGACTTAAAGGGTCAGTTATGTGACCTAAATGCAGAACTAAAA
CGGTGCCGTGAGAGGACTCAAACGTTGGACCAAGAGAACCAGCAGCTTCAGGACCAGCTCAGAGATGCCCAGCAGCAGGTCAAGGCCCTG
GGGACAGAGCGCACAACACTGGAGGGGCATTTAGCCAAGGTACAGGCCCAGGCTGAGCAGGGCCAACAGGAGCTGAAGAACTTGCGTGCT
TGTGTCCTGGAGCTGGAAGAGCGGCTGAGCACGCAGGAGGGCTTGGTGCAAGAGCTTCAGAAAAAACAGGTGGAATTGCAGGAAGAACGG
AGGGGACTGATGTCCCAACTAGAGGAGAAGGAGAGGAGGCTGCAGACATCAGAAGCAGCCCTGTCAAGCAGCCAAGCAGAGGTGGCATCT
CTGCGGCAGGAGACTGTGGCCCAGGCAGCCTTACTGACTGAGCGGGAAGAACGTCTTCATGGGCTAGAAATGGAGCGCCGGCGACTGCAC
AACCAGCTGCAGGAACTCAAGGGCAACATCCGTGTATTCTGCCGGGTCCGCCCTGTCCTGCCGGGGGAGCCCACTCCACCCCCTGGCCTC
CTCCTGTTTCCCTCTGGCCCTGGTGGGCCCTCTGATCCTCCAACCCGCCTTAGCCTCTCCCGGTCTGACGAGCGGCGTGGGACCCTGAGT
GGGGCACCAGCTCCCCCAACTCGCCATGATTTTTCCTTTGACCGGGTATTCCCACCAGGAAGTGGACAGGATGAAGTGTTTGAAGAGATT
GCCATGCTTGTCCAGTCAGCCCTGGATGGCTATCCAGTATGCATCTTTGCCTATGGCCAGACAGGCAGTGGCAAGACCTTCACAATGGAG
GGTGGGCCTGGGGGAGACCCCCAGTTGGAGGGGCTGATCCCTCGGGCCCTGCGGCACCTCTTCTCTGTGGCTCAGGAGCTGAGTGGTCAG
GGCTGGACCTACAGCTTTGTAGCAAGCTACGTAGAGATCTACAATGAGACTGTCCGGGACCTGCTGGCCACTGGAACCCGGAAGGGTCAA
GGGGGCGAGTGTGAGATTCGCCGTGCAGGGCCAGGGAGTGAGGAGCTCACTGTCACCAATGCTCGATATGTCCCTGTCTCCTGTGAGAAA
GAAGTGGACGCCCTGCTTCATCTGGCCCGCCAGAATCGGGCTGTGGCCCGCACAGCCCAGAATGAACGGTCATCACGCAGCCACAGTGTA
TTCCAGCTACAGATTTCTGGGGAGCACTCCAGCCGAGGCCTGCAGTGTGGGGCCCCCCTCAGTCTTGTGGACCTGGCCGGGAGTGAGCGA
CTTGACCCCGGCTTAGCCCTCGGCCCCGGGGAGCGGGAACGCCTTCGGGAAACACAGGCCATTAACAGCAGCCTGTCCACGCTGGGGCTG
GTTATCATGGCCCTGAGCAACAAGGAGTCCCACGTGCCTTACCGGAACAGCAAACTGACCTACCTGCTGCAGAACTCTCTGGGTGGTAGT
GCTAAGATGCTCATGTTTGTGAACATTTCTCCACTGGAAGAGAACGTCTCCGAGTCCCTCAACTCTCTACGCTTTGCCTCCAAGGTGAAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_RPS6KA2_ENST00000265678_chr6_167040409_-_KIFC1_ENST00000428849_chr6_33365806_+_2567nt
GGGAGGCGGAGAAGGAGGCGGAGGGAGCGATTGTGGCCCCGGCCGCGGTGGCCGGCGCGGCCTGCCCTTTGTGACCGCAGCTCGCGCCCC
ACGCCCCGCGCCCATGGCCGCCGTGCCGGGCTCCCTGGCCACGCGTGCCCGCCCGCGGACCTGAGCCCCGCGCCTGGGATGCCGGGGATG
CGCGTCCCCCGGCCCTGCGGCTGCTCCGGGCTGGGCGCGGGGCGATGGACCTGAGCATGAAGAAGTTCGCCGTGCGCAGGTTCTTCTCTG
TGTACCTGCGCAGGAAGTCGCGCTCCAAGAGCTCCAGCCTGAGCCGGCTCGAGAGGTCCCCCCTATTGGAAGTAAAGGGGAACATAGAAC
TGAAGAGACCTCTGATTAAGGCCCCTTCCCAGCTGCCTCTCTCAGGAAGCAGACTCAAGAGGAGGCCTGACCAGATGGAAGATGGCCTGG
AGCCTGAGAAGAAACGGACAAGAGGCCTGGGTGCAACGACCAAAATTACCACATCCCACCCAAGAGTTCCATCCCTCACTACAGTGCCAC
AGACACAAGGCCAGACCACAGCTCAAAAAGTTTCCAAGAAGACAGGACCCCGGTGTTCCACAGCTATTGCCACAGGGTTGAAGAACCAGA
AGCCAGTTCCTGCTGTTCCTGTCCAGAAGTCTGGCACATCAGGTGTTCCTCCCATGGCAGGAGGGAAGAAACCCAGCAAACGTCCAGCCT
GGGACTTAAAGGGTCAGTTATGTGACCTAAATGCAGAACTAAAACGGTGCCGTGAGAGGACTCAAACGTTGGACCAAGAGAACCAGCAGC
TTCAGGACCAGCTCAGAGATGCCCAGCAGCAGGTCAAGGCCCTGGGGACAGAGCGCACAACACTGGAGGGGCATTTAGCCAAGGTACAGG
CCCAGGCTGAGCAGGGCCAACAGGAGCTGAAGAACTTGCGTGCTTGTGTCCTGGAGCTGGAAGAGCGGCTGAGCACGCAGGAGGGCTTGG
TGCAAGAGCTTCAGAAAAAACAGGTGGAATTGCAGGAAGAACGGAGGGGACTGATGTCCCAACTAGAGGAGAAGGAGAGGAGGCTGCAGA
CATCAGAAGCAGCCCTGTCAAGCAGCCAAGCAGAGGTGGCATCTCTGCGGCAGGAGACTGTGGCCCAGGCAGCCTTACTGACTGAGCGGG
AAGAACGTCTTCATGGGCTAGAAATGGAGCGCCGGCGACTGCACAACCAGCTGCAGGAACTCAAGGGCAACATCCGTGTATTCTGCCGGG
TCCGCCCTGTCCTGCCGGGGGAGCCCACTCCACCCCCTGGCCTCCTCCTGTTTCCCTCTGGCCCTGGTGGGCCCTCTGATCCTCCAACCC
GCCTTAGCCTCTCCCGGTCTGACGAGCGGCGTGGGACCCTGAGTGGGGCACCAGCTCCCCCAACTCGCCATGATTTTTCCTTTGACCGGG
TATTCCCACCAGGAAGTGGACAGGATGAAGTGTTTGAAGAGATTGCCATGCTTGTCCAGTCAGCCCTGGATGGCTATCCAGTATGCATCT
TTGCCTATGGCCAGACAGGCAGTGGCAAGACCTTCACAATGGAGGGTGGGCCTGGGGGAGACCCCCAGTTGGAGGGGCTGATCCCTCGGG
CCCTGCGGCACCTCTTCTCTGTGGCTCAGGAGCTGAGTGGTCAGGGCTGGACCTACAGCTTTGTAGCAAGCTACGTAGAGATCTACAATG
AGACTGTCCGGGACCTGCTGGCCACTGGAACCCGGAAGGGTCAAGGGGGCGAGTGTGAGATTCGCCGTGCAGGGCCAGGGAGTGAGGAGC
TCACTGTCACCAATGCTCGATATGTCCCTGTCTCCTGTGAGAAAGAAGTGGACGCCCTGCTTCATCTGGCCCGCCAGAATCGGGCTGTGG
CCCGCACAGCCCAGAATGAACGGTCATCACGCAGCCACAGTGTATTCCAGCTACAGATTTCTGGGGAGCACTCCAGCCGAGGCCTGCAGT
GTGGGGCCCCCCTCAGTCTTGTGGACCTGGCCGGGAGTGAGCGACTTGACCCCGGCTTAGCCCTCGGCCCCGGGGAGCGGGAACGCCTTC
GGGAAACACAGGCCATTAACAGCAGCCTGTCCACGCTGGGGCTGGTTATCATGGCCCTGAGCAACAAGGAGTCCCACGTGCCTTACCGGA
ACAGCAAACTGACCTACCTGCTGCAGAACTCTCTGGGTGGTAGTGCTAAGATGCTCATGTTTGTGAACATTTCTCCACTGGAAGAGAACG
TCTCCGAGTCCCTCAACTCTCTACGCTTTGCCTCCAAGGTGAACCAGTGTGTTATTGGTACTGCTCAGGCCAACAGGAAGTGAAGACGGA
TCCAGATCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCCCTATGTCTATGTATCGGGTGAGGGGTGGGAG
GGTTGCTGGAGGGTGCTTTATTGGGTGGAGGGCACCATGTCCCAGGGCTATCAAATAAAGAATAGTTTGGTTTTTTTTTTAAATAAAGGT


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FusionGenePPI for RPS6KA2_KIFC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RPS6KA2MAPK3, MAPK1, CREBBP, RPS6KA2, JUN, FOS, NQO2, STXBP2, HSP90AA1, CSNK2B, FLNC, RPS6KA1, FAT1, GRSF1, SHROOM3, ECE2, ZMYM5, MISP, FYN, IL17RA, TRIM11, FGFR2, STRADB, SPRED2, IRGC, ALOX5, TRIM25KIFC1CXXC1, APP, CCDC8, FAM188A, NUP50, BAG1, MPG, STK10, HIST1H2BG, HIST1H3A, KPNB1, NUP153, PARD6B, UBXN7, U2AF2, RALBP1, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPS6KA2_KIFC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RPS6KA2_KIFC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource