![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 32117 |
FusionGeneSummary for RPS4Y1_ARGLU1 |
![]() |
Fusion gene information | Fusion gene name: RPS4Y1_ARGLU1 | Fusion gene ID: 32117 | Hgene | Tgene | Gene symbol | RPS4Y1 | ARGLU1 | Gene ID | 6192 | 55082 |
Gene name | ribosomal protein S4 Y-linked 1 | arginine and glutamate rich 1 | |
Synonyms | RPS4Y|S4 | - | |
Cytomap | Yp11.2 | 13q33.3 | |
Type of gene | protein-coding | protein-coding | |
Description | 40S ribosomal protein S4, Y isoform 140S ribosomal protein S4, Yribosomal protein S4, Y-linkedribosomal protein S4Ysmall ribosomal subunit protein eS4 | arginine and glutamate-rich protein 1 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | P22090 | Q9NWB6 | |
Ensembl transtripts involved in fusion gene | ENST00000250784, ENST00000477725, | ENST00000400198, ENST00000472226, ENST00000375926, | |
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 3 X 3 X 1=9 |
# samples | 4 | 3 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: RPS4Y1 [Title/Abstract] AND ARGLU1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BI047537 | RPS4Y1 | chrY | 2733176 | + | ARGLU1 | chr13 | 107220075 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000250784 | ENST00000400198 | RPS4Y1 | chrY | 2733176 | + | ARGLU1 | chr13 | 107220075 | + |
5CDS-intron | ENST00000250784 | ENST00000472226 | RPS4Y1 | chrY | 2733176 | + | ARGLU1 | chr13 | 107220075 | + |
5CDS-intron | ENST00000250784 | ENST00000375926 | RPS4Y1 | chrY | 2733176 | + | ARGLU1 | chr13 | 107220075 | + |
3UTR-3CDS | ENST00000477725 | ENST00000400198 | RPS4Y1 | chrY | 2733176 | + | ARGLU1 | chr13 | 107220075 | + |
3UTR-intron | ENST00000477725 | ENST00000472226 | RPS4Y1 | chrY | 2733176 | + | ARGLU1 | chr13 | 107220075 | + |
3UTR-intron | ENST00000477725 | ENST00000375926 | RPS4Y1 | chrY | 2733176 | + | ARGLU1 | chr13 | 107220075 | + |
Top |
FusionProtFeatures for RPS4Y1_ARGLU1 |
![]() |
Hgene | Tgene |
RPS4Y1 | ARGLU1 |
Required for the estrogen-dependent expression of ESR1target genes. Can act in cooperation with MED1.{ECO:0000269|PubMed:21454576}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for RPS4Y1_ARGLU1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_RPS4Y1_ENST00000250784_chrY_2733176_+_ARGLU1_ENST00000400198_chr13_107220075_+_0aa |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_RPS4Y1_ENST00000250784_chrY_2733176_+_ARGLU1_ENST00000400198_chr13_107220075_+_0nt |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_RPS4Y1_ENST00000250784_chrY_2733176_+_ARGLU1_ENST00000400198_chr13_107220075_+_0nt |
Top |
FusionGenePPI for RPS4Y1_ARGLU1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for RPS4Y1_ARGLU1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for RPS4Y1_ARGLU1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |