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Fusion gene ID: 32108 |
FusionGeneSummary for RPS3_C7orf31 |
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Fusion gene information | Fusion gene name: RPS3_C7orf31 | Fusion gene ID: 32108 | Hgene | Tgene | Gene symbol | RPS3 | C7orf31 | Gene ID | 6188 | 136895 |
Gene name | ribosomal protein S3 | chromosome 7 open reading frame 31 | |
Synonyms | S3 | - | |
Cytomap | 11q13.4 | 7p15.3 | |
Type of gene | protein-coding | protein-coding | |
Description | 40S ribosomal protein S3IMR-90 ribosomal protein S3small ribosomal subunit protein uS3 | uncharacterized protein C7orf31 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P23396 | Q8N865 | |
Ensembl transtripts involved in fusion gene | ENST00000531188, ENST00000530164, ENST00000278572, ENST00000534440, ENST00000527446, ENST00000526608, ENST00000524851, ENST00000529285, | ENST00000409280, ENST00000283905, | |
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 1 X 1 X 1=1 |
# samples | 4 | 1 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: RPS3 [Title/Abstract] AND C7orf31 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RPS3 | GO:0006979 | response to oxidative stress | 23911537 |
Hgene | RPS3 | GO:0017148 | negative regulation of translation | 20217897 |
Hgene | RPS3 | GO:0031397 | negative regulation of protein ubiquitination | 19656744 |
Hgene | RPS3 | GO:0032079 | positive regulation of endodeoxyribonuclease activity | 18973764 |
Hgene | RPS3 | GO:0042769 | DNA damage response, detection of DNA damage | 23911537 |
Hgene | RPS3 | GO:0045739 | positive regulation of DNA repair | 23911537 |
Hgene | RPS3 | GO:0061481 | response to TNF agonist | 20041225 |
Hgene | RPS3 | GO:0070301 | cellular response to hydrogen peroxide | 23911537 |
Hgene | RPS3 | GO:1901224 | positive regulation of NIK/NF-kappaB signaling | 20041225 |
Hgene | RPS3 | GO:1902546 | positive regulation of DNA N-glycosylase activity | 15518571 |
Hgene | RPS3 | GO:1905053 | positive regulation of base-excision repair | 18973764 |
Hgene | RPS3 | GO:2001235 | positive regulation of apoptotic signaling pathway | 14988002 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BP262829 | RPS3 | chr11 | 75113427 | + | C7orf31 | chr7 | 25219874 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000531188 | ENST00000409280 | RPS3 | chr11 | 75113427 | + | C7orf31 | chr7 | 25219874 | - |
5CDS-5UTR | ENST00000531188 | ENST00000283905 | RPS3 | chr11 | 75113427 | + | C7orf31 | chr7 | 25219874 | - |
5CDS-5UTR | ENST00000530164 | ENST00000409280 | RPS3 | chr11 | 75113427 | + | C7orf31 | chr7 | 25219874 | - |
5CDS-5UTR | ENST00000530164 | ENST00000283905 | RPS3 | chr11 | 75113427 | + | C7orf31 | chr7 | 25219874 | - |
5CDS-5UTR | ENST00000278572 | ENST00000409280 | RPS3 | chr11 | 75113427 | + | C7orf31 | chr7 | 25219874 | - |
5CDS-5UTR | ENST00000278572 | ENST00000283905 | RPS3 | chr11 | 75113427 | + | C7orf31 | chr7 | 25219874 | - |
5CDS-5UTR | ENST00000534440 | ENST00000409280 | RPS3 | chr11 | 75113427 | + | C7orf31 | chr7 | 25219874 | - |
5CDS-5UTR | ENST00000534440 | ENST00000283905 | RPS3 | chr11 | 75113427 | + | C7orf31 | chr7 | 25219874 | - |
5CDS-5UTR | ENST00000527446 | ENST00000409280 | RPS3 | chr11 | 75113427 | + | C7orf31 | chr7 | 25219874 | - |
5CDS-5UTR | ENST00000527446 | ENST00000283905 | RPS3 | chr11 | 75113427 | + | C7orf31 | chr7 | 25219874 | - |
intron-5UTR | ENST00000526608 | ENST00000409280 | RPS3 | chr11 | 75113427 | + | C7orf31 | chr7 | 25219874 | - |
intron-5UTR | ENST00000526608 | ENST00000283905 | RPS3 | chr11 | 75113427 | + | C7orf31 | chr7 | 25219874 | - |
5CDS-5UTR | ENST00000524851 | ENST00000409280 | RPS3 | chr11 | 75113427 | + | C7orf31 | chr7 | 25219874 | - |
5CDS-5UTR | ENST00000524851 | ENST00000283905 | RPS3 | chr11 | 75113427 | + | C7orf31 | chr7 | 25219874 | - |
3UTR-5UTR | ENST00000529285 | ENST00000409280 | RPS3 | chr11 | 75113427 | + | C7orf31 | chr7 | 25219874 | - |
3UTR-5UTR | ENST00000529285 | ENST00000283905 | RPS3 | chr11 | 75113427 | + | C7orf31 | chr7 | 25219874 | - |
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FusionProtFeatures for RPS3_C7orf31 |
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Hgene | Tgene |
RPS3 | C7orf31 |
Involved in translation as a component of the 40S smallribosomal subunit (PubMed:8706699). Has endonuclease activity andplays a role in repair of damaged DNA (PubMed:7775413). Cleavesphosphodiester bonds of DNAs containing altered bases with broadspecificity and cleaves supercoiled DNA more efficiently thanrelaxed DNA (PubMed:15707971). Displays high binding affinity for7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused byreactive oxygen species (ROS) (PubMed:14706345). Has also beenshown to bind with similar affinity to intact and damaged DNA(PubMed:18610840). Stimulates the N-glycosylase activity of thebase excision protein OGG1 (PubMed:15518571). Enhances the uracilexcision activity of UNG1 (PubMed:18973764). Also stimulates thecleavage of the phosphodiester backbone by APEX1(PubMed:18973764). When located in the mitochondrion, reducescellular ROS levels and mitochondrial DNA damage(PubMed:23911537). Has also been shown to negatively regulate DNArepair in cells exposed to hydrogen peroxide (PubMed:17049931).Plays a role in regulating transcription as part of the NF-kappa-Bp65-p50 complex where it binds to the RELA/p65 subunit, enhancesbinding of the complex to DNA and promotes transcription of targetgenes (PubMed:18045535). Represses its own translation by bindingto its cognate mRNA (PubMed:20217897). Binds to and protectsTP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744).Involved in spindle formation and chromosome movement duringmitosis by regulating microtubule polymerization(PubMed:23131551). Involved in induction of apoptosis through itsrole in activation of CASP8 (PubMed:14988002). Induces neuronalapoptosis by interacting with the E2F1 transcription factor andacting synergistically with it to up-regulate pro-apoptoticproteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts withTRADD following exposure to UV radiation and induces apoptosis bycaspase-dependent JNK activation (PubMed:22510408).{ECO:0000269|PubMed:14706345, ECO:0000269|PubMed:14988002,ECO:0000269|PubMed:15518571, ECO:0000269|PubMed:15707971,ECO:0000269|PubMed:17049931, ECO:0000269|PubMed:18045535,ECO:0000269|PubMed:18610840, ECO:0000269|PubMed:18973764,ECO:0000269|PubMed:19656744, ECO:0000269|PubMed:20217897,ECO:0000269|PubMed:20605787, ECO:0000269|PubMed:22510408,ECO:0000269|PubMed:23131551, ECO:0000269|PubMed:23911537,ECO:0000269|PubMed:7775413, ECO:0000269|PubMed:8706699}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RPS3_C7orf31 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RPS3_C7orf31 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RPS3_C7orf31 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RPS3_C7orf31 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RPS3 | C0025202 | melanoma | 1 | CTD_human |
Hgene | RPS3 | C1257806 | Chromosomal Instability | 1 | CTD_human |