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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32108

FusionGeneSummary for RPS3_C7orf31

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS3_C7orf31
Fusion gene ID: 32108
HgeneTgene
Gene symbol

RPS3

C7orf31

Gene ID

6188

136895

Gene nameribosomal protein S3chromosome 7 open reading frame 31
SynonymsS3-
Cytomap

11q13.4

7p15.3

Type of geneprotein-codingprotein-coding
Description40S ribosomal protein S3IMR-90 ribosomal protein S3small ribosomal subunit protein uS3uncharacterized protein C7orf31
Modification date2018052320180519
UniProtAcc

P23396

Q8N865

Ensembl transtripts involved in fusion geneENST00000531188, ENST00000530164, 
ENST00000278572, ENST00000534440, 
ENST00000527446, ENST00000526608, 
ENST00000524851, ENST00000529285, 
ENST00000409280, ENST00000283905, 
Fusion gene scores* DoF score4 X 4 X 2=321 X 1 X 1=1
# samples 41
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: RPS3 [Title/Abstract] AND C7orf31 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPS3

GO:0006979

response to oxidative stress

23911537

HgeneRPS3

GO:0017148

negative regulation of translation

20217897

HgeneRPS3

GO:0031397

negative regulation of protein ubiquitination

19656744

HgeneRPS3

GO:0032079

positive regulation of endodeoxyribonuclease activity

18973764

HgeneRPS3

GO:0042769

DNA damage response, detection of DNA damage

23911537

HgeneRPS3

GO:0045739

positive regulation of DNA repair

23911537

HgeneRPS3

GO:0061481

response to TNF agonist

20041225

HgeneRPS3

GO:0070301

cellular response to hydrogen peroxide

23911537

HgeneRPS3

GO:1901224

positive regulation of NIK/NF-kappaB signaling

20041225

HgeneRPS3

GO:1902546

positive regulation of DNA N-glycosylase activity

15518571

HgeneRPS3

GO:1905053

positive regulation of base-excision repair

18973764

HgeneRPS3

GO:2001235

positive regulation of apoptotic signaling pathway

14988002


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP262829RPS3chr11

75113427

+C7orf31chr7

25219874

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000531188ENST00000409280RPS3chr11

75113427

+C7orf31chr7

25219874

-
5CDS-5UTRENST00000531188ENST00000283905RPS3chr11

75113427

+C7orf31chr7

25219874

-
5CDS-5UTRENST00000530164ENST00000409280RPS3chr11

75113427

+C7orf31chr7

25219874

-
5CDS-5UTRENST00000530164ENST00000283905RPS3chr11

75113427

+C7orf31chr7

25219874

-
5CDS-5UTRENST00000278572ENST00000409280RPS3chr11

75113427

+C7orf31chr7

25219874

-
5CDS-5UTRENST00000278572ENST00000283905RPS3chr11

75113427

+C7orf31chr7

25219874

-
5CDS-5UTRENST00000534440ENST00000409280RPS3chr11

75113427

+C7orf31chr7

25219874

-
5CDS-5UTRENST00000534440ENST00000283905RPS3chr11

75113427

+C7orf31chr7

25219874

-
5CDS-5UTRENST00000527446ENST00000409280RPS3chr11

75113427

+C7orf31chr7

25219874

-
5CDS-5UTRENST00000527446ENST00000283905RPS3chr11

75113427

+C7orf31chr7

25219874

-
intron-5UTRENST00000526608ENST00000409280RPS3chr11

75113427

+C7orf31chr7

25219874

-
intron-5UTRENST00000526608ENST00000283905RPS3chr11

75113427

+C7orf31chr7

25219874

-
5CDS-5UTRENST00000524851ENST00000409280RPS3chr11

75113427

+C7orf31chr7

25219874

-
5CDS-5UTRENST00000524851ENST00000283905RPS3chr11

75113427

+C7orf31chr7

25219874

-
3UTR-5UTRENST00000529285ENST00000409280RPS3chr11

75113427

+C7orf31chr7

25219874

-
3UTR-5UTRENST00000529285ENST00000283905RPS3chr11

75113427

+C7orf31chr7

25219874

-

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FusionProtFeatures for RPS3_C7orf31


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPS3

P23396

C7orf31

Q8N865

Involved in translation as a component of the 40S smallribosomal subunit (PubMed:8706699). Has endonuclease activity andplays a role in repair of damaged DNA (PubMed:7775413). Cleavesphosphodiester bonds of DNAs containing altered bases with broadspecificity and cleaves supercoiled DNA more efficiently thanrelaxed DNA (PubMed:15707971). Displays high binding affinity for7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused byreactive oxygen species (ROS) (PubMed:14706345). Has also beenshown to bind with similar affinity to intact and damaged DNA(PubMed:18610840). Stimulates the N-glycosylase activity of thebase excision protein OGG1 (PubMed:15518571). Enhances the uracilexcision activity of UNG1 (PubMed:18973764). Also stimulates thecleavage of the phosphodiester backbone by APEX1(PubMed:18973764). When located in the mitochondrion, reducescellular ROS levels and mitochondrial DNA damage(PubMed:23911537). Has also been shown to negatively regulate DNArepair in cells exposed to hydrogen peroxide (PubMed:17049931).Plays a role in regulating transcription as part of the NF-kappa-Bp65-p50 complex where it binds to the RELA/p65 subunit, enhancesbinding of the complex to DNA and promotes transcription of targetgenes (PubMed:18045535). Represses its own translation by bindingto its cognate mRNA (PubMed:20217897). Binds to and protectsTP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744).Involved in spindle formation and chromosome movement duringmitosis by regulating microtubule polymerization(PubMed:23131551). Involved in induction of apoptosis through itsrole in activation of CASP8 (PubMed:14988002). Induces neuronalapoptosis by interacting with the E2F1 transcription factor andacting synergistically with it to up-regulate pro-apoptoticproteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts withTRADD following exposure to UV radiation and induces apoptosis bycaspase-dependent JNK activation (PubMed:22510408).{ECO:0000269|PubMed:14706345, ECO:0000269|PubMed:14988002,ECO:0000269|PubMed:15518571, ECO:0000269|PubMed:15707971,ECO:0000269|PubMed:17049931, ECO:0000269|PubMed:18045535,ECO:0000269|PubMed:18610840, ECO:0000269|PubMed:18973764,ECO:0000269|PubMed:19656744, ECO:0000269|PubMed:20217897,ECO:0000269|PubMed:20605787, ECO:0000269|PubMed:22510408,ECO:0000269|PubMed:23131551, ECO:0000269|PubMed:23911537,ECO:0000269|PubMed:7775413, ECO:0000269|PubMed:8706699}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPS3_C7orf31


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPS3_C7orf31


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPS3_C7orf31


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RPS3_C7orf31


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRPS3C0025202melanoma1CTD_human
HgeneRPS3C1257806Chromosomal Instability1CTD_human