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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32093

FusionGeneSummary for RPS24_CPEB2

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS24_CPEB2
Fusion gene ID: 32093
HgeneTgene
Gene symbol

RPS24

CPEB2

Gene ID

6229

132864

Gene nameribosomal protein S24cytoplasmic polyadenylation element binding protein 2
SynonymsDBA3|S24|eS24CPE-BP2|CPEB-2|hCPEB-2
Cytomap

10q22.3

4p15.32

Type of geneprotein-codingprotein-coding
Description40S ribosomal protein S24small ribosomal subunit protein eS24cytoplasmic polyadenylation element-binding protein 2CPE-binding protein 2
Modification date2018052220180523
UniProtAcc

P62847

Q7Z5Q1

Ensembl transtripts involved in fusion geneENST00000435275, ENST00000440692, 
ENST00000372360, ENST00000476545, 
ENST00000360830, 
ENST00000442003, 
ENST00000538197, ENST00000541112, 
ENST00000507071, ENST00000345451, 
ENST00000259997, ENST00000382401, 
ENST00000382395, 
Fusion gene scores* DoF score7 X 7 X 1=492 X 2 X 2=8
# samples 92
** MAII scorelog2(9/49*10)=0.877143252214467
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: RPS24 [Title/Abstract] AND CPEB2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCPEB2

GO:0032869

cellular response to insulin stimulus

18752464

TgeneCPEB2

GO:0071456

cellular response to hypoxia

18752464


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1N33853RPS24chr10

79795369

-CPEB2chr4

15069023

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000435275ENST00000442003RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-3UTRENST00000435275ENST00000538197RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-3UTRENST00000435275ENST00000541112RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-intronENST00000435275ENST00000507071RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-intronENST00000435275ENST00000345451RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-3UTRENST00000435275ENST00000259997RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-3UTRENST00000435275ENST00000382401RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-3UTRENST00000435275ENST00000382395RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-3UTRENST00000440692ENST00000442003RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-3UTRENST00000440692ENST00000538197RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-3UTRENST00000440692ENST00000541112RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-intronENST00000440692ENST00000507071RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-intronENST00000440692ENST00000345451RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-3UTRENST00000440692ENST00000259997RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-3UTRENST00000440692ENST00000382401RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-3UTRENST00000440692ENST00000382395RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-3UTRENST00000372360ENST00000442003RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-3UTRENST00000372360ENST00000538197RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-3UTRENST00000372360ENST00000541112RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-intronENST00000372360ENST00000507071RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-intronENST00000372360ENST00000345451RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-3UTRENST00000372360ENST00000259997RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-3UTRENST00000372360ENST00000382401RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-3UTRENST00000372360ENST00000382395RPS24chr10

79795369

-CPEB2chr4

15069023

-
3UTR-3UTRENST00000476545ENST00000442003RPS24chr10

79795369

-CPEB2chr4

15069023

-
3UTR-3UTRENST00000476545ENST00000538197RPS24chr10

79795369

-CPEB2chr4

15069023

-
3UTR-3UTRENST00000476545ENST00000541112RPS24chr10

79795369

-CPEB2chr4

15069023

-
3UTR-intronENST00000476545ENST00000507071RPS24chr10

79795369

-CPEB2chr4

15069023

-
3UTR-intronENST00000476545ENST00000345451RPS24chr10

79795369

-CPEB2chr4

15069023

-
3UTR-3UTRENST00000476545ENST00000259997RPS24chr10

79795369

-CPEB2chr4

15069023

-
3UTR-3UTRENST00000476545ENST00000382401RPS24chr10

79795369

-CPEB2chr4

15069023

-
3UTR-3UTRENST00000476545ENST00000382395RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-3UTRENST00000360830ENST00000442003RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-3UTRENST00000360830ENST00000538197RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-3UTRENST00000360830ENST00000541112RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-intronENST00000360830ENST00000507071RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-intronENST00000360830ENST00000345451RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-3UTRENST00000360830ENST00000259997RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-3UTRENST00000360830ENST00000382401RPS24chr10

79795369

-CPEB2chr4

15069023

-
5CDS-3UTRENST00000360830ENST00000382395RPS24chr10

79795369

-CPEB2chr4

15069023

-

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FusionProtFeatures for RPS24_CPEB2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPS24

P62847

CPEB2

Q7Z5Q1

Required for processing of pre-rRNA and maturation of40S ribosomal subunits. {ECO:0000269|PubMed:18230666}. May play a role in translational regulation of storedmRNAs in transcriptionally inactive haploid spermatids. Binds topoly(U) RNA oligomers (By similarity). Required for cell cycleprogression, specifically for the transition from metaphase toanaphase (PubMed:26398195). {ECO:0000250|UniProtKB:Q812E0,ECO:0000269|PubMed:26398195}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPS24_CPEB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPS24_CPEB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPS24_CPEB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RPS24_CPEB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource