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Fusion gene ID: 32093 |
FusionGeneSummary for RPS24_CPEB2 |
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Fusion gene information | Fusion gene name: RPS24_CPEB2 | Fusion gene ID: 32093 | Hgene | Tgene | Gene symbol | RPS24 | CPEB2 | Gene ID | 6229 | 132864 |
Gene name | ribosomal protein S24 | cytoplasmic polyadenylation element binding protein 2 | |
Synonyms | DBA3|S24|eS24 | CPE-BP2|CPEB-2|hCPEB-2 | |
Cytomap | 10q22.3 | 4p15.32 | |
Type of gene | protein-coding | protein-coding | |
Description | 40S ribosomal protein S24small ribosomal subunit protein eS24 | cytoplasmic polyadenylation element-binding protein 2CPE-binding protein 2 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | P62847 | Q7Z5Q1 | |
Ensembl transtripts involved in fusion gene | ENST00000435275, ENST00000440692, ENST00000372360, ENST00000476545, ENST00000360830, | ENST00000442003, ENST00000538197, ENST00000541112, ENST00000507071, ENST00000345451, ENST00000259997, ENST00000382401, ENST00000382395, | |
Fusion gene scores | * DoF score | 7 X 7 X 1=49 | 2 X 2 X 2=8 |
# samples | 9 | 2 | |
** MAII score | log2(9/49*10)=0.877143252214467 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: RPS24 [Title/Abstract] AND CPEB2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CPEB2 | GO:0032869 | cellular response to insulin stimulus | 18752464 |
Tgene | CPEB2 | GO:0071456 | cellular response to hypoxia | 18752464 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | N33853 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000435275 | ENST00000442003 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-3UTR | ENST00000435275 | ENST00000538197 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-3UTR | ENST00000435275 | ENST00000541112 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-intron | ENST00000435275 | ENST00000507071 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-intron | ENST00000435275 | ENST00000345451 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-3UTR | ENST00000435275 | ENST00000259997 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-3UTR | ENST00000435275 | ENST00000382401 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-3UTR | ENST00000435275 | ENST00000382395 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-3UTR | ENST00000440692 | ENST00000442003 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-3UTR | ENST00000440692 | ENST00000538197 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-3UTR | ENST00000440692 | ENST00000541112 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-intron | ENST00000440692 | ENST00000507071 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-intron | ENST00000440692 | ENST00000345451 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-3UTR | ENST00000440692 | ENST00000259997 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-3UTR | ENST00000440692 | ENST00000382401 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-3UTR | ENST00000440692 | ENST00000382395 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-3UTR | ENST00000372360 | ENST00000442003 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-3UTR | ENST00000372360 | ENST00000538197 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-3UTR | ENST00000372360 | ENST00000541112 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-intron | ENST00000372360 | ENST00000507071 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-intron | ENST00000372360 | ENST00000345451 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-3UTR | ENST00000372360 | ENST00000259997 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-3UTR | ENST00000372360 | ENST00000382401 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-3UTR | ENST00000372360 | ENST00000382395 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
3UTR-3UTR | ENST00000476545 | ENST00000442003 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
3UTR-3UTR | ENST00000476545 | ENST00000538197 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
3UTR-3UTR | ENST00000476545 | ENST00000541112 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
3UTR-intron | ENST00000476545 | ENST00000507071 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
3UTR-intron | ENST00000476545 | ENST00000345451 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
3UTR-3UTR | ENST00000476545 | ENST00000259997 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
3UTR-3UTR | ENST00000476545 | ENST00000382401 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
3UTR-3UTR | ENST00000476545 | ENST00000382395 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-3UTR | ENST00000360830 | ENST00000442003 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-3UTR | ENST00000360830 | ENST00000538197 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-3UTR | ENST00000360830 | ENST00000541112 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-intron | ENST00000360830 | ENST00000507071 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-intron | ENST00000360830 | ENST00000345451 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-3UTR | ENST00000360830 | ENST00000259997 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-3UTR | ENST00000360830 | ENST00000382401 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
5CDS-3UTR | ENST00000360830 | ENST00000382395 | RPS24 | chr10 | 79795369 | - | CPEB2 | chr4 | 15069023 | - |
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FusionProtFeatures for RPS24_CPEB2 |
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Hgene | Tgene |
RPS24 | CPEB2 |
Required for processing of pre-rRNA and maturation of40S ribosomal subunits. {ECO:0000269|PubMed:18230666}. | May play a role in translational regulation of storedmRNAs in transcriptionally inactive haploid spermatids. Binds topoly(U) RNA oligomers (By similarity). Required for cell cycleprogression, specifically for the transition from metaphase toanaphase (PubMed:26398195). {ECO:0000250|UniProtKB:Q812E0,ECO:0000269|PubMed:26398195}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RPS24_CPEB2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RPS24_CPEB2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RPS24_CPEB2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RPS24_CPEB2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |