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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32085

FusionGeneSummary for RPS21_LRBA

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS21_LRBA
Fusion gene ID: 32085
HgeneTgene
Gene symbol

RPS21

LRBA

Gene ID

6227

987

Gene nameribosomal protein S21LPS responsive beige-like anchor protein
SynonymsHLDF|S21BGL|CDC4L|CVID8|LAB300|LBA
Cytomap

20q13.33

4q31.3

Type of geneprotein-codingprotein-coding
Description40S ribosomal protein S218.2 kDa differentiation factorhuman leukemia differentiation factorsmall ribosomal subunit protein eS21lipopolysaccharide-responsive and beige-like anchor proteinCDC4-like proteinLPS-responsive vesicle trafficking, beach and anchor containingvesicle trafficking, beach and anchor containing
Modification date2018052320180519
UniProtAcc

P63220

P50851

Ensembl transtripts involved in fusion geneENST00000343986, ENST00000492356, 
ENST00000370562, ENST00000450116, 
ENST00000535741, ENST00000510413, 
ENST00000503716, ENST00000357115, 
ENST00000507224, 
Fusion gene scores* DoF score3 X 3 X 1=915 X 15 X 7=1575
# samples 318
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(18/1575*10)=-3.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPS21 [Title/Abstract] AND LRBA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPS21

GO:0002181

cytoplasmic translation

25957688


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP251502RPS21chr20

60963573

+LRBAchr4

151616197

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000343986ENST00000535741RPS21chr20

60963573

+LRBAchr4

151616197

-
5CDS-intronENST00000343986ENST00000510413RPS21chr20

60963573

+LRBAchr4

151616197

-
5CDS-intronENST00000343986ENST00000503716RPS21chr20

60963573

+LRBAchr4

151616197

-
5CDS-intronENST00000343986ENST00000357115RPS21chr20

60963573

+LRBAchr4

151616197

-
5CDS-intronENST00000343986ENST00000507224RPS21chr20

60963573

+LRBAchr4

151616197

-
5CDS-intronENST00000492356ENST00000535741RPS21chr20

60963573

+LRBAchr4

151616197

-
5CDS-intronENST00000492356ENST00000510413RPS21chr20

60963573

+LRBAchr4

151616197

-
5CDS-intronENST00000492356ENST00000503716RPS21chr20

60963573

+LRBAchr4

151616197

-
5CDS-intronENST00000492356ENST00000357115RPS21chr20

60963573

+LRBAchr4

151616197

-
5CDS-intronENST00000492356ENST00000507224RPS21chr20

60963573

+LRBAchr4

151616197

-
5CDS-intronENST00000370562ENST00000535741RPS21chr20

60963573

+LRBAchr4

151616197

-
5CDS-intronENST00000370562ENST00000510413RPS21chr20

60963573

+LRBAchr4

151616197

-
5CDS-intronENST00000370562ENST00000503716RPS21chr20

60963573

+LRBAchr4

151616197

-
5CDS-intronENST00000370562ENST00000357115RPS21chr20

60963573

+LRBAchr4

151616197

-
5CDS-intronENST00000370562ENST00000507224RPS21chr20

60963573

+LRBAchr4

151616197

-
5CDS-intronENST00000450116ENST00000535741RPS21chr20

60963573

+LRBAchr4

151616197

-
5CDS-intronENST00000450116ENST00000510413RPS21chr20

60963573

+LRBAchr4

151616197

-
5CDS-intronENST00000450116ENST00000503716RPS21chr20

60963573

+LRBAchr4

151616197

-
5CDS-intronENST00000450116ENST00000357115RPS21chr20

60963573

+LRBAchr4

151616197

-
5CDS-intronENST00000450116ENST00000507224RPS21chr20

60963573

+LRBAchr4

151616197

-

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FusionProtFeatures for RPS21_LRBA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPS21

P63220

LRBA

P50851

May be involved in coupling signal transduction andvesicle trafficking to enable polarized secretion and/or membranedeposition of immune effector molecules. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPS21_LRBA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPS21_LRBA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPS21_LRBA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RPS21_LRBA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRPS21C0038356Stomach Neoplasms1CTD_human
TgeneLRBAC3553512IMMUNODEFICIENCY, COMMON VARIABLE, 8, WITH AUTOIMMUNITY1ORPHANET;UNIPROT