![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 32060 |
FusionGeneSummary for RPS15A_ARL6IP1 |
![]() |
Fusion gene information | Fusion gene name: RPS15A_ARL6IP1 | Fusion gene ID: 32060 | Hgene | Tgene | Gene symbol | RPS15A | ARL6IP1 | Gene ID | 6210 | 23204 |
Gene name | ribosomal protein S15a | ADP ribosylation factor like GTPase 6 interacting protein 1 | |
Synonyms | S15a | AIP1|ARL6IP|ARMER|SPG61 | |
Cytomap | 16p12.3 | 16p12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | 40S ribosomal protein S15asmall ribosomal subunit protein uS8up-regulated by HBV X protein | ADP-ribosylation factor-like protein 6-interacting protein 1ADP-ribosylation factor GTPase 6 interacting protein 1ADP-ribosylation factor-like 6 interacting protein 1ARL-6-interacting protein 1aip-1apoptotic regulator in the membrane of the endoplasm | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P62244 | Q15041 | |
Ensembl transtripts involved in fusion gene | ENST00000322989, ENST00000563390, ENST00000575669, ENST00000576436, ENST00000565420, ENST00000569083, | ENST00000304414, ENST00000546206, ENST00000562819, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
# samples | 1 | 1 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: RPS15A [Title/Abstract] AND ARL6IP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RPS15A | GO:0008284 | positive regulation of cell proliferation | 15108328 |
Hgene | RPS15A | GO:0009615 | response to virus | 15108328 |
Hgene | RPS15A | GO:0045787 | positive regulation of cell cycle | 15108328 |
Tgene | ARL6IP1 | GO:0043066 | negative regulation of apoptotic process | 12754298 |
Tgene | ARL6IP1 | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 12754298 |
Tgene | ARL6IP1 | GO:0071787 | endoplasmic reticulum tubular network formation | 24262037 |
Tgene | ARL6IP1 | GO:1990809 | endoplasmic reticulum tubular network membrane organization | 24262037 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A2-A0D2-01A | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000322989 | ENST00000304414 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
5CDS-5UTR | ENST00000322989 | ENST00000546206 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
5CDS-5UTR | ENST00000322989 | ENST00000562819 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
Frame-shift | ENST00000563390 | ENST00000304414 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
5CDS-5UTR | ENST00000563390 | ENST00000546206 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
5CDS-5UTR | ENST00000563390 | ENST00000562819 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
intron-3CDS | ENST00000575669 | ENST00000304414 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
intron-5UTR | ENST00000575669 | ENST00000546206 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
intron-5UTR | ENST00000575669 | ENST00000562819 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
intron-3CDS | ENST00000576436 | ENST00000304414 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
intron-5UTR | ENST00000576436 | ENST00000546206 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
intron-5UTR | ENST00000576436 | ENST00000562819 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
Frame-shift | ENST00000565420 | ENST00000304414 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
5CDS-5UTR | ENST00000565420 | ENST00000546206 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
5CDS-5UTR | ENST00000565420 | ENST00000562819 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
intron-3CDS | ENST00000569083 | ENST00000304414 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
intron-5UTR | ENST00000569083 | ENST00000546206 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
intron-5UTR | ENST00000569083 | ENST00000562819 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
Top |
FusionProtFeatures for RPS15A_ARL6IP1 |
![]() |
Hgene | Tgene |
RPS15A | ARL6IP1 |
Positively regulates SLC1A1/EAAC1-mediated glutamatetransport by increasing its affinity for glutamate in a PKCactivity-dependent manner. Promotes the catalytic efficiency ofSLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, anegative regulator of SLC1A1/EAAC1-mediated glutamate transport(By similarity). Plays a role in the formation and stabilizationof endoplasmic reticulum tubules (PubMed:24262037). Negativelyregulates apoptosis, possibly by modulating the activity ofcaspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substratesand downstream markers of apoptosis but not CASP9 itself(PubMed:12754298). May be involved in protein transport, membranetrafficking, or cell signaling during hematopoietic maturation(PubMed:10995579). {ECO:0000250|UniProtKB:Q9JKW0,ECO:0000269|PubMed:12754298, ECO:0000269|PubMed:24262037,ECO:0000303|PubMed:10995579}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for RPS15A_ARL6IP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for RPS15A_ARL6IP1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RPS15A | EWSR1, ELF5, MGMT, CALM1, CDC37, PCK1, VHL, RAD21, HDGF, CUL3, CUL4A, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, CAND1, NEDD8, RPL10A, RPL10, RPL11, RPL12, RPL14, RPL15, RPL18A, RPL18, RPL19, RPL21, RPL23, RPL24, RPL27, RPL30, RPL31, RPL37A, RPL4, RPL5, RPL6, RPL7A, RPL7, RPL9, RPS10, RPS11, RPS12, RPS13, RPS14, RPS19, RPS26, RPS3A, RPS3, RPS4X, RPS5, RPS6, RPS7, RPS8, RPSA, RPS23, RPS16, RPS17, RPLP1, RPS24, RPLP2, RPL23A, RPS2, RPLP0, RPS20, RPS15, RPL3, RPL13, RPL38, RPL29, RPS21, RPL17, RPL32, RPS27A, EEF1A1, EEF2, NOP56, FBL, HNRNPU, GNL3, SLC25A5, ILF3, ILF2, NOP58, MOV10, TUFM, NHP2L1, HNRNPM, ACTA2, EIF6, HSP90AA1, RPLP0P6, RPL10L, GALNT2, NOP2, NIFK, MRPS14, UBA2, GNL1, HIST1H2AD, HSPA8, ATP5A1, HNRNPA0, PSMB1, ESR1, SMURF1, FN1, VCAM1, UBL4A, ITGA4, PAN2, PSMC1, PSMC6, PSMD11, PSMD3, FAU, PNO1, PSMD1, RPS18, RPS25, RPS27, RPS27L, RPS29, RPS9, WDR26, WIBG, RPS28, TSR1, ZBTB1, CEP250, CEP57, CEP76, TUBG1, HUWE1, RNF2, EGFR, DIMT1, IMP3, MPHOSPH10, MRPL14, MRPL16, MRPL22, MRPS7, RPL13A, RPL27A, RPL28, RPL34, RPL35, RPL37, DDX18, RPL22, RPL35A, RPL36, RPL8, VAPA, LOC101929876, TUBB, TUBB2B, TUBB4B, UBA52, SFN, PTEN, AHSA1, EXOSC1, UBE3A, MCM2, RHOU, RC3H1, ZNF746, HNRNPA1, CYLD, TRIM25, UBE2A, HEY1, BRCA1, HDAC6 | ARL6IP1 | ARL6, INPP5K, FXR2, FBXW7, FDFT1, HGS, NUDT3, HMGCL, ELAVL1, GAD2, PBX3, SHMT2, SNX1, TFAM, TUFM, SNX4, SNX3, SUCLA2, RAB33A, COL4A3BP, ARL6IP1, GORASP2, WIPI2, SNX10, SNX15, SNX11, SNX12, MTERF3, PAM16, SPG21, DIABLO, RTN4, SENP2, C12orf10, NAPB, GOLPH3, NDRG4, ZFYVE21, ACSF2, FAM134C, ZNF391, FAF2, UNK, GOLPH3L, ATP2B2, IPPK, FPR2, LMNA |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for RPS15A_ARL6IP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for RPS15A_ARL6IP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ARL6IP1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |