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Fusion gene ID: 32059 |
FusionGeneSummary for RPS14_WDR6 |
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Fusion gene information | Fusion gene name: RPS14_WDR6 | Fusion gene ID: 32059 | Hgene | Tgene | Gene symbol | RPS14 | WDR6 | Gene ID | 6208 | 11180 |
Gene name | ribosomal protein S14 | WD repeat domain 6 | |
Synonyms | EMTB|S14 | - | |
Cytomap | 5q33.1 | 3p21.31 | |
Type of gene | protein-coding | protein-coding | |
Description | 40S ribosomal protein S14emetine resistancesmall ribosomal subunit protein uS11 | WD repeat-containing protein 6 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P62263 | Q9NNW5 | |
Ensembl transtripts involved in fusion gene | ENST00000401695, ENST00000407193, ENST00000312037, | ENST00000395474, ENST00000489684, ENST00000608424, ENST00000415265, ENST00000448293, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 1 X 1 X 1=1 |
# samples | 4 | 1 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: RPS14 [Title/Abstract] AND WDR6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RPS14 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 7867928 |
Tgene | WDR6 | GO:0007050 | cell cycle arrest | 17216128 |
Tgene | WDR6 | GO:0008285 | negative regulation of cell proliferation | 17216128 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BM680717 | RPS14 | chr5 | 149823906 | + | WDR6 | chr3 | 49050987 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000401695 | ENST00000395474 | RPS14 | chr5 | 149823906 | + | WDR6 | chr3 | 49050987 | - |
intron-intron | ENST00000401695 | ENST00000489684 | RPS14 | chr5 | 149823906 | + | WDR6 | chr3 | 49050987 | - |
intron-intron | ENST00000401695 | ENST00000608424 | RPS14 | chr5 | 149823906 | + | WDR6 | chr3 | 49050987 | - |
intron-intron | ENST00000401695 | ENST00000415265 | RPS14 | chr5 | 149823906 | + | WDR6 | chr3 | 49050987 | - |
intron-intron | ENST00000401695 | ENST00000448293 | RPS14 | chr5 | 149823906 | + | WDR6 | chr3 | 49050987 | - |
intron-3CDS | ENST00000407193 | ENST00000395474 | RPS14 | chr5 | 149823906 | + | WDR6 | chr3 | 49050987 | - |
intron-intron | ENST00000407193 | ENST00000489684 | RPS14 | chr5 | 149823906 | + | WDR6 | chr3 | 49050987 | - |
intron-intron | ENST00000407193 | ENST00000608424 | RPS14 | chr5 | 149823906 | + | WDR6 | chr3 | 49050987 | - |
intron-intron | ENST00000407193 | ENST00000415265 | RPS14 | chr5 | 149823906 | + | WDR6 | chr3 | 49050987 | - |
intron-intron | ENST00000407193 | ENST00000448293 | RPS14 | chr5 | 149823906 | + | WDR6 | chr3 | 49050987 | - |
intron-3CDS | ENST00000312037 | ENST00000395474 | RPS14 | chr5 | 149823906 | + | WDR6 | chr3 | 49050987 | - |
intron-intron | ENST00000312037 | ENST00000489684 | RPS14 | chr5 | 149823906 | + | WDR6 | chr3 | 49050987 | - |
intron-intron | ENST00000312037 | ENST00000608424 | RPS14 | chr5 | 149823906 | + | WDR6 | chr3 | 49050987 | - |
intron-intron | ENST00000312037 | ENST00000415265 | RPS14 | chr5 | 149823906 | + | WDR6 | chr3 | 49050987 | - |
intron-intron | ENST00000312037 | ENST00000448293 | RPS14 | chr5 | 149823906 | + | WDR6 | chr3 | 49050987 | - |
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FusionProtFeatures for RPS14_WDR6 |
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Hgene | Tgene |
RPS14 | WDR6 |
Enhances the STK11/LKB1-induced cell growth suppressionactivity. Negative regulator of amino acid starvation-inducedautophagy. {ECO:0000269|PubMed:17216128,ECO:0000269|PubMed:22354037}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RPS14_WDR6 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RPS14_WDR6 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RPS14_WDR6 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RPS14_WDR6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RPS14 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | RPS14 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | RPS14 | C0242184 | Hypoxia | 1 | CTD_human |