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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32058

FusionGeneSummary for RPS14_RPS19

check button Fusion gene summary
Fusion gene informationFusion gene name: RPS14_RPS19
Fusion gene ID: 32058
HgeneTgene
Gene symbol

RPS14

RPS19

Gene ID

6208

6223

Gene nameribosomal protein S14ribosomal protein S19
SynonymsEMTB|S14DBA|DBA1|S19|eS19
Cytomap

5q33.1

19q13.2

Type of geneprotein-codingprotein-coding
Description40S ribosomal protein S14emetine resistancesmall ribosomal subunit protein uS1140S ribosomal protein S19small ribosomal subunit protein eS19
Modification date2018052320180523
UniProtAcc

P62263

P39019

Ensembl transtripts involved in fusion geneENST00000401695, ENST00000407193, 
ENST00000312037, 
ENST00000598742, 
ENST00000221975, ENST00000593863, 
Fusion gene scores* DoF score4 X 4 X 3=486 X 4 X 4=96
# samples 46
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPS14 [Title/Abstract] AND RPS19 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPS14

GO:0000122

negative regulation of transcription by RNA polymerase II

7867928

TgeneRPS19

GO:0002548

monocyte chemotaxis

11226885

TgeneRPS19

GO:0031640

killing of cells of other organism

15019208

TgeneRPS19

GO:0050829

defense response to Gram-negative bacterium

15019208

TgeneRPS19

GO:0051262

protein tetramerization

11226885

TgeneRPS19

GO:0060265

positive regulation of respiratory burst involved in inflammatory response

15750715

TgeneRPS19

GO:0060266

negative regulation of respiratory burst involved in inflammatory response

15750715

TgeneRPS19

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

15019208


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU602070RPS14chr5

149826368

-RPS19chr19

42373271

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000401695ENST00000598742RPS14chr5

149826368

-RPS19chr19

42373271

+
Frame-shiftENST00000401695ENST00000221975RPS14chr5

149826368

-RPS19chr19

42373271

+
Frame-shiftENST00000401695ENST00000593863RPS14chr5

149826368

-RPS19chr19

42373271

+
In-frameENST00000407193ENST00000598742RPS14chr5

149826368

-RPS19chr19

42373271

+
In-frameENST00000407193ENST00000221975RPS14chr5

149826368

-RPS19chr19

42373271

+
In-frameENST00000407193ENST00000593863RPS14chr5

149826368

-RPS19chr19

42373271

+
In-frameENST00000312037ENST00000598742RPS14chr5

149826368

-RPS19chr19

42373271

+
In-frameENST00000312037ENST00000221975RPS14chr5

149826368

-RPS19chr19

42373271

+
In-frameENST00000312037ENST00000593863RPS14chr5

149826368

-RPS19chr19

42373271

+

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FusionProtFeatures for RPS14_RPS19


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPS14

P62263

RPS19

P39019

Required for pre-rRNA processing and maturation of 40Sribosomal subunits. {ECO:0000269|PubMed:16990592}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPS14_RPS19


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RPS14_ENST00000407193_chr5_149826368_-_RPS19_ENST00000598742_chr19_42373271_+_0aa

>In-frame_RPS14_ENST00000407193_chr5_149826368_-_RPS19_ENST00000221975_chr19_42373271_+_0aa

>In-frame_RPS14_ENST00000407193_chr5_149826368_-_RPS19_ENST00000593863_chr19_42373271_+_0aa

>In-frame_RPS14_ENST00000312037_chr5_149826368_-_RPS19_ENST00000598742_chr19_42373271_+_0aa

>In-frame_RPS14_ENST00000312037_chr5_149826368_-_RPS19_ENST00000221975_chr19_42373271_+_0aa

>In-frame_RPS14_ENST00000312037_chr5_149826368_-_RPS19_ENST00000593863_chr19_42373271_+_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RPS14_ENST00000407193_chr5_149826368_-_RPS19_ENST00000598742_chr19_42373271_+_0nt

>In-frame_RPS14_ENST00000407193_chr5_149826368_-_RPS19_ENST00000221975_chr19_42373271_+_0nt

>In-frame_RPS14_ENST00000407193_chr5_149826368_-_RPS19_ENST00000593863_chr19_42373271_+_0nt

>In-frame_RPS14_ENST00000312037_chr5_149826368_-_RPS19_ENST00000598742_chr19_42373271_+_0nt

>In-frame_RPS14_ENST00000312037_chr5_149826368_-_RPS19_ENST00000221975_chr19_42373271_+_0nt

>In-frame_RPS14_ENST00000312037_chr5_149826368_-_RPS19_ENST00000593863_chr19_42373271_+_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_RPS14_ENST00000407193_chr5_149826368_-_RPS19_ENST00000598742_chr19_42373271_+_584nt
CTCCGCCCCCTCCCACTCTCTCTTTCCGGTGTGGAGTCTGGAGACGACGTGCAGGTAGGAGGCCCGGGCGCGACAATCGGGGGGCATCCT
GCGGCGAGGGGACCCTGTGGGGCTTGGGACGAGAGACGGGGGTCTTTCCGTGGGAACCGAGCTAGGTGCCGGGCAAGAGACGCGCGGCTG
GCCCACCTGGATCCTGGCCAACTCGGGATTGAGTTCGTTCCTGGTCTCAGAAGGCCCGTTTTGCTTTCAGGGAGGAGCTTGTGAAGTAAG
GAAATGGCACCTCGAAAGGGGAAGGAAAAGAAGGAAGAACAGGTCATCAGCCTCGGACCTCAGGTGGCTGAAGGAGAGAATGTATTTGGT
GTCTGCCATATCTTTGCATCCTTCAATGACACTTTTGTCCATGTCACTGATCTTTCTGGCAAGGAAACCATCTGCCGTGTGACTGGTGGG
ATGAAGGTAAAGGCAGACCGAGATGAATCCTCACCATATGCTGCTATGTTGGCTGCCCAGGATGTGGCCCAGAGGTGCAAGGAGCTGGGT

>In-frame_RPS14_ENST00000407193_chr5_149826368_-_RPS19_ENST00000221975_chr19_42373271_+_584nt
CTCCGCCCCCTCCCACTCTCTCTTTCCGGTGTGGAGTCTGGAGACGACGTGCAGGTAGGAGGCCCGGGCGCGACAATCGGGGGGCATCCT
GCGGCGAGGGGACCCTGTGGGGCTTGGGACGAGAGACGGGGGTCTTTCCGTGGGAACCGAGCTAGGTGCCGGGCAAGAGACGCGCGGCTG
GCCCACCTGGATCCTGGCCAACTCGGGATTGAGTTCGTTCCTGGTCTCAGAAGGCCCGTTTTGCTTTCAGGGAGGAGCTTGTGAAGTAAG
GAAATGGCACCTCGAAAGGGGAAGGAAAAGAAGGAAGAACAGGTCATCAGCCTCGGACCTCAGGTGGCTGAAGGAGAGAATGTATTTGGT
GTCTGCCATATCTTTGCATCCTTCAATGACACTTTTGTCCATGTCACTGATCTTTCTGGCAAGGAAACCATCTGCCGTGTGACTGGTGGG
ATGAAGGTAAAGGCAGACCGAGATGAATCCTCACCATATGCTGCTATGTTGGCTGCCCAGGATGTGGCCCAGAGGTGCAAGGAGCTGGGT

>In-frame_RPS14_ENST00000407193_chr5_149826368_-_RPS19_ENST00000593863_chr19_42373271_+_584nt
CTCCGCCCCCTCCCACTCTCTCTTTCCGGTGTGGAGTCTGGAGACGACGTGCAGGTAGGAGGCCCGGGCGCGACAATCGGGGGGCATCCT
GCGGCGAGGGGACCCTGTGGGGCTTGGGACGAGAGACGGGGGTCTTTCCGTGGGAACCGAGCTAGGTGCCGGGCAAGAGACGCGCGGCTG
GCCCACCTGGATCCTGGCCAACTCGGGATTGAGTTCGTTCCTGGTCTCAGAAGGCCCGTTTTGCTTTCAGGGAGGAGCTTGTGAAGTAAG
GAAATGGCACCTCGAAAGGGGAAGGAAAAGAAGGAAGAACAGGTCATCAGCCTCGGACCTCAGGTGGCTGAAGGAGAGAATGTATTTGGT
GTCTGCCATATCTTTGCATCCTTCAATGACACTTTTGTCCATGTCACTGATCTTTCTGGCAAGGAAACCATCTGCCGTGTGACTGGTGGG
ATGAAGGTAAAGGCAGACCGAGATGAATCCTCACCATATGCTGCTATGTTGGCTGCCCAGGATGTGGCCCAGAGGTGCAAGGAGCTGGGT

>In-frame_RPS14_ENST00000312037_chr5_149826368_-_RPS19_ENST00000598742_chr19_42373271_+_518nt
GGCCCGGGCGCGACAATCGGGGGGCATCCTGCGGCGAGGGGACCCTGTGGGGCTTGGGACGAGAGACGGGGGTCTTTCCGTGGGAACCGA
GCTAGGTGCCGGGCAAGAGACGCGCGGCTGGCCCACCTGGATCCTGGCCAACTCGGGATTGAGTTCGTTCCTGGTCTCAGAAGGCCCGTT
TTGCTTTCAGGGAGGAGCTTGTGAAAAATGGCACCTCGAAAGGGGAAGGAAAAGAAGGAAGAACAGGTCATCAGCCTCGGACCTCAGGTG
GCTGAAGGAGAGAATGTATTTGGTGTCTGCCATATCTTTGCATCCTTCAATGACACTTTTGTCCATGTCACTGATCTTTCTGGCAAGGAA
ACCATCTGCCGTGTGACTGGTGGGATGAAGGTAAAGGCAGACCGAGATGAATCCTCACCATATGCTGCTATGTTGGCTGCCCAGGATGTG

>In-frame_RPS14_ENST00000312037_chr5_149826368_-_RPS19_ENST00000221975_chr19_42373271_+_518nt
GGCCCGGGCGCGACAATCGGGGGGCATCCTGCGGCGAGGGGACCCTGTGGGGCTTGGGACGAGAGACGGGGGTCTTTCCGTGGGAACCGA
GCTAGGTGCCGGGCAAGAGACGCGCGGCTGGCCCACCTGGATCCTGGCCAACTCGGGATTGAGTTCGTTCCTGGTCTCAGAAGGCCCGTT
TTGCTTTCAGGGAGGAGCTTGTGAAAAATGGCACCTCGAAAGGGGAAGGAAAAGAAGGAAGAACAGGTCATCAGCCTCGGACCTCAGGTG
GCTGAAGGAGAGAATGTATTTGGTGTCTGCCATATCTTTGCATCCTTCAATGACACTTTTGTCCATGTCACTGATCTTTCTGGCAAGGAA
ACCATCTGCCGTGTGACTGGTGGGATGAAGGTAAAGGCAGACCGAGATGAATCCTCACCATATGCTGCTATGTTGGCTGCCCAGGATGTG

>In-frame_RPS14_ENST00000312037_chr5_149826368_-_RPS19_ENST00000593863_chr19_42373271_+_518nt
GGCCCGGGCGCGACAATCGGGGGGCATCCTGCGGCGAGGGGACCCTGTGGGGCTTGGGACGAGAGACGGGGGTCTTTCCGTGGGAACCGA
GCTAGGTGCCGGGCAAGAGACGCGCGGCTGGCCCACCTGGATCCTGGCCAACTCGGGATTGAGTTCGTTCCTGGTCTCAGAAGGCCCGTT
TTGCTTTCAGGGAGGAGCTTGTGAAAAATGGCACCTCGAAAGGGGAAGGAAAAGAAGGAAGAACAGGTCATCAGCCTCGGACCTCAGGTG
GCTGAAGGAGAGAATGTATTTGGTGTCTGCCATATCTTTGCATCCTTCAATGACACTTTTGTCCATGTCACTGATCTTTCTGGCAAGGAA
ACCATCTGCCGTGTGACTGGTGGGATGAAGGTAAAGGCAGACCGAGATGAATCCTCACCATATGCTGCTATGTTGGCTGCCCAGGATGTG


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FusionGenePPI for RPS14_RPS19


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPS14_RPS19


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneRPS19P39019DB11638Artenimol40S ribosomal protein S19small moleculeapproved|investigational

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RelatedDiseases for RPS14_RPS19


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRPS14C0024667Animal Mammary Neoplasms1CTD_human
HgeneRPS14C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneRPS14C0242184Hypoxia1CTD_human
TgeneRPS19C2676137Diamond-Blackfan Anemia 17UNIPROT
TgeneRPS19C0033578Prostatic Neoplasms1CTD_human
TgeneRPS19C0038356Stomach Neoplasms1CTD_human