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Fusion gene ID: 32058 |
FusionGeneSummary for RPS14_RPS19 |
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Fusion gene information | Fusion gene name: RPS14_RPS19 | Fusion gene ID: 32058 | Hgene | Tgene | Gene symbol | RPS14 | RPS19 | Gene ID | 6208 | 6223 |
Gene name | ribosomal protein S14 | ribosomal protein S19 | |
Synonyms | EMTB|S14 | DBA|DBA1|S19|eS19 | |
Cytomap | 5q33.1 | 19q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | 40S ribosomal protein S14emetine resistancesmall ribosomal subunit protein uS11 | 40S ribosomal protein S19small ribosomal subunit protein eS19 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P62263 | P39019 | |
Ensembl transtripts involved in fusion gene | ENST00000401695, ENST00000407193, ENST00000312037, | ENST00000598742, ENST00000221975, ENST00000593863, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 6 X 4 X 4=96 |
# samples | 4 | 6 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RPS14 [Title/Abstract] AND RPS19 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RPS14 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 7867928 |
Tgene | RPS19 | GO:0002548 | monocyte chemotaxis | 11226885 |
Tgene | RPS19 | GO:0031640 | killing of cells of other organism | 15019208 |
Tgene | RPS19 | GO:0050829 | defense response to Gram-negative bacterium | 15019208 |
Tgene | RPS19 | GO:0051262 | protein tetramerization | 11226885 |
Tgene | RPS19 | GO:0060265 | positive regulation of respiratory burst involved in inflammatory response | 15750715 |
Tgene | RPS19 | GO:0060266 | negative regulation of respiratory burst involved in inflammatory response | 15750715 |
Tgene | RPS19 | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide | 15019208 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BU602070 | RPS14 | chr5 | 149826368 | - | RPS19 | chr19 | 42373271 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000401695 | ENST00000598742 | RPS14 | chr5 | 149826368 | - | RPS19 | chr19 | 42373271 | + |
Frame-shift | ENST00000401695 | ENST00000221975 | RPS14 | chr5 | 149826368 | - | RPS19 | chr19 | 42373271 | + |
Frame-shift | ENST00000401695 | ENST00000593863 | RPS14 | chr5 | 149826368 | - | RPS19 | chr19 | 42373271 | + |
In-frame | ENST00000407193 | ENST00000598742 | RPS14 | chr5 | 149826368 | - | RPS19 | chr19 | 42373271 | + |
In-frame | ENST00000407193 | ENST00000221975 | RPS14 | chr5 | 149826368 | - | RPS19 | chr19 | 42373271 | + |
In-frame | ENST00000407193 | ENST00000593863 | RPS14 | chr5 | 149826368 | - | RPS19 | chr19 | 42373271 | + |
In-frame | ENST00000312037 | ENST00000598742 | RPS14 | chr5 | 149826368 | - | RPS19 | chr19 | 42373271 | + |
In-frame | ENST00000312037 | ENST00000221975 | RPS14 | chr5 | 149826368 | - | RPS19 | chr19 | 42373271 | + |
In-frame | ENST00000312037 | ENST00000593863 | RPS14 | chr5 | 149826368 | - | RPS19 | chr19 | 42373271 | + |
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FusionProtFeatures for RPS14_RPS19 |
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Hgene | Tgene |
RPS14 | RPS19 |
Required for pre-rRNA processing and maturation of 40Sribosomal subunits. {ECO:0000269|PubMed:16990592}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RPS14_RPS19 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_RPS14_ENST00000407193_chr5_149826368_-_RPS19_ENST00000598742_chr19_42373271_+_0aa >In-frame_RPS14_ENST00000407193_chr5_149826368_-_RPS19_ENST00000221975_chr19_42373271_+_0aa >In-frame_RPS14_ENST00000407193_chr5_149826368_-_RPS19_ENST00000593863_chr19_42373271_+_0aa >In-frame_RPS14_ENST00000312037_chr5_149826368_-_RPS19_ENST00000598742_chr19_42373271_+_0aa >In-frame_RPS14_ENST00000312037_chr5_149826368_-_RPS19_ENST00000221975_chr19_42373271_+_0aa >In-frame_RPS14_ENST00000312037_chr5_149826368_-_RPS19_ENST00000593863_chr19_42373271_+_0aa |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_RPS14_ENST00000407193_chr5_149826368_-_RPS19_ENST00000598742_chr19_42373271_+_0nt >In-frame_RPS14_ENST00000407193_chr5_149826368_-_RPS19_ENST00000221975_chr19_42373271_+_0nt >In-frame_RPS14_ENST00000407193_chr5_149826368_-_RPS19_ENST00000593863_chr19_42373271_+_0nt >In-frame_RPS14_ENST00000312037_chr5_149826368_-_RPS19_ENST00000598742_chr19_42373271_+_0nt >In-frame_RPS14_ENST00000312037_chr5_149826368_-_RPS19_ENST00000221975_chr19_42373271_+_0nt >In-frame_RPS14_ENST00000312037_chr5_149826368_-_RPS19_ENST00000593863_chr19_42373271_+_0nt |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_RPS14_ENST00000407193_chr5_149826368_-_RPS19_ENST00000598742_chr19_42373271_+_584nt CTCCGCCCCCTCCCACTCTCTCTTTCCGGTGTGGAGTCTGGAGACGACGTGCAGGTAGGAGGCCCGGGCGCGACAATCGGGGGGCATCCT GCGGCGAGGGGACCCTGTGGGGCTTGGGACGAGAGACGGGGGTCTTTCCGTGGGAACCGAGCTAGGTGCCGGGCAAGAGACGCGCGGCTG GCCCACCTGGATCCTGGCCAACTCGGGATTGAGTTCGTTCCTGGTCTCAGAAGGCCCGTTTTGCTTTCAGGGAGGAGCTTGTGAAGTAAG GAAATGGCACCTCGAAAGGGGAAGGAAAAGAAGGAAGAACAGGTCATCAGCCTCGGACCTCAGGTGGCTGAAGGAGAGAATGTATTTGGT GTCTGCCATATCTTTGCATCCTTCAATGACACTTTTGTCCATGTCACTGATCTTTCTGGCAAGGAAACCATCTGCCGTGTGACTGGTGGG ATGAAGGTAAAGGCAGACCGAGATGAATCCTCACCATATGCTGCTATGTTGGCTGCCCAGGATGTGGCCCAGAGGTGCAAGGAGCTGGGT >In-frame_RPS14_ENST00000407193_chr5_149826368_-_RPS19_ENST00000221975_chr19_42373271_+_584nt CTCCGCCCCCTCCCACTCTCTCTTTCCGGTGTGGAGTCTGGAGACGACGTGCAGGTAGGAGGCCCGGGCGCGACAATCGGGGGGCATCCT GCGGCGAGGGGACCCTGTGGGGCTTGGGACGAGAGACGGGGGTCTTTCCGTGGGAACCGAGCTAGGTGCCGGGCAAGAGACGCGCGGCTG GCCCACCTGGATCCTGGCCAACTCGGGATTGAGTTCGTTCCTGGTCTCAGAAGGCCCGTTTTGCTTTCAGGGAGGAGCTTGTGAAGTAAG GAAATGGCACCTCGAAAGGGGAAGGAAAAGAAGGAAGAACAGGTCATCAGCCTCGGACCTCAGGTGGCTGAAGGAGAGAATGTATTTGGT GTCTGCCATATCTTTGCATCCTTCAATGACACTTTTGTCCATGTCACTGATCTTTCTGGCAAGGAAACCATCTGCCGTGTGACTGGTGGG ATGAAGGTAAAGGCAGACCGAGATGAATCCTCACCATATGCTGCTATGTTGGCTGCCCAGGATGTGGCCCAGAGGTGCAAGGAGCTGGGT >In-frame_RPS14_ENST00000407193_chr5_149826368_-_RPS19_ENST00000593863_chr19_42373271_+_584nt CTCCGCCCCCTCCCACTCTCTCTTTCCGGTGTGGAGTCTGGAGACGACGTGCAGGTAGGAGGCCCGGGCGCGACAATCGGGGGGCATCCT GCGGCGAGGGGACCCTGTGGGGCTTGGGACGAGAGACGGGGGTCTTTCCGTGGGAACCGAGCTAGGTGCCGGGCAAGAGACGCGCGGCTG GCCCACCTGGATCCTGGCCAACTCGGGATTGAGTTCGTTCCTGGTCTCAGAAGGCCCGTTTTGCTTTCAGGGAGGAGCTTGTGAAGTAAG GAAATGGCACCTCGAAAGGGGAAGGAAAAGAAGGAAGAACAGGTCATCAGCCTCGGACCTCAGGTGGCTGAAGGAGAGAATGTATTTGGT GTCTGCCATATCTTTGCATCCTTCAATGACACTTTTGTCCATGTCACTGATCTTTCTGGCAAGGAAACCATCTGCCGTGTGACTGGTGGG ATGAAGGTAAAGGCAGACCGAGATGAATCCTCACCATATGCTGCTATGTTGGCTGCCCAGGATGTGGCCCAGAGGTGCAAGGAGCTGGGT >In-frame_RPS14_ENST00000312037_chr5_149826368_-_RPS19_ENST00000598742_chr19_42373271_+_518nt GGCCCGGGCGCGACAATCGGGGGGCATCCTGCGGCGAGGGGACCCTGTGGGGCTTGGGACGAGAGACGGGGGTCTTTCCGTGGGAACCGA GCTAGGTGCCGGGCAAGAGACGCGCGGCTGGCCCACCTGGATCCTGGCCAACTCGGGATTGAGTTCGTTCCTGGTCTCAGAAGGCCCGTT TTGCTTTCAGGGAGGAGCTTGTGAAAAATGGCACCTCGAAAGGGGAAGGAAAAGAAGGAAGAACAGGTCATCAGCCTCGGACCTCAGGTG GCTGAAGGAGAGAATGTATTTGGTGTCTGCCATATCTTTGCATCCTTCAATGACACTTTTGTCCATGTCACTGATCTTTCTGGCAAGGAA ACCATCTGCCGTGTGACTGGTGGGATGAAGGTAAAGGCAGACCGAGATGAATCCTCACCATATGCTGCTATGTTGGCTGCCCAGGATGTG >In-frame_RPS14_ENST00000312037_chr5_149826368_-_RPS19_ENST00000221975_chr19_42373271_+_518nt GGCCCGGGCGCGACAATCGGGGGGCATCCTGCGGCGAGGGGACCCTGTGGGGCTTGGGACGAGAGACGGGGGTCTTTCCGTGGGAACCGA GCTAGGTGCCGGGCAAGAGACGCGCGGCTGGCCCACCTGGATCCTGGCCAACTCGGGATTGAGTTCGTTCCTGGTCTCAGAAGGCCCGTT TTGCTTTCAGGGAGGAGCTTGTGAAAAATGGCACCTCGAAAGGGGAAGGAAAAGAAGGAAGAACAGGTCATCAGCCTCGGACCTCAGGTG GCTGAAGGAGAGAATGTATTTGGTGTCTGCCATATCTTTGCATCCTTCAATGACACTTTTGTCCATGTCACTGATCTTTCTGGCAAGGAA ACCATCTGCCGTGTGACTGGTGGGATGAAGGTAAAGGCAGACCGAGATGAATCCTCACCATATGCTGCTATGTTGGCTGCCCAGGATGTG >In-frame_RPS14_ENST00000312037_chr5_149826368_-_RPS19_ENST00000593863_chr19_42373271_+_518nt GGCCCGGGCGCGACAATCGGGGGGCATCCTGCGGCGAGGGGACCCTGTGGGGCTTGGGACGAGAGACGGGGGTCTTTCCGTGGGAACCGA GCTAGGTGCCGGGCAAGAGACGCGCGGCTGGCCCACCTGGATCCTGGCCAACTCGGGATTGAGTTCGTTCCTGGTCTCAGAAGGCCCGTT TTGCTTTCAGGGAGGAGCTTGTGAAAAATGGCACCTCGAAAGGGGAAGGAAAAGAAGGAAGAACAGGTCATCAGCCTCGGACCTCAGGTG GCTGAAGGAGAGAATGTATTTGGTGTCTGCCATATCTTTGCATCCTTCAATGACACTTTTGTCCATGTCACTGATCTTTCTGGCAAGGAA ACCATCTGCCGTGTGACTGGTGGGATGAAGGTAAAGGCAGACCGAGATGAATCCTCACCATATGCTGCTATGTTGGCTGCCCAGGATGTG |
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FusionGenePPI for RPS14_RPS19 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RPS14_RPS19 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | RPS19 | P39019 | DB11638 | Artenimol | 40S ribosomal protein S19 | small molecule | approved|investigational |
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RelatedDiseases for RPS14_RPS19 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RPS14 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | RPS14 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | RPS14 | C0242184 | Hypoxia | 1 | CTD_human |
Tgene | RPS19 | C2676137 | Diamond-Blackfan Anemia 1 | 7 | UNIPROT |
Tgene | RPS19 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | RPS19 | C0038356 | Stomach Neoplasms | 1 | CTD_human |