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Fusion gene ID: 32057 |
FusionGeneSummary for RPS14_MB21D2 |
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Fusion gene information | Fusion gene name: RPS14_MB21D2 | Fusion gene ID: 32057 | Hgene | Tgene | Gene symbol | RPS14 | MB21D2 | Gene ID | 6208 | 151963 |
Gene name | ribosomal protein S14 | Mab-21 domain containing 2 | |
Synonyms | EMTB|S14 | C3orf59 | |
Cytomap | 5q33.1 | 3q29 | |
Type of gene | protein-coding | protein-coding | |
Description | 40S ribosomal protein S14emetine resistancesmall ribosomal subunit protein uS11 | protein MB21D2mab-21 domain-containing protein 2 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | P62263 | Q8IYB1 | |
Ensembl transtripts involved in fusion gene | ENST00000401695, ENST00000407193, ENST00000312037, | ENST00000392452, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 2 X 1 X 2=4 |
# samples | 4 | 2 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: RPS14 [Title/Abstract] AND MB21D2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RPS14 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 7867928 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BLCA | TCGA-CU-A72E-01A | RPS14 | chr5 | 149826365 | - | MB21D2 | chr3 | 192517439 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000401695 | ENST00000392452 | RPS14 | chr5 | 149826365 | - | MB21D2 | chr3 | 192517439 | - |
Frame-shift | ENST00000407193 | ENST00000392452 | RPS14 | chr5 | 149826365 | - | MB21D2 | chr3 | 192517439 | - |
Frame-shift | ENST00000312037 | ENST00000392452 | RPS14 | chr5 | 149826365 | - | MB21D2 | chr3 | 192517439 | - |
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FusionProtFeatures for RPS14_MB21D2 |
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Hgene | Tgene |
RPS14 | MB21D2 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RPS14_MB21D2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RPS14_MB21D2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RPS14 | TAF9, MAGEB2, RIPK2, TRIP6, NELFCD, RBBP6, MEPCE, CALM1, VHL, RAD21, MDM2, SIRT7, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, CAND1, RPS4X, APP, RPL11, RPL15, RPL18, RPL19, RPL30, RPL31, RPL37A, RPL4, RPL6, RPL7, RPL9, RPS11, RPS13, RPS15A, RPS23, RPS24, RPS2, RPS6, RPS7, RPS8, RPL23, RPS3, RPL5, RPS5, RPS10, RPL18A, RPL23A, RPLP2, RPSA, RPS19, RPLP0, RPS16, RPS25, RPL7A, RPS15, RPS9, RPS26, RPS3A, RPS29, EEF1A1, NOLC1, MYBBP1A, FBL, NOP58, U2AF1, NHP2L1, HNRNPM, TOP1, ILF3, HNRNPU, DHX9, GNL3, RPLP0P6, NCSTN, PRPF8, RANBP2, RBM39, RPL10L, HIST1H2AA, HP1BP3, ESR1, SENP8, SMURF1, FN1, VCAM1, SMAD2, UBL4A, ITGA4, PAN2, CD81, IGSF8, ICAM1, PEX6, RLIM, TMEM33, TARDBP, PARK2, LARP1, RPS12, RPS18, RPS20, RPS27, RPS28, WIBG, SERBP1, TSR1, ZBTB1, AURKA, CEP250, CEP57, CEP76, TP53, TUBG1, TUBGCP3, HUWE1, FUS, CUL7, CCDC8, EED, RPS6KB2, HNRNPUL2, NDUFS4, RPL10A, RPL12, RPL17, RPL27A, RPL28, AK3, GGPS1, MRPL15, MRPL3, RPL10, RPL13, RPL13A, RPL14, RPL21, RPL22, RPL24, RPL26, RPL27, RPL3, RPL34, RPL35, RPL35A, RPL36, RPL38, RPL8, RPLP1, LOC101929876, SEC61A1, UBA52, BLM, XPO1, HIST1H3E, AHSA1, NPM1, NOP56, CENPQ, CBX8, TP73, CRY1, CRY2, MCM2, ESRRB, RC3H1, PCMTD1, NOB1, FRMD8, CENPV, RRP12, ZNF430, RBM19, CCZ1, TAF1D, SDAD1, CEBPZ, TAF1C, KRR1, RPL26L1, NAT10, NOC4L, RPL36AL, KRI1, NOC2L, RRS1, BMS1, YTHDC2, DDX18, LTV1, ZNF121, PDCD11, PPAN-P2RY11, RBM28, NGDN, PRKRIR, BUD13, REXO4, DDX31, CCDC137, STAU1, NOP14, PRPF4B, DDX24, DCAF5, RPL32, CDK12, KIAA0020, NKTR, RRP8, SPTY2D1, ZNF574, SRPK1, TTF1, RPF2, DDX54, NSA2, GTPBP4, RBM42, RBMX2, ZBTB24, DHX57, CCDC59, DHX30, L3HYPDH, NOP9, NCL, CYLD, TRIM25, HEY1, BRCA1 | MB21D2 | AHI1, MKS1, CC2D2A, CEP170, CEP104, CNTROB, CEP128, CEP89, STIL, TMEM17, TMEM216, CENPJ, CDH1, KCNJ6, PTRF, RAB3IP, TRAPPC9, TRAPPC10, TRAPPC3, TRAPPC4, TRAPPC1, TRAPPC2L, TMEM102, PDLIM7, RAB3IL1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RPS14_MB21D2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RPS14_MB21D2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RPS14 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | RPS14 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | RPS14 | C0242184 | Hypoxia | 1 | CTD_human |