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Fusion gene ID: 32046 |
FusionGeneSummary for RPS11_IDH2 |
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Fusion gene information | Fusion gene name: RPS11_IDH2 | Fusion gene ID: 32046 | Hgene | Tgene | Gene symbol | RPS11 | IDH2 | Gene ID | 6205 | 3418 |
Gene name | ribosomal protein S11 | isocitrate dehydrogenase (NADP(+)) 2, mitochondrial | |
Synonyms | S11 | D2HGA2|ICD-M|IDH|IDHM|IDP|IDPM|mNADP-IDH | |
Cytomap | 19q13.33 | 15q26.1 | |
Type of gene | protein-coding | protein-coding | |
Description | 40S ribosomal protein S11small ribosomal subunit protein uS17 | isocitrate dehydrogenase [NADP], mitochondrialNADP(+)-specific ICDHisocitrate dehydrogenase 2 (NADP+), mitochondrialoxalosuccinate decarboxylase | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | P62280 | P48735 | |
Ensembl transtripts involved in fusion gene | ENST00000270625, ENST00000596873, ENST00000594493, ENST00000599561, | ENST00000330062, ENST00000539790, ENST00000559482, ENST00000540499, | |
Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 4 X 4 X 3=48 |
# samples | 4 | 5 | |
** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: RPS11 [Title/Abstract] AND IDH2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | U52144 | RPS11 | chr19 | 50002769 | - | IDH2 | chr15 | 90633860 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000270625 | ENST00000330062 | RPS11 | chr19 | 50002769 | - | IDH2 | chr15 | 90633860 | - |
intron-intron | ENST00000270625 | ENST00000539790 | RPS11 | chr19 | 50002769 | - | IDH2 | chr15 | 90633860 | - |
intron-intron | ENST00000270625 | ENST00000559482 | RPS11 | chr19 | 50002769 | - | IDH2 | chr15 | 90633860 | - |
intron-intron | ENST00000270625 | ENST00000540499 | RPS11 | chr19 | 50002769 | - | IDH2 | chr15 | 90633860 | - |
intron-3CDS | ENST00000596873 | ENST00000330062 | RPS11 | chr19 | 50002769 | - | IDH2 | chr15 | 90633860 | - |
intron-intron | ENST00000596873 | ENST00000539790 | RPS11 | chr19 | 50002769 | - | IDH2 | chr15 | 90633860 | - |
intron-intron | ENST00000596873 | ENST00000559482 | RPS11 | chr19 | 50002769 | - | IDH2 | chr15 | 90633860 | - |
intron-intron | ENST00000596873 | ENST00000540499 | RPS11 | chr19 | 50002769 | - | IDH2 | chr15 | 90633860 | - |
intron-3CDS | ENST00000594493 | ENST00000330062 | RPS11 | chr19 | 50002769 | - | IDH2 | chr15 | 90633860 | - |
intron-intron | ENST00000594493 | ENST00000539790 | RPS11 | chr19 | 50002769 | - | IDH2 | chr15 | 90633860 | - |
intron-intron | ENST00000594493 | ENST00000559482 | RPS11 | chr19 | 50002769 | - | IDH2 | chr15 | 90633860 | - |
intron-intron | ENST00000594493 | ENST00000540499 | RPS11 | chr19 | 50002769 | - | IDH2 | chr15 | 90633860 | - |
intron-3CDS | ENST00000599561 | ENST00000330062 | RPS11 | chr19 | 50002769 | - | IDH2 | chr15 | 90633860 | - |
intron-intron | ENST00000599561 | ENST00000539790 | RPS11 | chr19 | 50002769 | - | IDH2 | chr15 | 90633860 | - |
intron-intron | ENST00000599561 | ENST00000559482 | RPS11 | chr19 | 50002769 | - | IDH2 | chr15 | 90633860 | - |
intron-intron | ENST00000599561 | ENST00000540499 | RPS11 | chr19 | 50002769 | - | IDH2 | chr15 | 90633860 | - |
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FusionProtFeatures for RPS11_IDH2 |
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Hgene | Tgene |
RPS11 | IDH2 |
Plays a role in intermediary metabolism and energyproduction. It may tightly associate or interact with the pyruvatedehydrogenase complex. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RPS11_IDH2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RPS11_IDH2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RPS11_IDH2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RPS11_IDH2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | IDH2 | C0014084 | Enchondromatosis | 2 | CTD_human;HPO;ORPHANET |
Tgene | IDH2 | C0079774 | Peripheral T-Cell Lymphoma | 2 | CTD_human |
Tgene | IDH2 | C0936248 | Chondroma | 2 | CTD_human |
Tgene | IDH2 | C2750850 | GLIOMA SUSCEPTIBILITY 1 | 2 | UNIPROT |
Tgene | IDH2 | C0018916 | Hemangioma | 1 | CTD_human |
Tgene | IDH2 | C0020981 | Angioimmunoblastic Lymphadenopathy | 1 | CTD_human |
Tgene | IDH2 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Tgene | IDH2 | C0023487 | Acute Promyelocytic Leukemia | 1 | CTD_human |
Tgene | IDH2 | C0027643 | Neoplasm Recurrence, Local | 1 | CTD_human |
Tgene | IDH2 | C0028945 | oligodendroglioma | 1 | CTD_human;ORPHANET |
Tgene | IDH2 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Tgene | IDH2 | C0029456 | Osteoporosis | 1 | CTD_human |
Tgene | IDH2 | C0206698 | Cholangiocarcinoma | 1 | CTD_human |
Tgene | IDH2 | C3150909 | D-2-HYDROXYGLUTARIC ACIDURIA 2 | 1 | UNIPROT |