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Fusion gene ID: 31998 |
FusionGeneSummary for RPN1_ALDOA |
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Fusion gene information | Fusion gene name: RPN1_ALDOA | Fusion gene ID: 31998 | Hgene | Tgene | Gene symbol | RPN1 | ALDOA | Gene ID | 6184 | 226 |
Gene name | ribophorin I | aldolase, fructose-bisphosphate A | |
Synonyms | OST1|RBPH1 | ALDA|GSD12|HEL-S-87p | |
Cytomap | 3q21.3 | 16p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1RPN-Idolichyl-diphosphooligosaccharide-protein glycosyltransferase 67 kDa subunitoligosaccharyltransferase 1 homologoligosaccharyltransferase complex subunit (non-catalytic)ribop | fructose-bisphosphate aldolase Aaldolase A, fructose-bisphosphateepididymis secretory sperm binding protein Li 87pfructose-1,6-bisphosphate triosephosphate-lyaselung cancer antigen NY-LU-1muscle-type aldolase | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | P04843 | P04075 | |
Ensembl transtripts involved in fusion gene | ENST00000296255, ENST00000497289, ENST00000490166, | ENST00000338110, ENST00000395248, ENST00000575627, ENST00000566897, ENST00000569545, ENST00000563060, ENST00000412304, ENST00000564546, ENST00000564595, ENST00000569798, ENST00000395240, | |
Fusion gene scores | * DoF score | 7 X 6 X 5=210 | 1 X 1 X 1=1 |
# samples | 7 | 1 | |
** MAII score | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: RPN1 [Title/Abstract] AND ALDOA [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ALDOA | GO:0008360 | regulation of cell shape | 9244396 |
Tgene | ALDOA | GO:0030388 | fructose 1,6-bisphosphate metabolic process | 9244396|14766013 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-CH-5789-01A | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000296255 | ENST00000338110 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
5CDS-intron | ENST00000296255 | ENST00000395248 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
5CDS-intron | ENST00000296255 | ENST00000575627 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
5CDS-intron | ENST00000296255 | ENST00000566897 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
5CDS-intron | ENST00000296255 | ENST00000569545 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
5CDS-intron | ENST00000296255 | ENST00000563060 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
5CDS-5UTR | ENST00000296255 | ENST00000412304 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
5CDS-intron | ENST00000296255 | ENST00000564546 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
5CDS-intron | ENST00000296255 | ENST00000564595 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
5CDS-intron | ENST00000296255 | ENST00000569798 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
5CDS-intron | ENST00000296255 | ENST00000395240 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
intron-intron | ENST00000497289 | ENST00000338110 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
intron-intron | ENST00000497289 | ENST00000395248 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
intron-intron | ENST00000497289 | ENST00000575627 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
intron-intron | ENST00000497289 | ENST00000566897 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
intron-intron | ENST00000497289 | ENST00000569545 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
intron-intron | ENST00000497289 | ENST00000563060 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
intron-5UTR | ENST00000497289 | ENST00000412304 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
intron-intron | ENST00000497289 | ENST00000564546 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
intron-intron | ENST00000497289 | ENST00000564595 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
intron-intron | ENST00000497289 | ENST00000569798 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
intron-intron | ENST00000497289 | ENST00000395240 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
intron-intron | ENST00000490166 | ENST00000338110 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
intron-intron | ENST00000490166 | ENST00000395248 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
intron-intron | ENST00000490166 | ENST00000575627 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
intron-intron | ENST00000490166 | ENST00000566897 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
intron-intron | ENST00000490166 | ENST00000569545 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
intron-intron | ENST00000490166 | ENST00000563060 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
intron-5UTR | ENST00000490166 | ENST00000412304 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
intron-intron | ENST00000490166 | ENST00000564546 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
intron-intron | ENST00000490166 | ENST00000564595 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
intron-intron | ENST00000490166 | ENST00000569798 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
intron-intron | ENST00000490166 | ENST00000395240 | RPN1 | chr3 | 128338817 | - | ALDOA | chr16 | 30075973 | + |
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FusionProtFeatures for RPN1_ALDOA |
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Hgene | Tgene |
RPN1 | ALDOA |
Essential subunit of the N-oligosaccharyl transferase(OST) complex which catalyzes the transfer of a high mannoseoligosaccharide from a lipid-linked oligosaccharide donor to anasparagine residue within an Asn-X-Ser/Thr consensus motif innascent polypeptide chains. {ECO:0000250|UniProtKB:E2RQ08,ECO:0000250|UniProtKB:Q9GMB0, ECO:0000305}. | Plays a key role in glycolysis and gluconeogenesis. Inaddition, may also function as scaffolding protein (Bysimilarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RPN1_ALDOA |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RPN1_ALDOA |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RPN1 | GSTK1, USP49, SLX4IP, ERBB3, FOXRED2, SEL1L, RNF185, MYC, HDAC5, INSIG2, CDK9, NELFB, ELAVL1, OS9, FBXO25, CUL3, COPS5, UBQLN4, NHS, HSPA5, FBXO6, STT3B, RPN2, SSR3, RPSA, TECR, ILF3, SLC25A5, VDAC2, SYNCRIP, SND1, ESR1, ECT2, VCP, FN1, VCAM1, ATF2, UBL4A, MMS19, OST4, CLN3, CLN5, ADRB2, EGFR, ASB5, ASB11, LGR4, STAU1, SGTA, UBQLN1, EED, RNF2, BMI1, ILK, SCCPDH, RPS6KB2, ATP5C1, CANX, CCDC47, CLGN, CYC1, IDH3A, COX2, NDUFA12, NDUFB8, PC, PPIB, RAB2A, RPL35, ABCB7, ACADM, AFG3L2, ATAD3A, ATAD3B, ATP1A1, ATP5A1, ATP5L, ATP6V0D1, ATP6V1A, BCAP29, CCT3, CCT6A, CCT7, CCT8, CDC5L, CLTC, DDOST, DDX39A, DDX39B, EIF2S1, EIF3M, HNRNPU, HSD17B12, HSP90B1, IPO5, IPO9, KDSR, MTCH1, MTCH2, NDUFB9, NOMO1, NOMO2, PDIA6, PKM, PPP2R1A, PPP2R1B, PRPF19, PSMC1, PSMC2, PSMC3, PSMC5, RAB1A, RAB1B, RAB5A, RAB5B, RAB5C, RDH13, SCAMP2, SLC25A3, SSR2, SUCLG2, TCP1, TMCO1, UQCRC2, VDAC1, VDAC3, SSR1, SSR4, TUFM, NTRK1, SCARNA22, BAG6, TCTN2, TCTN3, EVC2, TCTN1, TMEM67, TUBG1, TMEM63B, TUBA1C, CRY2, MCM2, U2AF2, RC3H1, UBC, TMEM258, CDC73, DERL1, ZNF746, NCDN, COX15, DLST, PDHA1, SDHA, EDEM3 | ALDOA | XRN1, FANCA, ATP6V1E1, PLD2, USP15, OSBPL10, EGFR, TRIM63, PSMD4, H2AFX, CACNA1A, HDAC5, PCNA, PSMA3, MYC, ISG15, TERF1, CUL3, CUL4B, CUL2, CDK2, MYOC, AKT1, PGK1, ALDOC, HSPD1, LGALS1, LIG4, HSP90AA1, HSP90AB1, VCAM1, FN1, ATF2, IQCB1, MLH1, VCPKMT, ITGA4, RAD52, ALDOB, ALDOA, BCAT2, GALNT6, PIAS4, CS, TNPO3, ADRB2, HUWE1, FUS, IFNA4, SUZ12, HNRNPA1, ACAA2, ACTN4, ACO2, ADI1, ARHGDIA, ASS1, CFL1, COX4I1, ECHS1, FKBP2, GPD1L, GPX4, HSD17B10, IMPA2, ISYNA1, LMAN1, MAP2K7, MYH7B, PKM, SUMO2, TAGLN, TAGLN2, TKT, TRAP1, ATP5J, CKB, CKMT1B, CKMT1A, CKMT2, DUT, ENO1, FABP5, FH, FKBP7, GAPDH, GLO1, HSPE1, KCNAB2, LDHA, LTA4H, NDUFS4, PGAM2, PREP, SOD2, SUMO4, TALDO1, UMPS, NTRK1, HSPB2, SRPK2, AHSA1, CDK2AP1, NCSTN, NCAPH, VPS18, DRC1, MCM2, CDC73, CDH1, CARM1, DNM1L, SOAT1, SOD1, TRIM25, BRCA1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RPN1_ALDOA |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | ALDOA | P04075 | DB01593 | Zinc | Fructose-bisphosphate aldolase A | small molecule | approved|investigational |
Tgene | ALDOA | P04075 | DB11638 | Artenimol | Fructose-bisphosphate aldolase A | small molecule | approved|investigational |
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RelatedDiseases for RPN1_ALDOA |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ALDOA | C0272066 | Glycogen Storage Disease XII | 3 | CTD_human;ORPHANET;UNIPROT |
Tgene | ALDOA | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Tgene | ALDOA | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Tgene | ALDOA | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Tgene | ALDOA | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
Tgene | ALDOA | C1458155 | Mammary Neoplasms | 1 | CTD_human |