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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31998

FusionGeneSummary for RPN1_ALDOA

check button Fusion gene summary
Fusion gene informationFusion gene name: RPN1_ALDOA
Fusion gene ID: 31998
HgeneTgene
Gene symbol

RPN1

ALDOA

Gene ID

6184

226

Gene nameribophorin Ialdolase, fructose-bisphosphate A
SynonymsOST1|RBPH1ALDA|GSD12|HEL-S-87p
Cytomap

3q21.3

16p11.2

Type of geneprotein-codingprotein-coding
Descriptiondolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1RPN-Idolichyl-diphosphooligosaccharide-protein glycosyltransferase 67 kDa subunitoligosaccharyltransferase 1 homologoligosaccharyltransferase complex subunit (non-catalytic)ribopfructose-bisphosphate aldolase Aaldolase A, fructose-bisphosphateepididymis secretory sperm binding protein Li 87pfructose-1,6-bisphosphate triosephosphate-lyaselung cancer antigen NY-LU-1muscle-type aldolase
Modification date2018052320180522
UniProtAcc

P04843

P04075

Ensembl transtripts involved in fusion geneENST00000296255, ENST00000497289, 
ENST00000490166, 		ENST00000338110, 
ENST00000395248, ENST00000575627, 
ENST00000566897, ENST00000569545, 
ENST00000563060, ENST00000412304, 
ENST00000564546, ENST00000564595, 
ENST00000569798, ENST00000395240, 
Fusion gene scores* DoF score7 X 6 X 5=2101 X 1 X 1=1
# samples 71
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: RPN1 [Title/Abstract] AND ALDOA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneALDOA

GO:0008360

regulation of cell shape

9244396

TgeneALDOA

GO:0030388

fructose 1,6-bisphosphate metabolic process

9244396|14766013


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-CH-5789-01ARPN1chr3

128338817

-ALDOAchr16

30075973

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000296255ENST00000338110RPN1chr3

128338817

-ALDOAchr16

30075973

+
5CDS-intronENST00000296255ENST00000395248RPN1chr3

128338817

-ALDOAchr16

30075973

+
5CDS-intronENST00000296255ENST00000575627RPN1chr3

128338817

-ALDOAchr16

30075973

+
5CDS-intronENST00000296255ENST00000566897RPN1chr3

128338817

-ALDOAchr16

30075973

+
5CDS-intronENST00000296255ENST00000569545RPN1chr3

128338817

-ALDOAchr16

30075973

+
5CDS-intronENST00000296255ENST00000563060RPN1chr3

128338817

-ALDOAchr16

30075973

+
5CDS-5UTRENST00000296255ENST00000412304RPN1chr3

128338817

-ALDOAchr16

30075973

+
5CDS-intronENST00000296255ENST00000564546RPN1chr3

128338817

-ALDOAchr16

30075973

+
5CDS-intronENST00000296255ENST00000564595RPN1chr3

128338817

-ALDOAchr16

30075973

+
5CDS-intronENST00000296255ENST00000569798RPN1chr3

128338817

-ALDOAchr16

30075973

+
5CDS-intronENST00000296255ENST00000395240RPN1chr3

128338817

-ALDOAchr16

30075973

+
intron-intronENST00000497289ENST00000338110RPN1chr3

128338817

-ALDOAchr16

30075973

+
intron-intronENST00000497289ENST00000395248RPN1chr3

128338817

-ALDOAchr16

30075973

+
intron-intronENST00000497289ENST00000575627RPN1chr3

128338817

-ALDOAchr16

30075973

+
intron-intronENST00000497289ENST00000566897RPN1chr3

128338817

-ALDOAchr16

30075973

+
intron-intronENST00000497289ENST00000569545RPN1chr3

128338817

-ALDOAchr16

30075973

+
intron-intronENST00000497289ENST00000563060RPN1chr3

128338817

-ALDOAchr16

30075973

+
intron-5UTRENST00000497289ENST00000412304RPN1chr3

128338817

-ALDOAchr16

30075973

+
intron-intronENST00000497289ENST00000564546RPN1chr3

128338817

-ALDOAchr16

30075973

+
intron-intronENST00000497289ENST00000564595RPN1chr3

128338817

-ALDOAchr16

30075973

+
intron-intronENST00000497289ENST00000569798RPN1chr3

128338817

-ALDOAchr16

30075973

+
intron-intronENST00000497289ENST00000395240RPN1chr3

128338817

-ALDOAchr16

30075973

+
intron-intronENST00000490166ENST00000338110RPN1chr3

128338817

-ALDOAchr16

30075973

+
intron-intronENST00000490166ENST00000395248RPN1chr3

128338817

-ALDOAchr16

30075973

+
intron-intronENST00000490166ENST00000575627RPN1chr3

128338817

-ALDOAchr16

30075973

+
intron-intronENST00000490166ENST00000566897RPN1chr3

128338817

-ALDOAchr16

30075973

+
intron-intronENST00000490166ENST00000569545RPN1chr3

128338817

-ALDOAchr16

30075973

+
intron-intronENST00000490166ENST00000563060RPN1chr3

128338817

-ALDOAchr16

30075973

+
intron-5UTRENST00000490166ENST00000412304RPN1chr3

128338817

-ALDOAchr16

30075973

+
intron-intronENST00000490166ENST00000564546RPN1chr3

128338817

-ALDOAchr16

30075973

+
intron-intronENST00000490166ENST00000564595RPN1chr3

128338817

-ALDOAchr16

30075973

+
intron-intronENST00000490166ENST00000569798RPN1chr3

128338817

-ALDOAchr16

30075973

+
intron-intronENST00000490166ENST00000395240RPN1chr3

128338817

-ALDOAchr16

30075973

+

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FusionProtFeatures for RPN1_ALDOA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPN1

P04843

ALDOA

P04075

Essential subunit of the N-oligosaccharyl transferase(OST) complex which catalyzes the transfer of a high mannoseoligosaccharide from a lipid-linked oligosaccharide donor to anasparagine residue within an Asn-X-Ser/Thr consensus motif innascent polypeptide chains. {ECO:0000250|UniProtKB:E2RQ08,ECO:0000250|UniProtKB:Q9GMB0, ECO:0000305}. Plays a key role in glycolysis and gluconeogenesis. Inaddition, may also function as scaffolding protein (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPN1_ALDOA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPN1_ALDOA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RPN1GSTK1, USP49, SLX4IP, ERBB3, FOXRED2, SEL1L, RNF185, MYC, HDAC5, INSIG2, CDK9, NELFB, ELAVL1, OS9, FBXO25, CUL3, COPS5, UBQLN4, NHS, HSPA5, FBXO6, STT3B, RPN2, SSR3, RPSA, TECR, ILF3, SLC25A5, VDAC2, SYNCRIP, SND1, ESR1, ECT2, VCP, FN1, VCAM1, ATF2, UBL4A, MMS19, OST4, CLN3, CLN5, ADRB2, EGFR, ASB5, ASB11, LGR4, STAU1, SGTA, UBQLN1, EED, RNF2, BMI1, ILK, SCCPDH, RPS6KB2, ATP5C1, CANX, CCDC47, CLGN, CYC1, IDH3A, COX2, NDUFA12, NDUFB8, PC, PPIB, RAB2A, RPL35, ABCB7, ACADM, AFG3L2, ATAD3A, ATAD3B, ATP1A1, ATP5A1, ATP5L, ATP6V0D1, ATP6V1A, BCAP29, CCT3, CCT6A, CCT7, CCT8, CDC5L, CLTC, DDOST, DDX39A, DDX39B, EIF2S1, EIF3M, HNRNPU, HSD17B12, HSP90B1, IPO5, IPO9, KDSR, MTCH1, MTCH2, NDUFB9, NOMO1, NOMO2, PDIA6, PKM, PPP2R1A, PPP2R1B, PRPF19, PSMC1, PSMC2, PSMC3, PSMC5, RAB1A, RAB1B, RAB5A, RAB5B, RAB5C, RDH13, SCAMP2, SLC25A3, SSR2, SUCLG2, TCP1, TMCO1, UQCRC2, VDAC1, VDAC3, SSR1, SSR4, TUFM, NTRK1, SCARNA22, BAG6, TCTN2, TCTN3, EVC2, TCTN1, TMEM67, TUBG1, TMEM63B, TUBA1C, CRY2, MCM2, U2AF2, RC3H1, UBC, TMEM258, CDC73, DERL1, ZNF746, NCDN, COX15, DLST, PDHA1, SDHA, EDEM3ALDOAXRN1, FANCA, ATP6V1E1, PLD2, USP15, OSBPL10, EGFR, TRIM63, PSMD4, H2AFX, CACNA1A, HDAC5, PCNA, PSMA3, MYC, ISG15, TERF1, CUL3, CUL4B, CUL2, CDK2, MYOC, AKT1, PGK1, ALDOC, HSPD1, LGALS1, LIG4, HSP90AA1, HSP90AB1, VCAM1, FN1, ATF2, IQCB1, MLH1, VCPKMT, ITGA4, RAD52, ALDOB, ALDOA, BCAT2, GALNT6, PIAS4, CS, TNPO3, ADRB2, HUWE1, FUS, IFNA4, SUZ12, HNRNPA1, ACAA2, ACTN4, ACO2, ADI1, ARHGDIA, ASS1, CFL1, COX4I1, ECHS1, FKBP2, GPD1L, GPX4, HSD17B10, IMPA2, ISYNA1, LMAN1, MAP2K7, MYH7B, PKM, SUMO2, TAGLN, TAGLN2, TKT, TRAP1, ATP5J, CKB, CKMT1B, CKMT1A, CKMT2, DUT, ENO1, FABP5, FH, FKBP7, GAPDH, GLO1, HSPE1, KCNAB2, LDHA, LTA4H, NDUFS4, PGAM2, PREP, SOD2, SUMO4, TALDO1, UMPS, NTRK1, HSPB2, SRPK2, AHSA1, CDK2AP1, NCSTN, NCAPH, VPS18, DRC1, MCM2, CDC73, CDH1, CARM1, DNM1L, SOAT1, SOD1, TRIM25, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPN1_ALDOA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneALDOAP04075DB01593ZincFructose-bisphosphate aldolase Asmall moleculeapproved|investigational
TgeneALDOAP04075DB11638ArtenimolFructose-bisphosphate aldolase Asmall moleculeapproved|investigational

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RelatedDiseases for RPN1_ALDOA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneALDOAC0272066Glycogen Storage Disease XII3CTD_human;ORPHANET;UNIPROT
TgeneALDOAC0027626Neoplasm Invasiveness1CTD_human
TgeneALDOAC0027627Neoplasm Metastasis1CTD_human
TgeneALDOAC0151744Myocardial Ischemia1CTD_human
TgeneALDOAC0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneALDOAC1458155Mammary Neoplasms1CTD_human