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Fusion gene ID: 3198 |
FusionGeneSummary for ATG5_NTM |
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Fusion gene information | Fusion gene name: ATG5_NTM | Fusion gene ID: 3198 | Hgene | Tgene | Gene symbol | ATG5 | NTM | Gene ID | 9474 | 50863 |
Gene name | autophagy related 5 | neurotrimin | |
Synonyms | APG5|APG5-LIKE|APG5L|ASP|SCAR25|hAPG5 | CEPU-1|HNT|IGLON2|NTRI | |
Cytomap | 6q21 | 11q25 | |
Type of gene | protein-coding | protein-coding | |
Description | autophagy protein 5APG5 autophagy 5-likeATG5 autophagy related 5 homologapoptosis-specific protein | neurotriminIgLON family member 2 | |
Modification date | 20180527 | 20180522 | |
UniProtAcc | Q9H1Y0 | Q9P121 | |
Ensembl transtripts involved in fusion gene | ENST00000343245, ENST00000369070, ENST00000369076, ENST00000360666, ENST00000475645, | ENST00000374791, ENST00000539799, ENST00000427481, ENST00000374786, ENST00000425719, ENST00000374784, ENST00000474900, | |
Fusion gene scores | * DoF score | 16 X 8 X 9=1152 | 2 X 3 X 2=12 |
# samples | 16 | 2 | |
** MAII score | log2(16/1152*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/12*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ATG5 [Title/Abstract] AND NTM [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUSC | TCGA-77-A5G6-01A | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
TCGA | LD | LUSC | TCGA-77-A5G6-01A | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000343245 | ENST00000374791 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
Frame-shift | ENST00000343245 | ENST00000539799 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
Frame-shift | ENST00000343245 | ENST00000427481 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
Frame-shift | ENST00000343245 | ENST00000374786 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
Frame-shift | ENST00000343245 | ENST00000425719 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
Frame-shift | ENST00000343245 | ENST00000374784 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
5CDS-intron | ENST00000343245 | ENST00000474900 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
Frame-shift | ENST00000369070 | ENST00000374791 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
Frame-shift | ENST00000369070 | ENST00000539799 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
Frame-shift | ENST00000369070 | ENST00000427481 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
Frame-shift | ENST00000369070 | ENST00000374786 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
Frame-shift | ENST00000369070 | ENST00000425719 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
Frame-shift | ENST00000369070 | ENST00000374784 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
5CDS-intron | ENST00000369070 | ENST00000474900 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
Frame-shift | ENST00000369076 | ENST00000374791 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
Frame-shift | ENST00000369076 | ENST00000539799 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
Frame-shift | ENST00000369076 | ENST00000427481 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
Frame-shift | ENST00000369076 | ENST00000374786 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
Frame-shift | ENST00000369076 | ENST00000425719 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
Frame-shift | ENST00000369076 | ENST00000374784 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
5CDS-intron | ENST00000369076 | ENST00000474900 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
Frame-shift | ENST00000360666 | ENST00000374791 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
Frame-shift | ENST00000360666 | ENST00000539799 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
Frame-shift | ENST00000360666 | ENST00000427481 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
Frame-shift | ENST00000360666 | ENST00000374786 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
Frame-shift | ENST00000360666 | ENST00000425719 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
Frame-shift | ENST00000360666 | ENST00000374784 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
5CDS-intron | ENST00000360666 | ENST00000474900 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
intron-3CDS | ENST00000475645 | ENST00000374791 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
intron-3CDS | ENST00000475645 | ENST00000539799 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
intron-3CDS | ENST00000475645 | ENST00000427481 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
intron-3CDS | ENST00000475645 | ENST00000374786 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
intron-3CDS | ENST00000475645 | ENST00000425719 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
intron-3CDS | ENST00000475645 | ENST00000374784 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
intron-intron | ENST00000475645 | ENST00000474900 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131781458 | + |
5CDS-intron | ENST00000343245 | ENST00000374791 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000343245 | ENST00000539799 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000343245 | ENST00000427481 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000343245 | ENST00000374786 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000343245 | ENST00000425719 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000343245 | ENST00000374784 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000343245 | ENST00000474900 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000369070 | ENST00000374791 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000369070 | ENST00000539799 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000369070 | ENST00000427481 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000369070 | ENST00000374786 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000369070 | ENST00000425719 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000369070 | ENST00000374784 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000369070 | ENST00000474900 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000369076 | ENST00000374791 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000369076 | ENST00000539799 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000369076 | ENST00000427481 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000369076 | ENST00000374786 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000369076 | ENST00000425719 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000369076 | ENST00000374784 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000369076 | ENST00000474900 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000360666 | ENST00000374791 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000360666 | ENST00000539799 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000360666 | ENST00000427481 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000360666 | ENST00000374786 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000360666 | ENST00000425719 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000360666 | ENST00000374784 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
5CDS-intron | ENST00000360666 | ENST00000474900 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
intron-intron | ENST00000475645 | ENST00000374791 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
intron-intron | ENST00000475645 | ENST00000539799 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
intron-intron | ENST00000475645 | ENST00000427481 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
intron-intron | ENST00000475645 | ENST00000374786 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
intron-intron | ENST00000475645 | ENST00000425719 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
intron-intron | ENST00000475645 | ENST00000374784 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
intron-intron | ENST00000475645 | ENST00000474900 | ATG5 | chr6 | 106696025 | - | NTM | chr11 | 131530823 | + |
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FusionProtFeatures for ATG5_NTM |
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Hgene | Tgene |
ATG5 | NTM |
Involved in autophagic vesicle formation. Conjugationwith ATG12, through a ubiquitin-like conjugating system involvingATG7 as an E1-like activating enzyme and ATG10 as an E2-likeconjugating enzyme, is essential for its function. The ATG12-ATG5conjugate acts as an E3-like enzyme which is required forlipidation of ATG8 family proteins and their association to thevesicle membranes. Involved in mitochondrial quality control afteroxidative damage, and in subsequent cellular longevity. Plays acritical role in multiple aspects of lymphocyte development and isessential for both B and T lymphocyte survival and proliferation.Required for optimal processing and presentation of antigens forMHC II. Involved in the maintenance of axon morphology andmembrane structures, as well as in normal adipocytedifferentiation. Promotes primary ciliogenesis through removal ofOFD1 from centriolar satellites and degradation of IFT20 via theautophagic pathway. {ECO:0000250|UniProtKB:Q99J83,ECO:0000269|PubMed:12207896, ECO:0000269|PubMed:20580051,ECO:0000269|PubMed:22170153, ECO:0000269|PubMed:26812546}. May play an important role in the apoptotic process,possibly within the modified cytoskeleton. Its expression is arelatively late event in the apoptotic process, occurringdownstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.{ECO:0000269|PubMed:15778222, ECO:0000269|PubMed:7796880}. (Microbial infection) May act as a proviral factor. Inassociation with ATG12, negatively regulates the innate antiviralimmune response by impairing the type I IFN production pathwayupon vesicular stomatitis virus (VSV) infection (PubMed:17709747).Required for the translation of incoming hepatitis C virus (HCV)RNA and, thereby, for initiation of HCV replication, but notrequired once infection is established (PubMed:19666601).{ECO:0000269|PubMed:17709747, ECO:0000269|PubMed:19666601}. | Neural cell adhesion molecule. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ATG5_NTM |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ATG5_NTM |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ATG5 | ATG12, IMPDH2, ATG16L1, ATG3, TECPR1, TKT, MAP1LC3B, MAP1LC3C, SIRT1, ELAVL1, TAB2, TAB3, WDFY3, HTT, CAV1, EXOC4, RB1CC1, FADD, WIPI2, MEOX2, VCP, KEAP1, CCHCR1, TEKT4, CAPN1, CAPN2, BCL2L1, XPO1, BCL10, SQSTM1, CALCOCO2, OPTN, BSN, IKBIP | NTM | APP, LSAMP, NEGR1, NTM, CCKBR, KRTAP5-9, KRTAP3-2, C19orf47, HAX1, NUFIP1, DGUOK, OPCML, CALR, PDIA5, FBXO2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ATG5_NTM |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ATG5_NTM |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ATG5 | C0002871 | Anemia | 1 | CTD_human |
Hgene | ATG5 | C0019209 | Hepatomegaly | 1 | CTD_human |
Hgene | ATG5 | C0023380 | Lethargy | 1 | CTD_human |
Hgene | ATG5 | C0024312 | Lymphopenia | 1 | CTD_human |
Hgene | ATG5 | C0027540 | Necrosis | 1 | CTD_human |
Hgene | ATG5 | C1262477 | Weight decreased | 1 | CTD_human |
Hgene | ATG5 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Tgene | NTM | C0041696 | Unipolar Depression | 1 | PSYGENET |
Tgene | NTM | C1269683 | Major Depressive Disorder | 1 | PSYGENET |