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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3198

FusionGeneSummary for ATG5_NTM

check button Fusion gene summary
Fusion gene informationFusion gene name: ATG5_NTM
Fusion gene ID: 3198
HgeneTgene
Gene symbol

ATG5

NTM

Gene ID

9474

50863

Gene nameautophagy related 5neurotrimin
SynonymsAPG5|APG5-LIKE|APG5L|ASP|SCAR25|hAPG5CEPU-1|HNT|IGLON2|NTRI
Cytomap

6q21

11q25

Type of geneprotein-codingprotein-coding
Descriptionautophagy protein 5APG5 autophagy 5-likeATG5 autophagy related 5 homologapoptosis-specific proteinneurotriminIgLON family member 2
Modification date2018052720180522
UniProtAcc

Q9H1Y0

Q9P121

Ensembl transtripts involved in fusion geneENST00000343245, ENST00000369070, 
ENST00000369076, ENST00000360666, 
ENST00000475645, 
ENST00000374791, 
ENST00000539799, ENST00000427481, 
ENST00000374786, ENST00000425719, 
ENST00000374784, ENST00000474900, 
Fusion gene scores* DoF score16 X 8 X 9=11522 X 3 X 2=12
# samples 162
** MAII scorelog2(16/1152*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ATG5 [Title/Abstract] AND NTM [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-77-A5G6-01AATG5chr6

106696025

-NTMchr11

131781458

+
TCGALDLUSCTCGA-77-A5G6-01AATG5chr6

106696025

-NTMchr11

131530823

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000343245ENST00000374791ATG5chr6

106696025

-NTMchr11

131781458

+
Frame-shiftENST00000343245ENST00000539799ATG5chr6

106696025

-NTMchr11

131781458

+
Frame-shiftENST00000343245ENST00000427481ATG5chr6

106696025

-NTMchr11

131781458

+
Frame-shiftENST00000343245ENST00000374786ATG5chr6

106696025

-NTMchr11

131781458

+
Frame-shiftENST00000343245ENST00000425719ATG5chr6

106696025

-NTMchr11

131781458

+
Frame-shiftENST00000343245ENST00000374784ATG5chr6

106696025

-NTMchr11

131781458

+
5CDS-intronENST00000343245ENST00000474900ATG5chr6

106696025

-NTMchr11

131781458

+
Frame-shiftENST00000369070ENST00000374791ATG5chr6

106696025

-NTMchr11

131781458

+
Frame-shiftENST00000369070ENST00000539799ATG5chr6

106696025

-NTMchr11

131781458

+
Frame-shiftENST00000369070ENST00000427481ATG5chr6

106696025

-NTMchr11

131781458

+
Frame-shiftENST00000369070ENST00000374786ATG5chr6

106696025

-NTMchr11

131781458

+
Frame-shiftENST00000369070ENST00000425719ATG5chr6

106696025

-NTMchr11

131781458

+
Frame-shiftENST00000369070ENST00000374784ATG5chr6

106696025

-NTMchr11

131781458

+
5CDS-intronENST00000369070ENST00000474900ATG5chr6

106696025

-NTMchr11

131781458

+
Frame-shiftENST00000369076ENST00000374791ATG5chr6

106696025

-NTMchr11

131781458

+
Frame-shiftENST00000369076ENST00000539799ATG5chr6

106696025

-NTMchr11

131781458

+
Frame-shiftENST00000369076ENST00000427481ATG5chr6

106696025

-NTMchr11

131781458

+
Frame-shiftENST00000369076ENST00000374786ATG5chr6

106696025

-NTMchr11

131781458

+
Frame-shiftENST00000369076ENST00000425719ATG5chr6

106696025

-NTMchr11

131781458

+
Frame-shiftENST00000369076ENST00000374784ATG5chr6

106696025

-NTMchr11

131781458

+
5CDS-intronENST00000369076ENST00000474900ATG5chr6

106696025

-NTMchr11

131781458

+
Frame-shiftENST00000360666ENST00000374791ATG5chr6

106696025

-NTMchr11

131781458

+
Frame-shiftENST00000360666ENST00000539799ATG5chr6

106696025

-NTMchr11

131781458

+
Frame-shiftENST00000360666ENST00000427481ATG5chr6

106696025

-NTMchr11

131781458

+
Frame-shiftENST00000360666ENST00000374786ATG5chr6

106696025

-NTMchr11

131781458

+
Frame-shiftENST00000360666ENST00000425719ATG5chr6

106696025

-NTMchr11

131781458

+
Frame-shiftENST00000360666ENST00000374784ATG5chr6

106696025

-NTMchr11

131781458

+
5CDS-intronENST00000360666ENST00000474900ATG5chr6

106696025

-NTMchr11

131781458

+
intron-3CDSENST00000475645ENST00000374791ATG5chr6

106696025

-NTMchr11

131781458

+
intron-3CDSENST00000475645ENST00000539799ATG5chr6

106696025

-NTMchr11

131781458

+
intron-3CDSENST00000475645ENST00000427481ATG5chr6

106696025

-NTMchr11

131781458

+
intron-3CDSENST00000475645ENST00000374786ATG5chr6

106696025

-NTMchr11

131781458

+
intron-3CDSENST00000475645ENST00000425719ATG5chr6

106696025

-NTMchr11

131781458

+
intron-3CDSENST00000475645ENST00000374784ATG5chr6

106696025

-NTMchr11

131781458

+
intron-intronENST00000475645ENST00000474900ATG5chr6

106696025

-NTMchr11

131781458

+
5CDS-intronENST00000343245ENST00000374791ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000343245ENST00000539799ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000343245ENST00000427481ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000343245ENST00000374786ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000343245ENST00000425719ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000343245ENST00000374784ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000343245ENST00000474900ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000369070ENST00000374791ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000369070ENST00000539799ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000369070ENST00000427481ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000369070ENST00000374786ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000369070ENST00000425719ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000369070ENST00000374784ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000369070ENST00000474900ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000369076ENST00000374791ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000369076ENST00000539799ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000369076ENST00000427481ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000369076ENST00000374786ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000369076ENST00000425719ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000369076ENST00000374784ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000369076ENST00000474900ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000360666ENST00000374791ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000360666ENST00000539799ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000360666ENST00000427481ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000360666ENST00000374786ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000360666ENST00000425719ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000360666ENST00000374784ATG5chr6

106696025

-NTMchr11

131530823

+
5CDS-intronENST00000360666ENST00000474900ATG5chr6

106696025

-NTMchr11

131530823

+
intron-intronENST00000475645ENST00000374791ATG5chr6

106696025

-NTMchr11

131530823

+
intron-intronENST00000475645ENST00000539799ATG5chr6

106696025

-NTMchr11

131530823

+
intron-intronENST00000475645ENST00000427481ATG5chr6

106696025

-NTMchr11

131530823

+
intron-intronENST00000475645ENST00000374786ATG5chr6

106696025

-NTMchr11

131530823

+
intron-intronENST00000475645ENST00000425719ATG5chr6

106696025

-NTMchr11

131530823

+
intron-intronENST00000475645ENST00000374784ATG5chr6

106696025

-NTMchr11

131530823

+
intron-intronENST00000475645ENST00000474900ATG5chr6

106696025

-NTMchr11

131530823

+

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FusionProtFeatures for ATG5_NTM


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATG5

Q9H1Y0

NTM

Q9P121

Involved in autophagic vesicle formation. Conjugationwith ATG12, through a ubiquitin-like conjugating system involvingATG7 as an E1-like activating enzyme and ATG10 as an E2-likeconjugating enzyme, is essential for its function. The ATG12-ATG5conjugate acts as an E3-like enzyme which is required forlipidation of ATG8 family proteins and their association to thevesicle membranes. Involved in mitochondrial quality control afteroxidative damage, and in subsequent cellular longevity. Plays acritical role in multiple aspects of lymphocyte development and isessential for both B and T lymphocyte survival and proliferation.Required for optimal processing and presentation of antigens forMHC II. Involved in the maintenance of axon morphology andmembrane structures, as well as in normal adipocytedifferentiation. Promotes primary ciliogenesis through removal ofOFD1 from centriolar satellites and degradation of IFT20 via theautophagic pathway. {ECO:0000250|UniProtKB:Q99J83,ECO:0000269|PubMed:12207896, ECO:0000269|PubMed:20580051,ECO:0000269|PubMed:22170153, ECO:0000269|PubMed:26812546}. May play an important role in the apoptotic process,possibly within the modified cytoskeleton. Its expression is arelatively late event in the apoptotic process, occurringdownstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.{ECO:0000269|PubMed:15778222, ECO:0000269|PubMed:7796880}. (Microbial infection) May act as a proviral factor. Inassociation with ATG12, negatively regulates the innate antiviralimmune response by impairing the type I IFN production pathwayupon vesicular stomatitis virus (VSV) infection (PubMed:17709747).Required for the translation of incoming hepatitis C virus (HCV)RNA and, thereby, for initiation of HCV replication, but notrequired once infection is established (PubMed:19666601).{ECO:0000269|PubMed:17709747, ECO:0000269|PubMed:19666601}. Neural cell adhesion molecule.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATG5_NTM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATG5_NTM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATG5ATG12, IMPDH2, ATG16L1, ATG3, TECPR1, TKT, MAP1LC3B, MAP1LC3C, SIRT1, ELAVL1, TAB2, TAB3, WDFY3, HTT, CAV1, EXOC4, RB1CC1, FADD, WIPI2, MEOX2, VCP, KEAP1, CCHCR1, TEKT4, CAPN1, CAPN2, BCL2L1, XPO1, BCL10, SQSTM1, CALCOCO2, OPTN, BSN, IKBIPNTMAPP, LSAMP, NEGR1, NTM, CCKBR, KRTAP5-9, KRTAP3-2, C19orf47, HAX1, NUFIP1, DGUOK, OPCML, CALR, PDIA5, FBXO2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATG5_NTM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATG5_NTM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATG5C0002871Anemia1CTD_human
HgeneATG5C0019209Hepatomegaly1CTD_human
HgeneATG5C0023380Lethargy1CTD_human
HgeneATG5C0024312Lymphopenia1CTD_human
HgeneATG5C0027540Necrosis1CTD_human
HgeneATG5C1262477Weight decreased1CTD_human
HgeneATG5C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneNTMC0041696Unipolar Depression1PSYGENET
TgeneNTMC1269683Major Depressive Disorder1PSYGENET