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Fusion gene ID: 31897 |
FusionGeneSummary for RPL35_NOC2L |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RPL35_NOC2L | Fusion gene ID: 31897 | Hgene | Tgene | Gene symbol | RPL35 | NOC2L | Gene ID | 11224 | 26155 |
| Gene name | ribosomal protein L35 | NOC2 like nucleolar associated transcriptional repressor | |
| Synonyms | L35 | NET15|NET7|NIR|PPP1R112 | |
| Cytomap | 9q33.3 | 1p36.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 60S ribosomal protein L35large ribosomal subunit protein uL29 | nucleolar complex protein 2 homologNOC2-like proteinNOC2L nucleolar associated transcriptional repressornovel INHAT (inhibitor of histone acetyltransferase) repressornovel INHAT repressornucleolar complex associated 2 homologprotein NOC2 homologpro | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P42766 | Q9Y3T9 | |
| Ensembl transtripts involved in fusion gene | ENST00000373570, ENST00000348462, | ENST00000327044, ENST00000487214, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: RPL35 [Title/Abstract] AND NOC2L [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NOC2L | GO:0000122 | negative regulation of transcription by RNA polymerase II | 20123734|20959462 |
| Tgene | NOC2L | GO:0031497 | chromatin assembly | 16322561 |
| Tgene | NOC2L | GO:0034644 | cellular response to UV | 20959462 |
| Tgene | NOC2L | GO:0035067 | negative regulation of histone acetylation | 16322561 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CA433490 | RPL35 | chr9 | 127620282 | + | NOC2L | chr1 | 892529 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000373570 | ENST00000327044 | RPL35 | chr9 | 127620282 | + | NOC2L | chr1 | 892529 | + |
| intron-5UTR | ENST00000373570 | ENST00000487214 | RPL35 | chr9 | 127620282 | + | NOC2L | chr1 | 892529 | + |
| intron-3CDS | ENST00000348462 | ENST00000327044 | RPL35 | chr9 | 127620282 | + | NOC2L | chr1 | 892529 | + |
| intron-5UTR | ENST00000348462 | ENST00000487214 | RPL35 | chr9 | 127620282 | + | NOC2L | chr1 | 892529 | + |
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FusionProtFeatures for RPL35_NOC2L |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RPL35 | NOC2L |
| Component of the large ribosomal subunit.{ECO:0000305|PubMed:12962325}. | Acts as an inhibitor of histone acetyltransferaseactivity; prevents acetylation of all core histones by theEP300/p300 histone acetyltransferase at p53/TP53-regulated targetpromoters in a histone deacetylases (HDAC)-independent manner.Acts as a transcription corepressor of p53/TP53- and TP63-mediatedtransactivation of the p21/CDKN1A promoter. Involved in theregulation of p53/TP53-dependent apoptosis. Associates togetherwith TP63 isoform TA*-gamma to the p21/CDKN1A promoter.{ECO:0000269|PubMed:16322561, ECO:0000269|PubMed:20123734,ECO:0000269|PubMed:20959462}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RPL35_NOC2L |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RPL35_NOC2L |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RPL35_NOC2L |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | RPL35 | P42766 | DB11638 | Artenimol | 60S ribosomal protein L35 | small molecule | approved|investigational |
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RelatedDiseases for RPL35_NOC2L |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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