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Fusion gene ID: 31890 |
FusionGeneSummary for RPL34_DHRS12 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RPL34_DHRS12 | Fusion gene ID: 31890 | Hgene | Tgene | Gene symbol | RPL34 | DHRS12 | Gene ID | 6164 | 79758 |
| Gene name | ribosomal protein L34 | dehydrogenase/reductase 12 | |
| Synonyms | L34 | SDR40C1 | |
| Cytomap | 4q25 | 13q14.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 60S ribosomal protein L34large ribosomal subunit protein eL34leukemia-associated protein | dehydrogenase/reductase SDR family member 12dehydrogenase/reductase (SDR family) member 12short-chain dehydrogenase/reductase family 40C member 1 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | P49207 | A0PJE2 | |
| Ensembl transtripts involved in fusion gene | ENST00000394667, ENST00000502534, ENST00000394665, ENST00000506397, ENST00000394668, | ENST00000444610, ENST00000218981, ENST00000280056, ENST00000490949, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 4 X 3 X 3=36 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: RPL34 [Title/Abstract] AND DHRS12 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AO-A1KS-01A | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000394667 | ENST00000444610 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
| 5CDS-3UTR | ENST00000394667 | ENST00000218981 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
| 5CDS-intron | ENST00000394667 | ENST00000280056 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
| 5CDS-intron | ENST00000394667 | ENST00000490949 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
| In-frame | ENST00000502534 | ENST00000444610 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
| 5CDS-3UTR | ENST00000502534 | ENST00000218981 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
| 5CDS-intron | ENST00000502534 | ENST00000280056 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
| 5CDS-intron | ENST00000502534 | ENST00000490949 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
| In-frame | ENST00000394665 | ENST00000444610 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
| 5CDS-3UTR | ENST00000394665 | ENST00000218981 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
| 5CDS-intron | ENST00000394665 | ENST00000280056 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
| 5CDS-intron | ENST00000394665 | ENST00000490949 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
| In-frame | ENST00000506397 | ENST00000444610 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
| 5CDS-3UTR | ENST00000506397 | ENST00000218981 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
| 5CDS-intron | ENST00000506397 | ENST00000280056 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
| 5CDS-intron | ENST00000506397 | ENST00000490949 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
| In-frame | ENST00000394668 | ENST00000444610 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
| 5CDS-3UTR | ENST00000394668 | ENST00000218981 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
| 5CDS-intron | ENST00000394668 | ENST00000280056 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
| 5CDS-intron | ENST00000394668 | ENST00000490949 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
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FusionProtFeatures for RPL34_DHRS12 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RPL34 | DHRS12 |
| Component of the large ribosomal subunit.{ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680,ECO:0000269|PubMed:25957688, ECO:0000305|PubMed:12962325}. | Putative oxidoreductase. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >DHRS12 | chr4:109543360 | chr13:52342432 | ENST00000218981 | - | 0 | 8 | 47_53 | -38 | 243 | Nucleotide binding | NAD or NADP |
| Tgene | >DHRS12 | chr4:109543360 | chr13:52342432 | ENST00000280056 | - | 0 | 8 | 47_53 | -18 | 272 | Nucleotide binding | NAD or NADP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | DHRS12 | chr4:109543360 | chr13:52342432 | ENST00000444610 | - | 8 | 10 | 47_53 | 281 | 318 | Nucleotide binding | NAD or NADP |
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FusionGeneSequence for RPL34_DHRS12 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RPL34_ENST00000394667_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_91aa MVQRLTYRRRLSYNTASNKTRLSRTPGNRIVYLYTKKVGKAPKSACGVCPGRLRGIGSQFLHTCLSLQRPPHRPKRRNSLKSWNSWLRHL >In-frame_RPL34_ENST00000502534_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_91aa MVQRLTYRRRLSYNTASNKTRLSRTPGNRIVYLYTKKVGKAPKSACGVCPGRLRGIGSQFLHTCLSLQRPPHRPKRRNSLKSWNSWLRHL >In-frame_RPL34_ENST00000394665_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_91aa MVQRLTYRRRLSYNTASNKTRLSRTPGNRIVYLYTKKVGKAPKSACGVCPGRLRGIGSQFLHTCLSLQRPPHRPKRRNSLKSWNSWLRHL >In-frame_RPL34_ENST00000506397_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_91aa MVQRLTYRRRLSYNTASNKTRLSRTPGNRIVYLYTKKVGKAPKSACGVCPGRLRGIGSQFLHTCLSLQRPPHRPKRRNSLKSWNSWLRHL >In-frame_RPL34_ENST00000394668_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_91aa MVQRLTYRRRLSYNTASNKTRLSRTPGNRIVYLYTKKVGKAPKSACGVCPGRLRGIGSQFLHTCLSLQRPPHRPKRRNSLKSWNSWLRHL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RPL34_ENST00000394667_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_275nt ATGGTCCAGCGTTTGACATACCGACGTAGGCTTTCCTACAATACAGCCTCTAACAAAACTAGGCTGTCCCGAACCCCTGGTAATAGAATT GTTTACCTTTATACCAAGAAGGTTGGGAAAGCACCAAAATCTGCATGTGGTGTGTGCCCAGGCAGACTTCGAGGGATCGGAAGCCAGTTT CTACACACTTGCCTCTCGCTACAGCGTCCTCCTCACCGGCCGAAGAGGAGAAACTCATTGAAATCCTGGAACAGCTGGCTCAGACATTTA >In-frame_RPL34_ENST00000502534_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_275nt ATGGTCCAGCGTTTGACATACCGACGTAGGCTTTCCTACAATACAGCCTCTAACAAAACTAGGCTGTCCCGAACCCCTGGTAATAGAATT GTTTACCTTTATACCAAGAAGGTTGGGAAAGCACCAAAATCTGCATGTGGTGTGTGCCCAGGCAGACTTCGAGGGATCGGAAGCCAGTTT CTACACACTTGCCTCTCGCTACAGCGTCCTCCTCACCGGCCGAAGAGGAGAAACTCATTGAAATCCTGGAACAGCTGGCTCAGACATTTA >In-frame_RPL34_ENST00000394665_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_275nt ATGGTCCAGCGTTTGACATACCGACGTAGGCTTTCCTACAATACAGCCTCTAACAAAACTAGGCTGTCCCGAACCCCTGGTAATAGAATT GTTTACCTTTATACCAAGAAGGTTGGGAAAGCACCAAAATCTGCATGTGGTGTGTGCCCAGGCAGACTTCGAGGGATCGGAAGCCAGTTT CTACACACTTGCCTCTCGCTACAGCGTCCTCCTCACCGGCCGAAGAGGAGAAACTCATTGAAATCCTGGAACAGCTGGCTCAGACATTTA >In-frame_RPL34_ENST00000506397_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_275nt ATGGTCCAGCGTTTGACATACCGACGTAGGCTTTCCTACAATACAGCCTCTAACAAAACTAGGCTGTCCCGAACCCCTGGTAATAGAATT GTTTACCTTTATACCAAGAAGGTTGGGAAAGCACCAAAATCTGCATGTGGTGTGTGCCCAGGCAGACTTCGAGGGATCGGAAGCCAGTTT CTACACACTTGCCTCTCGCTACAGCGTCCTCCTCACCGGCCGAAGAGGAGAAACTCATTGAAATCCTGGAACAGCTGGCTCAGACATTTA >In-frame_RPL34_ENST00000394668_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_275nt ATGGTCCAGCGTTTGACATACCGACGTAGGCTTTCCTACAATACAGCCTCTAACAAAACTAGGCTGTCCCGAACCCCTGGTAATAGAATT GTTTACCTTTATACCAAGAAGGTTGGGAAAGCACCAAAATCTGCATGTGGTGTGTGCCCAGGCAGACTTCGAGGGATCGGAAGCCAGTTT CTACACACTTGCCTCTCGCTACAGCGTCCTCCTCACCGGCCGAAGAGGAGAAACTCATTGAAATCCTGGAACAGCTGGCTCAGACATTTA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RPL34_ENST00000394667_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_513nt CTTTTTTCTTCCTCTTCCGGGGACGTTGTCTGCAGGCACTCAGAATGGTCCAGCGTTTGACATACCGACGTAGGCTTTCCTACAATACAG CCTCTAACAAAACTAGGCTGTCCCGAACCCCTGGTAATAGAATTGTTTACCTTTATACCAAGAAGGTTGGGAAAGCACCAAAATCTGCAT GTGGTGTGTGCCCAGGCAGACTTCGAGGGATCGGAAGCCAGTTTCTACACACTTGCCTCTCGCTACAGCGTCCTCCTCACCGGCCGAAGA GGAGAAACTCATTGAAATCCTGGAACAGCTGGCTCAGACATTTAAATAGGCCAACCCAGACACAGTGCGGTACCAGAATTGCCTTAGAAG ATACCAGAAGGTGCGGTCTAGGGACCAGTGAATAAGAAGACCCCACTTCAACTTCCCCTCGAAGACGTTGTGCCTCACAGCGAGGCCTAC >In-frame_RPL34_ENST00000502534_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_510nt TTTTCTTCCTCTTCCGGGGACGTTGTCTGCAGGCACTCAGAATGGTCCAGCGTTTGACATACCGACGTAGGCTTTCCTACAATACAGCCT CTAACAAAACTAGGCTGTCCCGAACCCCTGGTAATAGAATTGTTTACCTTTATACCAAGAAGGTTGGGAAAGCACCAAAATCTGCATGTG GTGTGTGCCCAGGCAGACTTCGAGGGATCGGAAGCCAGTTTCTACACACTTGCCTCTCGCTACAGCGTCCTCCTCACCGGCCGAAGAGGA GAAACTCATTGAAATCCTGGAACAGCTGGCTCAGACATTTAAATAGGCCAACCCAGACACAGTGCGGTACCAGAATTGCCTTAGAAGATA CCAGAAGGTGCGGTCTAGGGACCAGTGAATAAGAAGACCCCACTTCAACTTCCCCTCGAAGACGTTGTGCCTCACAGCGAGGCCTACAAG >In-frame_RPL34_ENST00000394665_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_601nt GTTGTCTGCAGGTATGGATGTTGTTCTCTTTTCCCTGTCTTTATTTCCTTACCAATCGGCTGCCATCCGAGGAGCTGAGGAAGCCTAGAG CTCTCAGAAGCAGTCCTTTGAGCTGGTGTAGGGGCACTCAGAATGGTCCAGCGTTTGACATACCGACGTAGGCTTTCCTACAATACAGCC TCTAACAAAACTAGGCTGTCCCGAACCCCTGGTAATAGAATTGTTTACCTTTATACCAAGAAGGTTGGGAAAGCACCAAAATCTGCATGT GGTGTGTGCCCAGGCAGACTTCGAGGGATCGGAAGCCAGTTTCTACACACTTGCCTCTCGCTACAGCGTCCTCCTCACCGGCCGAAGAGG AGAAACTCATTGAAATCCTGGAACAGCTGGCTCAGACATTTAAATAGGCCAACCCAGACACAGTGCGGTACCAGAATTGCCTTAGAAGAT ACCAGAAGGTGCGGTCTAGGGACCAGTGAATAAGAAGACCCCACTTCAACTTCCCCTCGAAGACGTTGTGCCTCACAGCGAGGCCTACAA >In-frame_RPL34_ENST00000506397_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_624nt TTTCCTTACCAATCGGCTGCCATCCGAGGAGCTGAGGAAGCCTAGAGCTCTCAGAAGCAGTCCTTTGAGCTGGTGTAGGGCGGTGTTTCT CCAACTGGGCTCGTGGCACTTTTCTGGACACCACTCCAAACAAAATTAGACTCTGAGCACTCAGAATGGTCCAGCGTTTGACATACCGAC GTAGGCTTTCCTACAATACAGCCTCTAACAAAACTAGGCTGTCCCGAACCCCTGGTAATAGAATTGTTTACCTTTATACCAAGAAGGTTG GGAAAGCACCAAAATCTGCATGTGGTGTGTGCCCAGGCAGACTTCGAGGGATCGGAAGCCAGTTTCTACACACTTGCCTCTCGCTACAGC GTCCTCCTCACCGGCCGAAGAGGAGAAACTCATTGAAATCCTGGAACAGCTGGCTCAGACATTTAAATAGGCCAACCCAGACACAGTGCG GTACCAGAATTGCCTTAGAAGATACCAGAAGGTGCGGTCTAGGGACCAGTGAATAAGAAGACCCCACTTCAACTTCCCCTCGAAGACGTT >In-frame_RPL34_ENST00000394668_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_535nt CCGAGGAGCTGAGGAAGCCTAGAGCTCTCAGAAGCAGTCCTTTGAGCTGGTGTAGGGGCACTCAGAATGGTCCAGCGTTTGACATACCGA CGTAGGCTTTCCTACAATACAGCCTCTAACAAAACTAGGCTGTCCCGAACCCCTGGTAATAGAATTGTTTACCTTTATACCAAGAAGGTT GGGAAAGCACCAAAATCTGCATGTGGTGTGTGCCCAGGCAGACTTCGAGGGATCGGAAGCCAGTTTCTACACACTTGCCTCTCGCTACAG CGTCCTCCTCACCGGCCGAAGAGGAGAAACTCATTGAAATCCTGGAACAGCTGGCTCAGACATTTAAATAGGCCAACCCAGACACAGTGC GGTACCAGAATTGCCTTAGAAGATACCAGAAGGTGCGGTCTAGGGACCAGTGAATAAGAAGACCCCACTTCAACTTCCCCTCGAAGACGT |
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FusionGenePPI for RPL34_DHRS12 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RPL34 | DDX56, CNBP, MAGEB2, EIF6, PSTPIP1, HDGF, CDK5, CDK4, CDK2, CUL1, CAND1, APP, UBL4A, PAN2, DAPK3, MAX, ZBTB1, MOV10, NXF1, BRCA1, RNF2, EBNA1BP2, RPL10A, RPL12, RPL13A, RPL14, RPL15, RPL21, RPL23, RPL23A, RPL24, RPL27, RPL27A, RPL28, RPL30, RPL32, RPL13, RPL18, RPL19, RPL22, RPL26, RPL26L1, RPL3, RPL31, RPL38, RPL6, RPL8, RPLP0, RPS13, RPS15A, RPS16, RPS20, RPL35, RPL35A, RPL36, RPL37A, RPL4, RPL5, RPL7, RPL7A, RPL9, RPLP1, RPS11, RPS14, RPS15, RPS18, RPS2, RPS21, RPS23, RPS25, LOC101929876, RPS26, RPS27, RPS3, RPS3A, RPS6, RPS8, RPS9, RPSA, UBA52, SFN, SRPK2, KBTBD7, MCM2, ZNF746, CDH1, MTMR6, RRS1, CYLD, TRIM25 | DHRS12 | H3F3A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RPL34_DHRS12 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RPL34_DHRS12 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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