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Fusion gene ID: 31890 |
FusionGeneSummary for RPL34_DHRS12 |
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Fusion gene information | Fusion gene name: RPL34_DHRS12 | Fusion gene ID: 31890 | Hgene | Tgene | Gene symbol | RPL34 | DHRS12 | Gene ID | 6164 | 79758 |
Gene name | ribosomal protein L34 | dehydrogenase/reductase 12 | |
Synonyms | L34 | SDR40C1 | |
Cytomap | 4q25 | 13q14.3 | |
Type of gene | protein-coding | protein-coding | |
Description | 60S ribosomal protein L34large ribosomal subunit protein eL34leukemia-associated protein | dehydrogenase/reductase SDR family member 12dehydrogenase/reductase (SDR family) member 12short-chain dehydrogenase/reductase family 40C member 1 | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | P49207 | A0PJE2 | |
Ensembl transtripts involved in fusion gene | ENST00000394667, ENST00000502534, ENST00000394665, ENST00000506397, ENST00000394668, | ENST00000444610, ENST00000218981, ENST00000280056, ENST00000490949, | |
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 4 X 3 X 3=36 |
# samples | 4 | 4 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: RPL34 [Title/Abstract] AND DHRS12 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AO-A1KS-01A | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000394667 | ENST00000444610 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
5CDS-3UTR | ENST00000394667 | ENST00000218981 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
5CDS-intron | ENST00000394667 | ENST00000280056 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
5CDS-intron | ENST00000394667 | ENST00000490949 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
In-frame | ENST00000502534 | ENST00000444610 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
5CDS-3UTR | ENST00000502534 | ENST00000218981 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
5CDS-intron | ENST00000502534 | ENST00000280056 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
5CDS-intron | ENST00000502534 | ENST00000490949 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
In-frame | ENST00000394665 | ENST00000444610 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
5CDS-3UTR | ENST00000394665 | ENST00000218981 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
5CDS-intron | ENST00000394665 | ENST00000280056 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
5CDS-intron | ENST00000394665 | ENST00000490949 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
In-frame | ENST00000506397 | ENST00000444610 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
5CDS-3UTR | ENST00000506397 | ENST00000218981 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
5CDS-intron | ENST00000506397 | ENST00000280056 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
5CDS-intron | ENST00000506397 | ENST00000490949 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
In-frame | ENST00000394668 | ENST00000444610 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
5CDS-3UTR | ENST00000394668 | ENST00000218981 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
5CDS-intron | ENST00000394668 | ENST00000280056 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
5CDS-intron | ENST00000394668 | ENST00000490949 | RPL34 | chr4 | 109543360 | + | DHRS12 | chr13 | 52342432 | - |
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FusionProtFeatures for RPL34_DHRS12 |
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Hgene | Tgene |
RPL34 | DHRS12 |
Component of the large ribosomal subunit.{ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680,ECO:0000269|PubMed:25957688, ECO:0000305|PubMed:12962325}. | Putative oxidoreductase. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >DHRS12 | chr4:109543360 | chr13:52342432 | ENST00000218981 | - | 0 | 8 | 47_53 | -38 | 243 | Nucleotide binding | NAD or NADP |
Tgene | >DHRS12 | chr4:109543360 | chr13:52342432 | ENST00000280056 | - | 0 | 8 | 47_53 | -18 | 272 | Nucleotide binding | NAD or NADP |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | DHRS12 | chr4:109543360 | chr13:52342432 | ENST00000444610 | - | 8 | 10 | 47_53 | 281 | 318 | Nucleotide binding | NAD or NADP |
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FusionGeneSequence for RPL34_DHRS12 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_RPL34_ENST00000394667_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_91aa MVQRLTYRRRLSYNTASNKTRLSRTPGNRIVYLYTKKVGKAPKSACGVCPGRLRGIGSQFLHTCLSLQRPPHRPKRRNSLKSWNSWLRHL >In-frame_RPL34_ENST00000502534_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_91aa MVQRLTYRRRLSYNTASNKTRLSRTPGNRIVYLYTKKVGKAPKSACGVCPGRLRGIGSQFLHTCLSLQRPPHRPKRRNSLKSWNSWLRHL >In-frame_RPL34_ENST00000394665_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_91aa MVQRLTYRRRLSYNTASNKTRLSRTPGNRIVYLYTKKVGKAPKSACGVCPGRLRGIGSQFLHTCLSLQRPPHRPKRRNSLKSWNSWLRHL >In-frame_RPL34_ENST00000506397_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_91aa MVQRLTYRRRLSYNTASNKTRLSRTPGNRIVYLYTKKVGKAPKSACGVCPGRLRGIGSQFLHTCLSLQRPPHRPKRRNSLKSWNSWLRHL >In-frame_RPL34_ENST00000394668_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_91aa MVQRLTYRRRLSYNTASNKTRLSRTPGNRIVYLYTKKVGKAPKSACGVCPGRLRGIGSQFLHTCLSLQRPPHRPKRRNSLKSWNSWLRHL |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_RPL34_ENST00000394667_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_275nt ATGGTCCAGCGTTTGACATACCGACGTAGGCTTTCCTACAATACAGCCTCTAACAAAACTAGGCTGTCCCGAACCCCTGGTAATAGAATT GTTTACCTTTATACCAAGAAGGTTGGGAAAGCACCAAAATCTGCATGTGGTGTGTGCCCAGGCAGACTTCGAGGGATCGGAAGCCAGTTT CTACACACTTGCCTCTCGCTACAGCGTCCTCCTCACCGGCCGAAGAGGAGAAACTCATTGAAATCCTGGAACAGCTGGCTCAGACATTTA >In-frame_RPL34_ENST00000502534_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_275nt ATGGTCCAGCGTTTGACATACCGACGTAGGCTTTCCTACAATACAGCCTCTAACAAAACTAGGCTGTCCCGAACCCCTGGTAATAGAATT GTTTACCTTTATACCAAGAAGGTTGGGAAAGCACCAAAATCTGCATGTGGTGTGTGCCCAGGCAGACTTCGAGGGATCGGAAGCCAGTTT CTACACACTTGCCTCTCGCTACAGCGTCCTCCTCACCGGCCGAAGAGGAGAAACTCATTGAAATCCTGGAACAGCTGGCTCAGACATTTA >In-frame_RPL34_ENST00000394665_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_275nt ATGGTCCAGCGTTTGACATACCGACGTAGGCTTTCCTACAATACAGCCTCTAACAAAACTAGGCTGTCCCGAACCCCTGGTAATAGAATT GTTTACCTTTATACCAAGAAGGTTGGGAAAGCACCAAAATCTGCATGTGGTGTGTGCCCAGGCAGACTTCGAGGGATCGGAAGCCAGTTT CTACACACTTGCCTCTCGCTACAGCGTCCTCCTCACCGGCCGAAGAGGAGAAACTCATTGAAATCCTGGAACAGCTGGCTCAGACATTTA >In-frame_RPL34_ENST00000506397_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_275nt ATGGTCCAGCGTTTGACATACCGACGTAGGCTTTCCTACAATACAGCCTCTAACAAAACTAGGCTGTCCCGAACCCCTGGTAATAGAATT GTTTACCTTTATACCAAGAAGGTTGGGAAAGCACCAAAATCTGCATGTGGTGTGTGCCCAGGCAGACTTCGAGGGATCGGAAGCCAGTTT CTACACACTTGCCTCTCGCTACAGCGTCCTCCTCACCGGCCGAAGAGGAGAAACTCATTGAAATCCTGGAACAGCTGGCTCAGACATTTA >In-frame_RPL34_ENST00000394668_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_275nt ATGGTCCAGCGTTTGACATACCGACGTAGGCTTTCCTACAATACAGCCTCTAACAAAACTAGGCTGTCCCGAACCCCTGGTAATAGAATT GTTTACCTTTATACCAAGAAGGTTGGGAAAGCACCAAAATCTGCATGTGGTGTGTGCCCAGGCAGACTTCGAGGGATCGGAAGCCAGTTT CTACACACTTGCCTCTCGCTACAGCGTCCTCCTCACCGGCCGAAGAGGAGAAACTCATTGAAATCCTGGAACAGCTGGCTCAGACATTTA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_RPL34_ENST00000394667_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_513nt CTTTTTTCTTCCTCTTCCGGGGACGTTGTCTGCAGGCACTCAGAATGGTCCAGCGTTTGACATACCGACGTAGGCTTTCCTACAATACAG CCTCTAACAAAACTAGGCTGTCCCGAACCCCTGGTAATAGAATTGTTTACCTTTATACCAAGAAGGTTGGGAAAGCACCAAAATCTGCAT GTGGTGTGTGCCCAGGCAGACTTCGAGGGATCGGAAGCCAGTTTCTACACACTTGCCTCTCGCTACAGCGTCCTCCTCACCGGCCGAAGA GGAGAAACTCATTGAAATCCTGGAACAGCTGGCTCAGACATTTAAATAGGCCAACCCAGACACAGTGCGGTACCAGAATTGCCTTAGAAG ATACCAGAAGGTGCGGTCTAGGGACCAGTGAATAAGAAGACCCCACTTCAACTTCCCCTCGAAGACGTTGTGCCTCACAGCGAGGCCTAC >In-frame_RPL34_ENST00000502534_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_510nt TTTTCTTCCTCTTCCGGGGACGTTGTCTGCAGGCACTCAGAATGGTCCAGCGTTTGACATACCGACGTAGGCTTTCCTACAATACAGCCT CTAACAAAACTAGGCTGTCCCGAACCCCTGGTAATAGAATTGTTTACCTTTATACCAAGAAGGTTGGGAAAGCACCAAAATCTGCATGTG GTGTGTGCCCAGGCAGACTTCGAGGGATCGGAAGCCAGTTTCTACACACTTGCCTCTCGCTACAGCGTCCTCCTCACCGGCCGAAGAGGA GAAACTCATTGAAATCCTGGAACAGCTGGCTCAGACATTTAAATAGGCCAACCCAGACACAGTGCGGTACCAGAATTGCCTTAGAAGATA CCAGAAGGTGCGGTCTAGGGACCAGTGAATAAGAAGACCCCACTTCAACTTCCCCTCGAAGACGTTGTGCCTCACAGCGAGGCCTACAAG >In-frame_RPL34_ENST00000394665_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_601nt GTTGTCTGCAGGTATGGATGTTGTTCTCTTTTCCCTGTCTTTATTTCCTTACCAATCGGCTGCCATCCGAGGAGCTGAGGAAGCCTAGAG CTCTCAGAAGCAGTCCTTTGAGCTGGTGTAGGGGCACTCAGAATGGTCCAGCGTTTGACATACCGACGTAGGCTTTCCTACAATACAGCC TCTAACAAAACTAGGCTGTCCCGAACCCCTGGTAATAGAATTGTTTACCTTTATACCAAGAAGGTTGGGAAAGCACCAAAATCTGCATGT GGTGTGTGCCCAGGCAGACTTCGAGGGATCGGAAGCCAGTTTCTACACACTTGCCTCTCGCTACAGCGTCCTCCTCACCGGCCGAAGAGG AGAAACTCATTGAAATCCTGGAACAGCTGGCTCAGACATTTAAATAGGCCAACCCAGACACAGTGCGGTACCAGAATTGCCTTAGAAGAT ACCAGAAGGTGCGGTCTAGGGACCAGTGAATAAGAAGACCCCACTTCAACTTCCCCTCGAAGACGTTGTGCCTCACAGCGAGGCCTACAA >In-frame_RPL34_ENST00000506397_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_624nt TTTCCTTACCAATCGGCTGCCATCCGAGGAGCTGAGGAAGCCTAGAGCTCTCAGAAGCAGTCCTTTGAGCTGGTGTAGGGCGGTGTTTCT CCAACTGGGCTCGTGGCACTTTTCTGGACACCACTCCAAACAAAATTAGACTCTGAGCACTCAGAATGGTCCAGCGTTTGACATACCGAC GTAGGCTTTCCTACAATACAGCCTCTAACAAAACTAGGCTGTCCCGAACCCCTGGTAATAGAATTGTTTACCTTTATACCAAGAAGGTTG GGAAAGCACCAAAATCTGCATGTGGTGTGTGCCCAGGCAGACTTCGAGGGATCGGAAGCCAGTTTCTACACACTTGCCTCTCGCTACAGC GTCCTCCTCACCGGCCGAAGAGGAGAAACTCATTGAAATCCTGGAACAGCTGGCTCAGACATTTAAATAGGCCAACCCAGACACAGTGCG GTACCAGAATTGCCTTAGAAGATACCAGAAGGTGCGGTCTAGGGACCAGTGAATAAGAAGACCCCACTTCAACTTCCCCTCGAAGACGTT >In-frame_RPL34_ENST00000394668_chr4_109543360_+_DHRS12_ENST00000444610_chr13_52342432_-_535nt CCGAGGAGCTGAGGAAGCCTAGAGCTCTCAGAAGCAGTCCTTTGAGCTGGTGTAGGGGCACTCAGAATGGTCCAGCGTTTGACATACCGA CGTAGGCTTTCCTACAATACAGCCTCTAACAAAACTAGGCTGTCCCGAACCCCTGGTAATAGAATTGTTTACCTTTATACCAAGAAGGTT GGGAAAGCACCAAAATCTGCATGTGGTGTGTGCCCAGGCAGACTTCGAGGGATCGGAAGCCAGTTTCTACACACTTGCCTCTCGCTACAG CGTCCTCCTCACCGGCCGAAGAGGAGAAACTCATTGAAATCCTGGAACAGCTGGCTCAGACATTTAAATAGGCCAACCCAGACACAGTGC GGTACCAGAATTGCCTTAGAAGATACCAGAAGGTGCGGTCTAGGGACCAGTGAATAAGAAGACCCCACTTCAACTTCCCCTCGAAGACGT |
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FusionGenePPI for RPL34_DHRS12 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RPL34 | DDX56, CNBP, MAGEB2, EIF6, PSTPIP1, HDGF, CDK5, CDK4, CDK2, CUL1, CAND1, APP, UBL4A, PAN2, DAPK3, MAX, ZBTB1, MOV10, NXF1, BRCA1, RNF2, EBNA1BP2, RPL10A, RPL12, RPL13A, RPL14, RPL15, RPL21, RPL23, RPL23A, RPL24, RPL27, RPL27A, RPL28, RPL30, RPL32, RPL13, RPL18, RPL19, RPL22, RPL26, RPL26L1, RPL3, RPL31, RPL38, RPL6, RPL8, RPLP0, RPS13, RPS15A, RPS16, RPS20, RPL35, RPL35A, RPL36, RPL37A, RPL4, RPL5, RPL7, RPL7A, RPL9, RPLP1, RPS11, RPS14, RPS15, RPS18, RPS2, RPS21, RPS23, RPS25, LOC101929876, RPS26, RPS27, RPS3, RPS3A, RPS6, RPS8, RPS9, RPSA, UBA52, SFN, SRPK2, KBTBD7, MCM2, ZNF746, CDH1, MTMR6, RRS1, CYLD, TRIM25 | DHRS12 | H3F3A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RPL34_DHRS12 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RPL34_DHRS12 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |