FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 31835

FusionGeneSummary for RPL22_PRDM16

check button Fusion gene summary
Fusion gene informationFusion gene name: RPL22_PRDM16
Fusion gene ID: 31835
HgeneTgene
Gene symbol

RPL22

PRDM16

Gene ID

6146

63976

Gene nameribosomal protein L22PR/SET domain 16
SynonymsEAP|HBP15|HBP15/L22|L22CMD1LL|KMT8F|LVNC8|MEL1|PFM13
Cytomap

1p36.31

1p36.32

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L22EBER-associated proteinEpstein-Barr virus small RNA-associated proteinEpstein-Barr-encoded RNA-associated proteinheparin-binding protein 15heparin-binding protein HBp15large ribosomal subunit protein eL22PR domain zinc finger protein 16MDS1/EVI1-like gene 1PR domain 16PR domain containing 16transcription factor MEL1
Modification date2018052320180522
UniProtAcc

P35268

Q9HAZ2

Ensembl transtripts involved in fusion geneENST00000484532, ENST00000234875, 
ENST00000497965, 
ENST00000511072, 
ENST00000442529, ENST00000378398, 
ENST00000441472, ENST00000378391, 
ENST00000514189, ENST00000270722, 
ENST00000512462, 
Fusion gene scores* DoF score6 X 4 X 5=1205 X 4 X 4=80
# samples 65
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPL22 [Title/Abstract] AND PRDM16 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePRDM16

GO:0000122

negative regulation of transcription by RNA polymerase II

19049980

TgenePRDM16

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

14656887

TgenePRDM16

GO:0045892

negative regulation of transcription, DNA-templated

12816872

TgenePRDM16

GO:0045893

positive regulation of transcription, DNA-templated

25578880


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-AB2X-01ARPL22chr1

6257712

-PRDM16chr1

3342145

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000484532ENST00000511072RPL22chr1

6257712

-PRDM16chr1

3342145

+
Frame-shitENST00000484532ENST00000442529RPL22chr1

6257712

-PRDM16chr1

3342145

+
Frame-shitENST00000484532ENST00000378398RPL22chr1

6257712

-PRDM16chr1

3342145

+
Frame-shitENST00000484532ENST00000441472RPL22chr1

6257712

-PRDM16chr1

3342145

+
Frame-shitENST00000484532ENST00000378391RPL22chr1

6257712

-PRDM16chr1

3342145

+
Frame-shitENST00000484532ENST00000514189RPL22chr1

6257712

-PRDM16chr1

3342145

+
Frame-shitENST00000484532ENST00000270722RPL22chr1

6257712

-PRDM16chr1

3342145

+
5CDS-3UTRENST00000484532ENST00000512462RPL22chr1

6257712

-PRDM16chr1

3342145

+
Frame-shitENST00000234875ENST00000511072RPL22chr1

6257712

-PRDM16chr1

3342145

+
Frame-shitENST00000234875ENST00000442529RPL22chr1

6257712

-PRDM16chr1

3342145

+
Frame-shitENST00000234875ENST00000378398RPL22chr1

6257712

-PRDM16chr1

3342145

+
Frame-shitENST00000234875ENST00000441472RPL22chr1

6257712

-PRDM16chr1

3342145

+
Frame-shitENST00000234875ENST00000378391RPL22chr1

6257712

-PRDM16chr1

3342145

+
Frame-shitENST00000234875ENST00000514189RPL22chr1

6257712

-PRDM16chr1

3342145

+
Frame-shitENST00000234875ENST00000270722RPL22chr1

6257712

-PRDM16chr1

3342145

+
5CDS-3UTRENST00000234875ENST00000512462RPL22chr1

6257712

-PRDM16chr1

3342145

+
Frame-shitENST00000497965ENST00000511072RPL22chr1

6257712

-PRDM16chr1

3342145

+
Frame-shitENST00000497965ENST00000442529RPL22chr1

6257712

-PRDM16chr1

3342145

+
Frame-shitENST00000497965ENST00000378398RPL22chr1

6257712

-PRDM16chr1

3342145

+
Frame-shitENST00000497965ENST00000441472RPL22chr1

6257712

-PRDM16chr1

3342145

+
Frame-shitENST00000497965ENST00000378391RPL22chr1

6257712

-PRDM16chr1

3342145

+
Frame-shitENST00000497965ENST00000514189RPL22chr1

6257712

-PRDM16chr1

3342145

+
Frame-shitENST00000497965ENST00000270722RPL22chr1

6257712

-PRDM16chr1

3342145

+
5CDS-3UTRENST00000497965ENST00000512462RPL22chr1

6257712

-PRDM16chr1

3342145

+

Top

FusionProtFeatures for RPL22_PRDM16


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPL22

P35268

PRDM16

Q9HAZ2

Binds DNA and functions as a transcriptional regulator.Functions in the differentiation of brown adipose tissue (BAT)which is specialized in dissipating chemical energy in the form ofheat in response to cold or excess feeding while white adiposetissue (WAT) is specialized in the storage of excess energy andthe control of systemic metabolism. Together with CEBPB, regulatesthe differentiation of myoblastic precursors into brown adiposecells. Functions also as a repressor of TGF-beta signaling.Isoform 4 may regulate granulocytes differentiation.{ECO:0000269|PubMed:12816872, ECO:0000269|PubMed:14656887,ECO:0000269|PubMed:19049980}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for RPL22_PRDM16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for RPL22_PRDM16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RPL22NSFL1C, CSE1L, CDC42, UBC, POU5F1, CD4, CALM1, MAPK14, RAD21, HDGF, ARRB1, ARRB2, NFX1, CUL3, CUL4A, CUL5, CUL2, CDK2, CUL1, COPS5, CAND1, PRAME, RPL15, RPL18, RPL19, RPL24, RPL37A, RPL14, RPS23, RPL11, RPL13, RPL4, RPS11, RPS13, RPS8, RPL6, RPL21, RPL27A, RPL5, RPL23A, RPS16, RPL7, RPL18A, RPS3A, RPL30, RPS26, RPS4X, RPS3, RPL7A, RPS6, RPS2, RPLP0, RPSA, RPS17, RPS24, RPS19, RPL23, RPL31, RPL12, RPL10A, RPS27A, RPS21, RPL17, ILF3, HNRNPM, RPS27L, RPL10L, STRAP, RPLP0P6, HSP90AA4P, DHX15, ESR1, SMURF1, VCAM1, FN1, IL7R, UBL4A, ITGA4, PAN2, CD81, IGSF8, ICAM1, SRPK2, TARDBP, PARK2, ARFGAP1, GTF3C4, HEXB, AURKA, CEP57, CEP76, TUBG1, VCP, HUWE1, PHF6, CCDC8, EED, RNF2, EGFR, LUZP4, WDR76, HNRNPU, LUC7L2, RPL10, RPL13A, ATP1B3, RPL38, RPL8, RPS12, RPS20, RPS5, RPL26, RPL26L1, RPL27, RPL3, RPL34, RPL35, RPL35A, RPL36, RPL9, RPLP2, RPS10, RPS14, RPS15, RPS15A, RPS18, RPS25, LOC101929876, RPS27, RPS7, RPS9, AHSA1, MYH9, NPM1, THOC5, NOP56, CBX8, MCM2, RC3H1, CDC73, NCL, CYLD, TRIM25PRDM16SMAD2, SMAD3, SKI, TFAP4, SPDEF


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RPL22_PRDM16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for RPL22_PRDM16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePRDM16C0149931Migraine Disorders1CTD_human
TgenePRDM16C3809288LEFT VENTRICULAR NONCOMPACTION 81ORPHANET;UNIPROT