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Fusion gene ID: 31824 |
FusionGeneSummary for RPL18_ZNF827 |
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Fusion gene information | Fusion gene name: RPL18_ZNF827 | Fusion gene ID: 31824 | Hgene | Tgene | Gene symbol | RPL18 | ZNF827 | Gene ID | 6141 | 152485 |
Gene name | ribosomal protein L18 | zinc finger protein 827 | |
Synonyms | L18 | - | |
Cytomap | 19q13.33 | 4q31.21-q31.22 | |
Type of gene | protein-coding | protein-coding | |
Description | 60S ribosomal protein L18large ribosomal subunit protein eL18 | zinc finger protein 827 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q07020 | Q17R98 | |
Ensembl transtripts involved in fusion gene | ENST00000549920, ENST00000550645, ENST00000552588, ENST00000549273, | ENST00000508784, ENST00000513320, ENST00000379448, ENST00000511534, | |
Fusion gene scores | * DoF score | 20 X 12 X 6=1440 | 10 X 4 X 7=280 |
# samples | 21 | 10 | |
** MAII score | log2(21/1440*10)=-2.77760757866355 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/280*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RPL18 [Title/Abstract] AND ZNF827 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RPL18 | GO:0002181 | cytoplasmic translation | 25957688 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-D9-A4Z3-01A | RPL18 | chr19 | 49118590 | - | ZNF827 | chr4 | 146859787 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000549920 | ENST00000508784 | RPL18 | chr19 | 49118590 | - | ZNF827 | chr4 | 146859787 | - |
5CDS-intron | ENST00000549920 | ENST00000513320 | RPL18 | chr19 | 49118590 | - | ZNF827 | chr4 | 146859787 | - |
5CDS-intron | ENST00000549920 | ENST00000379448 | RPL18 | chr19 | 49118590 | - | ZNF827 | chr4 | 146859787 | - |
5CDS-intron | ENST00000549920 | ENST00000511534 | RPL18 | chr19 | 49118590 | - | ZNF827 | chr4 | 146859787 | - |
Frame-shift | ENST00000550645 | ENST00000508784 | RPL18 | chr19 | 49118590 | - | ZNF827 | chr4 | 146859787 | - |
5CDS-intron | ENST00000550645 | ENST00000513320 | RPL18 | chr19 | 49118590 | - | ZNF827 | chr4 | 146859787 | - |
5CDS-intron | ENST00000550645 | ENST00000379448 | RPL18 | chr19 | 49118590 | - | ZNF827 | chr4 | 146859787 | - |
5CDS-intron | ENST00000550645 | ENST00000511534 | RPL18 | chr19 | 49118590 | - | ZNF827 | chr4 | 146859787 | - |
Frame-shift | ENST00000552588 | ENST00000508784 | RPL18 | chr19 | 49118590 | - | ZNF827 | chr4 | 146859787 | - |
5CDS-intron | ENST00000552588 | ENST00000513320 | RPL18 | chr19 | 49118590 | - | ZNF827 | chr4 | 146859787 | - |
5CDS-intron | ENST00000552588 | ENST00000379448 | RPL18 | chr19 | 49118590 | - | ZNF827 | chr4 | 146859787 | - |
5CDS-intron | ENST00000552588 | ENST00000511534 | RPL18 | chr19 | 49118590 | - | ZNF827 | chr4 | 146859787 | - |
intron-3CDS | ENST00000549273 | ENST00000508784 | RPL18 | chr19 | 49118590 | - | ZNF827 | chr4 | 146859787 | - |
intron-intron | ENST00000549273 | ENST00000513320 | RPL18 | chr19 | 49118590 | - | ZNF827 | chr4 | 146859787 | - |
intron-intron | ENST00000549273 | ENST00000379448 | RPL18 | chr19 | 49118590 | - | ZNF827 | chr4 | 146859787 | - |
intron-intron | ENST00000549273 | ENST00000511534 | RPL18 | chr19 | 49118590 | - | ZNF827 | chr4 | 146859787 | - |
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FusionProtFeatures for RPL18_ZNF827 |
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Hgene | Tgene |
RPL18 | ZNF827 |
Component of the large ribosomal subunit.{ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680,ECO:0000269|PubMed:25957688, ECO:0000305|PubMed:12962325}. | May be involved in transcriptional regulation.{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RPL18_ZNF827 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RPL18_ZNF827 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RPL18 | FANCA, FANCC, ESR1, CD4, NOP56, DYRK2, ARRB2, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, RPL10A, RPL11, RPL12, RPL13, RPL15, RPL18A, RPL19, RPL21, RPL22, RPL23, RPL24, RPL27A, RPL31, RPL37A, RPL3, RPL4, RPL5, RPL6, RPL7A, RPL7, RPL8, RPL9, RPS13, RPS14, RPS15A, RPS16, RPS19, RPS23, RPS25, RPS26, RPS28, RPS2, RPS3A, RPS3, RPS4X, RPS5, RPS6, RPS7, RPS8, RPSA, RPL23A, RPL14, RPL30, RPS24, RPS12, RPS20, RPS11, RPLP0, RPL36, RPL27, RPS9, RPL10, RPL35, RPS17, RPL38, RPL17, RPL32, RPS21, RPS27A, EEF2, EEF1A1, FBL, ILF3, HNRNPU, NCL, SLC25A5, ILF2, MYBBP1A, EEF1D, NHP2L1, ACTA2, HNRNPM, U2AF2, RPS27L, ATP5A1, MYL12A, RPL10L, RPLP0P6, NOP2, PTGES3, RPS10P5, ATP5B, HIST1H2AD, NIFK, HSP90AA5P, RHOA, TUBA1B, MRPL12, MAGOH, EIF4A3, PA2G4, FN1, VCAM1, IL7R, UBL4A, ITGA4, PAN2, IGSF8, ICAM1, CDKN1A, FBXO6, EEF1E1, FAU, IARS, NUDT21, RPA3, RPA2, RPA1, ZBTB1, STAU1, CEP250, TP53, HUWE1, FUS, CUL7, OBSL1, CCDC8, EED, RBM4B, NTRK1, HNRNPUL2, PABPC1, PABPC4, RPL13A, RPL26L1, RPL3L, RPLP1, RPS27, RPL26, RPL34, RPL35A, RPLP2, RPS10, RPS15, RPS18, LOC101929876, SFN, XPO1, NPM1, CENPQ, SKI, MCM2, NF2, RC3H1, ZNF746, CEBPZ, PDCD11, FNTB, VPRBP, UBE2O, NOC2L, RRP8, CNBP, NLE1, NSUN4, KIAA0020, MINA, GNL2, RRS1, EBNA1BP2, CENPC, REXO4, TTC19, RBM34, NOL8, NAP1L1, GTPBP4, RBM28, ZC3H10, SPTY2D1, DKC1, DDX10, C1QBP, FTSJ3, MRPL48, DDX27, FNTA, MECP2, BRIX1, NAP1L4, ZNF512, MRPS31, DDX51, ZNF22, ZC3HAV1, DDX24, DDX52, MRPL16, RRP7A, MRPS33, MRPL28, ZNF644, HERC5, MRPS9, FCF1, MRPL13, MRPS18C, MRPL32, MRPS35, RBM19, DDX54, NOC3L, RPL28, MRPL47, URB1, DDX56, DHX30, RRP1, ZNF771, BUD13, RPF2, PAK1IP1, MRPL27, MRPL24, NSA2, DDX18, C3orf17, MRPL20, PPAN-P2RY11, MRPL17, MRPS5, MRPL3, UTP3, GNL3, MRPS10, MRPL51, CYLD, INO80B, TRIM25, BRCA1, YAP1 | ZNF827 | PPP1CA, UBE2E1, ATP6V1E1, CHERP, VPS45, UNC80, HDAC1, GATAD2A, GATAD2B, RBBP7, RBBP4, CHD3, CHD4, MTA1, MTA2, MTA3, HDAC2, MCPH1, BRCA1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RPL18_ZNF827 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | RPL18 | Q07020 | DB11638 | Artenimol | 60S ribosomal protein L18 | small molecule | approved|investigational |
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RelatedDiseases for RPL18_ZNF827 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RPL18 | C0038356 | Stomach Neoplasms | 1 | CTD_human |