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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3181

FusionGeneSummary for ATG3_KCNIP4

check button Fusion gene summary
Fusion gene informationFusion gene name: ATG3_KCNIP4
Fusion gene ID: 3181
HgeneTgene
Gene symbol

ATG3

KCNIP4

Gene ID

64422

80333

Gene nameautophagy related 3potassium voltage-gated channel interacting protein 4
SynonymsAPG3|APG3-LIKE|APG3L|PC3-96CALP|KCHIP4
Cytomap

3q13.2

4p15.31-p15.2

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-like-conjugating enzyme ATG32610016C12RikAPG3 autophagy 3-likeATG3 autophagy related 3 homologautophagy-related protein 3hApg3Kv channel-interacting protein 4Kv channel interacting protein 4a-type potassium channel modulatory protein 4calsenilin-like protein
Modification date2018052620180523
UniProtAcc

Q9NT62

Q6PIL6

Ensembl transtripts involved in fusion geneENST00000283290, ENST00000402314, 
ENST00000495756, 
ENST00000382148, 
ENST00000447367, ENST00000382150, 
ENST00000382152, ENST00000509207, 
ENST00000382149, ENST00000359001, 
Fusion gene scores* DoF score1 X 1 X 1=112 X 7 X 9=756
# samples 213
** MAII scorelog2(2/1*10)=4.32192809488736log2(13/756*10)=-2.53987461119262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATG3 [Title/Abstract] AND KCNIP4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATG3

GO:0006464

cellular protein modification process

11825910

HgeneATG3

GO:0016567

protein ubiquitination

11825910


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW386111ATG3chr3

112260688

+KCNIP4chr4

21235057

-
ChiTaRS3.1AW386112ATG3chr3

112260688

+KCNIP4chr4

21235057

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000283290ENST00000382148ATG3chr3

112260688

+KCNIP4chr4

21235057

-
intron-intronENST00000283290ENST00000447367ATG3chr3

112260688

+KCNIP4chr4

21235057

-
intron-intronENST00000283290ENST00000382150ATG3chr3

112260688

+KCNIP4chr4

21235057

-
intron-intronENST00000283290ENST00000382152ATG3chr3

112260688

+KCNIP4chr4

21235057

-
intron-intronENST00000283290ENST00000509207ATG3chr3

112260688

+KCNIP4chr4

21235057

-
intron-intronENST00000283290ENST00000382149ATG3chr3

112260688

+KCNIP4chr4

21235057

-
intron-intronENST00000283290ENST00000359001ATG3chr3

112260688

+KCNIP4chr4

21235057

-
intron-intronENST00000402314ENST00000382148ATG3chr3

112260688

+KCNIP4chr4

21235057

-
intron-intronENST00000402314ENST00000447367ATG3chr3

112260688

+KCNIP4chr4

21235057

-
intron-intronENST00000402314ENST00000382150ATG3chr3

112260688

+KCNIP4chr4

21235057

-
intron-intronENST00000402314ENST00000382152ATG3chr3

112260688

+KCNIP4chr4

21235057

-
intron-intronENST00000402314ENST00000509207ATG3chr3

112260688

+KCNIP4chr4

21235057

-
intron-intronENST00000402314ENST00000382149ATG3chr3

112260688

+KCNIP4chr4

21235057

-
intron-intronENST00000402314ENST00000359001ATG3chr3

112260688

+KCNIP4chr4

21235057

-
intron-intronENST00000495756ENST00000382148ATG3chr3

112260688

+KCNIP4chr4

21235057

-
intron-intronENST00000495756ENST00000447367ATG3chr3

112260688

+KCNIP4chr4

21235057

-
intron-intronENST00000495756ENST00000382150ATG3chr3

112260688

+KCNIP4chr4

21235057

-
intron-intronENST00000495756ENST00000382152ATG3chr3

112260688

+KCNIP4chr4

21235057

-
intron-intronENST00000495756ENST00000509207ATG3chr3

112260688

+KCNIP4chr4

21235057

-
intron-intronENST00000495756ENST00000382149ATG3chr3

112260688

+KCNIP4chr4

21235057

-
intron-intronENST00000495756ENST00000359001ATG3chr3

112260688

+KCNIP4chr4

21235057

-

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FusionProtFeatures for ATG3_KCNIP4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATG3

Q9NT62

KCNIP4

Q6PIL6

E2 conjugating enzyme required for the cytoplasm tovacuole transport (Cvt), autophagy, and mitochondrial homeostasis.Responsible for the E2-like covalent binding ofphosphatidylethanolamine to the C-terminal Gly of ATG8-likeproteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer ofATG8-like proteins from ATG3 to phosphatidylethanolamine (PE).This step is required for the membrane association of ATG8-likeproteins. The formation of the ATG8-phosphatidylethanolamineconjugates is essential for autophagy and for the cytoplasm tovacuole transport (Cvt). Preferred substrate is MAP1LC3A. Alsoacts as an autocatalytic E2-like enzyme, catalyzing theconjugation of ATG12 to itself, ATG12 conjugation to ATG3 playinga role in mitochondrial homeostasis but not in autophagy. ATG7(E1-like enzyme) facilitates this reaction by forming an E1-E2complex with ATG3. Promotes primary ciliogenesis by removing OFD1from centriolar satellites via the autophagic pathway.{ECO:0000269|PubMed:11825910, ECO:0000269|PubMed:12207896,ECO:0000269|PubMed:12890687, ECO:0000269|PubMed:16704426,ECO:0000269|PubMed:20723759}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATG3_KCNIP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATG3_KCNIP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATG3_KCNIP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATG3_KCNIP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource