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Fusion gene ID: 3181 |
FusionGeneSummary for ATG3_KCNIP4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ATG3_KCNIP4 | Fusion gene ID: 3181 | Hgene | Tgene | Gene symbol | ATG3 | KCNIP4 | Gene ID | 64422 | 80333 |
| Gene name | autophagy related 3 | potassium voltage-gated channel interacting protein 4 | |
| Synonyms | APG3|APG3-LIKE|APG3L|PC3-96 | CALP|KCHIP4 | |
| Cytomap | 3q13.2 | 4p15.31-p15.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin-like-conjugating enzyme ATG32610016C12RikAPG3 autophagy 3-likeATG3 autophagy related 3 homologautophagy-related protein 3hApg3 | Kv channel-interacting protein 4Kv channel interacting protein 4a-type potassium channel modulatory protein 4calsenilin-like protein | |
| Modification date | 20180526 | 20180523 | |
| UniProtAcc | Q9NT62 | Q6PIL6 | |
| Ensembl transtripts involved in fusion gene | ENST00000283290, ENST00000402314, ENST00000495756, | ENST00000382148, ENST00000447367, ENST00000382150, ENST00000382152, ENST00000509207, ENST00000382149, ENST00000359001, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 12 X 7 X 9=756 |
| # samples | 2 | 13 | |
| ** MAII score | log2(2/1*10)=4.32192809488736 | log2(13/756*10)=-2.53987461119262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ATG3 [Title/Abstract] AND KCNIP4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ATG3 | GO:0006464 | cellular protein modification process | 11825910 |
| Hgene | ATG3 | GO:0016567 | protein ubiquitination | 11825910 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW386111 | ATG3 | chr3 | 112260688 | + | KCNIP4 | chr4 | 21235057 | - | ||
| ChiTaRS3.1 | AW386112 | ATG3 | chr3 | 112260688 | + | KCNIP4 | chr4 | 21235057 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000283290 | ENST00000382148 | ATG3 | chr3 | 112260688 | + | KCNIP4 | chr4 | 21235057 | - |
| intron-intron | ENST00000283290 | ENST00000447367 | ATG3 | chr3 | 112260688 | + | KCNIP4 | chr4 | 21235057 | - |
| intron-intron | ENST00000283290 | ENST00000382150 | ATG3 | chr3 | 112260688 | + | KCNIP4 | chr4 | 21235057 | - |
| intron-intron | ENST00000283290 | ENST00000382152 | ATG3 | chr3 | 112260688 | + | KCNIP4 | chr4 | 21235057 | - |
| intron-intron | ENST00000283290 | ENST00000509207 | ATG3 | chr3 | 112260688 | + | KCNIP4 | chr4 | 21235057 | - |
| intron-intron | ENST00000283290 | ENST00000382149 | ATG3 | chr3 | 112260688 | + | KCNIP4 | chr4 | 21235057 | - |
| intron-intron | ENST00000283290 | ENST00000359001 | ATG3 | chr3 | 112260688 | + | KCNIP4 | chr4 | 21235057 | - |
| intron-intron | ENST00000402314 | ENST00000382148 | ATG3 | chr3 | 112260688 | + | KCNIP4 | chr4 | 21235057 | - |
| intron-intron | ENST00000402314 | ENST00000447367 | ATG3 | chr3 | 112260688 | + | KCNIP4 | chr4 | 21235057 | - |
| intron-intron | ENST00000402314 | ENST00000382150 | ATG3 | chr3 | 112260688 | + | KCNIP4 | chr4 | 21235057 | - |
| intron-intron | ENST00000402314 | ENST00000382152 | ATG3 | chr3 | 112260688 | + | KCNIP4 | chr4 | 21235057 | - |
| intron-intron | ENST00000402314 | ENST00000509207 | ATG3 | chr3 | 112260688 | + | KCNIP4 | chr4 | 21235057 | - |
| intron-intron | ENST00000402314 | ENST00000382149 | ATG3 | chr3 | 112260688 | + | KCNIP4 | chr4 | 21235057 | - |
| intron-intron | ENST00000402314 | ENST00000359001 | ATG3 | chr3 | 112260688 | + | KCNIP4 | chr4 | 21235057 | - |
| intron-intron | ENST00000495756 | ENST00000382148 | ATG3 | chr3 | 112260688 | + | KCNIP4 | chr4 | 21235057 | - |
| intron-intron | ENST00000495756 | ENST00000447367 | ATG3 | chr3 | 112260688 | + | KCNIP4 | chr4 | 21235057 | - |
| intron-intron | ENST00000495756 | ENST00000382150 | ATG3 | chr3 | 112260688 | + | KCNIP4 | chr4 | 21235057 | - |
| intron-intron | ENST00000495756 | ENST00000382152 | ATG3 | chr3 | 112260688 | + | KCNIP4 | chr4 | 21235057 | - |
| intron-intron | ENST00000495756 | ENST00000509207 | ATG3 | chr3 | 112260688 | + | KCNIP4 | chr4 | 21235057 | - |
| intron-intron | ENST00000495756 | ENST00000382149 | ATG3 | chr3 | 112260688 | + | KCNIP4 | chr4 | 21235057 | - |
| intron-intron | ENST00000495756 | ENST00000359001 | ATG3 | chr3 | 112260688 | + | KCNIP4 | chr4 | 21235057 | - |
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FusionProtFeatures for ATG3_KCNIP4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ATG3 | KCNIP4 |
| E2 conjugating enzyme required for the cytoplasm tovacuole transport (Cvt), autophagy, and mitochondrial homeostasis.Responsible for the E2-like covalent binding ofphosphatidylethanolamine to the C-terminal Gly of ATG8-likeproteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer ofATG8-like proteins from ATG3 to phosphatidylethanolamine (PE).This step is required for the membrane association of ATG8-likeproteins. The formation of the ATG8-phosphatidylethanolamineconjugates is essential for autophagy and for the cytoplasm tovacuole transport (Cvt). Preferred substrate is MAP1LC3A. Alsoacts as an autocatalytic E2-like enzyme, catalyzing theconjugation of ATG12 to itself, ATG12 conjugation to ATG3 playinga role in mitochondrial homeostasis but not in autophagy. ATG7(E1-like enzyme) facilitates this reaction by forming an E1-E2complex with ATG3. Promotes primary ciliogenesis by removing OFD1from centriolar satellites via the autophagic pathway.{ECO:0000269|PubMed:11825910, ECO:0000269|PubMed:12207896,ECO:0000269|PubMed:12890687, ECO:0000269|PubMed:16704426,ECO:0000269|PubMed:20723759}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ATG3_KCNIP4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ATG3_KCNIP4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ATG3_KCNIP4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ATG3_KCNIP4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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