![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 31806 |
FusionGeneSummary for RPL18_AR |
![]() |
Fusion gene information | Fusion gene name: RPL18_AR | Fusion gene ID: 31806 | Hgene | Tgene | Gene symbol | RPL18 | AR | Gene ID | 6141 | 374 |
Gene name | ribosomal protein L18 | amphiregulin | |
Synonyms | L18 | AR|AREGB|CRDGF|SDGF | |
Cytomap | 19q13.33 | 4q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | 60S ribosomal protein L18large ribosomal subunit protein eL18 | amphiregulinamphiregulin Bcolorectum cell-derived growth factorschwannoma-derived growth factor | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q07020 | P10275 | |
Ensembl transtripts involved in fusion gene | ENST00000549920, ENST00000550645, ENST00000552588, ENST00000549273, | ENST00000374690, ENST00000513847, ENST00000504326, ENST00000396044, ENST00000396043, | |
Fusion gene scores | * DoF score | 20 X 12 X 6=1440 | 6 X 4 X 5=120 |
# samples | 21 | 6 | |
** MAII score | log2(21/1440*10)=-2.77760757866355 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RPL18 [Title/Abstract] AND AR [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RPL18 | GO:0002181 | cytoplasmic translation | 25957688 |
Tgene | AR | GO:0007173 | epidermal growth factor receptor signaling pathway | 12743035 |
Tgene | AR | GO:0007186 | G-protein coupled receptor signaling pathway | 12743035 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-XQ-A8TA-01A | RPL18 | chr19 | 49118588 | - | AR | chrX | 66914515 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000549920 | ENST00000374690 | RPL18 | chr19 | 49118588 | - | AR | chrX | 66914515 | + |
5CDS-intron | ENST00000549920 | ENST00000513847 | RPL18 | chr19 | 49118588 | - | AR | chrX | 66914515 | + |
5CDS-intron | ENST00000549920 | ENST00000504326 | RPL18 | chr19 | 49118588 | - | AR | chrX | 66914515 | + |
5CDS-intron | ENST00000549920 | ENST00000396044 | RPL18 | chr19 | 49118588 | - | AR | chrX | 66914515 | + |
5CDS-intron | ENST00000549920 | ENST00000396043 | RPL18 | chr19 | 49118588 | - | AR | chrX | 66914515 | + |
5CDS-intron | ENST00000550645 | ENST00000374690 | RPL18 | chr19 | 49118588 | - | AR | chrX | 66914515 | + |
5CDS-intron | ENST00000550645 | ENST00000513847 | RPL18 | chr19 | 49118588 | - | AR | chrX | 66914515 | + |
5CDS-intron | ENST00000550645 | ENST00000504326 | RPL18 | chr19 | 49118588 | - | AR | chrX | 66914515 | + |
5CDS-intron | ENST00000550645 | ENST00000396044 | RPL18 | chr19 | 49118588 | - | AR | chrX | 66914515 | + |
5CDS-intron | ENST00000550645 | ENST00000396043 | RPL18 | chr19 | 49118588 | - | AR | chrX | 66914515 | + |
5CDS-intron | ENST00000552588 | ENST00000374690 | RPL18 | chr19 | 49118588 | - | AR | chrX | 66914515 | + |
5CDS-intron | ENST00000552588 | ENST00000513847 | RPL18 | chr19 | 49118588 | - | AR | chrX | 66914515 | + |
5CDS-intron | ENST00000552588 | ENST00000504326 | RPL18 | chr19 | 49118588 | - | AR | chrX | 66914515 | + |
5CDS-intron | ENST00000552588 | ENST00000396044 | RPL18 | chr19 | 49118588 | - | AR | chrX | 66914515 | + |
5CDS-intron | ENST00000552588 | ENST00000396043 | RPL18 | chr19 | 49118588 | - | AR | chrX | 66914515 | + |
intron-intron | ENST00000549273 | ENST00000374690 | RPL18 | chr19 | 49118588 | - | AR | chrX | 66914515 | + |
intron-intron | ENST00000549273 | ENST00000513847 | RPL18 | chr19 | 49118588 | - | AR | chrX | 66914515 | + |
intron-intron | ENST00000549273 | ENST00000504326 | RPL18 | chr19 | 49118588 | - | AR | chrX | 66914515 | + |
intron-intron | ENST00000549273 | ENST00000396044 | RPL18 | chr19 | 49118588 | - | AR | chrX | 66914515 | + |
intron-intron | ENST00000549273 | ENST00000396043 | RPL18 | chr19 | 49118588 | - | AR | chrX | 66914515 | + |
Top |
FusionProtFeatures for RPL18_AR |
![]() |
Hgene | Tgene |
RPL18 | AR |
Component of the large ribosomal subunit.{ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680,ECO:0000269|PubMed:25957688, ECO:0000305|PubMed:12962325}. | Steroid hormone receptors are ligand-activatedtranscription factors that regulate eukaryotic gene expression andaffect cellular proliferation and differentiation in targettissues. Transcription factor activity is modulated by boundcoactivator and corepressor proteins. Transcription activation isdown-regulated by NR0B2. Activated, but not phosphorylated, byHIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718,ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767,ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323,ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20980437,ECO:0000269|PubMed:25091737}. Isoform 3 and isoform 4 lack the C-terminal ligand-binding domain and may therefore constitutively activate thetranscription of a specific set of genes independently of steroidhormones. {ECO:0000269|PubMed:19244107}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for RPL18_AR |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for RPL18_AR |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RPL18 | FANCA, FANCC, ESR1, CD4, NOP56, DYRK2, ARRB2, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, RPL10A, RPL11, RPL12, RPL13, RPL15, RPL18A, RPL19, RPL21, RPL22, RPL23, RPL24, RPL27A, RPL31, RPL37A, RPL3, RPL4, RPL5, RPL6, RPL7A, RPL7, RPL8, RPL9, RPS13, RPS14, RPS15A, RPS16, RPS19, RPS23, RPS25, RPS26, RPS28, RPS2, RPS3A, RPS3, RPS4X, RPS5, RPS6, RPS7, RPS8, RPSA, RPL23A, RPL14, RPL30, RPS24, RPS12, RPS20, RPS11, RPLP0, RPL36, RPL27, RPS9, RPL10, RPL35, RPS17, RPL38, RPL17, RPL32, RPS21, RPS27A, EEF2, EEF1A1, FBL, ILF3, HNRNPU, NCL, SLC25A5, ILF2, MYBBP1A, EEF1D, NHP2L1, ACTA2, HNRNPM, U2AF2, RPS27L, ATP5A1, MYL12A, RPL10L, RPLP0P6, NOP2, PTGES3, RPS10P5, ATP5B, HIST1H2AD, NIFK, HSP90AA5P, RHOA, TUBA1B, MRPL12, MAGOH, EIF4A3, PA2G4, FN1, VCAM1, IL7R, UBL4A, ITGA4, PAN2, IGSF8, ICAM1, CDKN1A, FBXO6, EEF1E1, FAU, IARS, NUDT21, RPA3, RPA2, RPA1, ZBTB1, STAU1, CEP250, TP53, HUWE1, FUS, CUL7, OBSL1, CCDC8, EED, RBM4B, NTRK1, HNRNPUL2, PABPC1, PABPC4, RPL13A, RPL26L1, RPL3L, RPLP1, RPS27, RPL26, RPL34, RPL35A, RPLP2, RPS10, RPS15, RPS18, LOC101929876, SFN, XPO1, NPM1, CENPQ, SKI, MCM2, NF2, RC3H1, ZNF746, CEBPZ, PDCD11, FNTB, VPRBP, UBE2O, NOC2L, RRP8, CNBP, NLE1, NSUN4, KIAA0020, MINA, GNL2, RRS1, EBNA1BP2, CENPC, REXO4, TTC19, RBM34, NOL8, NAP1L1, GTPBP4, RBM28, ZC3H10, SPTY2D1, DKC1, DDX10, C1QBP, FTSJ3, MRPL48, DDX27, FNTA, MECP2, BRIX1, NAP1L4, ZNF512, MRPS31, DDX51, ZNF22, ZC3HAV1, DDX24, DDX52, MRPL16, RRP7A, MRPS33, MRPL28, ZNF644, HERC5, MRPS9, FCF1, MRPL13, MRPS18C, MRPL32, MRPS35, RBM19, DDX54, NOC3L, RPL28, MRPL47, URB1, DDX56, DHX30, RRP1, ZNF771, BUD13, RPF2, PAK1IP1, MRPL27, MRPL24, NSA2, DDX18, C3orf17, MRPL20, PPAN-P2RY11, MRPL17, MRPS5, MRPL3, UTP3, GNL3, MRPS10, MRPL51, CYLD, INO80B, TRIM25, BRCA1, YAP1 | AR | GNB2L1, FLNA, RAN, NR2C2, NCOA3, RNF4, NCOA4, PAK6, RANBP9, RCHY1, PIAS2, HNF4A, AKT1, IL6ST, CALM1, RAD9A, SMAD3, NCOA6, CTNNB1, CCNH, CDK7, AR, DAXX, STAT3, SP1, GSK3B, GSN, SELENBP1, HSPA1A, HSP90AA1, UXT, CAV1, JUN, PRKDC, XRCC5, XRCC6, BAG1, CREBBP, NCOA1, NCOR1, NCOR2, NCOA2, CCND1, FOXO1, FOXA1, RNF14, DCC, MAGEA11, SRC, PTEN, RB1, BRCA1, ZMIZ1, TP53, TGFB1I1, MAPK1, EGFR, GSK3A, KAT7, NR2C1, GRIP1, PELP1, SART3, HDAC3, HDAC4, TDG, PSPC1, NONO, EFCAB6, KAT5, HDAC1, CDK9, NSD1, YWHAQ, PRMT1, TSG101, COX5B, RAF1, NR0B2, POU2F1, POU2F2, DAP3, CEBPA, CEBPB, SVIL, AES, FHL2, CDC37, PIAS4, NR0B1, TMF1, SRY, CCNE1, UBE2I, SMAD4, CALR, SPDEF, PATZ1, ETV5, PA2G4, PIAS1, PIAS3, HMGB1, HMGB2, PRPF6, TRIM24, GTF2F1, GTF2F2, TBP, GTF2H1, MED1, GAPDH, CDC25B, PMEPA1, SMARCA4, SMARCC1, TRIM68, HSPB2, MDM2, WHSC1, MDN1, NLRP10, SMARCA2, ZBTB16, MED24, DENND5A, ZBTB1, MED12L, SMARCD1, SPOP, MLH3, KIFAP3, PHB, SIRT1, HDAC7, ZNF318, SMARCE1, RAD54L2, EP300, ZMIZ2, TGIF1, SREBF1, RUVBL1, KDM5B, SFPQ, GADD45GIP1, ERG, KDM4A, KDM4D, RREB1, SRCAP, TADA3, USP26, RNF6, NELFCD, STUB1, REPS2, KIF1A, RNF40, RNF20, ERCC3, ERCC2, GTF2H2, GTF2H3, CHD8, SETD7, ZBTB7A, E2F1, E2F4, PSMC3, LCOR, LATS2, ZNF451, COPS2, USP10, TAF1, TNK2, DDB2, PAX6, ARID5A, WDR77, TCF20, DCAF6, FKBP5, FKBP4, PPP5C, DNAJC7, PPID, ZBTB32, TAB2, TBL1XR1, SIN3A, SIN3B, PARK7, UBE3A, KDM3A, APPL1, SIAH2, ACTB, JMJD1C, SMAD1, VHL, CUL2, PTGES3, RBL1, USP12, SKP2, REL, WIPI1, NDE1, VCP, DAPK3, AATF, TTC5, KAT2B, IFI16, EZH2, SUZ12, EED, RNF2, BMI1, RELA, PRKG1, MID1, TCF7L2, ELF3, IDE, CDK6, ETS1, KLK3, USP7, HOTAIR, PPP1CA, AHR, WDR20, WDR48, PRPF8, PPP2CA, CACUL1, KDM1A, USP14, SMARCC2, TLE3, GSE1, ARID1A, ARID1B, BCOR, SMARCB1, KMT2D, CHD7, RCOR1, DPF1, RAI1, TFAP2A, PPP2R2A, DPF2, ARID3B, CNBP, ARID5B, NEFL, RPS21, SPATS2L, RCC2, DDX19A, KARS, SUV39H2, BRD4, BRD2, BRD3 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for RPL18_AR |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | RPL18 | Q07020 | DB11638 | Artenimol | 60S ribosomal protein L18 | small molecule | approved|investigational |
Tgene | AR | P10275 | DB00421 | Spironolactone | Androgen receptor | small molecule | approved |
Tgene | AR | P10275 | DB00623 | Fluphenazine | Androgen receptor | small molecule | approved |
Tgene | AR | P10275 | DB00648 | Mitotane | Androgen receptor | small molecule | approved |
Tgene | AR | P10275 | DB00655 | Estrone | Androgen receptor | small molecule | approved |
Tgene | AR | P10275 | DB00675 | Tamoxifen | Androgen receptor | small molecule | approved |
Tgene | AR | P10275 | DB01063 | Acetophenazine | Androgen receptor | small molecule | approved |
Tgene | AR | P10275 | DB01128 | Bicalutamide | Androgen receptor | small molecule | approved |
Tgene | AR | P10275 | DB01395 | Drospirenone | Androgen receptor | small molecule | approved |
Tgene | AR | P10275 | DB01406 | Danazol | Androgen receptor | small molecule | approved |
Tgene | AR | P10275 | DB06710 | Methyltestosterone | Androgen receptor | small molecule | approved |
Tgene | AR | P10275 | DB08867 | Ulipristal | Androgen receptor | small molecule | approved |
Tgene | AR | P10275 | DB08899 | Enzalutamide | Androgen receptor | small molecule | approved |
Tgene | AR | P10275 | DB09123 | Dienogest | Androgen receptor | small molecule | approved |
Tgene | AR | P10275 | DB09371 | Norethynodrel | Androgen receptor | small molecule | approved |
Tgene | AR | P10275 | DB09389 | Norgestrel | Androgen receptor | small molecule | approved |
Tgene | AR | P10275 | DB11619 | Gestrinone | Androgen receptor | small molecule | approved |
Tgene | AR | P10275 | DB01185 | Fluoxymesterone | Androgen receptor | small molecule | approved|illicit |
Tgene | AR | P10275 | DB06412 | Oxymetholone | Androgen receptor | small molecule | approved|illicit |
Tgene | AR | P10275 | DB00255 | Diethylstilbestrol | Androgen receptor | small molecule | approved|investigational |
Tgene | AR | P10275 | DB00367 | Levonorgestrel | Androgen receptor | small molecule | approved|investigational |
Tgene | AR | P10275 | DB00499 | Flutamide | Androgen receptor | small molecule | approved|investigational |
Tgene | AR | P10275 | DB00621 | Oxandrolone | Androgen receptor | small molecule | approved|investigational |
Tgene | AR | P10275 | DB00624 | Testosterone | Androgen receptor | small molecule | approved|investigational |
Tgene | AR | P10275 | DB00665 | Nilutamide | Androgen receptor | small molecule | approved|investigational |
Tgene | AR | P10275 | DB00687 | Fludrocortisone | Androgen receptor | small molecule | approved|investigational |
Tgene | AR | P10275 | DB00957 | Norgestimate | Androgen receptor | small molecule | approved|investigational |
Tgene | AR | P10275 | DB01026 | Ketoconazole | Androgen receptor | small molecule | approved|investigational |
Tgene | AR | P10275 | DB01608 | Propericiazine | Androgen receptor | small molecule | approved|investigational |
Tgene | AR | P10275 | DB04839 | Cyproterone acetate | Androgen receptor | small molecule | approved|investigational |
Tgene | AR | P10275 | DB06713 | Norelgestromin | Androgen receptor | small molecule | approved|investigational |
Tgene | AR | P10275 | DB08604 | Triclosan | Androgen receptor | small molecule | approved|investigational |
Tgene | AR | P10275 | DB01708 | Prasterone | Androgen receptor | small molecule | approved|investigational|nutraceutical |
Tgene | AR | P10275 | DB00396 | Progesterone | Androgen receptor | small molecule | approved|vet_approved |
Top |
RelatedDiseases for RPL18_AR |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RPL18 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Tgene | AR | C0039585 | Androgen-Insensitivity Syndrome | 73 | CTD_human;ORPHANET;UNIPROT |
Tgene | AR | C0268301 | Reifenstein Syndrome | 49 | ORPHANET;UNIPROT |
Tgene | AR | C0033578 | Prostatic Neoplasms | 20 | CTD_human |
Tgene | AR | C0011570 | Mental Depression | 5 | PSYGENET |
Tgene | AR | C0011581 | Depressive disorder | 5 | PSYGENET |
Tgene | AR | C0021364 | Male infertility | 3 | CTD_human |
Tgene | AR | C0236663 | Alcohol withdrawal syndrome | 3 | PSYGENET |
Tgene | AR | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |
Tgene | AR | C0242788 | Breast Neoplasms, Male | 2 | CTD_human |
Tgene | AR | C1458155 | Mammary Neoplasms | 2 | CTD_human |
Tgene | AR | C3658267 | Prostatic Neoplasms, Castration-Resistant | 2 | CTD_human |
Tgene | AR | C0002170 | Alopecia | 1 | CTD_human |
Tgene | AR | C0004114 | Astrocytoma | 1 | CTD_human |
Tgene | AR | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | AR | C0017412 | Genital Diseases, Male | 1 | CTD_human |
Tgene | AR | C0020538 | Hypertensive disease | 1 | CTD_human |
Tgene | AR | C0021361 | Female infertility | 1 | CTD_human |
Tgene | AR | C0021655 | Insulin Resistance | 1 | CTD_human |
Tgene | AR | C0023418 | leukemia | 1 | CTD_human |
Tgene | AR | C0027643 | Neoplasm Recurrence, Local | 1 | CTD_human |
Tgene | AR | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | AR | C0085207 | Gestational Diabetes | 1 | CTD_human |
Tgene | AR | C0282612 | Prostatic Intraepithelial Neoplasias | 1 | CTD_human |
Tgene | AR | C0525045 | Mood Disorders | 1 | PSYGENET |
Tgene | AR | C0556385 | Craving for alcohol | 1 | PSYGENET |
Tgene | AR | C2239176 | Liver carcinoma | 1 | CTD_human |