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Fusion gene ID: 31755 |
FusionGeneSummary for RPF1_PRKACB |
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Fusion gene information | Fusion gene name: RPF1_PRKACB | Fusion gene ID: 31755 | Hgene | Tgene | Gene symbol | RPF1 | PRKACB | Gene ID | 80135 | 5567 |
Gene name | ribosome production factor 1 homolog | protein kinase cAMP-activated catalytic subunit beta | |
Synonyms | BXDC5 | PKA C-beta|PKACB | |
Cytomap | 1p22.3 | 1p31.1 | |
Type of gene | protein-coding | protein-coding | |
Description | ribosome production factor 12310066N05RikRNA processing factor 1 (RPF1)brix domain containing 5brix domain-containing protein 5ribosome biogenesis protein RPF1 | cAMP-dependent protein kinase catalytic subunit betacAMP-dependent protein kinase catalytic beta subunit isoform 4abprotein kinase A catalytic subunit betaprotein kinase, cAMP-dependent, beta catalytic subunitprotein kinase, cAMP-dependent, catalytic, | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9H9Y2 | P22694 | |
Ensembl transtripts involved in fusion gene | ENST00000370656, ENST00000370654, | ENST00000370689, ENST00000370685, ENST00000394838, ENST00000370682, ENST00000394839, ENST00000370688, ENST00000470673, ENST00000370680, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 5 X 5=150 |
# samples | 1 | 6 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RPF1 [Title/Abstract] AND PRKACB [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PRKACB | GO:0006468 | protein phosphorylation | 12420224|21880142 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-D3-A3C1-06A | RPF1 | chr1 | 84945192 | + | PRKACB | chr1 | 84700863 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000370656 | ENST00000370689 | RPF1 | chr1 | 84945192 | + | PRKACB | chr1 | 84700863 | + |
Frame-shift | ENST00000370656 | ENST00000370685 | RPF1 | chr1 | 84945192 | + | PRKACB | chr1 | 84700863 | + |
Frame-shift | ENST00000370656 | ENST00000394838 | RPF1 | chr1 | 84945192 | + | PRKACB | chr1 | 84700863 | + |
Frame-shift | ENST00000370656 | ENST00000370682 | RPF1 | chr1 | 84945192 | + | PRKACB | chr1 | 84700863 | + |
Frame-shift | ENST00000370656 | ENST00000394839 | RPF1 | chr1 | 84945192 | + | PRKACB | chr1 | 84700863 | + |
5CDS-intron | ENST00000370656 | ENST00000370688 | RPF1 | chr1 | 84945192 | + | PRKACB | chr1 | 84700863 | + |
5CDS-intron | ENST00000370656 | ENST00000470673 | RPF1 | chr1 | 84945192 | + | PRKACB | chr1 | 84700863 | + |
5CDS-intron | ENST00000370656 | ENST00000370680 | RPF1 | chr1 | 84945192 | + | PRKACB | chr1 | 84700863 | + |
Frame-shift | ENST00000370654 | ENST00000370689 | RPF1 | chr1 | 84945192 | + | PRKACB | chr1 | 84700863 | + |
Frame-shift | ENST00000370654 | ENST00000370685 | RPF1 | chr1 | 84945192 | + | PRKACB | chr1 | 84700863 | + |
Frame-shift | ENST00000370654 | ENST00000394838 | RPF1 | chr1 | 84945192 | + | PRKACB | chr1 | 84700863 | + |
Frame-shift | ENST00000370654 | ENST00000370682 | RPF1 | chr1 | 84945192 | + | PRKACB | chr1 | 84700863 | + |
Frame-shift | ENST00000370654 | ENST00000394839 | RPF1 | chr1 | 84945192 | + | PRKACB | chr1 | 84700863 | + |
5CDS-intron | ENST00000370654 | ENST00000370688 | RPF1 | chr1 | 84945192 | + | PRKACB | chr1 | 84700863 | + |
5CDS-intron | ENST00000370654 | ENST00000470673 | RPF1 | chr1 | 84945192 | + | PRKACB | chr1 | 84700863 | + |
5CDS-intron | ENST00000370654 | ENST00000370680 | RPF1 | chr1 | 84945192 | + | PRKACB | chr1 | 84700863 | + |
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FusionProtFeatures for RPF1_PRKACB |
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Hgene | Tgene |
RPF1 | PRKACB |
May be required for ribosome biogenesis.{ECO:0000269|PubMed:11864606}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RPF1_PRKACB |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RPF1_PRKACB |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RPF1 | KRTAP10-7, NOL12, RPL14, NIFK, NPM1, ZC3H3, KIAA0020, RPF2, RPL5, KRAS, IFI16, C10orf12, EGFR, MAK16, ZNF324, WDR74, ZNF324B, RPL26L1, CNBP, ZNF460, ZNF689, MAGEB10, RRP8, ZNF512, RPL30, E4F1, RPL18A, ZBTB11, RPL37A, H2AFY2, RPS16, SART3, ZCRB1, STAU2, UPF1, MRPS5, RPS6, FOXA1 | PRKACB | NGFR, RYR2, TNP1, TNP2, SPP1, PRKAR2A, PRKACA, HSP90AA1, CSNK2A1, ARFGAP1, RPS6, RPL27A, ACVR1B, KIAA1279, ACTR2, ACTR3, ARPC1B, ARPC2, ARPC4, PFDN1, SUMO1, TP53RK, TPRKB, VAPB, HSP90AB1, PRKAR1A, AKAP5, PRKAR1B, PRKAR2B, DCAF7, DYNLL1, TRAP1, DYRK1A, MAPRE1, PDE4DIP, AKAP1, CDK5RAP2, AKAP9, VAPA, AKAP7, AKAP11, APPBP2, MLF1, NAPG, PER1, TALDO1, RABGGTB, C11orf49, AP2M1, DCLRE1C, CCNL2, AKAP14, ARF1, RPE, NTRK1, XPO1, FGFR1OP, CEP170P1, GPR161, PRKACG, HSP90AB4P, FKBP5, PKIG, BMP1, MRPS15, ETFB, NPAS1, DFFB, RAPGEF5, KLHL28, DNA2, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RPF1_PRKACB |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RPF1_PRKACB |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PRKACB | C0005426 | Biliary Tract Neoplasm | 1 | CTD_human |
Tgene | PRKACB | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | PRKACB | C0206698 | Cholangiocarcinoma | 1 | CTD_human |