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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 31754

FusionGeneSummary for RPE_PRDM5

check button Fusion gene summary
Fusion gene informationFusion gene name: RPE_PRDM5
Fusion gene ID: 31754
HgeneTgene
Gene symbol

RPE

PRDM5

Gene ID

6120

11107

Gene nameribulose-5-phosphate-3-epimerasePR/SET domain 5
SynonymsRPE2-1BCS2|PFM2
Cytomap

2q34

4q27

Type of geneprotein-codingprotein-coding
Descriptionribulose-phosphate 3-epimerasePR domain zinc finger protein 5PR domain 5PR domain containing 5
Modification date2018052320180523
UniProtAcc

Q96AT9

Q9NQX1

Ensembl transtripts involved in fusion geneENST00000359429, ENST00000436630, 
ENST00000454822, ENST00000429921, 
ENST00000540255, ENST00000429907, 
ENST00000445268, ENST00000452025, 
ENST00000438204, ENST00000411934, 
ENST00000435437, ENST00000354506, 
ENST00000264808, ENST00000428209, 
ENST00000515109, ENST00000506065, 
ENST00000394435, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 2 X 3=18
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RPE [Title/Abstract] AND PRDM5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPE

GO:0005975

carbohydrate metabolic process

20923965

HgeneRPE

GO:0006098

pentose-phosphate shunt

20923965

TgenePRDM5

GO:0000122

negative regulation of transcription by RNA polymerase II

17636019

TgenePRDM5

GO:0045892

negative regulation of transcription, DNA-templated

17636019

TgenePRDM5

GO:0051567

histone H3-K9 methylation

17636019


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPCPGTCGA-WB-A81J-01ARPEchr2

210867507

+PRDM5chr4

121742500

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000359429ENST00000264808RPEchr2

210867507

+PRDM5chr4

121742500

-
Frame-shiftENST00000359429ENST00000428209RPEchr2

210867507

+PRDM5chr4

121742500

-
Frame-shiftENST00000359429ENST00000515109RPEchr2

210867507

+PRDM5chr4

121742500

-
5CDS-intronENST00000359429ENST00000506065RPEchr2

210867507

+PRDM5chr4

121742500

-
5CDS-intronENST00000359429ENST00000394435RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-3CDSENST00000436630ENST00000264808RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-3CDSENST00000436630ENST00000428209RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-3CDSENST00000436630ENST00000515109RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-intronENST00000436630ENST00000506065RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-intronENST00000436630ENST00000394435RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-3CDSENST00000454822ENST00000264808RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-3CDSENST00000454822ENST00000428209RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-3CDSENST00000454822ENST00000515109RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-intronENST00000454822ENST00000506065RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-intronENST00000454822ENST00000394435RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-3CDSENST00000429921ENST00000264808RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-3CDSENST00000429921ENST00000428209RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-3CDSENST00000429921ENST00000515109RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-intronENST00000429921ENST00000506065RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-intronENST00000429921ENST00000394435RPEchr2

210867507

+PRDM5chr4

121742500

-
Frame-shiftENST00000540255ENST00000264808RPEchr2

210867507

+PRDM5chr4

121742500

-
Frame-shiftENST00000540255ENST00000428209RPEchr2

210867507

+PRDM5chr4

121742500

-
Frame-shiftENST00000540255ENST00000515109RPEchr2

210867507

+PRDM5chr4

121742500

-
5CDS-intronENST00000540255ENST00000506065RPEchr2

210867507

+PRDM5chr4

121742500

-
5CDS-intronENST00000540255ENST00000394435RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-3CDSENST00000429907ENST00000264808RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-3CDSENST00000429907ENST00000428209RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-3CDSENST00000429907ENST00000515109RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-intronENST00000429907ENST00000506065RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-intronENST00000429907ENST00000394435RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-3CDSENST00000445268ENST00000264808RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-3CDSENST00000445268ENST00000428209RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-3CDSENST00000445268ENST00000515109RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-intronENST00000445268ENST00000506065RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-intronENST00000445268ENST00000394435RPEchr2

210867507

+PRDM5chr4

121742500

-
Frame-shiftENST00000452025ENST00000264808RPEchr2

210867507

+PRDM5chr4

121742500

-
Frame-shiftENST00000452025ENST00000428209RPEchr2

210867507

+PRDM5chr4

121742500

-
Frame-shiftENST00000452025ENST00000515109RPEchr2

210867507

+PRDM5chr4

121742500

-
5CDS-intronENST00000452025ENST00000506065RPEchr2

210867507

+PRDM5chr4

121742500

-
5CDS-intronENST00000452025ENST00000394435RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-3CDSENST00000438204ENST00000264808RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-3CDSENST00000438204ENST00000428209RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-3CDSENST00000438204ENST00000515109RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-intronENST00000438204ENST00000506065RPEchr2

210867507

+PRDM5chr4

121742500

-
5UTR-intronENST00000438204ENST00000394435RPEchr2

210867507

+PRDM5chr4

121742500

-
intron-3CDSENST00000411934ENST00000264808RPEchr2

210867507

+PRDM5chr4

121742500

-
intron-3CDSENST00000411934ENST00000428209RPEchr2

210867507

+PRDM5chr4

121742500

-
intron-3CDSENST00000411934ENST00000515109RPEchr2

210867507

+PRDM5chr4

121742500

-
intron-intronENST00000411934ENST00000506065RPEchr2

210867507

+PRDM5chr4

121742500

-
intron-intronENST00000411934ENST00000394435RPEchr2

210867507

+PRDM5chr4

121742500

-
Frame-shiftENST00000435437ENST00000264808RPEchr2

210867507

+PRDM5chr4

121742500

-
Frame-shiftENST00000435437ENST00000428209RPEchr2

210867507

+PRDM5chr4

121742500

-
Frame-shiftENST00000435437ENST00000515109RPEchr2

210867507

+PRDM5chr4

121742500

-
5CDS-intronENST00000435437ENST00000506065RPEchr2

210867507

+PRDM5chr4

121742500

-
5CDS-intronENST00000435437ENST00000394435RPEchr2

210867507

+PRDM5chr4

121742500

-
Frame-shiftENST00000354506ENST00000264808RPEchr2

210867507

+PRDM5chr4

121742500

-
Frame-shiftENST00000354506ENST00000428209RPEchr2

210867507

+PRDM5chr4

121742500

-
Frame-shiftENST00000354506ENST00000515109RPEchr2

210867507

+PRDM5chr4

121742500

-
5CDS-intronENST00000354506ENST00000506065RPEchr2

210867507

+PRDM5chr4

121742500

-
5CDS-intronENST00000354506ENST00000394435RPEchr2

210867507

+PRDM5chr4

121742500

-

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FusionProtFeatures for RPE_PRDM5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPE

Q96AT9

PRDM5

Q9NQX1

Sequence-specific DNA-binding transcription factor.Represses transcription at least in part by recruitment of thehistone methyltransferase EHMT2/G9A and histone deacetylases suchas HDAC1. Regulates hematopoiesis-associated protein-coding andmicroRNA (miRNA) genes. May regulate the expression of proteinsinvolved in extracellular matrix development and maintenance,including fibrillar collagens, such as COL4A1 and COL11A1,connective tissue components, such as HAPLN1, and moleculesregulating cell migration and adhesion, including EDIL3 and TGFB2.May caused G2/M arrest and apoptosis in cancer cells.{ECO:0000269|PubMed:15077163, ECO:0000269|PubMed:17636019,ECO:0000269|PubMed:21664999}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RPE_PRDM5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RPE_PRDM5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RPERPE, MRI1, EXOSC10, CLU, APOD, ADSL, ALDH2, ALDH5A1, ALDOB, IDE, IMPA2, MAP2K1, MAP2K2, NRBP1, NUTF2, PGK2, PPCS, ACLY, ADSS, AKT1, AKT2, AKT3, CDK2, CDK5, CTH, DNM1, DNM2, DNM3, DPYD, G6PD, MAGI3, MAT1A, NSUN6, PKN2, PRKACA, PRKACB, RBKS, RHOA, RPIA, SOD1, TKT, TLE3, TRIO, XYLB, TALDO1, TEC, TRAP1, UPP1, NANOG, POU5F1PRDM5GFI1, EHMT2, HDAC1, CCDC77, FAM102B, FBXO11, ZNF687, THAP11, TNRC18, YBX2, ABT1, ZFP91, ZBTB4, BAG1, RPL26L1, WHSC1, RBM34, RPL10A, UPF1, RBM28, PRDM10, BRIX1, FTSJ3, PGK2, GLYR1, KIF1C, RPL8, NGRN, CASC3, RPL4, HIST2H2AB, SURF6, KIAA0020, GAR1, RPL18A, RPF2, ZFP62, SAP130, RPL36


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RPE_PRDM5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RPE_PRDM5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePRDM5C3280011BRITTLE CORNEA SYNDROME 21UNIPROT