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Fusion gene ID: 31753 |
FusionGeneSummary for RPAP3_SYT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RPAP3_SYT1 | Fusion gene ID: 31753 | Hgene | Tgene | Gene symbol | RPAP3 | SYT1 | Gene ID | 79657 | 6857 |
| Gene name | RNA polymerase II associated protein 3 | synaptotagmin 1 | |
| Synonyms | hSpagh | P65|SVP65|SYT | |
| Cytomap | 12q13.11 | 12q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RNA polymerase II-associated protein 3 | synaptotagmin-1synaptotagmin IsytI | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9H6T3 | P21579 | |
| Ensembl transtripts involved in fusion gene | ENST00000005386, ENST00000548211, ENST00000432584, ENST00000380650, | ENST00000393240, ENST00000261205, ENST00000457153, ENST00000552744, ENST00000549454, | |
| Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 15 X 9 X 6=810 |
| # samples | 4 | 16 | |
| ** MAII score | log2(4/60*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/810*10)=-2.33985000288462 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RPAP3 [Title/Abstract] AND SYT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SYT1 | GO:1903861 | positive regulation of dendrite extension | 23999003 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PCPG | TCGA-W2-A7HB-01A | RPAP3 | chr12 | 48090059 | - | SYT1 | chr12 | 79747282 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000005386 | ENST00000393240 | RPAP3 | chr12 | 48090059 | - | SYT1 | chr12 | 79747282 | + |
| Frame-shift | ENST00000005386 | ENST00000261205 | RPAP3 | chr12 | 48090059 | - | SYT1 | chr12 | 79747282 | + |
| Frame-shift | ENST00000005386 | ENST00000457153 | RPAP3 | chr12 | 48090059 | - | SYT1 | chr12 | 79747282 | + |
| Frame-shift | ENST00000005386 | ENST00000552744 | RPAP3 | chr12 | 48090059 | - | SYT1 | chr12 | 79747282 | + |
| 5CDS-intron | ENST00000005386 | ENST00000549454 | RPAP3 | chr12 | 48090059 | - | SYT1 | chr12 | 79747282 | + |
| intron-3CDS | ENST00000548211 | ENST00000393240 | RPAP3 | chr12 | 48090059 | - | SYT1 | chr12 | 79747282 | + |
| intron-3CDS | ENST00000548211 | ENST00000261205 | RPAP3 | chr12 | 48090059 | - | SYT1 | chr12 | 79747282 | + |
| intron-3CDS | ENST00000548211 | ENST00000457153 | RPAP3 | chr12 | 48090059 | - | SYT1 | chr12 | 79747282 | + |
| intron-3CDS | ENST00000548211 | ENST00000552744 | RPAP3 | chr12 | 48090059 | - | SYT1 | chr12 | 79747282 | + |
| intron-intron | ENST00000548211 | ENST00000549454 | RPAP3 | chr12 | 48090059 | - | SYT1 | chr12 | 79747282 | + |
| In-frame | ENST00000432584 | ENST00000393240 | RPAP3 | chr12 | 48090059 | - | SYT1 | chr12 | 79747282 | + |
| In-frame | ENST00000432584 | ENST00000261205 | RPAP3 | chr12 | 48090059 | - | SYT1 | chr12 | 79747282 | + |
| In-frame | ENST00000432584 | ENST00000457153 | RPAP3 | chr12 | 48090059 | - | SYT1 | chr12 | 79747282 | + |
| In-frame | ENST00000432584 | ENST00000552744 | RPAP3 | chr12 | 48090059 | - | SYT1 | chr12 | 79747282 | + |
| 5CDS-intron | ENST00000432584 | ENST00000549454 | RPAP3 | chr12 | 48090059 | - | SYT1 | chr12 | 79747282 | + |
| Frame-shift | ENST00000380650 | ENST00000393240 | RPAP3 | chr12 | 48090059 | - | SYT1 | chr12 | 79747282 | + |
| Frame-shift | ENST00000380650 | ENST00000261205 | RPAP3 | chr12 | 48090059 | - | SYT1 | chr12 | 79747282 | + |
| Frame-shift | ENST00000380650 | ENST00000457153 | RPAP3 | chr12 | 48090059 | - | SYT1 | chr12 | 79747282 | + |
| Frame-shift | ENST00000380650 | ENST00000552744 | RPAP3 | chr12 | 48090059 | - | SYT1 | chr12 | 79747282 | + |
| 5CDS-intron | ENST00000380650 | ENST00000549454 | RPAP3 | chr12 | 48090059 | - | SYT1 | chr12 | 79747282 | + |
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FusionProtFeatures for RPAP3_SYT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RPAP3 | SYT1 |
| Forms an interface between the RNA polymerase II enzymeand chaperone/scaffolding protein, suggesting that it is requiredto connect RNA polymerase II to regulators of protein complexformation. {ECO:0000269|PubMed:17643375}. | May have a regulatory role in the membrane interactionsduring trafficking of synaptic vesicles at the active zone of thesynapse. It binds acidic phospholipids with a specificity thatrequires the presence of both an acidic head group and a diacylbackbone. A Ca(2+)-dependent interaction between synaptotagmin andputative receptors for activated protein kinase C has also beenreported. It can bind to at least three additional proteins in aCa(2+)-independent manner; these are neurexins, syntaxin and AP2.Plays a role in dendrite formation by melanocytes(PubMed:23999003). {ECO:0000269|PubMed:23999003}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RPAP3_SYT1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RPAP3_ENST00000432584_chr12_48090059_-_SYT1_ENST00000393240_chr12_79747282_+_175aa MDADPYNPVLPTNRASAYFRLKNKRNWVISASPFATYLLLVSXLLSFWRQRTXRRWMWVAYPILMXRFIXCRMVRGXRRKRQQLKRTHLT >In-frame_RPAP3_ENST00000432584_chr12_48090059_-_SYT1_ENST00000261205_chr12_79747282_+_175aa MDADPYNPVLPTNRASAYFRLKNKRNWVISASPFATYLLLVSXLLSFWRQRTXRRWMWVAYPILMXRFIXCRMVRGXRRKRQQLKRTHLT >In-frame_RPAP3_ENST00000432584_chr12_48090059_-_SYT1_ENST00000457153_chr12_79747282_+_175aa MDADPYNPVLPTNRASAYFRLKNKRNWVISASPFATYLLLVSXLLSFWRQRTXRRWMWVAYPILMXRFIXCRMVRGXRRKRQQLKRTHLT >In-frame_RPAP3_ENST00000432584_chr12_48090059_-_SYT1_ENST00000552744_chr12_79747282_+_175aa MDADPYNPVLPTNRASAYFRLKNKRNWVISASPFATYLLLVSXLLSFWRQRTXRRWMWVAYPILMXRFIXCRMVRGXRRKRQQLKRTHLT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RPAP3_ENST00000432584_chr12_48090059_-_SYT1_ENST00000393240_chr12_79747282_+_527nt ATGGATGCCGATCCATATAATCCCGTGTTGCCAACGAACAGAGCGTCAGCATATTTTAGACTGAAAAACAAGAGAAATTGGGTGATATCT GCTTCTCCCTTCGCTACGTACCTACTGCTGGTAAGCTGACTGTTGTCATTCTGGAGGCAAAGAACCTGAAGAAGATGGATGTGGGTGGCT TATCCGATCCTTATGTGAAGATTCATCTGATGCAGAATGGTAAGAGGCTGAAGAAGAAAAAGACAACAATTAAAAAGAACACACTTAACC CCTACTACAATGAGTCATTCAGCTTTGAAGTACCTTTTGAACAAATCCAGAAAGTGCAGGTGGTGGTAACTGTTTTGGACTATGACAAGA TTGGCAAGAACGATGCCATCGGCAAAGTCTTTGTGGGCTACAACAGCACCGGCGCGGAGCTGCGACACTGGTCAGACATGCTGGCCAACC >In-frame_RPAP3_ENST00000432584_chr12_48090059_-_SYT1_ENST00000261205_chr12_79747282_+_527nt ATGGATGCCGATCCATATAATCCCGTGTTGCCAACGAACAGAGCGTCAGCATATTTTAGACTGAAAAACAAGAGAAATTGGGTGATATCT GCTTCTCCCTTCGCTACGTACCTACTGCTGGTAAGCTGACTGTTGTCATTCTGGAGGCAAAGAACCTGAAGAAGATGGATGTGGGTGGCT TATCCGATCCTTATGTGAAGATTCATCTGATGCAGAATGGTAAGAGGCTGAAGAAGAAAAAGACAACAATTAAAAAGAACACACTTAACC CCTACTACAATGAGTCATTCAGCTTTGAAGTACCTTTTGAACAAATCCAGAAAGTGCAGGTGGTGGTAACTGTTTTGGACTATGACAAGA TTGGCAAGAACGATGCCATCGGCAAAGTCTTTGTGGGCTACAACAGCACCGGCGCGGAGCTGCGACACTGGTCAGACATGCTGGCCAACC >In-frame_RPAP3_ENST00000432584_chr12_48090059_-_SYT1_ENST00000457153_chr12_79747282_+_527nt ATGGATGCCGATCCATATAATCCCGTGTTGCCAACGAACAGAGCGTCAGCATATTTTAGACTGAAAAACAAGAGAAATTGGGTGATATCT GCTTCTCCCTTCGCTACGTACCTACTGCTGGTAAGCTGACTGTTGTCATTCTGGAGGCAAAGAACCTGAAGAAGATGGATGTGGGTGGCT TATCCGATCCTTATGTGAAGATTCATCTGATGCAGAATGGTAAGAGGCTGAAGAAGAAAAAGACAACAATTAAAAAGAACACACTTAACC CCTACTACAATGAGTCATTCAGCTTTGAAGTACCTTTTGAACAAATCCAGAAAGTGCAGGTGGTGGTAACTGTTTTGGACTATGACAAGA TTGGCAAGAACGATGCCATCGGCAAAGTCTTTGTGGGCTACAACAGCACCGGCGCGGAGCTGCGACACTGGTCAGACATGCTGGCCAACC >In-frame_RPAP3_ENST00000432584_chr12_48090059_-_SYT1_ENST00000552744_chr12_79747282_+_527nt ATGGATGCCGATCCATATAATCCCGTGTTGCCAACGAACAGAGCGTCAGCATATTTTAGACTGAAAAACAAGAGAAATTGGGTGATATCT GCTTCTCCCTTCGCTACGTACCTACTGCTGGTAAGCTGACTGTTGTCATTCTGGAGGCAAAGAACCTGAAGAAGATGGATGTGGGTGGCT TATCCGATCCTTATGTGAAGATTCATCTGATGCAGAATGGTAAGAGGCTGAAGAAGAAAAAGACAACAATTAAAAAGAACACACTTAACC CCTACTACAATGAGTCATTCAGCTTTGAAGTACCTTTTGAACAAATCCAGAAAGTGCAGGTGGTGGTAACTGTTTTGGACTATGACAAGA TTGGCAAGAACGATGCCATCGGCAAAGTCTTTGTGGGCTACAACAGCACCGGCGCGGAGCTGCGACACTGGTCAGACATGCTGGCCAACC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RPAP3_ENST00000432584_chr12_48090059_-_SYT1_ENST00000393240_chr12_79747282_+_2081nt GAGTCACTGCCGGGCTCGGCGTGAGTCGCTGCGGGGCTGACGGGGTGGCAGTGCGGCGGGTTACGGCCTGGTCAGAATTTACCTCCTATT CGAAATGGGAATTTTAGGAAAAAGAAGAAAGGCAAAGCTAAAGAGTCTTCCAAAAAAACCAGAGAGGAAAACACAAAAAACAGGATAAAA TCTTATGATTATGAGGCATGGGCAAAACTTGATGTGGACCGTATCCTTGATGAGCTTGACAAAGACGATAGTACCCATGAGTCTCTGTCT CAAGAATCAGAGTCGGAAGAAGATGGGATTCATGTAGATTCACAAAAGGCTCTTGTTTTAAAAGAAAAGGGCAATAAATACTTCAAACAA GGAAAATATGATGAAGCAATTGACTGCTACACAAAAGGCATGGATGCCGATCCATATAATCCCGTGTTGCCAACGAACAGAGCGTCAGCA TATTTTAGACTGAAAAACAAGAGAAATTGGGTGATATCTGCTTCTCCCTTCGCTACGTACCTACTGCTGGTAAGCTGACTGTTGTCATTC TGGAGGCAAAGAACCTGAAGAAGATGGATGTGGGTGGCTTATCCGATCCTTATGTGAAGATTCATCTGATGCAGAATGGTAAGAGGCTGA AGAAGAAAAAGACAACAATTAAAAAGAACACACTTAACCCCTACTACAATGAGTCATTCAGCTTTGAAGTACCTTTTGAACAAATCCAGA AAGTGCAGGTGGTGGTAACTGTTTTGGACTATGACAAGATTGGCAAGAACGATGCCATCGGCAAAGTCTTTGTGGGCTACAACAGCACCG GCGCGGAGCTGCGACACTGGTCAGACATGCTGGCCAACCCCAGGCGACCTATTGCCCAGTGGCACACCCTGCAGGTAGAGGAGGAAGTTG ATGCCATGCTGGCCGTCAAGAAGTAAAGGAAAGAAGAAGCCTTTCTGCATTTGCCCATATAGTGCTCTTTAGCCAGTATCTGTAAATACC TCAGTAATATGGGTCCTTTCATTTTTCCAGCCATGCATTCCTAACACAATTCAGTGGTACTTGGAATCCTGTTTTAATTTGCACAAATTT AAATGTAGAGAGCCCCTAAGTCCTTCATCATACCACTGCCCTCCAAATCTACTCTTCTTTTAAGCAATATGATGTGTAGATAGAGCATGA ATGAAATTATTTATTGTATCACACTGTTGTATATACCAGTATGCTAAAGATTTATTTCTAGTTTGTGTATTTGTATGTTGTAAGCGTTTC CTAATCTGTGTATATCTAGATGTTTTTAATAAGATGTTCTATTTTAAACTATGTAAATTGACTGAGATATAGGAGAGCTGATAATATATT ATACGGTAAATATAGTATCGTCTGCATTCCAGCAAAAATATCAACTCGTAAGGCACTAGTACAGTTAAACTGACATCTTAAAGGACAACT TAAACCTGAGCTTTCTATTGAATCATTTGAGTACCAAGATAAACTTACACCACATACTTGGTGGGTGAATCCAATTTTGTAGAATTCCTA CACAGGCAAAATAGCATGATCTGAGCAGCAGCATCCAGGCTGACCTCAAGGAAGCATAGCCACAAAACAGAATAGCACCTGTCTGTACAT ATTTACAAAGCTAAAATAATGGCTTCACTCTTATATTTGAGGAAGCAACTGAACAGGAGTCAATGATTTCATATTACTGCATATAGAATA ACAACAAGGTGTTCCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCACATTTGTTTGGGGATGGGGGAGAAGAAGCTAAGGGGAG AAGTCAACATTTATGAAATATTGCCTGACTATTTAAAAAGAAAAAAGTAGCTCTCCATTATCACCTTTATACAAAATGTACATCCTGTGA ATTCTGTTCCAGATTTCACACCTACAATAATTCCAAAAGGTTTGCACATTAGAGTTTGTAACAAAATATTTTATTATATAAAACCAGGTT AGAAGGAATGCAGGATATTTTTAACACAACAATCTGTGCTTATTACACAAAATTACTTTGTGGTAAACAGACAGTATTGTAATCCCATCA >In-frame_RPAP3_ENST00000432584_chr12_48090059_-_SYT1_ENST00000261205_chr12_79747282_+_3808nt GAGTCACTGCCGGGCTCGGCGTGAGTCGCTGCGGGGCTGACGGGGTGGCAGTGCGGCGGGTTACGGCCTGGTCAGAATTTACCTCCTATT CGAAATGGGAATTTTAGGAAAAAGAAGAAAGGCAAAGCTAAAGAGTCTTCCAAAAAAACCAGAGAGGAAAACACAAAAAACAGGATAAAA TCTTATGATTATGAGGCATGGGCAAAACTTGATGTGGACCGTATCCTTGATGAGCTTGACAAAGACGATAGTACCCATGAGTCTCTGTCT CAAGAATCAGAGTCGGAAGAAGATGGGATTCATGTAGATTCACAAAAGGCTCTTGTTTTAAAAGAAAAGGGCAATAAATACTTCAAACAA GGAAAATATGATGAAGCAATTGACTGCTACACAAAAGGCATGGATGCCGATCCATATAATCCCGTGTTGCCAACGAACAGAGCGTCAGCA TATTTTAGACTGAAAAACAAGAGAAATTGGGTGATATCTGCTTCTCCCTTCGCTACGTACCTACTGCTGGTAAGCTGACTGTTGTCATTC TGGAGGCAAAGAACCTGAAGAAGATGGATGTGGGTGGCTTATCCGATCCTTATGTGAAGATTCATCTGATGCAGAATGGTAAGAGGCTGA AGAAGAAAAAGACAACAATTAAAAAGAACACACTTAACCCCTACTACAATGAGTCATTCAGCTTTGAAGTACCTTTTGAACAAATCCAGA AAGTGCAGGTGGTGGTAACTGTTTTGGACTATGACAAGATTGGCAAGAACGATGCCATCGGCAAAGTCTTTGTGGGCTACAACAGCACCG GCGCGGAGCTGCGACACTGGTCAGACATGCTGGCCAACCCCAGGCGACCTATTGCCCAGTGGCACACCCTGCAGGTAGAGGAGGAAGTTG ATGCCATGCTGGCCGTCAAGAAGTAAAGGAAAGAAGAAGCCTTTCTGCATTTGCCCATATAGTGCTCTTTAGCCAGTATCTGTAAATACC TCAGTAATATGGGTCCTTTCATTTTTCCAGCCATGCATTCCTAACACAATTCAGTGGTACTTGGAATCCTGTTTTAATTTGCACAAATTT AAATGTAGAGAGCCCCTAAGTCCTTCATCATACCACTGCCCTCCAAATCTACTCTTCTTTTAAGCAATATGATGTGTAGATAGAGCATGA ATGAAATTATTTATTGTATCACACTGTTGTATATACCAGTATGCTAAAGATTTATTTCTAGTTTGTGTATTTGTATGTTGTAAGCGTTTC CTAATCTGTGTATATCTAGATGTTTTTAATAAGATGTTCTATTTTAAACTATGTAAATTGACTGAGATATAGGAGAGCTGATAATATATT ATACGGTAAATATAGTATCGTCTGCATTCCAGCAAAAATATCAACTCGTAAGGCACTAGTACAGTTAAACTGACATCTTAAAGGACAACT TAAACCTGAGCTTTCTATTGAATCATTTGAGTACCAAGATAAACTTACACCACATACTTGGTGGGTGAATCCAATTTTGTAGAATTCCTA CACAGGCAAAATAGCATGATCTGAGCAGCAGCATCCAGGCTGACCTCAAGGAAGCATAGCCACAAAACAGAATAGCACCTGTCTGTACAT ATTTACAAAGCTAAAATAATGGCTTCACTCTTATATTTGAGGAAGCAACTGAACAGGAGTCAATGATTTCATATTACTGCATATAGAATA ACAACAAGGTGTTCCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCACATTTGTTTGGGGATGGGGGAGAAGAAGCTAAGGGGAG AAGTCAACATTTATGAAATATTGCCTGACTATTTAAAAAGAAAAAAGTAGCTCTCCATTATCACCTTTATACAAAATGTACATCCTGTGA ATTCTGTTCCAGATTTCACACCTACAATAATTCCAAAAGGTTTGCACATTAGAGTTTGTAACAAAATATTTTATTATATAAAACCAGGTT AGAAGGAATGCAGGATATTTTTAACACAACAATCTGTGCTTATTACACAAAATTACTTTGTGGTAAACAGACAGTATTGTAATCCCATCA AAAGATGAAAGAAAAACAAAAACAAAAACCAACAACAATTAGCCATAGTTCTGAATGCACTTCAATTAAGCCAAAACAGACAGCTAGTGA TCTTTTTATATGCTCTTTTTACTTAAGTTTTAATTTGTCCTTTAAAAAAAGGTGAAACAAACCAAGAACAAGTTCTAGAAAACTGAAGCA ACCTCTTATGTATACTAGATGCTTGATTTAGGAGGAGTTTTTAAACGTTTTCAATGTTATTATGTAGTAAATGACACTATTATGAAGCTA CTAGTCATTCCATAAGAGTCTTAAAGGACTGCTCTGTGTAACACTGTGACTGCCGTGTGTGCTTAGACCCGTAGTTTCCTCAGTGGATAG CACTCAATTTATTCCGTAGTGATATTGTAACAATACTGCCATTCCCTTCTACTGCACTGCCCAAGGTGTGTGTAGCACAAACAGTTCTCA TTACAAAGGACCAATTCAGAACTGAAAAGCTATGCATAGGACAAGGAAGATACATAGAATGGGGTGGAACACAGCATTTTGTCAAGCACT GTGCAATATTCCATATTTTTCCCCACTATGGTAGACAACCATTTCGTGGAAGGGCAGCCTATTATCCCACACTGCATCTAGCCTTTTGTC CCATTCACTTCTGTGATCCATTTTAATTTCCAGGCCACAAGACAGTAGTGATGCTCTGAAATGAAAGTTTGTCTTCACAAATATCAAAAC AAAATGGAGGAAAACTAAGCATTGGCCTCATGTTCAGTCTTCAGGATATCACACCACGTCTTTTCAAAAACTAAAGAGAATTCAAAAAGG GCTGATGGTAGGCTTTGAACATGGGGTTGGCTGTTTCCCAGTAAAACTGGAATTCCTGTCGTTACTGTTTCCTTATCAAAGAAGGGGCAA GCTCTTTTGCCTTTTAGGCCAGACATAGCAAACGCTTTATAATTGGCATAGACATAAAGGATAAAAGGAAAATAACCGTCTGCCGATGGT CCGTACTTCTTAAAAAACATAGGTAATAGAAAATATACACAAGTCAGAATGTGAAATTAAATAATGGTTTGAACAGAAAATTCAAACAAG ACTCTTTCCAATTTAAAGGGCCAAACCCTACCAAAGAGAGGGAGTTGACTGGCTTTTAAAAAGTATTTAAATACCACAAATGACATTTAA TTTCACTGTATTCAGCTTTAAGTTGTTCACAATGAAACCACACTTTCAAACAAGCAGGTTCAAGCTGCTGAATAGACATTATTTCTTGCA TTAAAATACCACTAATGCATTCTCTTGCAACACTGCCAGACATGGGATTGTCACCATAGAATTAGTTGGTACTATGCCATCTTTCACTCT TTCACAAGTCAGTGATGGAACCTGCTTTATGACCAAGATTCATCCTCAAATAAGCCACATGTACCCTTCTGACAAAGCTGTGTAAAGTAT TAGAATCTGATGCTCTAGAAAGATCCTAGTTGCCTTTGTGTATATTTACTGCCTGCTTGAGTGTTTCTATGTGTGGGTTTTCCCTGTATC TTGTAGAAATGTTGGGGTGTTTTCCTCTGCCATATGGCTCGTGGCCTGCGAGCCAACTATTTCAGCTGTATTTTACCTTCATTTTTGATG AGGTGATTTAAATTTTGTTTCACTTTGTGTAGTGAATTCCACAGTAGTTTTCTGATTGTTGTTAAAAATGACTTAACATATTACACAGAT >In-frame_RPAP3_ENST00000432584_chr12_48090059_-_SYT1_ENST00000457153_chr12_79747282_+_3810nt GAGTCACTGCCGGGCTCGGCGTGAGTCGCTGCGGGGCTGACGGGGTGGCAGTGCGGCGGGTTACGGCCTGGTCAGAATTTACCTCCTATT CGAAATGGGAATTTTAGGAAAAAGAAGAAAGGCAAAGCTAAAGAGTCTTCCAAAAAAACCAGAGAGGAAAACACAAAAAACAGGATAAAA TCTTATGATTATGAGGCATGGGCAAAACTTGATGTGGACCGTATCCTTGATGAGCTTGACAAAGACGATAGTACCCATGAGTCTCTGTCT CAAGAATCAGAGTCGGAAGAAGATGGGATTCATGTAGATTCACAAAAGGCTCTTGTTTTAAAAGAAAAGGGCAATAAATACTTCAAACAA GGAAAATATGATGAAGCAATTGACTGCTACACAAAAGGCATGGATGCCGATCCATATAATCCCGTGTTGCCAACGAACAGAGCGTCAGCA TATTTTAGACTGAAAAACAAGAGAAATTGGGTGATATCTGCTTCTCCCTTCGCTACGTACCTACTGCTGGTAAGCTGACTGTTGTCATTC TGGAGGCAAAGAACCTGAAGAAGATGGATGTGGGTGGCTTATCCGATCCTTATGTGAAGATTCATCTGATGCAGAATGGTAAGAGGCTGA AGAAGAAAAAGACAACAATTAAAAAGAACACACTTAACCCCTACTACAATGAGTCATTCAGCTTTGAAGTACCTTTTGAACAAATCCAGA AAGTGCAGGTGGTGGTAACTGTTTTGGACTATGACAAGATTGGCAAGAACGATGCCATCGGCAAAGTCTTTGTGGGCTACAACAGCACCG GCGCGGAGCTGCGACACTGGTCAGACATGCTGGCCAACCCCAGGCGACCTATTGCCCAGTGGCACACCCTGCAGGTAGAGGAGGAAGTTG ATGCCATGCTGGCCGTCAAGAAGTAAAGGAAAGAAGAAGCCTTTCTGCATTTGCCCATATAGTGCTCTTTAGCCAGTATCTGTAAATACC TCAGTAATATGGGTCCTTTCATTTTTCCAGCCATGCATTCCTAACACAATTCAGTGGTACTTGGAATCCTGTTTTAATTTGCACAAATTT AAATGTAGAGAGCCCCTAAGTCCTTCATCATACCACTGCCCTCCAAATCTACTCTTCTTTTAAGCAATATGATGTGTAGATAGAGCATGA ATGAAATTATTTATTGTATCACACTGTTGTATATACCAGTATGCTAAAGATTTATTTCTAGTTTGTGTATTTGTATGTTGTAAGCGTTTC CTAATCTGTGTATATCTAGATGTTTTTAATAAGATGTTCTATTTTAAACTATGTAAATTGACTGAGATATAGGAGAGCTGATAATATATT ATACGGTAAATATAGTATCGTCTGCATTCCAGCAAAAATATCAACTCGTAAGGCACTAGTACAGTTAAACTGACATCTTAAAGGACAACT TAAACCTGAGCTTTCTATTGAATCATTTGAGTACCAAGATAAACTTACACCACATACTTGGTGGGTGAATCCAATTTTGTAGAATTCCTA CACAGGCAAAATAGCATGATCTGAGCAGCAGCATCCAGGCTGACCTCAAGGAAGCATAGCCACAAAACAGAATAGCACCTGTCTGTACAT ATTTACAAAGCTAAAATAATGGCTTCACTCTTATATTTGAGGAAGCAACTGAACAGGAGTCAATGATTTCATATTACTGCATATAGAATA ACAACAAGGTGTTCCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCACATTTGTTTGGGGATGGGGGAGAAGAAGCTAAGGGGAG AAGTCAACATTTATGAAATATTGCCTGACTATTTAAAAAGAAAAAAGTAGCTCTCCATTATCACCTTTATACAAAATGTACATCCTGTGA ATTCTGTTCCAGATTTCACACCTACAATAATTCCAAAAGGTTTGCACATTAGAGTTTGTAACAAAATATTTTATTATATAAAACCAGGTT AGAAGGAATGCAGGATATTTTTAACACAACAATCTGTGCTTATTACACAAAATTACTTTGTGGTAAACAGACAGTATTGTAATCCCATCA AAAGATGAAAGAAAAACAAAAACAAAAACCAACAACAATTAGCCATAGTTCTGAATGCACTTCAATTAAGCCAAAACAGACAGCTAGTGA TCTTTTTATATGCTCTTTTTACTTAAGTTTTAATTTGTCCTTTAAAAAAAGGTGAAACAAACCAAGAACAAGTTCTAGAAAACTGAAGCA ACCTCTTATGTATACTAGATGCTTGATTTAGGAGGAGTTTTTAAACGTTTTCAATGTTATTATGTAGTAAATGACACTATTATGAAGCTA CTAGTCATTCCATAAGAGTCTTAAAGGACTGCTCTGTGTAACACTGTGACTGCCGTGTGTGCTTAGACCCGTAGTTTCCTCAGTGGATAG CACTCAATTTATTCCGTAGTGATATTGTAACAATACTGCCATTCCCTTCTACTGCACTGCCCAAGGTGTGTGTAGCACAAACAGTTCTCA TTACAAAGGACCAATTCAGAACTGAAAAGCTATGCATAGGACAAGGAAGATACATAGAATGGGGTGGAACACAGCATTTTGTCAAGCACT GTGCAATATTCCATATTTTTCCCCACTATGGTAGACAACCATTTCGTGGAAGGGCAGCCTATTATCCCACACTGCATCTAGCCTTTTGTC CCATTCACTTCTGTGATCCATTTTAATTTCCAGGCCACAAGACAGTAGTGATGCTCTGAAATGAAAGTTTGTCTTCACAAATATCAAAAC AAAATGGAGGAAAACTAAGCATTGGCCTCATGTTCAGTCTTCAGGATATCACACCACGTCTTTTCAAAAACTAAAGAGAATTCAAAAAGG GCTGATGGTAGGCTTTGAACATGGGGTTGGCTGTTTCCCAGTAAAACTGGAATTCCTGTCGTTACTGTTTCCTTATCAAAGAAGGGGCAA GCTCTTTTGCCTTTTAGGCCAGACATAGCAAACGCTTTATAATTGGCATAGACATAAAGGATAAAAGGAAAATAACCGTCTGCCGATGGT CCGTACTTCTTAAAAAACATAGGTAATAGAAAATATACACAAGTCAGAATGTGAAATTAAATAATGGTTTGAACAGAAAATTCAAACAAG ACTCTTTCCAATTTAAAGGGCCAAACCCTACCAAAGAGAGGGAGTTGACTGGCTTTTAAAAAGTATTTAAATACCACAAATGACATTTAA TTTCACTGTATTCAGCTTTAAGTTGTTCACAATGAAACCACACTTTCAAACAAGCAGGTTCAAGCTGCTGAATAGACATTATTTCTTGCA TTAAAATACCACTAATGCATTCTCTTGCAACACTGCCAGACATGGGATTGTCACCATAGAATTAGTTGGTACTATGCCATCTTTCACTCT TTCACAAGTCAGTGATGGAACCTGCTTTATGACCAAGATTCATCCTCAAATAAGCCACATGTACCCTTCTGACAAAGCTGTGTAAAGTAT TAGAATCTGATGCTCTAGAAAGATCCTAGTTGCCTTTGTGTATATTTACTGCCTGCTTGAGTGTTTCTATGTGTGGGTTTTCCCTGTATC TTGTAGAAATGTTGGGGTGTTTTCCTCTGCCATATGGCTCGTGGCCTGCGAGCCAACTATTTCAGCTGTATTTTACCTTCATTTTTGATG AGGTGATTTAAATTTTGTTTCACTTTGTGTAGTGAATTCCACAGTAGTTTTCTGATTGTTGTTAAAAATGACTTAACATATTACACAGAT >In-frame_RPAP3_ENST00000432584_chr12_48090059_-_SYT1_ENST00000552744_chr12_79747282_+_2096nt GAGTCACTGCCGGGCTCGGCGTGAGTCGCTGCGGGGCTGACGGGGTGGCAGTGCGGCGGGTTACGGCCTGGTCAGAATTTACCTCCTATT CGAAATGGGAATTTTAGGAAAAAGAAGAAAGGCAAAGCTAAAGAGTCTTCCAAAAAAACCAGAGAGGAAAACACAAAAAACAGGATAAAA TCTTATGATTATGAGGCATGGGCAAAACTTGATGTGGACCGTATCCTTGATGAGCTTGACAAAGACGATAGTACCCATGAGTCTCTGTCT CAAGAATCAGAGTCGGAAGAAGATGGGATTCATGTAGATTCACAAAAGGCTCTTGTTTTAAAAGAAAAGGGCAATAAATACTTCAAACAA GGAAAATATGATGAAGCAATTGACTGCTACACAAAAGGCATGGATGCCGATCCATATAATCCCGTGTTGCCAACGAACAGAGCGTCAGCA TATTTTAGACTGAAAAACAAGAGAAATTGGGTGATATCTGCTTCTCCCTTCGCTACGTACCTACTGCTGGTAAGCTGACTGTTGTCATTC TGGAGGCAAAGAACCTGAAGAAGATGGATGTGGGTGGCTTATCCGATCCTTATGTGAAGATTCATCTGATGCAGAATGGTAAGAGGCTGA AGAAGAAAAAGACAACAATTAAAAAGAACACACTTAACCCCTACTACAATGAGTCATTCAGCTTTGAAGTACCTTTTGAACAAATCCAGA AAGTGCAGGTGGTGGTAACTGTTTTGGACTATGACAAGATTGGCAAGAACGATGCCATCGGCAAAGTCTTTGTGGGCTACAACAGCACCG GCGCGGAGCTGCGACACTGGTCAGACATGCTGGCCAACCCCAGGCGACCTATTGCCCAGTGGCACACCCTGCAGGTAGAGGAGGAAGTTG ATGCCATGCTGGCCGTCAAGAAGTAAAGGAAAGAAGAAGCCTTTCTGCATTTGCCCATATAGTGCTCTTTAGCCAGTATCTGTAAATACC TCAGTAATATGGGTCCTTTCATTTTTCCAGCCATGCATTCCTAACACAATTCAGTGGTACTTGGAATCCTGTTTTAATTTGCACAAATTT AAATGTAGAGAGCCCCTAAGTCCTTCATCATACCACTGCCCTCCAAATCTACTCTTCTTTTAAGCAATATGATGTGTAGATAGAGCATGA ATGAAATTATTTATTGTATCACACTGTTGTATATACCAGTATGCTAAAGATTTATTTCTAGTTTGTGTATTTGTATGTTGTAAGCGTTTC CTAATCTGTGTATATCTAGATGTTTTTAATAAGATGTTCTATTTTAAACTATGTAAATTGACTGAGATATAGGAGAGCTGATAATATATT ATACGGTAAATATAGTATCGTCTGCATTCCAGCAAAAATATCAACTCGTAAGGCACTAGTACAGTTAAACTGACATCTTAAAGGACAACT TAAACCTGAGCTTTCTATTGAATCATTTGAGTACCAAGATAAACTTACACCACATACTTGGTGGGTGAATCCAATTTTGTAGAATTCCTA CACAGGCAAAATAGCATGATCTGAGCAGCAGCATCCAGGCTGACCTCAAGGAAGCATAGCCACAAAACAGAATAGCACCTGTCTGTACAT ATTTACAAAGCTAAAATAATGGCTTCACTCTTATATTTGAGGAAGCAACTGAACAGGAGTCAATGATTTCATATTACTGCATATAGAATA ACAACAAGGTGTTCCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCACATTTGTTTGGGGATGGGGGAGAAGAAGCTAAGGGGAG AAGTCAACATTTATGAAATATTGCCTGACTATTTAAAAAGAAAAAAGTAGCTCTCCATTATCACCTTTATACAAAATGTACATCCTGTGA ATTCTGTTCCAGATTTCACACCTACAATAATTCCAAAAGGTTTGCACATTAGAGTTTGTAACAAAATATTTTATTATATAAAACCAGGTT AGAAGGAATGCAGGATATTTTTAACACAACAATCTGTGCTTATTACACAAAATTACTTTGTGGTAAACAGACAGTATTGTAATCCCATCA |
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FusionGenePPI for RPAP3_SYT1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RPAP3 | RPAP2, URI1, PIH1D1, POLR2B, GPN1, POLR2J, RUVBL2, POLR2E, POLR3A, POLR2A, PPP1CA, UXT, RFC5, EFTUD2, PDRG1, CCT5, POLR1A, HSP90AB1, PFDN2, EIF4A1, HSPA6, PFDN6, LRCH2, INTS1, ANAPC1, HELLS, HSP90AA2P, RGPD1, IKBKG, TELO2, TTI2, STK11, PARD6A, PIDD1, NEDD4, TERF1, CUL3, ST3, RUVBL1, WDR92, APP, BRCA1, HSP90AA1, TTI1, FBXO25, ITCH, WWOX, CDC37, CACYBP, ZNHIT2, PHGDH, USP19, DPCD, SUGT1, PRPS1, PPP1CC, PPP1R3A, HSPB1, FBXW11, CAPZB, NTRK1, OFD1, MKS1, CEP104, NPHP1, NPHP4, NEK8, POC1A, STIL, XPO1, TM9SF4, POLR3E, LDHD, WWP2, PHLPP1, SBF1, PPEF2, ASB7, TPTE, PPP1R7, PPP1CB, CIT, HSPA4, LUC7L2, POLR1C, RPAP3, TANGO6, TSC1 | SYT1 | SV2B, C6orf15, SV2C, GOLM1, S100A13, CALM1, STX1A, STON2, SYNCRIP, SNAP25, CACNA1A, STX2, STX3, STX4, FGF1, IKBKG, RBM14, SIN3A, NEDD4, VAMP2, SMAD2, ARMC1, HAX1, NUFIP1, DGUOK, DNAAF2, SYT5, NTRK1, SYT2, VLDLR, CWC22, EIF2B3, EIF2B5, EIF2B4, PGK2, EIF2B2, LRP2, CDCA8, RRP7A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RPAP3_SYT1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RPAP3_SYT1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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