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Fusion gene ID: 31745 |
FusionGeneSummary for RPAP1_IGKJ4 |
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Fusion gene information | Fusion gene name: RPAP1_IGKJ4 | Fusion gene ID: 31745 | Hgene | Tgene | Gene symbol | RPAP1 | IGKJ4 | Gene ID | 26015 | 28947 |
Gene name | RNA polymerase II associated protein 1 | immunoglobulin kappa joining 4 | |
Synonyms | - | J4 | |
Cytomap | 15q15.1 | 2p11.2 | |
Type of gene | protein-coding | other | |
Description | RNA polymerase II-associated protein 1 | - | |
Modification date | 20180523 | 20180329 | |
UniProtAcc | Q9BWH6 | ||
Ensembl transtripts involved in fusion gene | ENST00000561603, ENST00000304330, ENST00000568413, | ENST00000390239, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 7 X 4 X 7=196 |
# samples | 4 | 7 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RPAP1 [Title/Abstract] AND IGKJ4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | MESO | TCGA-3U-A98H-01A | RPAP1 | chr15 | 41815105 | - | IGKJ4 | chr2 | 89160432 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000561603 | ENST00000390239 | RPAP1 | chr15 | 41815105 | - | IGKJ4 | chr2 | 89160432 | - |
intron-3CDS | ENST00000304330 | ENST00000390239 | RPAP1 | chr15 | 41815105 | - | IGKJ4 | chr2 | 89160432 | - |
intron-3CDS | ENST00000568413 | ENST00000390239 | RPAP1 | chr15 | 41815105 | - | IGKJ4 | chr2 | 89160432 | - |
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FusionProtFeatures for RPAP1_IGKJ4 |
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Hgene | Tgene |
RPAP1 | IGKJ4 |
Forms an interface between the RNA polymerase II enzymeand chaperone/scaffolding protein, suggesting that it is requiredto connect RNA polymerase II to regulators of protein complexformation. Required for interaction of the RNA polymerase IIcomplex with acetylated histone H3. {ECO:0000269|PubMed:17643375}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RPAP1_IGKJ4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RPAP1_IGKJ4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RPAP1 | MEPCE, POLR2J, ARHGAP23, HNRNPA1, IGF2BP1, GPN1, POLR2B, HSPD1, POLR2C, SRP72, EFTUD2, ZFR, POLR3A, ELAVL1, CENPC, ILF3, POLR3B, HSPA8, BAG6, KIF11, CCT6A, DDX3Y, PHF8, NUMA1, IPO9, SLFN11, CSNK2B, MAGED2, HLTF, MCM10, SYTL2, ERBB2IP, ANAPC1, TERF2IP, POT1, LAGE3, IGBP1, PPIL3, PAICS, POLR2L, CCDC8, GPN2, POLR2M, NHP2L1, NTRK1, XPO1, POLK, C1orf94, POLR1C | IGKJ4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RPAP1_IGKJ4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RPAP1_IGKJ4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |