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Fusion gene ID: 31735 |
FusionGeneSummary for RPA2_SERPING1 |
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Fusion gene information | Fusion gene name: RPA2_SERPING1 | Fusion gene ID: 31735 | Hgene | Tgene | Gene symbol | RPA2 | SERPING1 | Gene ID | 84172 | 710 |
Gene name | RNA polymerase I subunit B | serpin family G member 1 | |
Synonyms | RPA135|RPA2|Rpo1-2 | C1IN|C1INH|C1NH|HAE1|HAE2 | |
Cytomap | 2q14.1 | 11q12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | DNA-directed RNA polymerase I subunit RPA2DNA-directed RNA polymerase I 135 kDa polypeptideDNA-directed RNA polymerase I 135kDa polypeptideRNA polymerase I subunit 2polymerase (RNA) I polypeptide B, 128kDapolymerase (RNA) I subunit B | plasma protease C1 inhibitorC1 esterase inhibitorC1-inhibiting factorcomplement component 1 inhibitorserine/cysteine proteinase inhibitor clade G member 1serpin G1serpin peptidase inhibitor clade G member 1serpin peptidase inhibitor, clade G (C1 in | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P15927 | P05155 | |
Ensembl transtripts involved in fusion gene | ENST00000373912, ENST00000373909, ENST00000313433, | ENST00000278407, ENST00000340687, ENST00000378323, ENST00000378324, ENST00000403558, ENST00000531605, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 6 X 6 X 2=72 |
# samples | 2 | 7 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RPA2 [Title/Abstract] AND SERPING1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SERPING1 | GO:0001869 | negative regulation of complement activation, lectin pathway | 10946292 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CA309301 | RPA2 | chr1 | 28218257 | + | SERPING1 | chr11 | 57374011 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000373912 | ENST00000278407 | RPA2 | chr1 | 28218257 | + | SERPING1 | chr11 | 57374011 | - |
intron-3CDS | ENST00000373912 | ENST00000340687 | RPA2 | chr1 | 28218257 | + | SERPING1 | chr11 | 57374011 | - |
intron-3CDS | ENST00000373912 | ENST00000378323 | RPA2 | chr1 | 28218257 | + | SERPING1 | chr11 | 57374011 | - |
intron-3CDS | ENST00000373912 | ENST00000378324 | RPA2 | chr1 | 28218257 | + | SERPING1 | chr11 | 57374011 | - |
intron-3CDS | ENST00000373912 | ENST00000403558 | RPA2 | chr1 | 28218257 | + | SERPING1 | chr11 | 57374011 | - |
intron-intron | ENST00000373912 | ENST00000531605 | RPA2 | chr1 | 28218257 | + | SERPING1 | chr11 | 57374011 | - |
intron-3CDS | ENST00000373909 | ENST00000278407 | RPA2 | chr1 | 28218257 | + | SERPING1 | chr11 | 57374011 | - |
intron-3CDS | ENST00000373909 | ENST00000340687 | RPA2 | chr1 | 28218257 | + | SERPING1 | chr11 | 57374011 | - |
intron-3CDS | ENST00000373909 | ENST00000378323 | RPA2 | chr1 | 28218257 | + | SERPING1 | chr11 | 57374011 | - |
intron-3CDS | ENST00000373909 | ENST00000378324 | RPA2 | chr1 | 28218257 | + | SERPING1 | chr11 | 57374011 | - |
intron-3CDS | ENST00000373909 | ENST00000403558 | RPA2 | chr1 | 28218257 | + | SERPING1 | chr11 | 57374011 | - |
intron-intron | ENST00000373909 | ENST00000531605 | RPA2 | chr1 | 28218257 | + | SERPING1 | chr11 | 57374011 | - |
intron-3CDS | ENST00000313433 | ENST00000278407 | RPA2 | chr1 | 28218257 | + | SERPING1 | chr11 | 57374011 | - |
intron-3CDS | ENST00000313433 | ENST00000340687 | RPA2 | chr1 | 28218257 | + | SERPING1 | chr11 | 57374011 | - |
intron-3CDS | ENST00000313433 | ENST00000378323 | RPA2 | chr1 | 28218257 | + | SERPING1 | chr11 | 57374011 | - |
intron-3CDS | ENST00000313433 | ENST00000378324 | RPA2 | chr1 | 28218257 | + | SERPING1 | chr11 | 57374011 | - |
intron-3CDS | ENST00000313433 | ENST00000403558 | RPA2 | chr1 | 28218257 | + | SERPING1 | chr11 | 57374011 | - |
intron-intron | ENST00000313433 | ENST00000531605 | RPA2 | chr1 | 28218257 | + | SERPING1 | chr11 | 57374011 | - |
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FusionProtFeatures for RPA2_SERPING1 |
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Hgene | Tgene |
RPA2 | SERPING1 |
As part of the heterotrimeric replication protein Acomplex (RPA/RP-A), binds and stabilizes single-stranded DNAintermediates, that form during DNA replication or upon DNAstress. It prevents their reannealing and in parallel, recruitsand activates different proteins and complexes involved in DNAmetabolism. Thereby, it plays an essential role both in DNAreplication and the cellular response to DNA damage. In thecellular response to DNA damage, the RPA complex controls DNArepair and DNA damage checkpoint activation. Through recruitmentof ATRIP activates the ATR kinase a master regulator of the DNAdamage response. It is required for the recruitment of the DNAdouble-strand break repair factors RAD51 and RAD52 to chromatin inresponse to DNA damage. Also recruits to sites of DNA damageproteins like XPA and XPG that are involved in nucleotide excisionrepair and is required for this mechanism of DNA repair. Playsalso a role in base excision repair (BER) probably throughinteraction with UNG. Also recruits SMARCAL1/HARP, which isinvolved in replication fork restart, to sites of DNA damage. Mayalso play a role in telomere maintenance.{ECO:0000269|PubMed:15205463, ECO:0000269|PubMed:17765923,ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208,ECO:0000269|PubMed:20154705, ECO:0000269|PubMed:21504906,ECO:0000269|PubMed:2406247, ECO:0000269|PubMed:24332808,ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386,ECO:0000269|PubMed:8702565, ECO:0000269|PubMed:9430682,ECO:0000269|PubMed:9765279}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RPA2_SERPING1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RPA2_SERPING1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RPA2_SERPING1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RPA2_SERPING1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SERPING1 | C2717906 | Hereditary Angioedema Type I | 10 | ORPHANET;UNIPROT |
Tgene | SERPING1 | C0019243 | Angioedemas, Hereditary | 6 | CTD_human |
Tgene | SERPING1 | C2717905 | Hereditary Angioedema Types I and II | 3 | CTD_human |
Tgene | SERPING1 | C2931758 | Acquired angioedema | 2 | CTD_human |
Tgene | SERPING1 | C0021400 | Influenza | 1 | CTD_human |
Tgene | SERPING1 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
Tgene | SERPING1 | C0024143 | Lupus Nephritis | 1 | CTD_human |
Tgene | SERPING1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |