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Fusion gene ID: 31733 |
FusionGeneSummary for RPA1_WDR81 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RPA1_WDR81 | Fusion gene ID: 31733 | Hgene | Tgene | Gene symbol | RPA1 | WDR81 | Gene ID | 25885 | 124997 |
| Gene name | RNA polymerase I subunit A | WD repeat domain 81 | |
| Synonyms | A190|AFDCIN|RPA1|RPA194|RPO1-4|RPO14 | CAMRQ2|PPP1R166|SORF-2 | |
| Cytomap | 2p11.2 | 17p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA-directed RNA polymerase I subunit RPA1DNA-directed RNA polymerase I largest subunitDNA-directed RNA polymerase I subunit ADNA-directed RNA polymerase I subunit A1RNA polymerase I 194 kDa subunitpolymerase (RNA) I polypeptide A, 194kDapolymerase | WD repeat-containing protein 81protein phosphatase 1, regulatory subunit 166 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P27694 | Q562E7 | |
| Ensembl transtripts involved in fusion gene | ENST00000254719, ENST00000573924, | ENST00000437219, ENST00000309182, ENST00000446363, ENST00000419248, ENST00000409644, ENST00000545662, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 3=27 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: RPA1 [Title/Abstract] AND WDR81 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | WDR81 | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | CHOL | TCGA-W5-AA31-01A | RPA1 | chr17 | 1756483 | + | WDR81 | chr17 | 1633674 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000254719 | ENST00000437219 | RPA1 | chr17 | 1756483 | + | WDR81 | chr17 | 1633674 | + |
| In-frame | ENST00000254719 | ENST00000309182 | RPA1 | chr17 | 1756483 | + | WDR81 | chr17 | 1633674 | + |
| 5CDS-intron | ENST00000254719 | ENST00000446363 | RPA1 | chr17 | 1756483 | + | WDR81 | chr17 | 1633674 | + |
| 5CDS-5UTR | ENST00000254719 | ENST00000419248 | RPA1 | chr17 | 1756483 | + | WDR81 | chr17 | 1633674 | + |
| 5CDS-5UTR | ENST00000254719 | ENST00000409644 | RPA1 | chr17 | 1756483 | + | WDR81 | chr17 | 1633674 | + |
| 5CDS-intron | ENST00000254719 | ENST00000545662 | RPA1 | chr17 | 1756483 | + | WDR81 | chr17 | 1633674 | + |
| intron-3CDS | ENST00000573924 | ENST00000437219 | RPA1 | chr17 | 1756483 | + | WDR81 | chr17 | 1633674 | + |
| intron-3CDS | ENST00000573924 | ENST00000309182 | RPA1 | chr17 | 1756483 | + | WDR81 | chr17 | 1633674 | + |
| intron-intron | ENST00000573924 | ENST00000446363 | RPA1 | chr17 | 1756483 | + | WDR81 | chr17 | 1633674 | + |
| intron-5UTR | ENST00000573924 | ENST00000419248 | RPA1 | chr17 | 1756483 | + | WDR81 | chr17 | 1633674 | + |
| intron-5UTR | ENST00000573924 | ENST00000409644 | RPA1 | chr17 | 1756483 | + | WDR81 | chr17 | 1633674 | + |
| intron-intron | ENST00000573924 | ENST00000545662 | RPA1 | chr17 | 1756483 | + | WDR81 | chr17 | 1633674 | + |
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FusionProtFeatures for RPA1_WDR81 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RPA1 | WDR81 |
| As part of the heterotrimeric replication protein Acomplex (RPA/RP-A), binds and stabilizes single-stranded DNAintermediates, that form during DNA replication or upon DNAstress. It prevents their reannealing and in parallel, recruitsand activates different proteins and complexes involved in DNAmetabolism (PubMed:27723720, PubMed:27723717). Thereby, it playsan essential role both in DNA replication and the cellularresponse to DNA damage (PubMed:9430682). In the cellular responseto DNA damage, the RPA complex controls DNA repair and DNA damagecheckpoint activation. Through recruitment of ATRIP activates theATR kinase a master regulator of the DNA damage response(PubMed:24332808). It is required for the recruitment of the DNAdouble-strand break repair factors RAD51 and RAD52 to chromatin inresponse to DNA damage (PubMed:17765923). Also recruits to sitesof DNA damage proteins like XPA and XPG that are involved innucleotide excision repair and is required for this mechanism ofDNA repair (PubMed:7697716). Plays also a role in base excisionrepair (BER) probably through interaction with UNG(PubMed:9765279). Also recruits SMARCAL1/HARP, which is involvedin replication fork restart, to sites of DNA damage. May also playa role in telomere maintenance (PubMed:17959650). As part of thealternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared tothe RPA2-containing, canonical RPA complex, may not supportchromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNApolymerase alpha but could support DNA synthesis by polymerasedelta in presence of PCNA and replication factor C (RFC), the dualincision/excision reaction of nucleotide excision repair andRAD51-dependent strand exchange (PubMed:19996105).{ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:17765923,ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208,ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:24332808,ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720,ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386,ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000309182 | + | 1 | 11 | 1150_1217 | 171 | 891 | Compositional bias | Note=Glu-rich |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000309182 | + | 1 | 11 | 1587_1596 | 171 | 891 | Compositional bias | Note=Poly-Gly |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000409644 | + | 0 | 10 | 1587_1596 | 1222 | 1942 | Compositional bias | Note=Poly-Gly |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000419248 | + | 0 | 10 | 1150_1217 | -5 | 715 | Compositional bias | Note=Glu-rich |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000419248 | + | 0 | 10 | 1587_1596 | -5 | 715 | Compositional bias | Note=Poly-Gly |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000437219 | + | 0 | 10 | 1150_1217 | 19 | 739 | Compositional bias | Note=Glu-rich |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000437219 | + | 0 | 10 | 1587_1596 | 19 | 739 | Compositional bias | Note=Poly-Gly |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000309182 | + | 1 | 11 | 337_614 | 171 | 891 | Domain | BEACH |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000419248 | + | 0 | 10 | 337_614 | -5 | 715 | Domain | BEACH |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000437219 | + | 0 | 10 | 337_614 | 19 | 739 | Domain | BEACH |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000309182 | + | 1 | 11 | 1639_1677 | 171 | 891 | Repeat | Note=WD 1 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000309182 | + | 1 | 11 | 1686_1724 | 171 | 891 | Repeat | Note=WD 2 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000309182 | + | 1 | 11 | 1729_1769 | 171 | 891 | Repeat | Note=WD 3 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000309182 | + | 1 | 11 | 1777_1815 | 171 | 891 | Repeat | Note=WD 4 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000309182 | + | 1 | 11 | 1819_1856 | 171 | 891 | Repeat | Note=WD 5 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000309182 | + | 1 | 11 | 1860_1896 | 171 | 891 | Repeat | Note=WD 6 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000309182 | + | 1 | 11 | 1902_1941 | 171 | 891 | Repeat | Note=WD 7 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000409644 | + | 0 | 10 | 1639_1677 | 1222 | 1942 | Repeat | Note=WD 1 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000409644 | + | 0 | 10 | 1686_1724 | 1222 | 1942 | Repeat | Note=WD 2 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000409644 | + | 0 | 10 | 1729_1769 | 1222 | 1942 | Repeat | Note=WD 3 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000409644 | + | 0 | 10 | 1777_1815 | 1222 | 1942 | Repeat | Note=WD 4 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000409644 | + | 0 | 10 | 1819_1856 | 1222 | 1942 | Repeat | Note=WD 5 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000409644 | + | 0 | 10 | 1860_1896 | 1222 | 1942 | Repeat | Note=WD 6 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000409644 | + | 0 | 10 | 1902_1941 | 1222 | 1942 | Repeat | Note=WD 7 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000419248 | + | 0 | 10 | 1639_1677 | -5 | 715 | Repeat | Note=WD 1 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000419248 | + | 0 | 10 | 1686_1724 | -5 | 715 | Repeat | Note=WD 2 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000419248 | + | 0 | 10 | 1729_1769 | -5 | 715 | Repeat | Note=WD 3 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000419248 | + | 0 | 10 | 1777_1815 | -5 | 715 | Repeat | Note=WD 4 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000419248 | + | 0 | 10 | 1819_1856 | -5 | 715 | Repeat | Note=WD 5 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000419248 | + | 0 | 10 | 1860_1896 | -5 | 715 | Repeat | Note=WD 6 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000419248 | + | 0 | 10 | 1902_1941 | -5 | 715 | Repeat | Note=WD 7 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000437219 | + | 0 | 10 | 1639_1677 | 19 | 739 | Repeat | Note=WD 1 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000437219 | + | 0 | 10 | 1686_1724 | 19 | 739 | Repeat | Note=WD 2 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000437219 | + | 0 | 10 | 1729_1769 | 19 | 739 | Repeat | Note=WD 3 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000437219 | + | 0 | 10 | 1777_1815 | 19 | 739 | Repeat | Note=WD 4 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000437219 | + | 0 | 10 | 1819_1856 | 19 | 739 | Repeat | Note=WD 5 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000437219 | + | 0 | 10 | 1860_1896 | 19 | 739 | Repeat | Note=WD 6 |
| Tgene | >WDR81 | chr17:1756483 | chr17:1633674 | ENST00000437219 | + | 0 | 10 | 1902_1941 | 19 | 739 | Repeat | Note=WD 7 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RPA1 | chr17:1756483 | chr17:1633674 | ENST00000254719 | + | 5 | 17 | 197_281 | 120 | 617 | DNA binding | Note=OB |
| Hgene | >RPA1 | chr17:1756483 | chr17:1633674 | ENST00000254719 | + | 5 | 17 | 481_503 | 120 | 617 | Zinc finger | C4-type |
| Tgene | WDR81 | chr17:1756483 | chr17:1633674 | ENST00000409644 | + | 0 | 10 | 1150_1217 | 1222 | 1942 | Compositional bias | Note=Glu-rich |
| Tgene | WDR81 | chr17:1756483 | chr17:1633674 | ENST00000409644 | + | 0 | 10 | 337_614 | 1222 | 1942 | Domain | BEACH |
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FusionGeneSequence for RPA1_WDR81 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RPA1_ENST00000254719_chr17_1756483_+_WDR81_ENST00000437219_chr17_1633674_+_840aa MVGQLSEGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDG RRVVILMELEVLKSAEAVGVKIGNPVPYNEDTACKMVRWLSAKLGPTVASRHVARNLLRLLTSCYVGPTRQQFTVSSGESPPLSAGNIYQ KRPVLGDIVSGPVLSCLLHIARLYGEPVLTYQYLPYISYLVAPGSASGPSRLNSRKEAGLLAAVTLTQKIIVYLSDTTLMDILPRISHEV LLPVLSFLTSLVTGFPSGAQARTILCVKTISLIALICLRIGQEMVQQHLSEPVATFFQVFSQLHELRQQDLKLDPAGRGEGQLPQVVFSD GQQRPVDPALLDELQKVFTLEMAYTIYVPFSCLLGDIIRKIIPNHELVGELAALYLESISPSSRNPASVEPTMPGTGPEWDPHGGGCPQD DGHSGTFGSVLVGNRIQIPNDSRPENPGPLGPISGVGGGGLGSGSDDNALKQELPRSVHGLSGNWLAYWQYEIGVSQQDAHFHFHQIRLQ SFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLYNYGDGTSETAPRLVYTQHRKSVFFVGQLEAPQHVVSCDGAVHVWDPFTGKTLRT VEPLDSRVPLTAVAVMPAPHTSITMASSDSTLRFVDCRKPGLQHEFRLGGGLNPGLVRALAISPSGRSVVAGFSSGFMVLLDTRTGLVLR GWPAHEGDILQIKAVEGSVLVSSSSDHSLTVWKELEQKPTHHYKSASDPIHTFDLYGSEVVTGTVSNKIGVCSLLEPPSQATTKLSSENF >In-frame_RPA1_ENST00000254719_chr17_1756483_+_WDR81_ENST00000309182_chr17_1633674_+_840aa MVGQLSEGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDG RRVVILMELEVLKSAEAVGVKIGNPVPYNEDTACKMVRWLSAKLGPTVASRHVARNLLRLLTSCYVGPTRQQFTVSSGESPPLSAGNIYQ KRPVLGDIVSGPVLSCLLHIARLYGEPVLTYQYLPYISYLVAPGSASGPSRLNSRKEAGLLAAVTLTQKIIVYLSDTTLMDILPRISHEV LLPVLSFLTSLVTGFPSGAQARTILCVKTISLIALICLRIGQEMVQQHLSEPVATFFQVFSQLHELRQQDLKLDPAGRGEGQLPQVVFSD GQQRPVDPALLDELQKVFTLEMAYTIYVPFSCLLGDIIRKIIPNHELVGELAALYLESISPSSRNPASVEPTMPGTGPEWDPHGGGCPQD DGHSGTFGSVLVGNRIQIPNDSRPENPGPLGPISGVGGGGLGSGSDDNALKQELPRSVHGLSGNWLAYWQYEIGVSQQDAHFHFHQIRLQ SFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLYNYGDGTSETAPRLVYTQHRKSVFFVGQLEAPQHVVSCDGAVHVWDPFTGKTLRT VEPLDSRVPLTAVAVMPAPHTSITMASSDSTLRFVDCRKPGLQHEFRLGGGLNPGLVRALAISPSGRSVVAGFSSGFMVLLDTRTGLVLR GWPAHEGDILQIKAVEGSVLVSSSSDHSLTVWKELEQKPTHHYKSASDPIHTFDLYGSEVVTGTVSNKIGVCSLLEPPSQATTKLSSENF |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RPA1_ENST00000254719_chr17_1756483_+_WDR81_ENST00000437219_chr17_1633674_+_2520nt ATGGTCGGCCAACTGAGCGAGGGGGCCATTGCGGCCATCATGCAGAAGGGGGATACAAACATAAAGCCCATCCTCCAAGTCATCAACATC CGTCCCATTACTACGGGGAATAGTCCGCCGCGTTATCGACTGCTCATGAGTGATGGATTGAACACTCTATCCTCTTTCATGTTGGCGACA CAGTTGAACCCTCTCGTGGAGGAAGAACAATTGTCCAGCAACTGTGTATGCCAGATTCACAGATTTATTGTGAACACTCTGAAAGACGGA AGGAGAGTAGTTATCTTGATGGAATTAGAAGTTTTGAAGTCAGCTGAAGCAGTTGGAGTGAAGATTGGCAATCCAGTGCCCTATAATGAA GATACAGCCTGCAAGATGGTCCGCTGGCTGTCTGCCAAGCTCGGCCCCACAGTGGCCTCTCGCCACGTGGCCCGGAACCTGCTCCGCCTG CTGACGTCTTGTTATGTTGGACCCACTCGGCAGCAGTTCACAGTGAGCAGTGGCGAGAGCCCACCGCTGAGCGCCGGCAACATCTACCAG AAGAGGCCGGTCCTGGGCGACATCGTGTCAGGGCCTGTGCTCAGCTGCCTCCTCCACATCGCCCGCCTGTATGGGGAGCCTGTCCTCACC TACCAGTACCTGCCCTACATCAGCTACCTGGTGGCCCCAGGGAGTGCCTCAGGCCCCAGCCGACTGAACAGCCGTAAGGAGGCGGGGCTG CTGGCCGCGGTGACGCTGACTCAGAAGATCATCGTGTACCTCTCAGACACCACACTCATGGACATCCTGCCCCGGATCAGCCATGAGGTC CTGCTGCCCGTGCTCAGCTTCCTCACCTCCCTCGTCACGGGGTTCCCAAGTGGGGCCCAGGCTCGGACCATCCTGTGTGTGAAAACCATC AGCCTCATCGCCCTCATCTGCCTGCGCATTGGACAGGAGATGGTCCAGCAGCACCTGAGCGAGCCCGTGGCCACCTTTTTCCAGGTCTTC TCTCAGCTGCATGAGCTTCGGCAACAGGATCTGAAGCTGGACCCTGCGGGCCGTGGTGAGGGCCAGCTGCCACAGGTGGTCTTCTCTGAT GGGCAGCAGCGGCCCGTGGACCCCGCCCTGCTGGACGAGCTGCAGAAGGTGTTCACCCTGGAGATGGCATACACAATCTACGTGCCCTTC TCCTGCCTGTTGGGTGACATCATCCGGAAAATCATCCCCAACCACGAGCTGGTTGGGGAGCTGGCGGCGCTGTACTTGGAGAGCATCAGC CCCAGCAGTCGCAACCCTGCCAGCGTGGAGCCCACCATGCCCGGCACCGGGCCCGAGTGGGACCCCCATGGTGGGGGCTGCCCTCAGGAT GACGGCCACTCAGGGACCTTTGGGAGCGTCCTGGTGGGGAACCGCATTCAGATCCCCAATGACTCTCGGCCTGAGAACCCCGGACCACTG GGCCCCATCTCGGGGGTGGGTGGCGGGGGCCTGGGCAGCGGGAGCGACGACAACGCCCTGAAGCAGGAGCTGCCGCGGAGCGTGCACGGG CTGAGCGGAAACTGGCTGGCGTACTGGCAGTACGAGATCGGCGTGAGCCAGCAGGATGCCCACTTTCACTTCCACCAGATCCGCCTGCAG AGCTTCCCGGGCCACTCGGGGGCCGTCAAGTGCGTGGCACCCCTAAGCAGCGAGGACTTCTTCCTGAGCGGCAGCAAGGATCGTACCGTG CGCCTCTGGCCGCTGTACAACTACGGCGACGGGACCAGCGAGACGGCCCCACGCCTCGTCTACACCCAGCACCGCAAGAGCGTCTTCTTC GTGGGCCAGCTTGAGGCCCCGCAGCACGTGGTGAGCTGTGACGGGGCTGTGCACGTCTGGGACCCCTTCACAGGGAAGACCCTTCGCACA GTGGAGCCGCTGGACAGCCGGGTGCCCCTGACTGCGGTGGCTGTCATGCCCGCCCCCCACACCAGCATCACCATGGCCAGCTCTGACTCT ACCCTGCGCTTTGTGGACTGCAGGAAGCCTGGTCTGCAGCACGAGTTCCGACTGGGCGGTGGGCTGAACCCTGGGCTTGTCCGTGCCCTG GCCATCAGCCCCAGTGGCCGTAGTGTCGTGGCCGGCTTCTCCTCAGGCTTCATGGTGCTCCTGGACACCCGCACAGGCCTGGTTCTGCGA GGCTGGCCAGCCCACGAGGGGGACATTCTGCAGATCAAGGCGGTGGAGGGCAGCGTCCTGGTCAGCTCCTCCTCTGACCATTCCTTGACC GTCTGGAAGGAGCTGGAGCAGAAGCCCACCCATCACTACAAGTCAGCATCCGACCCCATCCACACCTTTGACCTGTACGGCAGCGAGGTG GTCACTGGCACCGTGTCCAACAAGATTGGCGTCTGCTCCCTGCTTGAGCCACCCTCGCAGGCCACCACGAAGCTCAGCTCTGAGAACTTC CGCGGCACGCTCACCAGCCTGGCCTTGCTGCCCACTAAACGCCACCTCCTGCTGGGCTCAGACAACGGGGTTATCCGCCTCCTGGCATAG >In-frame_RPA1_ENST00000254719_chr17_1756483_+_WDR81_ENST00000309182_chr17_1633674_+_2520nt ATGGTCGGCCAACTGAGCGAGGGGGCCATTGCGGCCATCATGCAGAAGGGGGATACAAACATAAAGCCCATCCTCCAAGTCATCAACATC CGTCCCATTACTACGGGGAATAGTCCGCCGCGTTATCGACTGCTCATGAGTGATGGATTGAACACTCTATCCTCTTTCATGTTGGCGACA CAGTTGAACCCTCTCGTGGAGGAAGAACAATTGTCCAGCAACTGTGTATGCCAGATTCACAGATTTATTGTGAACACTCTGAAAGACGGA AGGAGAGTAGTTATCTTGATGGAATTAGAAGTTTTGAAGTCAGCTGAAGCAGTTGGAGTGAAGATTGGCAATCCAGTGCCCTATAATGAA GATACAGCCTGCAAGATGGTCCGCTGGCTGTCTGCCAAGCTCGGCCCCACAGTGGCCTCTCGCCACGTGGCCCGGAACCTGCTCCGCCTG CTGACGTCTTGTTATGTTGGACCCACTCGGCAGCAGTTCACAGTGAGCAGTGGCGAGAGCCCACCGCTGAGCGCCGGCAACATCTACCAG AAGAGGCCGGTCCTGGGCGACATCGTGTCAGGGCCTGTGCTCAGCTGCCTCCTCCACATCGCCCGCCTGTATGGGGAGCCTGTCCTCACC TACCAGTACCTGCCCTACATCAGCTACCTGGTGGCCCCAGGGAGTGCCTCAGGCCCCAGCCGACTGAACAGCCGTAAGGAGGCGGGGCTG CTGGCCGCGGTGACGCTGACTCAGAAGATCATCGTGTACCTCTCAGACACCACACTCATGGACATCCTGCCCCGGATCAGCCATGAGGTC CTGCTGCCCGTGCTCAGCTTCCTCACCTCCCTCGTCACGGGGTTCCCAAGTGGGGCCCAGGCTCGGACCATCCTGTGTGTGAAAACCATC AGCCTCATCGCCCTCATCTGCCTGCGCATTGGACAGGAGATGGTCCAGCAGCACCTGAGCGAGCCCGTGGCCACCTTTTTCCAGGTCTTC TCTCAGCTGCATGAGCTTCGGCAACAGGATCTGAAGCTGGACCCTGCGGGCCGTGGTGAGGGCCAGCTGCCACAGGTGGTCTTCTCTGAT GGGCAGCAGCGGCCCGTGGACCCCGCCCTGCTGGACGAGCTGCAGAAGGTGTTCACCCTGGAGATGGCATACACAATCTACGTGCCCTTC TCCTGCCTGTTGGGTGACATCATCCGGAAAATCATCCCCAACCACGAGCTGGTTGGGGAGCTGGCGGCGCTGTACTTGGAGAGCATCAGC CCCAGCAGTCGCAACCCTGCCAGCGTGGAGCCCACCATGCCCGGCACCGGGCCCGAGTGGGACCCCCATGGTGGGGGCTGCCCTCAGGAT GACGGCCACTCAGGGACCTTTGGGAGCGTCCTGGTGGGGAACCGCATTCAGATCCCCAATGACTCTCGGCCTGAGAACCCCGGACCACTG GGCCCCATCTCGGGGGTGGGTGGCGGGGGCCTGGGCAGCGGGAGCGACGACAACGCCCTGAAGCAGGAGCTGCCGCGGAGCGTGCACGGG CTGAGCGGAAACTGGCTGGCGTACTGGCAGTACGAGATCGGCGTGAGCCAGCAGGATGCCCACTTTCACTTCCACCAGATCCGCCTGCAG AGCTTCCCGGGCCACTCGGGGGCCGTCAAGTGCGTGGCACCCCTAAGCAGCGAGGACTTCTTCCTGAGCGGCAGCAAGGATCGTACCGTG CGCCTCTGGCCGCTGTACAACTACGGCGACGGGACCAGCGAGACGGCCCCACGCCTCGTCTACACCCAGCACCGCAAGAGCGTCTTCTTC GTGGGCCAGCTTGAGGCCCCGCAGCACGTGGTGAGCTGTGACGGGGCTGTGCACGTCTGGGACCCCTTCACAGGGAAGACCCTTCGCACA GTGGAGCCGCTGGACAGCCGGGTGCCCCTGACTGCGGTGGCTGTCATGCCCGCCCCCCACACCAGCATCACCATGGCCAGCTCTGACTCT ACCCTGCGCTTTGTGGACTGCAGGAAGCCTGGTCTGCAGCACGAGTTCCGACTGGGCGGTGGGCTGAACCCTGGGCTTGTCCGTGCCCTG GCCATCAGCCCCAGTGGCCGTAGTGTCGTGGCCGGCTTCTCCTCAGGCTTCATGGTGCTCCTGGACACCCGCACAGGCCTGGTTCTGCGA GGCTGGCCAGCCCACGAGGGGGACATTCTGCAGATCAAGGCGGTGGAGGGCAGCGTCCTGGTCAGCTCCTCCTCTGACCATTCCTTGACC GTCTGGAAGGAGCTGGAGCAGAAGCCCACCCATCACTACAAGTCAGCATCCGACCCCATCCACACCTTTGACCTGTACGGCAGCGAGGTG GTCACTGGCACCGTGTCCAACAAGATTGGCGTCTGCTCCCTGCTTGAGCCACCCTCGCAGGCCACCACGAAGCTCAGCTCTGAGAACTTC CGCGGCACGCTCACCAGCCTGGCCTTGCTGCCCACTAAACGCCACCTCCTGCTGGGCTCAGACAACGGGGTTATCCGCCTCCTGGCATAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RPA1_ENST00000254719_chr17_1756483_+_WDR81_ENST00000437219_chr17_1633674_+_3544nt CGGGAGCGGTGCGCGCAACTTCTCGGGCCAATAACTGCGCAGCGCGCGGGACCCGGGTGGGGAAGCTGGAGCTGTTGCGGGGTCCGCGGG GAAGTCTTGGCGGTGGAGCCATGGTCGGCCAACTGAGCGAGGGGGCCATTGCGGCCATCATGCAGAAGGGGGATACAAACATAAAGCCCA TCCTCCAAGTCATCAACATCCGTCCCATTACTACGGGGAATAGTCCGCCGCGTTATCGACTGCTCATGAGTGATGGATTGAACACTCTAT CCTCTTTCATGTTGGCGACACAGTTGAACCCTCTCGTGGAGGAAGAACAATTGTCCAGCAACTGTGTATGCCAGATTCACAGATTTATTG TGAACACTCTGAAAGACGGAAGGAGAGTAGTTATCTTGATGGAATTAGAAGTTTTGAAGTCAGCTGAAGCAGTTGGAGTGAAGATTGGCA ATCCAGTGCCCTATAATGAAGATACAGCCTGCAAGATGGTCCGCTGGCTGTCTGCCAAGCTCGGCCCCACAGTGGCCTCTCGCCACGTGG CCCGGAACCTGCTCCGCCTGCTGACGTCTTGTTATGTTGGACCCACTCGGCAGCAGTTCACAGTGAGCAGTGGCGAGAGCCCACCGCTGA GCGCCGGCAACATCTACCAGAAGAGGCCGGTCCTGGGCGACATCGTGTCAGGGCCTGTGCTCAGCTGCCTCCTCCACATCGCCCGCCTGT ATGGGGAGCCTGTCCTCACCTACCAGTACCTGCCCTACATCAGCTACCTGGTGGCCCCAGGGAGTGCCTCAGGCCCCAGCCGACTGAACA GCCGTAAGGAGGCGGGGCTGCTGGCCGCGGTGACGCTGACTCAGAAGATCATCGTGTACCTCTCAGACACCACACTCATGGACATCCTGC CCCGGATCAGCCATGAGGTCCTGCTGCCCGTGCTCAGCTTCCTCACCTCCCTCGTCACGGGGTTCCCAAGTGGGGCCCAGGCTCGGACCA TCCTGTGTGTGAAAACCATCAGCCTCATCGCCCTCATCTGCCTGCGCATTGGACAGGAGATGGTCCAGCAGCACCTGAGCGAGCCCGTGG CCACCTTTTTCCAGGTCTTCTCTCAGCTGCATGAGCTTCGGCAACAGGATCTGAAGCTGGACCCTGCGGGCCGTGGTGAGGGCCAGCTGC CACAGGTGGTCTTCTCTGATGGGCAGCAGCGGCCCGTGGACCCCGCCCTGCTGGACGAGCTGCAGAAGGTGTTCACCCTGGAGATGGCAT ACACAATCTACGTGCCCTTCTCCTGCCTGTTGGGTGACATCATCCGGAAAATCATCCCCAACCACGAGCTGGTTGGGGAGCTGGCGGCGC TGTACTTGGAGAGCATCAGCCCCAGCAGTCGCAACCCTGCCAGCGTGGAGCCCACCATGCCCGGCACCGGGCCCGAGTGGGACCCCCATG GTGGGGGCTGCCCTCAGGATGACGGCCACTCAGGGACCTTTGGGAGCGTCCTGGTGGGGAACCGCATTCAGATCCCCAATGACTCTCGGC CTGAGAACCCCGGACCACTGGGCCCCATCTCGGGGGTGGGTGGCGGGGGCCTGGGCAGCGGGAGCGACGACAACGCCCTGAAGCAGGAGC TGCCGCGGAGCGTGCACGGGCTGAGCGGAAACTGGCTGGCGTACTGGCAGTACGAGATCGGCGTGAGCCAGCAGGATGCCCACTTTCACT TCCACCAGATCCGCCTGCAGAGCTTCCCGGGCCACTCGGGGGCCGTCAAGTGCGTGGCACCCCTAAGCAGCGAGGACTTCTTCCTGAGCG GCAGCAAGGATCGTACCGTGCGCCTCTGGCCGCTGTACAACTACGGCGACGGGACCAGCGAGACGGCCCCACGCCTCGTCTACACCCAGC ACCGCAAGAGCGTCTTCTTCGTGGGCCAGCTTGAGGCCCCGCAGCACGTGGTGAGCTGTGACGGGGCTGTGCACGTCTGGGACCCCTTCA CAGGGAAGACCCTTCGCACAGTGGAGCCGCTGGACAGCCGGGTGCCCCTGACTGCGGTGGCTGTCATGCCCGCCCCCCACACCAGCATCA CCATGGCCAGCTCTGACTCTACCCTGCGCTTTGTGGACTGCAGGAAGCCTGGTCTGCAGCACGAGTTCCGACTGGGCGGTGGGCTGAACC CTGGGCTTGTCCGTGCCCTGGCCATCAGCCCCAGTGGCCGTAGTGTCGTGGCCGGCTTCTCCTCAGGCTTCATGGTGCTCCTGGACACCC GCACAGGCCTGGTTCTGCGAGGCTGGCCAGCCCACGAGGGGGACATTCTGCAGATCAAGGCGGTGGAGGGCAGCGTCCTGGTCAGCTCCT CCTCTGACCATTCCTTGACCGTCTGGAAGGAGCTGGAGCAGAAGCCCACCCATCACTACAAGTCAGCATCCGACCCCATCCACACCTTTG ACCTGTACGGCAGCGAGGTGGTCACTGGCACCGTGTCCAACAAGATTGGCGTCTGCTCCCTGCTTGAGCCACCCTCGCAGGCCACCACGA AGCTCAGCTCTGAGAACTTCCGCGGCACGCTCACCAGCCTGGCCTTGCTGCCCACTAAACGCCACCTCCTGCTGGGCTCAGACAACGGGG TTATCCGCCTCCTGGCATAGACTGAGGCAGGAGCTGGCCGGGCAAGGGTGGGAAGACATCTGCGGGCGCGTGTCCACTCACCCTGTTCCC TGAGCAGCAGCTCCCTCCAGGGAGGCCCTGGGTCCCACGCCCTGGGTGCCCACATGGCCTGCCAACTAGGGCCTGCAAATGGAGTGGGGG AGTCCTGGCCCCTGAATCACCAGAGCCACCAAGCCTGCCAGAGGGGTCTCATTCATGGCTTGGGGACACAGGGCTCCTAGCAAGCAGGAA GTTAAGAGCAGGAGGAAGCGTTGCTACCTTCACTTCTCCCCAGCTCTGCCCTCTGGGTCCACATGAGGACAGGGAAGCTCGGGAAGGGGA AGGGAGACTGGCCCTGCCCAGCCGGTCTCTAGCCCCTCAGCCCCCGCTGGGCACTCTCTGTCCCATCCCTCTAGGACAGGGAAGCTGGCC TGGTCCAGGGCACTGATGGTGCTTGGATTCCAGCCTAAGGAAGGCTGGCCGTGGTCCAGGAGTTAAGGGCTTGGGTCTGGGGTTTAAGTG GCCACCCATCCAGGCCCTGGCCAGTGTGGGACCGGGACGGGAAGGAAGAAGGAGGCTAGGAGCAGGGGGAAAAGGTGCACTTGGCCAGTG GCGCCTGCCAGGAGTGAGTCCATGCGTTGTCTGCCCACCCCTACCACAGTGTTTGTGCCTTCAGCTGAGGGGGCAGCCTCTGGGCCCTGA ACCCCTGCTGGGGCTCCACGACCCTGAGAGAAGGGGTGAGAAGAATCATCTCTGCACCTCGGGTCTCTGCCAGAGGAAGACTTAAGCATC CCTGCGACCTCACATTCTAGACAGAGATGAGGTCCAGGGGTTGGCCCCTGCTGCCTTCTCACAATTTGCAATAGATGTAAATAGGACCAA >In-frame_RPA1_ENST00000254719_chr17_1756483_+_WDR81_ENST00000309182_chr17_1633674_+_3544nt CGGGAGCGGTGCGCGCAACTTCTCGGGCCAATAACTGCGCAGCGCGCGGGACCCGGGTGGGGAAGCTGGAGCTGTTGCGGGGTCCGCGGG GAAGTCTTGGCGGTGGAGCCATGGTCGGCCAACTGAGCGAGGGGGCCATTGCGGCCATCATGCAGAAGGGGGATACAAACATAAAGCCCA TCCTCCAAGTCATCAACATCCGTCCCATTACTACGGGGAATAGTCCGCCGCGTTATCGACTGCTCATGAGTGATGGATTGAACACTCTAT CCTCTTTCATGTTGGCGACACAGTTGAACCCTCTCGTGGAGGAAGAACAATTGTCCAGCAACTGTGTATGCCAGATTCACAGATTTATTG TGAACACTCTGAAAGACGGAAGGAGAGTAGTTATCTTGATGGAATTAGAAGTTTTGAAGTCAGCTGAAGCAGTTGGAGTGAAGATTGGCA ATCCAGTGCCCTATAATGAAGATACAGCCTGCAAGATGGTCCGCTGGCTGTCTGCCAAGCTCGGCCCCACAGTGGCCTCTCGCCACGTGG CCCGGAACCTGCTCCGCCTGCTGACGTCTTGTTATGTTGGACCCACTCGGCAGCAGTTCACAGTGAGCAGTGGCGAGAGCCCACCGCTGA GCGCCGGCAACATCTACCAGAAGAGGCCGGTCCTGGGCGACATCGTGTCAGGGCCTGTGCTCAGCTGCCTCCTCCACATCGCCCGCCTGT ATGGGGAGCCTGTCCTCACCTACCAGTACCTGCCCTACATCAGCTACCTGGTGGCCCCAGGGAGTGCCTCAGGCCCCAGCCGACTGAACA GCCGTAAGGAGGCGGGGCTGCTGGCCGCGGTGACGCTGACTCAGAAGATCATCGTGTACCTCTCAGACACCACACTCATGGACATCCTGC CCCGGATCAGCCATGAGGTCCTGCTGCCCGTGCTCAGCTTCCTCACCTCCCTCGTCACGGGGTTCCCAAGTGGGGCCCAGGCTCGGACCA TCCTGTGTGTGAAAACCATCAGCCTCATCGCCCTCATCTGCCTGCGCATTGGACAGGAGATGGTCCAGCAGCACCTGAGCGAGCCCGTGG CCACCTTTTTCCAGGTCTTCTCTCAGCTGCATGAGCTTCGGCAACAGGATCTGAAGCTGGACCCTGCGGGCCGTGGTGAGGGCCAGCTGC CACAGGTGGTCTTCTCTGATGGGCAGCAGCGGCCCGTGGACCCCGCCCTGCTGGACGAGCTGCAGAAGGTGTTCACCCTGGAGATGGCAT ACACAATCTACGTGCCCTTCTCCTGCCTGTTGGGTGACATCATCCGGAAAATCATCCCCAACCACGAGCTGGTTGGGGAGCTGGCGGCGC TGTACTTGGAGAGCATCAGCCCCAGCAGTCGCAACCCTGCCAGCGTGGAGCCCACCATGCCCGGCACCGGGCCCGAGTGGGACCCCCATG GTGGGGGCTGCCCTCAGGATGACGGCCACTCAGGGACCTTTGGGAGCGTCCTGGTGGGGAACCGCATTCAGATCCCCAATGACTCTCGGC CTGAGAACCCCGGACCACTGGGCCCCATCTCGGGGGTGGGTGGCGGGGGCCTGGGCAGCGGGAGCGACGACAACGCCCTGAAGCAGGAGC TGCCGCGGAGCGTGCACGGGCTGAGCGGAAACTGGCTGGCGTACTGGCAGTACGAGATCGGCGTGAGCCAGCAGGATGCCCACTTTCACT TCCACCAGATCCGCCTGCAGAGCTTCCCGGGCCACTCGGGGGCCGTCAAGTGCGTGGCACCCCTAAGCAGCGAGGACTTCTTCCTGAGCG GCAGCAAGGATCGTACCGTGCGCCTCTGGCCGCTGTACAACTACGGCGACGGGACCAGCGAGACGGCCCCACGCCTCGTCTACACCCAGC ACCGCAAGAGCGTCTTCTTCGTGGGCCAGCTTGAGGCCCCGCAGCACGTGGTGAGCTGTGACGGGGCTGTGCACGTCTGGGACCCCTTCA CAGGGAAGACCCTTCGCACAGTGGAGCCGCTGGACAGCCGGGTGCCCCTGACTGCGGTGGCTGTCATGCCCGCCCCCCACACCAGCATCA CCATGGCCAGCTCTGACTCTACCCTGCGCTTTGTGGACTGCAGGAAGCCTGGTCTGCAGCACGAGTTCCGACTGGGCGGTGGGCTGAACC CTGGGCTTGTCCGTGCCCTGGCCATCAGCCCCAGTGGCCGTAGTGTCGTGGCCGGCTTCTCCTCAGGCTTCATGGTGCTCCTGGACACCC GCACAGGCCTGGTTCTGCGAGGCTGGCCAGCCCACGAGGGGGACATTCTGCAGATCAAGGCGGTGGAGGGCAGCGTCCTGGTCAGCTCCT CCTCTGACCATTCCTTGACCGTCTGGAAGGAGCTGGAGCAGAAGCCCACCCATCACTACAAGTCAGCATCCGACCCCATCCACACCTTTG ACCTGTACGGCAGCGAGGTGGTCACTGGCACCGTGTCCAACAAGATTGGCGTCTGCTCCCTGCTTGAGCCACCCTCGCAGGCCACCACGA AGCTCAGCTCTGAGAACTTCCGCGGCACGCTCACCAGCCTGGCCTTGCTGCCCACTAAACGCCACCTCCTGCTGGGCTCAGACAACGGGG TTATCCGCCTCCTGGCATAGACTGAGGCAGGAGCTGGCCGGGCAAGGGTGGGAAGACATCTGCGGGCGCGTGTCCACTCACCCTGTTCCC TGAGCAGCAGCTCCCTCCAGGGAGGCCCTGGGTCCCACGCCCTGGGTGCCCACATGGCCTGCCAACTAGGGCCTGCAAATGGAGTGGGGG AGTCCTGGCCCCTGAATCACCAGAGCCACCAAGCCTGCCAGAGGGGTCTCATTCATGGCTTGGGGACACAGGGCTCCTAGCAAGCAGGAA GTTAAGAGCAGGAGGAAGCGTTGCTACCTTCACTTCTCCCCAGCTCTGCCCTCTGGGTCCACATGAGGACAGGGAAGCTCGGGAAGGGGA AGGGAGACTGGCCCTGCCCAGCCGGTCTCTAGCCCCTCAGCCCCCGCTGGGCACTCTCTGTCCCATCCCTCTAGGACAGGGAAGCTGGCC TGGTCCAGGGCACTGATGGTGCTTGGATTCCAGCCTAAGGAAGGCTGGCCGTGGTCCAGGAGTTAAGGGCTTGGGTCTGGGGTTTAAGTG GCCACCCATCCAGGCCCTGGCCAGTGTGGGACCGGGACGGGAAGGAAGAAGGAGGCTAGGAGCAGGGGGAAAAGGTGCACTTGGCCAGTG GCGCCTGCCAGGAGTGAGTCCATGCGTTGTCTGCCCACCCCTACCACAGTGTTTGTGCCTTCAGCTGAGGGGGCAGCCTCTGGGCCCTGA ACCCCTGCTGGGGCTCCACGACCCTGAGAGAAGGGGTGAGAAGAATCATCTCTGCACCTCGGGTCTCTGCCAGAGGAAGACTTAAGCATC CCTGCGACCTCACATTCTAGACAGAGATGAGGTCCAGGGGTTGGCCCCTGCTGCCTTCTCACAATTTGCAATAGATGTAAATAGGACCAA |
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FusionGenePPI for RPA1_WDR81 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RPA1 | MCM2, MCM7, ORC2, BRCA2, TP53, BLM, ATR, TP53BP1, FANCA, TIPIN, KIN, ORC6, MCM4, MCM6, TCEA2, ASCC2, CPE, AKTIP, HGH1, RBM23, SELENBP1, RPA2, PRKDC, ATRIP, RPA4, RPA3, MUTYH, RAD52, RAD51, MSH4, XPA, RPA1, PCNA, RAD9A, RAD1, HUS1, CCNA2, FANCM, ATG101, FYCO1, RB1CC1, CHAF1A, CHD1L, PRIM1, MCPH1, HNRNPUL1, BRCA1, TOPBP1, BRIP1, TOP3A, FANCG, POLK, RFWD3, CENPA, DYRK2, CSNK2B, TK1, ANXA1, RCC1, ANXA7, GTF2H1, HDGF, PSMD4, RNF4, ARRB2, SH3KBP1, CDK1, CDK2, CCNA1, CCNB1, BID, POLR2A, ERCC6, HERC2, NEURL4, SPRTN, SMARCAL1, MCM3, SMC2, XPC, RAD23B, POLD1, UBXN1, MSH3, PPME1, PAXIP1, FN1, ATM, AICDA, PAN2, HAX1, VIM, SMAD3, RPS6KA5, GNB5, FBXO6, AARSD1, FUBP1, GRPEL1, ACTR2, ACTR3, ANP32B, ARPC2, ARPC4, CALR, NSUN2, PFDN5, PPP1R12A, PUS1, RPRD1B, SH3GL1, EXO5, PARP1, HNRNPM, MYH9, PARP14, LIG3, FBXO18, DHX36, DNA2, XRCC1, HLTF, XRN2, HNRNPD, XRCC6, GTF2I, MYH10, IQGAP1, CDKN2AIP, SFPQ, RMI1, MSI2, RTEL1, XRCC5, TIAL1, WRN, FUS, MPG, TARDBP, HNRNPA0, UNG, PARP9, HNRNPA2B1, ANXA2P2, PURB, GAPDH, PNKP, MSH2, RFC5, RBM4, NPM1, RBFOX2, FLNA, EIF2S1, ACTB, HNRNPA1, NUDT21, HNRNPAB, KCNAB2, YTHDF1, XRN1, YTHDF3, SNRNP200, NONO, INTS6, C14orf166, ELAVL1, CSNK1A1, CUL1, RBM14, DTX3L, FUBP3, RFC4, HNRNPU, RPLP0, RAVER1, ACTA2, PTBP1, EWSR1, PRDX1, IMPDH2, PARP12, RNASEH1, SLFN11, RAB11B, RPL7, EEF1A2, RAB13, SERPINB12, ANXA2, NTHL1, TAF15, NTPCR, DAZAP1, EEF1A1, YTHDF2, CELF1, ESRP2, HNRNPDL, MATR3, SF3B1, TUBB4B, DHX15, TUBA4A, ACTBL2, HNRNPA3, KHDRBS1, RAB5C, HSPB1, SNRPB, TUBA1C, APEX1, MYH11, DDX5, PRPF6, DDX17, RPS9, RAB7A, SEC22B, RAB1A, TUBB, RPS7, CAPZA1, EMG1, RAB8A, RAI14, HNRNPK, PDS5A, LMO7, RBM27, SF3B2, NCL, RPL13A, RPS5, LDHA, PPP1CC, RFC2, EFTUD2, SF3A1, MPRIP, CHTF18, RBM25, ILF3, SF3B3, RBM26, SPTAN1, BCAP31, MNAT1, DDX3X, BCAS2, MDC1, RAB35, RBM39, RPL19, RPL9, BUB3, RPS8, CSNK1A1L, RAB10, TMEM33, MYO1C, DSP, PRPF8, TOP2B, PABPC1, TCOF1, TFRC, MYO1E, RBM15, PRPF40A, SKIV2L2, MYOF, PPP1R10, SMC3, INTS3, THOC2, RAD50, SYMPK, CLTC, KIAA0196, TRIM28, ARHGEF2, HNRNPR, LIMCH1, ALPP, CDC5L, CKAP5, RPL6, SMC1A, HSPA8, CCAR2, LIMA1, LMAN2, MYO1B, WDR82, ADAR, FKBP15, HNRNPL, ILF2, MOV10, RFC1, SPTBN1, THOC6, AHNAK, PRRC2A, CHD4, DHX9, HSPA5, KDM1A, MRE11A, MTHFD1, NAPA, SYNCRIP, TOP2A, DDX23, DNTTIP1, LOC442497, SCAMP3, U2SURP, TSR1, WDR3, ADD1, CAPRIN1, CCNH, CPSF7, EXOSC10, GTF2H3, MAP4, NBN, POLA1, PSIP1, RAB2A, RFC3, RPL18A, SNRNP40, SRBD1, TAGLN2, TMPO, TPX2, AP1B1, BAG2, BBX, ELMSAN1, CALD1, CANX, CDK7, COPA, CSNK2A2, DDX46, EGFR, ERGIC1, GEMIN5, GTF3C2, PKP3, POLR1B, POLR2E, RALY, SMC4, STRBP, THOC7, TRIP12, WDR33, ATP6V0D1, C7orf50, CAV1, CLINT1, COBL, CPSF1, CTTN, DDB1, DDX1, DIDO1, DNAJC9, EDC4, EIF2S2, ESYT1, HCFC1, INTS1, MORF4L2, PCF11, PPP2CA, RAB14, RAB6B, RPL15, RPS7P4, SMARCA5, THOC1, TPM2, UBC, ZNF638, AKAP8, AP2A1, AP2A2, AP2B1, ARG1, CHERP, EPRS, EXOSC7, EXOSC8, FBL, GEMIN4, HNRNPCL1, HNRNPF, HNRNPH1, ITGB1, KIAA1033, MED4, MYO1F, NIPBL, NUMA1, PABPC4, PELP1, PGRMC1, PRPF19, RAB6A, RAD21, RBM10, RPL10L, RPL13P12, RPL18, RPRD2, RPS3A, RTN4, RUVBL2, SEH1L, SCAF4, SMARCC2, TCERG1, TERF2, TEX10, USP7, WAPAL, WDHD1, ZCCHC8, ZFR, ZNF598, TRIM25, ATRX, APITD1, STRA13, MTUS2, CUL7, CCDC8, RNF2, LUZP4, RPAIN, LTN1, CORO1C, LMNA, LMNB1, TFAM, NTRK1, CEP162, TOP3B, KIF3A, PROSC, DROSHA, OBSCN, SLX4, NF2, USP37, SHFM1, SNW1, NFATC1, NFATC2, DERL1, EYA1, MACROD1, RBM3, POLL, ERCC1, HELQ, FANCD2, SPTA1, DLD, PDHA1, CCND2, UHRF2 | WDR81 | PPP4C, BLNK, CUL3, MAPK15, ENO1, SHMT2, MOV10, NXF1, NTRK1, TMEM237, XPO1, WFDC2, BECN1, SQSTM1, MAP1LC3C, UBC, WDR91 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RPA1_WDR81 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RPA1_WDR81 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RPA1 | C0263454 | Chloracne | 1 | CTD_human |
| Tgene | WDR81 | C2750234 | Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 2 | 1 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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