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Fusion gene ID: 31724 |
FusionGeneSummary for ROS1_CD74 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ROS1_CD74 | Fusion gene ID: 31724 | Hgene | Tgene | Gene symbol | ROS1 | CD74 | Gene ID | 6098 | 972 |
| Gene name | ROS proto-oncogene 1, receptor tyrosine kinase | CD74 molecule | |
| Synonyms | MCF3|ROS|c-ros-1 | DHLAG|HLADG|II|Ia-GAMMA | |
| Cytomap | 6q22.1 | 5q33.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | proto-oncogene tyrosine-protein kinase ROSROS proto-oncogene 1 , receptor tyrosine kinasec-ros oncogene 1 , receptor tyrosine kinaseproto-oncogene c-Ros-1transmembrane tyrosine-specific protein kinasev-ros avian UR2 sarcoma virus oncogene homolog 1 | HLA class II histocompatibility antigen gamma chainCD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)CD74 molecule, major histocompatibility complex, class II invariant chainHLA-DR antigens-associated | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P08922 | P04233 | |
| Ensembl transtripts involved in fusion gene | ENST00000368508, ENST00000368507, | ENST00000377795, ENST00000353334, ENST00000524315, ENST00000009530, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 16 X 15 X 5=1200 |
| # samples | 3 | 27 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(27/1200*10)=-2.15200309344505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ROS1 [Title/Abstract] AND CD74 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ROS1 | GO:0001558 | regulation of cell growth | 16885344 |
| Hgene | ROS1 | GO:0006468 | protein phosphorylation | 16885344 |
| Hgene | ROS1 | GO:0032006 | regulation of TOR signaling | 16885344 |
| Tgene | CD74 | GO:0001516 | prostaglandin biosynthetic process | 12782713 |
| Tgene | CD74 | GO:0001934 | positive regulation of protein phosphorylation | 24942581 |
| Tgene | CD74 | GO:0002792 | negative regulation of peptide secretion | 19849849 |
| Tgene | CD74 | GO:0007165 | signal transduction | 12782713 |
| Tgene | CD74 | GO:0008283 | cell proliferation | 12782713 |
| Tgene | CD74 | GO:0033674 | positive regulation of kinase activity | 24942581 |
| Tgene | CD74 | GO:0043066 | negative regulation of apoptotic process | 12782713 |
| Tgene | CD74 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 24942581 |
| Tgene | CD74 | GO:0043410 | positive regulation of MAPK cascade | 24942581 |
| Tgene | CD74 | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator | 17045821 |
| Tgene | CD74 | GO:0045657 | positive regulation of monocyte differentiation | 24942581 |
| Tgene | CD74 | GO:0045893 | positive regulation of transcription, DNA-templated | 24942581 |
| Tgene | CD74 | GO:0046598 | positive regulation of viral entry into host cell | 24942581 |
| Tgene | CD74 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 17045821 |
| Tgene | CD74 | GO:0051290 | protein heterotetramerization | 24942581 |
| Tgene | CD74 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 17045821|24942581 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-86-8278-01A | ROS1 | chr6 | 117700222 | - | CD74 | chr5 | 149782188 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000368508 | ENST00000377795 | ROS1 | chr6 | 117700222 | - | CD74 | chr5 | 149782188 | - |
| Frame-shift | ENST00000368508 | ENST00000353334 | ROS1 | chr6 | 117700222 | - | CD74 | chr5 | 149782188 | - |
| 5CDS-intron | ENST00000368508 | ENST00000524315 | ROS1 | chr6 | 117700222 | - | CD74 | chr5 | 149782188 | - |
| 5CDS-intron | ENST00000368508 | ENST00000009530 | ROS1 | chr6 | 117700222 | - | CD74 | chr5 | 149782188 | - |
| In-frame | ENST00000368507 | ENST00000377795 | ROS1 | chr6 | 117700222 | - | CD74 | chr5 | 149782188 | - |
| Frame-shift | ENST00000368507 | ENST00000353334 | ROS1 | chr6 | 117700222 | - | CD74 | chr5 | 149782188 | - |
| 5CDS-intron | ENST00000368507 | ENST00000524315 | ROS1 | chr6 | 117700222 | - | CD74 | chr5 | 149782188 | - |
| 5CDS-intron | ENST00000368507 | ENST00000009530 | ROS1 | chr6 | 117700222 | - | CD74 | chr5 | 149782188 | - |
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FusionProtFeatures for ROS1_CD74 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ROS1 | CD74 |
| Orphan receptor tyrosine kinase (RTK) that plays a rolein epithelial cell differentiation and regionalization of theproximal epididymal epithelium. May activate several downstreamsignaling pathways related to cell differentiation, proliferation,growth and survival including the PI3 kinase-mTOR signalingpathway. Mediates the phosphorylation of PTPN11, an activator ofthis pathway. May also phosphorylate and activate thetranscription factor STAT3 to control anchorage-independent cellgrowth. Mediates the phosphorylation and the activation of VAV3, aguanine nucleotide exchange factor regulating cell morphology. Mayactivate other downstream signaling proteins including AKT1,MAPK1, MAPK3, IRS1 and PLCG2. {ECO:0000269|PubMed:11094073,ECO:0000269|PubMed:16885344}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ROS1 | chr6:117700222 | chr5:149782188 | ENST00000368508 | - | 17 | 43 | 101_196 | 865 | 2348 | Domain | Fibronectin type-III 1 |
| Hgene | ROS1 | chr6:117700222 | chr5:149782188 | ENST00000368508 | - | 17 | 43 | 197_285 | 865 | 2348 | Domain | Fibronectin type-III 2 |
| Hgene | ROS1 | chr6:117700222 | chr5:149782188 | ENST00000368508 | - | 17 | 43 | 557_671 | 865 | 2348 | Domain | Fibronectin type-III 3 |
| Tgene | >CD74 | chr6:117700222 | chr5:149782188 | ENST00000353334 | - | 5 | 8 | 210_271 | 208 | 233 | Domain | Thyroglobulin type-1 |
| Tgene | >CD74 | chr6:117700222 | chr5:149782188 | ENST00000377795 | - | 3 | 6 | 210_271 | 147 | 280 | Domain | Thyroglobulin type-1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ROS1 | chr6:117700222 | chr5:149782188 | ENST00000368508 | - | 17 | 43 | 1043_1150 | 865 | 2348 | Domain | Fibronectin type-III 5 |
| Hgene | >ROS1 | chr6:117700222 | chr5:149782188 | ENST00000368508 | - | 17 | 43 | 1450_1556 | 865 | 2348 | Domain | Fibronectin type-III 6 |
| Hgene | >ROS1 | chr6:117700222 | chr5:149782188 | ENST00000368508 | - | 17 | 43 | 1557_1656 | 865 | 2348 | Domain | Fibronectin type-III 7 |
| Hgene | >ROS1 | chr6:117700222 | chr5:149782188 | ENST00000368508 | - | 17 | 43 | 1658_1751 | 865 | 2348 | Domain | Fibronectin type-III 8 |
| Hgene | >ROS1 | chr6:117700222 | chr5:149782188 | ENST00000368508 | - | 17 | 43 | 1752_1854 | 865 | 2348 | Domain | Fibronectin type-III 9 |
| Hgene | >ROS1 | chr6:117700222 | chr5:149782188 | ENST00000368508 | - | 17 | 43 | 1945_2222 | 865 | 2348 | Domain | Protein kinase |
| Hgene | >ROS1 | chr6:117700222 | chr5:149782188 | ENST00000368508 | - | 17 | 43 | 947_1042 | 865 | 2348 | Domain | Fibronectin type-III 4 |
| Hgene | >ROS1 | chr6:117700222 | chr5:149782188 | ENST00000368508 | - | 17 | 43 | 1951_1959 | 865 | 2348 | Nucleotide binding | ATP |
| Hgene | >ROS1 | chr6:117700222 | chr5:149782188 | ENST00000368508 | - | 17 | 43 | 1883_2347 | 865 | 2348 | Topological domain | Cytoplasmic |
| Hgene | >ROS1 | chr6:117700222 | chr5:149782188 | ENST00000368508 | - | 17 | 43 | 28_1859 | 865 | 2348 | Topological domain | Extracellular |
| Hgene | >ROS1 | chr6:117700222 | chr5:149782188 | ENST00000368508 | - | 17 | 43 | 1860_1882 | 865 | 2348 | Transmembrane | Helical |
| Tgene | CD74 | chr6:117700222 | chr5:149782188 | ENST00000009530 | - | 6 | 9 | 210_271 | 272 | 297 | Domain | Thyroglobulin type-1 |
| Tgene | CD74 | chr6:117700222 | chr5:149782188 | ENST00000009530 | - | 6 | 9 | 103_117 | 272 | 297 | Region | Note=CLIP |
| Tgene | CD74 | chr6:117700222 | chr5:149782188 | ENST00000353334 | - | 5 | 8 | 103_117 | 208 | 233 | Region | Note=CLIP |
| Tgene | CD74 | chr6:117700222 | chr5:149782188 | ENST00000377795 | - | 3 | 6 | 103_117 | 147 | 280 | Region | Note=CLIP |
| Tgene | CD74 | chr6:117700222 | chr5:149782188 | ENST00000009530 | - | 6 | 9 | 1_46 | 272 | 297 | Topological domain | Cytoplasmic |
| Tgene | CD74 | chr6:117700222 | chr5:149782188 | ENST00000009530 | - | 6 | 9 | 73_296 | 272 | 297 | Topological domain | Extracellular |
| Tgene | CD74 | chr6:117700222 | chr5:149782188 | ENST00000353334 | - | 5 | 8 | 1_46 | 208 | 233 | Topological domain | Cytoplasmic |
| Tgene | CD74 | chr6:117700222 | chr5:149782188 | ENST00000353334 | - | 5 | 8 | 73_296 | 208 | 233 | Topological domain | Extracellular |
| Tgene | CD74 | chr6:117700222 | chr5:149782188 | ENST00000377795 | - | 3 | 6 | 1_46 | 147 | 280 | Topological domain | Cytoplasmic |
| Tgene | CD74 | chr6:117700222 | chr5:149782188 | ENST00000377795 | - | 3 | 6 | 73_296 | 147 | 280 | Topological domain | Extracellular |
| Tgene | CD74 | chr6:117700222 | chr5:149782188 | ENST00000009530 | - | 6 | 9 | 47_72 | 272 | 297 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Tgene | CD74 | chr6:117700222 | chr5:149782188 | ENST00000353334 | - | 5 | 8 | 47_72 | 208 | 233 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Tgene | CD74 | chr6:117700222 | chr5:149782188 | ENST00000377795 | - | 3 | 6 | 47_72 | 147 | 280 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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FusionGeneSequence for ROS1_CD74 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ROS1_ENST00000368508_chr6_117700222_-_CD74_ENST00000377795_chr5_149782188_-_879aa MKNIYCLIPKLVNFATLGCLWISVVQCTVLNSCLKSCVTNLGQQLDLGTPHNLSEPCIQGCHFWNSVDQKNCALKCRESCEVGCSSAEGA YEEEVLENADLPTAPFASSIGSHNMTLRWKSANFSGVKYIIQWKYAQLLGSWTYTKTVSRPSYVVKPLHPFTEYIFRVVWIFTAQLQLYS PPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKNQKLDAGTQRTSFQFYSTLPNTIYRFSIAAVNEVG EGPEAESSITTSSSAVQQEEQWLFLSRKTSLRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFSEGTLIWAKKAANMSDVSDLR IFYRGSGLISSISIDWLYQRMYFIMDELVCVCDLENCSNIEEITPPSISAPQKIVADSYNGYVFYLLRDGIYRADLPVPSGRCAEAVRIV ESCTLKDFAIKPQAKRIIYFNDTAQVFMSTFLDGSASHLILPRIPFADVKSFACENNDFLVTDGKVIFQQDALSFNEFIVGCDLSHIEEF GFGNLVIFGSSSQLHPLPGRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFELGPSAWQNWTYEVKVSTQDPPEVTHIFLNIS GTMLNVPELQSAMKYKVSVRASSPKRPGPWSEPSVGTTLVPASEPPFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDWYNNSLYYS DTKGDVFVWLLNGTDISENYHLPSIAGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTDIVTHVKLLVNDMVVDSVGGYLYWTTLYSVE >In-frame_ROS1_ENST00000368507_chr6_117700222_-_CD74_ENST00000377795_chr5_149782188_-_874aa MKNIYCLIPKLVNFATLGCLWISVVQCTVLNSCLKSCVTNLGQQLDLGTPHNLSEPCIQGCHFWNSVDQKNCALKCNDTYATVCERESCE VGCSSAEGAYEEEVLENADLPTAPFASSIGSHNMTLRWKSANFSGVKYIIQWKYAQLLGSWTYTKTVSRPSYVVKPLHPFTEYIFRVVWI FTAQLQLYSPPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKNQKLDAGTQRTSFQFYSTLPNTIYRF SIAAVNEVGEGPEAESSITTSSSAVQQEEQWLFLSRKTSLRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFSEGTLIWAKKAA NMSDVSDLRIFYRGSGLISSISIDWLYQRMYFIMDELVCVCDLENCSNIEEITPPSISAPQKIVADSYNGYVFYLLRDGIYRADLPVPSG RCAEAVRIVESCTLKDFAIKPQAKRIIYFNDTAQVFMSTFLDGSASHLILPRIPFADVKSFACENNDFLVTDGKVIFQQDALSFNEFIVG CDLSHIEEFGFGNLVIFGSSSQLHPLPGRPQELSVLFGSHQALVQWKPPALAIGASPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLN VPELQSAMKYKVSVRASSPKRPGPWSEPSVGTTLVPASEPPFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDWYNNSLYYSDTKGD VFVWLLNGTDISENYHLPSIAGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTDIVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ROS1_ENST00000368508_chr6_117700222_-_CD74_ENST00000377795_chr5_149782188_-_2639nt ATGAAGAACATTTACTGTCTTATTCCGAAGCTTGTCAATTTTGCAACTCTTGGCTGCCTATGGATTTCTGTGGTGCAGTGTACAGTTTTA AATAGCTGCCTAAAGTCGTGTGTAACTAATCTGGGCCAGCAGCTTGACCTTGGCACACCACATAATCTGAGTGAACCGTGTATCCAAGGA TGTCACTTTTGGAACTCTGTAGATCAGAAAAACTGTGCTTTAAAGTGTCGGGAGTCGTGTGAGGTTGGCTGTAGCAGCGCGGAAGGTGCA TATGAAGAGGAAGTACTGGAAAATGCAGACCTACCAACTGCTCCCTTTGCTTCTTCCATTGGAAGCCACAATATGACATTACGATGGAAA TCTGCAAACTTCTCTGGAGTAAAATACATCATTCAGTGGAAATATGCACAACTTCTGGGAAGCTGGACTTATACTAAGACTGTGTCCAGA CCGTCCTATGTGGTCAAGCCCCTGCACCCCTTCACTGAGTACATTTTCCGAGTGGTTTGGATCTTCACAGCGCAGCTGCAGCTCTACTCC CCTCCAAGTCCCAGTTACAGGACTCATCCTCATGGAGTTCCTGAAACTGCACCTTTGATTAGGAATATTGAGAGCTCAAGTCCCGACACT GTGGAAGTCAGCTGGGATCCACCTCAATTCCCAGGTGGACCTATTTTGGGTTATAACTTAAGGCTGATCAGCAAAAATCAAAAATTAGAT GCAGGGACACAGAGAACCAGTTTCCAGTTTTACTCCACTTTACCAAATACTATCTACAGGTTTTCTATTGCAGCAGTAAATGAAGTTGGT GAGGGTCCAGAAGCAGAATCTAGTATTACCACTTCATCTTCAGCAGTTCAACAAGAGGAACAGTGGCTCTTTTTATCCAGAAAAACTTCT CTAAGAAAGAGATCTTTAAAACATTTAGTAGATGAAGCACATTGCCTTCGGTTGGATGCTATATACCATAATATTACAGGAATATCTGTT GATGTCCACCAGCAAATTGTTTATTTCTCTGAAGGAACTCTCATATGGGCGAAGAAGGCTGCCAACATGTCTGATGTATCTGACCTGAGA ATTTTTTACAGAGGTTCAGGATTAATTTCTTCTATCTCCATAGATTGGCTTTATCAAAGAATGTATTTCATCATGGATGAACTGGTATGT GTCTGTGATTTAGAGAACTGCTCAAACATCGAGGAAATTACTCCACCCTCTATTAGTGCACCTCAAAAAATTGTGGCTGATTCATACAAT GGGTATGTCTTTTACCTCCTGAGAGATGGCATTTATAGAGCAGACCTTCCTGTACCATCTGGCCGGTGTGCAGAAGCTGTGCGTATTGTG GAGAGTTGCACGTTAAAGGACTTTGCAATCAAGCCACAAGCCAAGCGAATCATTTACTTCAATGACACTGCCCAAGTCTTCATGTCAACA TTTCTGGATGGCTCTGCTTCCCATCTCATCCTACCTCGCATCCCCTTTGCTGATGTGAAAAGTTTTGCTTGTGAAAACAATGACTTTCTT GTCACAGATGGCAAGGTCATTTTCCAACAGGATGCTTTGTCTTTTAATGAATTCATCGTGGGATGTGACCTGAGTCACATAGAAGAATTT GGGTTTGGTAACTTGGTCATCTTTGGCTCATCCTCCCAGCTGCACCCTCTGCCAGGCCGCCCGCAGGAGCTTTCGGTGCTGTTTGGCTCT CACCAGGCTCTTGTTCAATGGAAGCCTCCTGCCCTTGCCATAGGAGCCAATGTCATCCTGATCAGTGATATTATTGAACTCTTTGAATTA GGCCCTTCTGCCTGGCAGAACTGGACCTATGAGGTGAAAGTATCCACCCAAGACCCTCCTGAAGTCACTCATATTTTCTTGAACATAAGT GGAACCATGCTGAATGTACCTGAGCTGCAGAGTGCTATGAAATACAAGGTTTCTGTGAGAGCAAGTTCTCCAAAGAGGCCAGGCCCCTGG TCAGAGCCCTCAGTGGGTACTACCCTGGTGCCAGCTAGTGAACCACCATTTATCATGGCTGTGAAAGAAGATGGGCTTTGGAGTAAACCA TTAAATAGCTTTGGCCCAGGAGAGTTCTTATCCTCTGATATAGGAAATGTGTCAGACATGGATTGGTATAACAACAGCCTCTACTACAGT GACACGAAAGGCGACGTTTTTGTGTGGCTGCTGAATGGGACGGATATCTCAGAGAATTATCACCTACCCAGCATTGCAGGAGCAGGGGCT TTAGCTTTTGAGTGGCTGGGTCACTTTCTCTACTGGGCTGGAAAGACATATGTGATACAAAGGCAGTCTGTGTTGACGGGACACACAGAC ATTGTTACCCACGTGAAGCTATTGGTGAATGACATGGTGGTGGATTCAGTTGGTGGATATCTCTACTGGACCACACTCTATTCAGTGGAA AGCACCAGACTAAATGGGGAAAGTTCCCTTGTACTACAGACACAGCCTTGGTTTTCTGGGAAAAAGGTAATTGCTCTAACTTTAGACCTC AGTGATGGGCTCCTGTATTGGTTGGTTCAAGACAGTCAATGTATTCACCTGTACACAGCTGTTCTTCGGGGACAGAGAGTCACTGGAACT >In-frame_ROS1_ENST00000368507_chr6_117700222_-_CD74_ENST00000377795_chr5_149782188_-_2624nt ATGAAGAACATTTACTGTCTTATTCCGAAGCTTGTCAATTTTGCAACTCTTGGCTGCCTATGGATTTCTGTGGTGCAGTGTACAGTTTTA AATAGCTGCCTAAAGTCGTGTGTAACTAATCTGGGCCAGCAGCTTGACCTTGGCACACCACATAATCTGAGTGAACCGTGTATCCAAGGA TGTCACTTTTGGAACTCTGTAGATCAGAAAAACTGTGCTTTAAAGTGTAATGATACTTATGCCACCGTTTGTGAGCGGGAGTCGTGTGAG GTTGGCTGTAGCAGCGCGGAAGGTGCATATGAAGAGGAAGTACTGGAAAATGCAGACCTACCAACTGCTCCCTTTGCTTCTTCCATTGGA AGCCACAATATGACATTACGATGGAAATCTGCAAACTTCTCTGGAGTAAAATACATCATTCAGTGGAAATATGCACAACTTCTGGGAAGC TGGACTTATACTAAGACTGTGTCCAGACCGTCCTATGTGGTCAAGCCCCTGCACCCCTTCACTGAGTACATTTTCCGAGTGGTTTGGATC TTCACAGCGCAGCTGCAGCTCTACTCCCCTCCAAGTCCCAGTTACAGGACTCATCCTCATGGAGTTCCTGAAACTGCACCTTTGATTAGG AATATTGAGAGCTCAAGTCCCGACACTGTGGAAGTCAGCTGGGATCCACCTCAATTCCCAGGTGGACCTATTTTGGGTTATAACTTAAGG CTGATCAGCAAAAATCAAAAATTAGATGCAGGGACACAGAGAACCAGTTTCCAGTTTTACTCCACTTTACCAAATACTATCTACAGGTTT TCTATTGCAGCAGTAAATGAAGTTGGTGAGGGTCCAGAAGCAGAATCTAGTATTACCACTTCATCTTCAGCAGTTCAACAAGAGGAACAG TGGCTCTTTTTATCCAGAAAAACTTCTCTAAGAAAGAGATCTTTAAAACATTTAGTAGATGAAGCACATTGCCTTCGGTTGGATGCTATA TACCATAATATTACAGGAATATCTGTTGATGTCCACCAGCAAATTGTTTATTTCTCTGAAGGAACTCTCATATGGGCGAAGAAGGCTGCC AACATGTCTGATGTATCTGACCTGAGAATTTTTTACAGAGGTTCAGGATTAATTTCTTCTATCTCCATAGATTGGCTTTATCAAAGAATG TATTTCATCATGGATGAACTGGTATGTGTCTGTGATTTAGAGAACTGCTCAAACATCGAGGAAATTACTCCACCCTCTATTAGTGCACCT CAAAAAATTGTGGCTGATTCATACAATGGGTATGTCTTTTACCTCCTGAGAGATGGCATTTATAGAGCAGACCTTCCTGTACCATCTGGC CGGTGTGCAGAAGCTGTGCGTATTGTGGAGAGTTGCACGTTAAAGGACTTTGCAATCAAGCCACAAGCCAAGCGAATCATTTACTTCAAT GACACTGCCCAAGTCTTCATGTCAACATTTCTGGATGGCTCTGCTTCCCATCTCATCCTACCTCGCATCCCCTTTGCTGATGTGAAAAGT TTTGCTTGTGAAAACAATGACTTTCTTGTCACAGATGGCAAGGTCATTTTCCAACAGGATGCTTTGTCTTTTAATGAATTCATCGTGGGA TGTGACCTGAGTCACATAGAAGAATTTGGGTTTGGTAACTTGGTCATCTTTGGCTCATCCTCCCAGCTGCACCCTCTGCCAGGCCGCCCG CAGGAGCTTTCGGTGCTGTTTGGCTCTCACCAGGCTCTTGTTCAATGGAAGCCTCCTGCCCTTGCCATAGGAGCCAGCCCTTCTGCCTGG CAGAACTGGACCTATGAGGTGAAAGTATCCACCCAAGACCCTCCTGAAGTCACTCATATTTTCTTGAACATAAGTGGAACCATGCTGAAT GTACCTGAGCTGCAGAGTGCTATGAAATACAAGGTTTCTGTGAGAGCAAGTTCTCCAAAGAGGCCAGGCCCCTGGTCAGAGCCCTCAGTG GGTACTACCCTGGTGCCAGCTAGTGAACCACCATTTATCATGGCTGTGAAAGAAGATGGGCTTTGGAGTAAACCATTAAATAGCTTTGGC CCAGGAGAGTTCTTATCCTCTGATATAGGAAATGTGTCAGACATGGATTGGTATAACAACAGCCTCTACTACAGTGACACGAAAGGCGAC GTTTTTGTGTGGCTGCTGAATGGGACGGATATCTCAGAGAATTATCACCTACCCAGCATTGCAGGAGCAGGGGCTTTAGCTTTTGAGTGG CTGGGTCACTTTCTCTACTGGGCTGGAAAGACATATGTGATACAAAGGCAGTCTGTGTTGACGGGACACACAGACATTGTTACCCACGTG AAGCTATTGGTGAATGACATGGTGGTGGATTCAGTTGGTGGATATCTCTACTGGACCACACTCTATTCAGTGGAAAGCACCAGACTAAAT GGGGAAAGTTCCCTTGTACTACAGACACAGCCTTGGTTTTCTGGGAAAAAGGTAATTGCTCTAACTTTAGACCTCAGTGATGGGCTCCTG TATTGGTTGGTTCAAGACAGTCAATGTATTCACCTGTACACAGCTGTTCTTCGGGGACAGAGAGTCACTGGAACTGGAGGACCCGTCTTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ROS1_ENST00000368508_chr6_117700222_-_CD74_ENST00000377795_chr5_149782188_-_3473nt CAAGCTTTCAAGCATTCAAAGGTCTAAATGAAAAAGGCTAAGTATTATTTCAAAAGGCAAGTATATCCTAATATAGCAAAACAAACAAAG CAAAATCCATCAGCTACTCCTCCAATTGAAGTGATGAAGCCCAAATAATTCATATAGCAAAATGGAGAAAATTAGACCGGCCATCTAAAA ATCTGCCATTGGTGAAGTGATGAAGAACATTTACTGTCTTATTCCGAAGCTTGTCAATTTTGCAACTCTTGGCTGCCTATGGATTTCTGT GGTGCAGTGTACAGTTTTAAATAGCTGCCTAAAGTCGTGTGTAACTAATCTGGGCCAGCAGCTTGACCTTGGCACACCACATAATCTGAG TGAACCGTGTATCCAAGGATGTCACTTTTGGAACTCTGTAGATCAGAAAAACTGTGCTTTAAAGTGTCGGGAGTCGTGTGAGGTTGGCTG TAGCAGCGCGGAAGGTGCATATGAAGAGGAAGTACTGGAAAATGCAGACCTACCAACTGCTCCCTTTGCTTCTTCCATTGGAAGCCACAA TATGACATTACGATGGAAATCTGCAAACTTCTCTGGAGTAAAATACATCATTCAGTGGAAATATGCACAACTTCTGGGAAGCTGGACTTA TACTAAGACTGTGTCCAGACCGTCCTATGTGGTCAAGCCCCTGCACCCCTTCACTGAGTACATTTTCCGAGTGGTTTGGATCTTCACAGC GCAGCTGCAGCTCTACTCCCCTCCAAGTCCCAGTTACAGGACTCATCCTCATGGAGTTCCTGAAACTGCACCTTTGATTAGGAATATTGA GAGCTCAAGTCCCGACACTGTGGAAGTCAGCTGGGATCCACCTCAATTCCCAGGTGGACCTATTTTGGGTTATAACTTAAGGCTGATCAG CAAAAATCAAAAATTAGATGCAGGGACACAGAGAACCAGTTTCCAGTTTTACTCCACTTTACCAAATACTATCTACAGGTTTTCTATTGC AGCAGTAAATGAAGTTGGTGAGGGTCCAGAAGCAGAATCTAGTATTACCACTTCATCTTCAGCAGTTCAACAAGAGGAACAGTGGCTCTT TTTATCCAGAAAAACTTCTCTAAGAAAGAGATCTTTAAAACATTTAGTAGATGAAGCACATTGCCTTCGGTTGGATGCTATATACCATAA TATTACAGGAATATCTGTTGATGTCCACCAGCAAATTGTTTATTTCTCTGAAGGAACTCTCATATGGGCGAAGAAGGCTGCCAACATGTC TGATGTATCTGACCTGAGAATTTTTTACAGAGGTTCAGGATTAATTTCTTCTATCTCCATAGATTGGCTTTATCAAAGAATGTATTTCAT CATGGATGAACTGGTATGTGTCTGTGATTTAGAGAACTGCTCAAACATCGAGGAAATTACTCCACCCTCTATTAGTGCACCTCAAAAAAT TGTGGCTGATTCATACAATGGGTATGTCTTTTACCTCCTGAGAGATGGCATTTATAGAGCAGACCTTCCTGTACCATCTGGCCGGTGTGC AGAAGCTGTGCGTATTGTGGAGAGTTGCACGTTAAAGGACTTTGCAATCAAGCCACAAGCCAAGCGAATCATTTACTTCAATGACACTGC CCAAGTCTTCATGTCAACATTTCTGGATGGCTCTGCTTCCCATCTCATCCTACCTCGCATCCCCTTTGCTGATGTGAAAAGTTTTGCTTG TGAAAACAATGACTTTCTTGTCACAGATGGCAAGGTCATTTTCCAACAGGATGCTTTGTCTTTTAATGAATTCATCGTGGGATGTGACCT GAGTCACATAGAAGAATTTGGGTTTGGTAACTTGGTCATCTTTGGCTCATCCTCCCAGCTGCACCCTCTGCCAGGCCGCCCGCAGGAGCT TTCGGTGCTGTTTGGCTCTCACCAGGCTCTTGTTCAATGGAAGCCTCCTGCCCTTGCCATAGGAGCCAATGTCATCCTGATCAGTGATAT TATTGAACTCTTTGAATTAGGCCCTTCTGCCTGGCAGAACTGGACCTATGAGGTGAAAGTATCCACCCAAGACCCTCCTGAAGTCACTCA TATTTTCTTGAACATAAGTGGAACCATGCTGAATGTACCTGAGCTGCAGAGTGCTATGAAATACAAGGTTTCTGTGAGAGCAAGTTCTCC AAAGAGGCCAGGCCCCTGGTCAGAGCCCTCAGTGGGTACTACCCTGGTGCCAGCTAGTGAACCACCATTTATCATGGCTGTGAAAGAAGA TGGGCTTTGGAGTAAACCATTAAATAGCTTTGGCCCAGGAGAGTTCTTATCCTCTGATATAGGAAATGTGTCAGACATGGATTGGTATAA CAACAGCCTCTACTACAGTGACACGAAAGGCGACGTTTTTGTGTGGCTGCTGAATGGGACGGATATCTCAGAGAATTATCACCTACCCAG CATTGCAGGAGCAGGGGCTTTAGCTTTTGAGTGGCTGGGTCACTTTCTCTACTGGGCTGGAAAGACATATGTGATACAAAGGCAGTCTGT GTTGACGGGACACACAGACATTGTTACCCACGTGAAGCTATTGGTGAATGACATGGTGGTGGATTCAGTTGGTGGATATCTCTACTGGAC CACACTCTATTCAGTGGAAAGCACCAGACTAAATGGGGAAAGTTCCCTTGTACTACAGACACAGCCTTGGTTTTCTGGGAAAAAGGTAAT TGCTCTAACTTTAGACCTCAGTGATGGGCTCCTGTATTGGTTGGTTCAAGACAGTCAATGTATTCACCTGTACACAGCTGTTCTTCGGGG ACAGAGAGTCACTGGAACTGGAGGACCCGTCTTCTGGGCTGGGTGTGACCAAGCAGGATCTGGGCCCAGTCCCCATGTGAGAGCAGCAGA GGCGGTCTTCAACATCCTGCCAGCCCCACACAGCTACAGCTTTCTTGCTCCCTTCAGCCCCCAGCCCCTCCCCCATCTCCCACCCTGTAC CTCATCCCATGAGACCCTGGTGCCTGGCTCTTTCGTCACCCTTGGACAAGACAAACCAAGTCGGAACAGCAGATAACAATGCAGCAAGGC CCTGCTGCCCAATCTCCATCTGTCAACAGGGGCGTGAGGTCCCAGGAAGTGGCCAAAAGCTAGACAGATCCCCGTTCCTGACATCACAGC AGCCTCCAACACAAGGCTCCAAGACCTAGGCTCATGGACGAGATGGGAAGGCACAGGGAGAAGGGATAACCCTACACCCAGACCCCAGGC TGGACATGCTGACTGTCCTCTCCCCTCCAGCCTTTGGCCTTGGCTTTTCTAGCCTATTTACCTGCAGGCTGAGCCACTCTCTTCCCTTTC CCCAGCATCACTCCCCAAGGAAGAGCCAATGTTTTCCACCCATAATCCTTTCTGCCGACCCCTAGTTCCCTCTGCTCAGCCAAGCTTGTT >In-frame_ROS1_ENST00000368507_chr6_117700222_-_CD74_ENST00000377795_chr5_149782188_-_3458nt CAAGCTTTCAAGCATTCAAAGGTCTAAATGAAAAAGGCTAAGTATTATTTCAAAAGGCAAGTATATCCTAATATAGCAAAACAAACAAAG CAAAATCCATCAGCTACTCCTCCAATTGAAGTGATGAAGCCCAAATAATTCATATAGCAAAATGGAGAAAATTAGACCGGCCATCTAAAA ATCTGCCATTGGTGAAGTGATGAAGAACATTTACTGTCTTATTCCGAAGCTTGTCAATTTTGCAACTCTTGGCTGCCTATGGATTTCTGT GGTGCAGTGTACAGTTTTAAATAGCTGCCTAAAGTCGTGTGTAACTAATCTGGGCCAGCAGCTTGACCTTGGCACACCACATAATCTGAG TGAACCGTGTATCCAAGGATGTCACTTTTGGAACTCTGTAGATCAGAAAAACTGTGCTTTAAAGTGTAATGATACTTATGCCACCGTTTG TGAGCGGGAGTCGTGTGAGGTTGGCTGTAGCAGCGCGGAAGGTGCATATGAAGAGGAAGTACTGGAAAATGCAGACCTACCAACTGCTCC CTTTGCTTCTTCCATTGGAAGCCACAATATGACATTACGATGGAAATCTGCAAACTTCTCTGGAGTAAAATACATCATTCAGTGGAAATA TGCACAACTTCTGGGAAGCTGGACTTATACTAAGACTGTGTCCAGACCGTCCTATGTGGTCAAGCCCCTGCACCCCTTCACTGAGTACAT TTTCCGAGTGGTTTGGATCTTCACAGCGCAGCTGCAGCTCTACTCCCCTCCAAGTCCCAGTTACAGGACTCATCCTCATGGAGTTCCTGA AACTGCACCTTTGATTAGGAATATTGAGAGCTCAAGTCCCGACACTGTGGAAGTCAGCTGGGATCCACCTCAATTCCCAGGTGGACCTAT TTTGGGTTATAACTTAAGGCTGATCAGCAAAAATCAAAAATTAGATGCAGGGACACAGAGAACCAGTTTCCAGTTTTACTCCACTTTACC AAATACTATCTACAGGTTTTCTATTGCAGCAGTAAATGAAGTTGGTGAGGGTCCAGAAGCAGAATCTAGTATTACCACTTCATCTTCAGC AGTTCAACAAGAGGAACAGTGGCTCTTTTTATCCAGAAAAACTTCTCTAAGAAAGAGATCTTTAAAACATTTAGTAGATGAAGCACATTG CCTTCGGTTGGATGCTATATACCATAATATTACAGGAATATCTGTTGATGTCCACCAGCAAATTGTTTATTTCTCTGAAGGAACTCTCAT ATGGGCGAAGAAGGCTGCCAACATGTCTGATGTATCTGACCTGAGAATTTTTTACAGAGGTTCAGGATTAATTTCTTCTATCTCCATAGA TTGGCTTTATCAAAGAATGTATTTCATCATGGATGAACTGGTATGTGTCTGTGATTTAGAGAACTGCTCAAACATCGAGGAAATTACTCC ACCCTCTATTAGTGCACCTCAAAAAATTGTGGCTGATTCATACAATGGGTATGTCTTTTACCTCCTGAGAGATGGCATTTATAGAGCAGA CCTTCCTGTACCATCTGGCCGGTGTGCAGAAGCTGTGCGTATTGTGGAGAGTTGCACGTTAAAGGACTTTGCAATCAAGCCACAAGCCAA GCGAATCATTTACTTCAATGACACTGCCCAAGTCTTCATGTCAACATTTCTGGATGGCTCTGCTTCCCATCTCATCCTACCTCGCATCCC CTTTGCTGATGTGAAAAGTTTTGCTTGTGAAAACAATGACTTTCTTGTCACAGATGGCAAGGTCATTTTCCAACAGGATGCTTTGTCTTT TAATGAATTCATCGTGGGATGTGACCTGAGTCACATAGAAGAATTTGGGTTTGGTAACTTGGTCATCTTTGGCTCATCCTCCCAGCTGCA CCCTCTGCCAGGCCGCCCGCAGGAGCTTTCGGTGCTGTTTGGCTCTCACCAGGCTCTTGTTCAATGGAAGCCTCCTGCCCTTGCCATAGG AGCCAGCCCTTCTGCCTGGCAGAACTGGACCTATGAGGTGAAAGTATCCACCCAAGACCCTCCTGAAGTCACTCATATTTTCTTGAACAT AAGTGGAACCATGCTGAATGTACCTGAGCTGCAGAGTGCTATGAAATACAAGGTTTCTGTGAGAGCAAGTTCTCCAAAGAGGCCAGGCCC CTGGTCAGAGCCCTCAGTGGGTACTACCCTGGTGCCAGCTAGTGAACCACCATTTATCATGGCTGTGAAAGAAGATGGGCTTTGGAGTAA ACCATTAAATAGCTTTGGCCCAGGAGAGTTCTTATCCTCTGATATAGGAAATGTGTCAGACATGGATTGGTATAACAACAGCCTCTACTA CAGTGACACGAAAGGCGACGTTTTTGTGTGGCTGCTGAATGGGACGGATATCTCAGAGAATTATCACCTACCCAGCATTGCAGGAGCAGG GGCTTTAGCTTTTGAGTGGCTGGGTCACTTTCTCTACTGGGCTGGAAAGACATATGTGATACAAAGGCAGTCTGTGTTGACGGGACACAC AGACATTGTTACCCACGTGAAGCTATTGGTGAATGACATGGTGGTGGATTCAGTTGGTGGATATCTCTACTGGACCACACTCTATTCAGT GGAAAGCACCAGACTAAATGGGGAAAGTTCCCTTGTACTACAGACACAGCCTTGGTTTTCTGGGAAAAAGGTAATTGCTCTAACTTTAGA CCTCAGTGATGGGCTCCTGTATTGGTTGGTTCAAGACAGTCAATGTATTCACCTGTACACAGCTGTTCTTCGGGGACAGAGAGTCACTGG AACTGGAGGACCCGTCTTCTGGGCTGGGTGTGACCAAGCAGGATCTGGGCCCAGTCCCCATGTGAGAGCAGCAGAGGCGGTCTTCAACAT CCTGCCAGCCCCACACAGCTACAGCTTTCTTGCTCCCTTCAGCCCCCAGCCCCTCCCCCATCTCCCACCCTGTACCTCATCCCATGAGAC CCTGGTGCCTGGCTCTTTCGTCACCCTTGGACAAGACAAACCAAGTCGGAACAGCAGATAACAATGCAGCAAGGCCCTGCTGCCCAATCT CCATCTGTCAACAGGGGCGTGAGGTCCCAGGAAGTGGCCAAAAGCTAGACAGATCCCCGTTCCTGACATCACAGCAGCCTCCAACACAAG GCTCCAAGACCTAGGCTCATGGACGAGATGGGAAGGCACAGGGAGAAGGGATAACCCTACACCCAGACCCCAGGCTGGACATGCTGACTG TCCTCTCCCCTCCAGCCTTTGGCCTTGGCTTTTCTAGCCTATTTACCTGCAGGCTGAGCCACTCTCTTCCCTTTCCCCAGCATCACTCCC CAAGGAAGAGCCAATGTTTTCCACCCATAATCCTTTCTGCCGACCCCTAGTTCCCTCTGCTCAGCCAAGCTTGTTATCAGCTTTCAGGGC |
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FusionGenePPI for ROS1_CD74 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ROS1 | PTPN6, PTPN11, VAV3, IKBKG, GRB2 | CD74 | MIF, CD74, APP, HADHA, LAMTOR5, MAP3K1, TM4SF20, COPG1, COPG2, HLA-DPB1, HLA-DQA1, CD44 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ROS1_CD74 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ROS1_CD74 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ROS1 | C0007131 | Non-Small Cell Lung Carcinoma | 4 | CTD_human |
| Hgene | ROS1 | C0017638 | Glioma | 1 | CTD_human |
| Hgene | ROS1 | C0025202 | melanoma | 1 | CTD_human |
| Hgene | ROS1 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
| Tgene | CD74 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Tgene | CD74 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | CD74 | C0162557 | Liver Failure, Acute | 1 | CTD_human |
| Tgene | CD74 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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