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Fusion gene ID: 31703 |
FusionGeneSummary for ROCK2_PPP2CA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ROCK2_PPP2CA | Fusion gene ID: 31703 | Hgene | Tgene | Gene symbol | ROCK2 | PPP2CA | Gene ID | 9475 | 5515 |
| Gene name | Rho associated coiled-coil containing protein kinase 2 | protein phosphatase 2 catalytic subunit alpha | |
| Synonyms | ROCK-II | PP2Ac|PP2CA|PP2Calpha|RP-C | |
| Cytomap | 2p25.1 | 5q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho-associated protein kinase 2p164 ROCK-2rho-associated, coiled-coil-containing protein kinase II | serine/threonine-protein phosphatase 2A catalytic subunit alpha isoformPP2A-alphaprotein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoformprotein phosphatase 2, catalytic subunit, alpha isozymereplication protein Cserine/threonine protein | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | O75116 | P67775 | |
| Ensembl transtripts involved in fusion gene | ENST00000315872, ENST00000462366, ENST00000401753, | ENST00000481195, ENST00000231504, | |
| Fusion gene scores | * DoF score | 10 X 6 X 8=480 | 4 X 6 X 3=72 |
| # samples | 10 | 6 | |
| ** MAII score | log2(10/480*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ROCK2 [Title/Abstract] AND PPP2CA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ROCK2 | GO:0006468 | protein phosphorylation | 18559669 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-BH-A0HL-01A | ROCK2 | chr2 | 11484122 | - | PPP2CA | chr5 | 133541822 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000315872 | ENST00000481195 | ROCK2 | chr2 | 11484122 | - | PPP2CA | chr5 | 133541822 | - |
| 5CDS-5UTR | ENST00000315872 | ENST00000231504 | ROCK2 | chr2 | 11484122 | - | PPP2CA | chr5 | 133541822 | - |
| intron-3CDS | ENST00000462366 | ENST00000481195 | ROCK2 | chr2 | 11484122 | - | PPP2CA | chr5 | 133541822 | - |
| intron-5UTR | ENST00000462366 | ENST00000231504 | ROCK2 | chr2 | 11484122 | - | PPP2CA | chr5 | 133541822 | - |
| intron-3CDS | ENST00000401753 | ENST00000481195 | ROCK2 | chr2 | 11484122 | - | PPP2CA | chr5 | 133541822 | - |
| intron-5UTR | ENST00000401753 | ENST00000231504 | ROCK2 | chr2 | 11484122 | - | PPP2CA | chr5 | 133541822 | - |
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FusionProtFeatures for ROCK2_PPP2CA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ROCK2 | PPP2CA |
| Protein kinase which is a key regulator of actincytoskeleton and cell polarity. Involved in regulation of smoothmuscle contraction, actin cytoskeleton organization, stress fiberand focal adhesion formation, neurite retraction, cell adhesionand motility via phosphorylation of ADD1, BRCA2, CNN1, EZR,DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM.Phosphorylates SORL1 and IRF4. Acts as a negative regulator ofVEGF-induced angiogenic endothelial cell activation. Positivelyregulates the activation of p42/MAPK1-p44/MAPK3 and ofp90RSK/RPS6KA1 during myogenic differentiation. Plays an importantrole in the timely initiation of centrosome duplication. Inhibitskeratinocyte terminal differentiation. May regulate closure of theeyelids and ventral body wall through organization of actomyosinbundles. Plays a critical role in the regulation of spine andsynaptic properties in the hippocampus. Plays an important role ingenerating the circadian rhythm of the aortic myofilament Ca(2+)sensitivity and vascular contractility by modulating the myosinlight chain phosphorylation. {ECO:0000269|PubMed:10579722,ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662,ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646,ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279,ECO:0000269|PubMed:21147781}. | PP2A is the major phosphatase for microtubule-associatedproteins (MAPs). PP2A can modulate the activity of phosphorylase Bkinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2kinase. Cooperates with SGO2 to protect centromeric cohesin fromseparase-mediated cleavage in oocytes specifically during meiosisI (By similarity). Can dephosphorylate SV40 large T antigen andp53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.{ECO:0000250, ECO:0000269|PubMed:10801873,ECO:0000269|PubMed:22613722, ECO:0000269|PubMed:9920888}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ROCK2 | chr2:11484122 | chr5:133541822 | ENST00000315872 | - | 1 | 33 | 1053_1131 | 47 | 1389 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >ROCK2 | chr2:11484122 | chr5:133541822 | ENST00000315872 | - | 1 | 33 | 429_1024 | 47 | 1389 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >ROCK2 | chr2:11484122 | chr5:133541822 | ENST00000315872 | - | 1 | 33 | 1150_1349 | 47 | 1389 | Domain | PH |
| Hgene | >ROCK2 | chr2:11484122 | chr5:133541822 | ENST00000315872 | - | 1 | 33 | 357_425 | 47 | 1389 | Domain | Note=AGC-kinase C-terminal |
| Hgene | >ROCK2 | chr2:11484122 | chr5:133541822 | ENST00000315872 | - | 1 | 33 | 497_573 | 47 | 1389 | Domain | REM-1 |
| Hgene | >ROCK2 | chr2:11484122 | chr5:133541822 | ENST00000315872 | - | 1 | 33 | 92_354 | 47 | 1389 | Domain | Protein kinase |
| Hgene | >ROCK2 | chr2:11484122 | chr5:133541822 | ENST00000315872 | - | 1 | 33 | 98_106 | 47 | 1389 | Nucleotide binding | ATP |
| Hgene | >ROCK2 | chr2:11484122 | chr5:133541822 | ENST00000315872 | - | 1 | 33 | 979_1047 | 47 | 1389 | Region | RHOA binding |
| Hgene | >ROCK2 | chr2:11484122 | chr5:133541822 | ENST00000315872 | - | 1 | 33 | 1260_1315 | 47 | 1389 | Zinc finger | Phorbol-ester/DAG-type |
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FusionGeneSequence for ROCK2_PPP2CA |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_PPP2CA_ENST00000481195_chr5_133541822_-_323aa MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPD TNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLH GGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_PPP2CA_ENST00000481195_chr5_133541822_-_969nt ATGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTG GAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGGCTAAAGAAATCCTGACAAAAGAATCCAACGTGCAAGAG GTTCGATGTCCAGTTACTGTCTGTGGAGATGTGCATGGGCAATTTCATGATCTCATGGAACTGTTTAGAATTGGTGGCAAATCACCAGAT ACAAATTACTTGTTTATGGGAGATTATGTTGACAGAGGATATTATTCAGTTGAAACAGTTACACTGCTTGTAGCTCTTAAGGTTCGTTAC CGTGAACGCATCACCATTCTTCGAGGGAATCATGAGAGCAGACAGATCACACAAGTTTATGGTTTCTATGATGAATGTTTAAGAAAATAT GGAAATGCAAATGTTTGGAAATATTTTACAGATCTTTTTGACTATCTTCCTCTCACTGCCTTGGTGGATGGGCAGATCTTCTGTCTACAT GGTGGTCTCTCGCCATCTATAGATACACTGGATCATATCAGAGCACTTGATCGCCTACAAGAAGTTCCCCATGAGGGTCCAATGTGTGAC TTGCTGTGGTCAGATCCAGATGACCGTGGTGGTTGGGGTATATCTCCTCGAGGAGCTGGTTACACCTTTGGGCAAGATATTTCTGAGACA TTTAATCATGCCAATGGCCTCACGTTGGTGTCTAGAGCTCACCAGCTAGTGATGGAGGGATATAACTGGTGCCATGACCGGAATGTAGTA ACGATTTTCAGTGCTCCAAACTATTGTTATCGTTGTGGTAACCAAGCTGCAATCATGGAACTTGACGATACTCTAAAATACTCTTTCTTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_PPP2CA_ENST00000481195_chr5_133541822_-_4856nt CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGGCTAAAGAAATCCTGACAAAAGAATCCAACGTGCAAGAGG TTCGATGTCCAGTTACTGTCTGTGGAGATGTGCATGGGCAATTTCATGATCTCATGGAACTGTTTAGAATTGGTGGCAAATCACCAGATA CAAATTACTTGTTTATGGGAGATTATGTTGACAGAGGATATTATTCAGTTGAAACAGTTACACTGCTTGTAGCTCTTAAGGTTCGTTACC GTGAACGCATCACCATTCTTCGAGGGAATCATGAGAGCAGACAGATCACACAAGTTTATGGTTTCTATGATGAATGTTTAAGAAAATATG GAAATGCAAATGTTTGGAAATATTTTACAGATCTTTTTGACTATCTTCCTCTCACTGCCTTGGTGGATGGGCAGATCTTCTGTCTACATG GTGGTCTCTCGCCATCTATAGATACACTGGATCATATCAGAGCACTTGATCGCCTACAAGAAGTTCCCCATGAGGGTCCAATGTGTGACT TGCTGTGGTCAGATCCAGATGACCGTGGTGGTTGGGGTATATCTCCTCGAGGAGCTGGTTACACCTTTGGGCAAGATATTTCTGAGACAT TTAATCATGCCAATGGCCTCACGTTGGTGTCTAGAGCTCACCAGCTAGTGATGGAGGGATATAACTGGTGCCATGACCGGAATGTAGTAA CGATTTTCAGTGCTCCAAACTATTGTTATCGTTGTGGTAACCAAGCTGCAATCATGGAACTTGACGATACTCTAAAATACTCTTTCTTGC AGTTTGACCCAGCACCTCGTAGAGGCGAGCCACATGTTACTCGTCGTACCCCAGACTACTTCCTGTAATGAAATTTTAAACTTGTACAGT ATTGCCATGAACCATATATCGACCTAATGGAAATGGGAAGAGCAACAGTAACTCCAAAGTGTCAGAAAATAGTTAACATTCAAAAAACTT GTTTTCACATGGACCAAAAGATGTGCCATATAAAAATACAAAGCCTCTTGTCATCAACAGCCGTGACCACTTTAGAATGAACCAGTTCAT TGCATGCTGAAGCGACATTGTTGGTCAAGAAACCAGTTTCTGGCATAGCGCTATTTGTAGTTACTTTTGCTTTCTCTGAGAGACTGCAGA TAATAAGATGTAAACATTAACACCTCGTGAATACAATTTAACTTCCATTTAGCTATAGCTTTACTCAGCATGACTGTAGATAAGGATAGC AGCAAACAATCATTGGAGCTTAATGAACATTTTTAAAAATAATTACCAAGGCCTCCCTTCTACTTGTGAGTTTTGAAATTGTTCTTTTTA TTTTCAGGGATACCGTTTAATTTAATTATATGATTTGTCTGCACTCAGTTTATTCCCTACTCAAATCTCAGCCCCATGTTGTTCTTTGTT ATTGTCAGAACCTGGTGAGTTGTTTTGAACAGAACTGTTTTTTCCCCTTCCTGTAAGACGATGTGACTGCACAAGAGCACTGCAGTGTTT TTCATAATAAACTTGTGAACTAAGAACTGAGAAGGTCAAATTTTAATTGTATCAATGGGCAAGACTGGTGCTGTTTATTAAAAAAGTTAA ATCAATTGAGTAAATTTTAGAATTTGTAGACTTGTAGGTAAAATAAAAATCAAGGGCACTACATAACCTCTCTGGTAACTCCTTGACATT CTTCAGATTAACTTCAGGATTTATTTGTATTTCACATATTACAATTTGTCACATTGTTGGTGTGCACTTTGTGGGTTCTTCCTGCATATT AACTTGTTTGTAAGAAAGGAAATCTGTGCTGCTTCAGTAAGACTTAATTGTAAAACCATATAACTTGAGATTTAAGTCTTTGGGTTTTGT TTTAATAAAACAGCATGTTTTCAGGTAGAGCTTAAACTAAATGATGTGTTTACTTAGTGCAGTTTCTGGTTATGAATATTATATTGCTAT GTGTATATTATATGGACTCTTTAAAATGATTGACAGATTGGCAAATTCTTAAATCTTTGTACATTGTTGAGTCATATGTTCTTAGAGTTA AATTTGTCTCAGATAAGAAAGTGTTAAAGCATTAGCCTGTGTCAAGTTCTTTGAGTGATACTAGTGAAACCAAATAGAAAACTATTGTTG GATCATGATTTAGTCTTATGTACATTCACCCGAAGACAAAAATGGTACTTAAAGTGGCAGTGTTCAACATTTAATGAGTTTTTCCCCTTT TATCCTTCGAATAGGATTAGATGTTTAAAAAAAAGTTCTTCTGTGGGAACTAATATTTGATATTTTAACCTACCAGAGTAAACAGGAACA CTTAATCATACTTGTGAGTGTAGTAAATAAAAGTTTTCTTGCTTTGTGCTGTGTTGAATCTGGAACCAACAGGGAAGTTATAGCATATCC CCTTTCTAAAATGCTTGAGGAACACATACATACCGAATGTCTTTTCTGATCTAATTGATAGTATTTTTAGTGGCTTGTGGAGTTAATTTT CCAAAGCAAAAGGCCATTAGGGTTTCTACATTTCATTTCATTTCATTCTTTTCTTTCACAAGAAATACATTCTCTGTGTGTCTTTTTGTT GCTCTGTCACTCTATGCCCTTTCTCTCCGACTGAACAAATAGCTTATCCATGTGCAGTGGTTTTAATACCCAAACAATCTAGACACCAAG CAGCTATTTTTTCCGGTCCTGTGATATCAGAATTGACCAAGGAATACGTATATTGTAATTGACACGTGGTGGTATCTTCCAGGTACAAAT TCTCTAAATTTTGTGGTTAGCAGAATGGGACTTGTGATAAGAATAGCTTGGTTTTAGCATAACTAGGGTTTAAAATAATTGTTTAATTAT AGAGACTGACCGGGCTTTGGCCATCTAAACTGGAAAGTGTTAGTACCCTACCTTCTTTTGAAAATGGCTATGGTAAGGAAAATGTGTTAG TAAATTATGTATTTTCTTGAAAAATACATAATTATGGTTGGATGGGAATCACTAAGTTGGGTGTTAACTGATGTCTCAATTAGTAACATT AGGATTTTCATTAATAAACCTAAAAAGCTTTCCCTAAGAACAGGCCTGGCACAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGACC AGGGTGGGTGGATCCCTTGAGGTCAGGAGTTGAAGAGCAGCCTGGCCAACATGGCAAAACCCCATCTCTACAAAAAATATGAAAATCAGC CGGGCTTGGTGGCATACCATAGTCCCAGCTACTTGGGAGGCTGAGGTGAGAGGATCGCCTGAGCCCAGGAGATGGAGGTTGCAGTGGGCT GAGATTGTGCCACTGTACTCCAGTCTGGGTGACAGAGCCAGACCCTGTCTCAAAAATAAAGAGGATTCTGAGTTTGTATAGTGAGGGCTT GCAGAAATTTTGAAACTTATTTTGTAAGTTTACAATGAATTTGTACATGATGTGCTCATGTCTTGGGTTGAGTATCCTAGACATGATTTT TTCATTTGCTGCATATTAAACATTTGTTGGTTGTAGTCGGTATTTCTTAAATAGAAGTTTGTCAATATTAGATTAGTTTCAAGAAGGACT TAGCTCAGGAAAAGGATAGTTATTTCTGTGGTTCTCAGCTTTGATGCCTACAGAGATTCTGATTTAAATTGCTGGAGGAGGGCCCAGGCA TACATTTTTTAAGTTTCCCAAGTGATTCTAATTTACATCTAGGGTTAAAAACAGCCAGGCGCGGTGGCTCATGCCTGTAATCCCAGCACT TGGGGAGGCCGGGGTGGGTGGATCACCTGATGTCAGGAGATCGAGACCAGCCTGGCCAGCGTGGTGAAACCCCATCTCTATTAAAAATAC AAAACTGACCGGTGTGGTGGCAGGAGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACTCAGGAGGAGGAGGT TACAGTGAGCCCAGATCGTGCCATTGCACTCCAGCCTGGGCAAAAAGAGCAAAACTCCATCTCAAAAAACAAAAACACCTCACTGCTGTT TCCTAAGTACATACTTAAGAAAATTGGGATACATGGTGGTGGTTCATGGATGTTGATAAGGAATTAAAATGTACCGTGCGACTCTCTGTT TCAGTGGTGACTTTTACCTGTTTAGTATAAATATTCCTTTGCTTCCAACCATAAATGTGTTCTTAGAAATGGGCCTATAGTTTAGTAACC |
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FusionGenePPI for ROCK2_PPP2CA |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ROCK2 | IKBKE, STK16, RHOA, ELAVL1, MAGEC1, KIAA0196, RABGEF1, FAM21A, GPHN, LMNA, MTA2, NHP2L1, ZW10, DNAJB11, RACGAP1, NTRK1, SNW1, CDC5L, CDKN3, POLR1C, ROCK1, FBXO42, LRPAP1, ADD2, MYL2, LZTFL1, CYLD | PPP2CA | TRIP13, TBCD, ARL2, TLX1, ISYNA1, MRPS26, PTN, CSNK1A1, PPM1B, CDK2, CDK6, ETF1, RELA, CCNG2, PPP2R5C, PXN, PPP2R3B, PPP2R3A, PPP2R2A, BEST1, CTTNBP2, CTTNBP2NL, STRIP1, MOB4, PDCD10, PPP2R1A, STRN, STRN3, PPP2R5D, PPP2R1B, STRN4, PPP2R2D, PPME1, PPP2R5E, PPFIA1, IGBP1, CCT2, CCT8, CCT3, TCP1, CCT5, CCT6A, CCT7, PPFIA3, PPP2R5A, CCT4, PPFIA2, FGFR1OP, PPP2R5B, STK26, SIKE1, STK24, STK25, TRAF3IP3, PPP2R2C, PRKCD, BCL2, SGK1, SPRY2, PMS2, RBL2, HDAC7, HDAC4, HDAC5, MID1, INTS1, INTS6, PRKDC, TERF1, IRAK1, PRR14L, SGOL1, PRR14, TUBA8, ANKLE2, CEP350, SLMAP, KPNB1, PPP2R2B, PPP2R4, FGFR1OP2, PRKAA1, RALA, AXIN1, MYC, MAPK3, AKT1, CHEK2, TWIST1, PABPC1, CUL3, CUL5, CUL1, MAP3K3, CHUK, IKBKB, IKBKG, VCP, CAV1, PSMC6, NUBP2, CLNS1A, PIN1, DDTL, PIR, PSMD1, SOD1, PSMD3, AURKB, BRCA1, ECT2, MDC1, PAXIP1, CBX5, NOTCH1, KLHL15, SMURF1, VCAM1, FN1, ITGA4, CFTR, RAF1, CTDP1, ID1, NPM1, POLA1, BAG3, CDKN2C, MYH9, XRN1, NRD1, AHCYL1, ARPC4, HNRNPH1, NIF3L1, PFDN1, SSB, TNPO1, TNPO3, RPA3, RPA2, RPA1, ZNF346, HTT, ESPL1, ZFP36, SETBP1, VAC14, EP300, DAPK1, UNC5B, PYGM, CSNK2B, DEC1, RORC, FOXS1, LCMT1, SERTAD4, GRN, SGOL2, KNG1, ZNF114, FOXD4L6, LACC1, SIK2, CAMK1, RPS6KB2, TIPRL, UNK, FNBP1, PPAT, PPP2CB, NTRK1, RAC1, PIM1, AHI1, FECH, NPTX1, PCM1, PPP4R1, PPP4C, RP9, CCDC6, CEP131, PKN3, ATP6V1D, CPSF3L, INTS10, INTS9, INTS12, STRIP2, INTS2, INTS5, INTS4, USP7, ESR1, CDC20, CDC27, NOSIP, ESRRB, CARD11, BCL10, AMBRA1, KISS1R, AR, DUSP19, ARHGEF2, ENSA, FAM122A, FAM122B, FBXL16, TBC1D4, TTC33, UNG, WDR61, PTPDC1, FOXD4, TBCCD1, CDCA4, NCAPD3, FAM19A3, ZNF331, RFWD2, LRRC56, WNT7A, ZNF550, ZNF517, EEF1A1, ZNF785, ZFC3H1, ZNF764, TINAG, KLHDC8A, WDR86, PAK1, VHL, AKT3, AKT2, BRCA2, TRIM25, CCND2, CEBPA, URI1, TRIM28 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | ROCK2 | chr2:11484122 | chr5:133541822 | ENST00000315872 | - | 1 | 33 | 373_420 | 47 | 1389 | NPM1 |
| Hgene | ROCK2 | chr2:11484122 | chr5:133541822 | ENST00000315872 | - | 1 | 33 | 363_784 | 47 | 1389 | PPP1R12A |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ROCK2_PPP2CA |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ROCK2_PPP2CA |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PPP2CA | C0004096 | Asthma | 1 | CTD_human |
| Tgene | PPP2CA | C0018799 | Heart Diseases | 1 | CTD_human |
| Tgene | PPP2CA | C0151744 | Myocardial Ischemia | 1 | CTD_human |
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