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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 31700

FusionGeneSummary for ROCK2_MEIS1

check button Fusion gene summary
Fusion gene informationFusion gene name: ROCK2_MEIS1
Fusion gene ID: 31700
HgeneTgene
Gene symbol

ROCK2

MEIS1

Gene ID

9475

4211

Gene nameRho associated coiled-coil containing protein kinase 2Meis homeobox 1
SynonymsROCK-II-
Cytomap

2p25.1

2p14

Type of geneprotein-codingprotein-coding
Descriptionrho-associated protein kinase 2p164 ROCK-2rho-associated, coiled-coil-containing protein kinase IIhomeobox protein Meis1Meis1, myeloid ecotropic viral integration site 1 homologWUGSC:H_NH0444B04.1leukemogenic homolog protein
Modification date2018052720180523
UniProtAcc

O75116

O00470

Ensembl transtripts involved in fusion geneENST00000315872, ENST00000462366, 
ENST00000401753, 		ENST00000560281, 
ENST00000407092, ENST00000272369, 
ENST00000488550, ENST00000398506, 
ENST00000444274, ENST00000495021, 
ENST00000409517, 
Fusion gene scores* DoF score10 X 6 X 8=4803 X 3 X 2=18
# samples 103
** MAII scorelog2(10/480*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ROCK2 [Title/Abstract] AND MEIS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneROCK2

GO:0006468

protein phosphorylation

18559669


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-29-1691-01AROCK2chr2

11484122

-MEIS1chr2

66775075

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000315872ENST00000560281ROCK2chr2

11484122

-MEIS1chr2

66775075

+
In-frameENST00000315872ENST00000407092ROCK2chr2

11484122

-MEIS1chr2

66775075

+
In-frameENST00000315872ENST00000272369ROCK2chr2

11484122

-MEIS1chr2

66775075

+
In-frameENST00000315872ENST00000488550ROCK2chr2

11484122

-MEIS1chr2

66775075

+
In-frameENST00000315872ENST00000398506ROCK2chr2

11484122

-MEIS1chr2

66775075

+
In-frameENST00000315872ENST00000444274ROCK2chr2

11484122

-MEIS1chr2

66775075

+
In-frameENST00000315872ENST00000495021ROCK2chr2

11484122

-MEIS1chr2

66775075

+
5CDS-3UTRENST00000315872ENST00000409517ROCK2chr2

11484122

-MEIS1chr2

66775075

+
intron-3CDSENST00000462366ENST00000560281ROCK2chr2

11484122

-MEIS1chr2

66775075

+
intron-3CDSENST00000462366ENST00000407092ROCK2chr2

11484122

-MEIS1chr2

66775075

+
intron-3CDSENST00000462366ENST00000272369ROCK2chr2

11484122

-MEIS1chr2

66775075

+
intron-3CDSENST00000462366ENST00000488550ROCK2chr2

11484122

-MEIS1chr2

66775075

+
intron-3CDSENST00000462366ENST00000398506ROCK2chr2

11484122

-MEIS1chr2

66775075

+
intron-3CDSENST00000462366ENST00000444274ROCK2chr2

11484122

-MEIS1chr2

66775075

+
intron-3CDSENST00000462366ENST00000495021ROCK2chr2

11484122

-MEIS1chr2

66775075

+
intron-3UTRENST00000462366ENST00000409517ROCK2chr2

11484122

-MEIS1chr2

66775075

+
intron-3CDSENST00000401753ENST00000560281ROCK2chr2

11484122

-MEIS1chr2

66775075

+
intron-3CDSENST00000401753ENST00000407092ROCK2chr2

11484122

-MEIS1chr2

66775075

+
intron-3CDSENST00000401753ENST00000272369ROCK2chr2

11484122

-MEIS1chr2

66775075

+
intron-3CDSENST00000401753ENST00000488550ROCK2chr2

11484122

-MEIS1chr2

66775075

+
intron-3CDSENST00000401753ENST00000398506ROCK2chr2

11484122

-MEIS1chr2

66775075

+
intron-3CDSENST00000401753ENST00000444274ROCK2chr2

11484122

-MEIS1chr2

66775075

+
intron-3CDSENST00000401753ENST00000495021ROCK2chr2

11484122

-MEIS1chr2

66775075

+
intron-3UTRENST00000401753ENST00000409517ROCK2chr2

11484122

-MEIS1chr2

66775075

+

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FusionProtFeatures for ROCK2_MEIS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ROCK2

O75116

MEIS1

O00470

Protein kinase which is a key regulator of actincytoskeleton and cell polarity. Involved in regulation of smoothmuscle contraction, actin cytoskeleton organization, stress fiberand focal adhesion formation, neurite retraction, cell adhesionand motility via phosphorylation of ADD1, BRCA2, CNN1, EZR,DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM.Phosphorylates SORL1 and IRF4. Acts as a negative regulator ofVEGF-induced angiogenic endothelial cell activation. Positivelyregulates the activation of p42/MAPK1-p44/MAPK3 and ofp90RSK/RPS6KA1 during myogenic differentiation. Plays an importantrole in the timely initiation of centrosome duplication. Inhibitskeratinocyte terminal differentiation. May regulate closure of theeyelids and ventral body wall through organization of actomyosinbundles. Plays a critical role in the regulation of spine andsynaptic properties in the hippocampus. Plays an important role ingenerating the circadian rhythm of the aortic myofilament Ca(2+)sensitivity and vascular contractility by modulating the myosinlight chain phosphorylation. {ECO:0000269|PubMed:10579722,ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662,ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646,ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279,ECO:0000269|PubMed:21147781}. Acts as a transcriptional regulator of PAX6. Acts as atranscriptional activator of PF4 in complex with PBX1 or PBX2.Required for hematopoiesis, megakaryocyte lineage development andvascular patterning. May function as a cofactor for HOXA7 andHOXA9 in the induction of myeloid leukemias.{ECO:0000269|PubMed:12609849}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMEIS1chr2:11484122chr2:66775075ENST00000272369+713335_3902961109RegionRequired for transcriptional activation
TgeneMEIS1chr2:11484122chr2:66775075ENST00000398506+611335_390294464RegionRequired for transcriptional activation

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneROCK2chr2:11484122chr2:66775075ENST00000315872-1331053_1131471389Coiled coilOntology_term=ECO:0000255
HgeneROCK2chr2:11484122chr2:66775075ENST00000315872-133429_1024471389Coiled coilOntology_term=ECO:0000255
HgeneROCK2chr2:11484122chr2:66775075ENST00000315872-1331150_1349471389DomainPH
HgeneROCK2chr2:11484122chr2:66775075ENST00000315872-133357_425471389DomainNote=AGC-kinase C-terminal
HgeneROCK2chr2:11484122chr2:66775075ENST00000315872-133497_573471389DomainREM-1
HgeneROCK2chr2:11484122chr2:66775075ENST00000315872-13392_354471389DomainProtein kinase
HgeneROCK2chr2:11484122chr2:66775075ENST00000315872-13398_106471389Nucleotide bindingATP
HgeneROCK2chr2:11484122chr2:66775075ENST00000315872-133979_1047471389RegionRHOA binding
HgeneROCK2chr2:11484122chr2:66775075ENST00000315872-1331260_1315471389Zinc fingerPhorbol-ester/DAG-type
TgeneMEIS1chr2:11484122chr2:66775075ENST00000272369+713194_2402961109Compositional biasNote=Ser/Thr-rich
TgeneMEIS1chr2:11484122chr2:66775075ENST00000272369+713242_2692961109Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMEIS1chr2:11484122chr2:66775075ENST00000272369+713262_2692961109Compositional biasNote=Poly-Asp
TgeneMEIS1chr2:11484122chr2:66775075ENST00000398506+611194_240294464Compositional biasNote=Ser/Thr-rich
TgeneMEIS1chr2:11484122chr2:66775075ENST00000398506+611242_269294464Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMEIS1chr2:11484122chr2:66775075ENST00000398506+611262_269294464Compositional biasNote=Poly-Asp
TgeneMEIS1chr2:11484122chr2:66775075ENST00000272369+713272_3342961109DNA bindingHomeobox%3B TALE-type
TgeneMEIS1chr2:11484122chr2:66775075ENST00000398506+611272_334294464DNA bindingHomeobox%3B TALE-type


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FusionGeneSequence for ROCK2_MEIS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ROCK2_ENST00000315872_chr2_11484122_-_MEIS1_ENST00000560281_chr2_66775075_+_122aa
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSN

>In-frame_ROCK2_ENST00000315872_chr2_11484122_-_MEIS1_ENST00000407092_chr2_66775075_+_217aa
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSN
RAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGLQSMPGEYVARGGPMGVSMGQPSYTQPQMPPHPAQLRHGPPMHTYIPGHPHHPTVMM

>In-frame_ROCK2_ENST00000315872_chr2_11484122_-_MEIS1_ENST00000272369_chr2_66775075_+_142aa
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSN

>In-frame_ROCK2_ENST00000315872_chr2_11484122_-_MEIS1_ENST00000488550_chr2_66775075_+_130aa
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSN

>In-frame_ROCK2_ENST00000315872_chr2_11484122_-_MEIS1_ENST00000398506_chr2_66775075_+_217aa
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSN
RAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGLQSMPGEYVARGGPMGVSMGQPSYTQPQMPPHPAQLRHGPPMHTYIPGHPHHPTVMM

>In-frame_ROCK2_ENST00000315872_chr2_11484122_-_MEIS1_ENST00000444274_chr2_66775075_+_52aa

>In-frame_ROCK2_ENST00000315872_chr2_11484122_-_MEIS1_ENST00000495021_chr2_66775075_+_142aa
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSN


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ROCK2_ENST00000315872_chr2_11484122_-_MEIS1_ENST00000560281_chr2_66775075_+_366nt
ATGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTG
GAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGCACCCTTACCCTTCTGAAGAACAGAAAAAGCAGTTGGCA
CAAGACACGGGACTCACCATCCTTCAAGTGAACAATTGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAAC
CGAGCAGGCAAGTCCCCCATAGTGACTGTATTCAAGTCACGCAAGCGAAAACCATCCTCAAGCCATTCACCGGGAGGTCCGCTACCTGGT

>In-frame_ROCK2_ENST00000315872_chr2_11484122_-_MEIS1_ENST00000407092_chr2_66775075_+_651nt
ATGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTG
GAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGCACCCTTACCCTTCTGAAGAACAGAAAAAGCAGTTGGCA
CAAGACACGGGACTCACCATCCTTCAAGTGAACAATTGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAAC
CGAGCAGTAAGTCAAGGAACACCTTATAATCCTGATGGACAGCCCATGGGAGGTTTCGTAATGGACGGTCAGCAACATATGGGAATTAGA
GCACCAGGGCTGCAAAGTATGCCAGGGGAGTATGTAGCCCGGGGTGGTCCAATGGGTGTGAGTATGGGACAGCCAAGTTATACCCAACCC
CAGATGCCCCCCCATCCTGCTCAGCTGCGTCATGGGCCCCCCATGCATACGTACATTCCTGGACACCCTCACCACCCAACAGTGATGATG
CATGGAGGACCGCCCCACCCTGGAATGCCAATGTCAGCATCAAGCCCCACAGTTCTTAATACAGGAGACCCAACAATGAGTGGACAAGTC

>In-frame_ROCK2_ENST00000315872_chr2_11484122_-_MEIS1_ENST00000272369_chr2_66775075_+_426nt
ATGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTG
GAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGCACCCTTACCCTTCTGAAGAACAGAAAAAGCAGTTGGCA
CAAGACACGGGACTCACCATCCTTCAAGTGAACAATTGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAAC
CGAGCAGTAAGTCAAGGAACACCTTATAATCCTGATGGACAGCCCATGGGAGGTTTCGTAATGGACGGTCAGCAACATATGGGAATTAGA

>In-frame_ROCK2_ENST00000315872_chr2_11484122_-_MEIS1_ENST00000488550_chr2_66775075_+_390nt
ATGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTG
GAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGCACCCTTACCCTTCTGAAGAACAGAAAAAGCAGTTGGCA
CAAGACACGGGACTCACCATCCTTCAAGTGAACAATTGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAAC
CGAGCAGTAAGTCAAGGAACACCTTATAATCCTGATGGACAGCCCATGGGAGGTTTCGTAATGGACGGTCAGCAACATATGGGAATTAGA

>In-frame_ROCK2_ENST00000315872_chr2_11484122_-_MEIS1_ENST00000398506_chr2_66775075_+_651nt
ATGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTG
GAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGCACCCTTACCCTTCTGAAGAACAGAAAAAGCAGTTGGCA
CAAGACACGGGACTCACCATCCTTCAAGTGAACAATTGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAAC
CGAGCAGTAAGTCAAGGAACACCTTATAATCCTGATGGACAGCCCATGGGAGGTTTCGTAATGGACGGTCAGCAACATATGGGAATTAGA
GCACCAGGGCTGCAAAGTATGCCAGGGGAGTATGTAGCCCGGGGTGGTCCAATGGGTGTGAGTATGGGACAGCCAAGTTATACCCAACCC
CAGATGCCCCCCCATCCTGCTCAGCTGCGTCATGGGCCCCCCATGCATACGTACATTCCTGGACACCCTCACCACCCAACAGTGATGATG
CATGGAGGACCGCCCCACCCTGGAATGCCAATGTCAGCATCAAGCCCCACAGTTCTTAATACAGGAGACCCAACAATGAGTGGACAAGTC

>In-frame_ROCK2_ENST00000315872_chr2_11484122_-_MEIS1_ENST00000444274_chr2_66775075_+_158nt
ATGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTG

>In-frame_ROCK2_ENST00000315872_chr2_11484122_-_MEIS1_ENST00000495021_chr2_66775075_+_426nt
ATGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTG
GAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGCACCCTTACCCTTCTGAAGAACAGAAAAAGCAGTTGGCA
CAAGACACGGGACTCACCATCCTTCAAGTGAACAATTGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAAC
CGAGCAGTAAGTCAAGGAACACCTTATAATCCTGATGGACAGCCCATGGGAGGTTTCGTAATGGACGGTCAGCAACATATGGGAATTAGA


* Fusion transcript sequences (Full-length transcript).
>In-frame_ROCK2_ENST00000315872_chr2_11484122_-_MEIS1_ENST00000560281_chr2_66775075_+_1751nt
CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG
GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC
GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG
GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG
CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA
TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG
AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGCACCCTTACCCTTCTGAAGAACAGAAAAAGCAGTTGGCAC
AAGACACGGGACTCACCATCCTTCAAGTGAACAATTGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAACC
GAGCAGGCAAGTCCCCCATAGTGACTGTATTCAAGTCACGCAAGCGAAAACCATCCTCAAGCCATTCACCGGGAGGTCCGCTACCTGGTA
AATAAACTGGGAGTGAGTATAGGAACGCCTGGCAATTAAAATTAAACCAGTTTCGTTTCATAACAACACTAATCAATTTAACATCATTAT
AAAACGTTTGGAGAAGGTGGAAAAAAAAAGCCAACAGAGAAAAGTAACTCTTAAATAATATGCTCAGTTACAATATTCTTTGTACACATT
CAATATATTAATGTTATTTTTTTTCTGAGTTTGCCTTCCCAGCTCTTTCTGCTACTATGACCACTCCCTGGTGCATGGCTTGGTGTGGAA
TTGCTGTAAACTTTATTACCTGTCAAAAGGGCAAAGGGGTCAGGATTGCTTGTGGGACTCAGTAAAGTTCAAAGACATTCAATGAGGTAG
AGCTTTTGTGTGCTTTAATAACCCAAGGCAGCTTACTTCTGAAGCAGCTTTTCATGTACAGTTAAAACACGGGATTCAGGTAGTGGTATA
AATACATGGTTCTTATTTCTCAGACCTTCTCTTGTTAATATCCATCTTCTGGTGTTCGACTTTTTTTTTTTTTAATAACAGTCTTTTTGT
TTTGTTTTTAAATTATGAGCTTAAAATGGCGATACTTCTATGGGATCCTGGCTTGTGGATCTAAAAATCCAAGAAACATCTCTCTAGGAT
TTGTTTTTGCATTATAATATGCCAGTAAGATAACAAGAGTATTTGCTAGGGGTGATGTGAGTCTTTACTTTCTTTATGAAATACTCTCTC
ATCTCTTAGGGAGCACTATGGAAAACTATGTTAGCATCGCATTGAGGCAACACACATTTACTCCTGTAACTTTTTTTCTTCCAACACCCA
TTATGTGGTCACCAGACAAAACCCAAGCAGAAAGTTTCCACACCTTAACTGTTCCCTCTTTGAGCTAGATGTTTTAAAAACTCAGTCACA

>In-frame_ROCK2_ENST00000315872_chr2_11484122_-_MEIS1_ENST00000407092_chr2_66775075_+_2329nt
CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG
GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC
GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG
GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG
CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA
TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG
AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGCACCCTTACCCTTCTGAAGAACAGAAAAAGCAGTTGGCAC
AAGACACGGGACTCACCATCCTTCAAGTGAACAATTGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAACC
GAGCAGTAAGTCAAGGAACACCTTATAATCCTGATGGACAGCCCATGGGAGGTTTCGTAATGGACGGTCAGCAACATATGGGAATTAGAG
CACCAGGGCTGCAAAGTATGCCAGGGGAGTATGTAGCCCGGGGTGGTCCAATGGGTGTGAGTATGGGACAGCCAAGTTATACCCAACCCC
AGATGCCCCCCCATCCTGCTCAGCTGCGTCATGGGCCCCCCATGCATACGTACATTCCTGGACACCCTCACCACCCAACAGTGATGATGC
ATGGAGGACCGCCCCACCCTGGAATGCCAATGTCAGCATCAAGCCCCACAGTTCTTAATACAGGAGACCCAACAATGAGTGGACAAGTCA
TGGACATTCATGCTCAGTAGCTTAAGGGAATATGCATTGTCTGCAATGGTGACTGATTTCAAATCATGTTTTTTCTGCAATGACTGTGGA
GTTCCATTCTTGGCATCTACTCTGGACCAAGGAGCATCCCTAATTCTTCATAGGGACCTTTAAAAAGCAGGAAATACCAACTGAAGTCAA
TTTGGGGGACATGCTAAATAACTATATAAGACATTAAGAGAACAAAGAGTGAAATATTGTAAATGCTATTATACTGTTATCCATATTACG
TTGTTTCTTATAGATTTTTTAAAAAAAATGTGAAATTTTTCCACACTATGTGTGTTGTTTCCATAGCTCTTCACTTCCTCCAGAAGCCTC
CTTACATTAAAAAGCCTTACAGTTATCCTGCAAGGGACAGGAAGGTCTGATTTGCAGGATTTTTAGAGCATTAAAATAACTATCAGGCAG
AAGAATCTTTCTTCTCGCCTAGGATTTCAGCCATGCGCGCGCTCTCTCTCTTTCTCTCTCTTTTCCTCTCTCTCCCTCTTTCTAGCCTGG
GGCTTGAATTTGCATGTCTAATTCATTTACTCACCATATTTGAATTGGCCTGAACAGATGTAAATCGGGAAGGATGGGAAAAACTGCAGT
CATCAACAATGATTAATCAGCTGTTGCAGGCAGTGTCTTAAGGAGACTGGTAGGAGGAGGCATGGAAACCAAAAGGCCGTGTGTTTAGAA
GCCTAATTGTCACATCAAGCATCATTGTCCCCATGCAACAACCACCACCTTATACATCACTTCCTGTTTTAAGCAGCTCTAAAACATAGA
CTGAAGATTTATTTTTAATATGTTGACTTTATTTCTGAGCAAAGCATCGGTCATGTGTGTATTTTTTCATAGTCCCACCTTGGAGCATTT
ATGTAGACATTGTAAATAAATTTTGTGCAAAAAGGACTGGAAAAATGAACTGTATTATTGCAATTTTTTTTTGTAAAAGTAGCAGTTTGG
TATGAGTTGGCATGCATACAAGATTTACTAAGTGGGATAAGCTAATTATACTTTTTGTTGTGGATAAACAAATGCTTGTTGATAGCCTTT
TTCTATCAAGAAACCAAGGAGCTAATTATTAATAACAATCATTGCACACTGAGTCTTAGCGTTTCTGATGGAAACAGTTTGGATTGTATA

>In-frame_ROCK2_ENST00000315872_chr2_11484122_-_MEIS1_ENST00000272369_chr2_66775075_+_3536nt
CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG
GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC
GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG
GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG
CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA
TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG
AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGCACCCTTACCCTTCTGAAGAACAGAAAAAGCAGTTGGCAC
AAGACACGGGACTCACCATCCTTCAAGTGAACAATTGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAACC
GAGCAGTAAGTCAAGGAACACCTTATAATCCTGATGGACAGCCCATGGGAGGTTTCGTAATGGACGGTCAGCAACATATGGGAATTAGAG
CACCAGGACCTATGAGTGGAATGGGCATGAATATGGGCATGGAGGGGCAGTGGCACTACATGTAACCTTCATCTAGTTAACCAATCGCAA
AGCAAGGGGGAAGGCTGCAAAGTATGCCAGGGGAGTATGTAGCCCGGGGTGGTCCAATGGGTGTGAGTATGGGACAGCCAAGTTATACCC
AACCCCAGATGCCCCCCCATCCTGCTCAGCTGCGTCATGGGCCCCCCATGCATACGTACATTCCTGGACACCCTCACCACCCAACAGTGA
TGATGCATGGAGGACCGCCCCACCCTGGAATGCCAATGTCAGCATCAAGCCCCACAGTTCTTAATACAGGAGACCCAACAATGAGTGGAC
AAGTCATGGACATTCATGCTCAGTAGCTTAAGGGAATATGCATTGTCTGCAATGGTGACTGATTTCAAATCATGTTTTTTCTGCAATGAC
TGTGGAGTTCCATTCTTGGCATCTACTCTGGACCAAGGAGCATCCCTAATTCTTCATAGGGACCTTTAAAAAGCAGGAAATACCAACTGA
AGTCAATTTGGGGGACATGCTAAATAACTATATAAGACATTAAGAGAACAAAGAGTGAAATATTGTAAATGCTATTATACTGTTATCCAT
ATTACGTTGTTTCTTATAGATTTTTTAAAAAAAATGTGAAATTTTTCCACACTATGTGTGTTGTTTCCATAGCTCTTCACTTCCTCCAGA
AGCCTCCTTACATTAAAAAGCCTTACAGTTATCCTGCAAGGGACAGGAAGGTCTGATTTGCAGGATTTTTAGAGCATTAAAATAACTATC
AGGCAGAAGAATCTTTCTTCTCGCCTAGGATTTCAGCCATGCGCGCGCTCTCTCTCTTTCTCTCTCTTTTCCTCTCTCTCCCTCTTTCTA
GCCTGGGGCTTGAATTTGCATGTCTAATTCATTTACTCACCATATTTGAATTGGCCTGAACAGATGTAAATCGGGAAGGATGGGAAAAAC
TGCAGTCATCAACAATGATTAATCAGCTGTTGCAGGCAGTGTCTTAAGGAGACTGGTAGGAGGAGGCATGGAAACCAAAAGGCCGTGTGT
TTAGAAGCCTAATTGTCACATCAAGCATCATTGTCCCCATGCAACAACCACCACCTTATACATCACTTCCTGTTTTAAGCAGCTCTAAAA
CATAGACTGAAGATTTATTTTTAATATGTTGACTTTATTTCTGAGCAAAGCATCGGTCATGTGTGTATTTTTTCATAGTCCCACCTTGGA
GCATTTATGTAGACATTGTAAATAAATTTTGTGCAAAAAGGACTGGAAAAATGAACTGTATTATTGCAATTTTTTTTTGTAAAAGTAGCA
GTTTGGTATGAGTTGGCATGCATACAAGATTTACTAAGTGGGATAAGCTAATTATACTTTTTGTTGTGGATAAACAAATGCTTGTTGATA
GCCTTTTTCTATCAAGAAACCAAGGAGCTAATTATTAATAACAATCATTGCACACTGAGTCTTAGCGTTTCTGATGGAAACAGTTTGGAT
TGTATAATAACGCCAAGCCCAGTTGTAGTCGTTTGAGTGCAGTAATGAAATCTGAATCTAAAATAAAAACAAGATTATTTTTGTCATGCT
GACTCCACTGCTTGAAAAATTTGTTTACTGCCCCCCAGATTTTTAAAGATTAATACAGTAAATATAAAAATTAATTTTGGCTCCCTAAGC
CATATATGTATTTGACAATTTTAACCGCAAAGTAAGTTGTTTAATAATAACCACTGATTTCTTTAAGCTGACTTAATGAACTCCTAATAT
CAGCAAATTTGAGGCCTAAAGGCACTAAACTAACTCTAGACTCAGAATTACATCCAACAGAATTACTCATCTAATATCAGTGAAATTATT
CTTGCACATAAAGGCAAACCTAAGTACAAAGTTAAGTCTTTTACTAAAGGATGTTACCTAGGATGAGCAGTATATGTTTATTAGGAAATT
AACTACATGAATTGAAGAGACCAGACTTCAAAATCTAATTTTTATAAATATGCTCTATGTTCTCATTGGATAAAACTGGTTATTAACCAA
TTTTCCAGAACAGCTGTACAAGATTTCTGCATGGCAGCCGGCTAAATGGTAGAAAATAATATGTTTAAGCTGGAATAGCTTATAATTTTA
TTTAAATAAAATTGCTGCTATAAAAAGTGCTTCCCAAAGCTAAGGAAAATATACAAATATTTTAATTAAGGCAAATTCGTTTTAAAAAAT
AAGCCTTTCAGTAGTGATTGCTTTGTAAACAAAGGATGGGTCGGAGGAGAGAGAGCCTTAAACTCAAGTCTGACATTCAGGCCCAAGTCA
CCCTATAAACCGGCCCTTAGCAATTCTATTTTCTATTCGAAAAGAGAAACCAGCTGTGGGTTGGCTTTACTAGGTGATGTGTGATTGACT
GACTCACCTGCTGGAGTAGCAATGCATTCTCACCTTTTGCTGATGGGGCCTTGTTTCTAAACACGTGGATGCGCAGAGAGCAAGGCTCAG
CCTACTGCAGCCATCTCTGGCAGCGCTTCTACCCCTCCCCAGCCCATAGATGGGATTGTTTAAATCTCCCTTGTTGACCTAGTGGCAATT
CTTCCTCTACCTAAATAGTCGATGTGAGTGAAATCATTCTCTTTTGATAGGTGGTTGCTAGCAGTTAACAACCATTTATTTACTTTAACA

>In-frame_ROCK2_ENST00000315872_chr2_11484122_-_MEIS1_ENST00000488550_chr2_66775075_+_4514nt
CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG
GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC
GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG
GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG
CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA
TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG
AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGCACCCTTACCCTTCTGAAGAACAGAAAAAGCAGTTGGCAC
AAGACACGGGACTCACCATCCTTCAAGTGAACAATTGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAACC
GAGCAGTAAGTCAAGGAACACCTTATAATCCTGATGGACAGCCCATGGGAGGTTTCGTAATGGACGGTCAGCAACATATGGGAATTAGAG
CACCAGGTAAGACTTTGTTTTTGTGGTAGTTCCTCATTTTTGACTCCAAGAGTGTCATCCCCTCATCAACACAGGTAAATCCGCCTCATC
CTTTTCTGTTATCTCAAGCTGGCTGCCTTGCCTTGTCTGCTATCTGTGCATCTAAGATATTGCAGAGGGGAAGCCAGGATCTTTATGCAC
TGAAGATCTCACTATTTCTCAACCCTCTAGATCCTGTTTTTTTTTTAAGGGTCTTTTGGCACTATCTGTTGACTTTGCTCATTTTCTGGC
CTCTTCTTGGATTTTTATCTCCCTTCTAGGACCTATGAGTGGAATGGGCATGAATATGGGCATGGAGGGGCAGTGGCACTACATGTAACC
TTCATCTAGTTAACCAATCGCAAAGCAAGGGGGAAGTAAGTACAAATGGGGTCTTTGTTTTCACTTTGTCCTAGGAATATTTTTCCTCTT
GCATTTTCTTATGTTCTCCTTGCCCATAGCTTCATGCTTGTTCATTCCTTTCCATTAAACTCCTGGTTTCTTGCTTCCATCATTTTCTTT
TTGGTTGTGATCAAGCTTTTAAGCTTATAAATACTGTGTATGATGTACATTTATCCTGTGTGTTGCTATTGTACAGTACTGACCACATGA
CAAAACAAGAAGCAGTCAGGAGGTGGGGGAGTGGGTTGTCATAGCAACAGACTGATTTGCAAAATGTAAGCAGTCTGCAGCAGTGCAAGG
AGAGGGAAGAGCATGTCCCCAAAGTGTCATAAATCTGTCTAACCGCAGTTGATGCATGAGTTACATTTCTACACTAACCTGCAAGACACC
GAAAAGCTAAACAGAGACTTCTTTTAGGTAAAATAAACACAAGCTTTACTTAGGGTAAGTAAAGGCATATTTTGAGCTCCAGTCAACTAA
ACTTTGATTTTTTTTCTTAGTTTATTCCTTTGTCTGTCCATCATAATGGGATTACGTGTGGCAATGGGAAAAGGGAGAATACAAAATAGA
GGTGTGCACAGCAGGCTGCGGGGCTTAGCCCAGGCTAATTGACTATATCCAAATTAAGTATGCCATCACTTGCAGTGTGACAAATGGATT
TGACTTATTCAGTATACAAAAATAGAGATCATTAATGCAATCATCAGTGGCAGGCCTAGTGAAGTGGGCCTAGGAAAACTGTCCCAGATT
CTCACTCTTGCATTTTCTCTCCTATAAAGACACTCCAGCAATTCGAGTTCAAACAAGTAAAACTGTTTTGAACACCAAGGCTCTTGTTCA
CTTCCTAAATTACCCCTAATAGCACTGTTCTTGCTTTGTTTTTGAAATTAAAAGCAGTTATTTCAGAGTCTTGCTTGTGTCTCTGATTAT
ATTTATGCACTATTTAAAATCACTGCTGAGGCCAGGGGTAATTCGTACTGGTCATCTTCTCTGGGTGTGAGTCAAATATAAGTTTAACAA
TTAGCTCTGAAAACATTCCATTGAGCTGGGGAATGCAACAGTCTTATTACCTCATCATGGAATTCTCTAGCTTAGTTAATTTAAATATTG
TTTCTTAGTTTCTGGGTCAATTAAATTTAAATGATGTATTTTATGCTTCGTGACCAATTAAATTACTAGGTTATTACAAAAAAAATTATC
ATCTTTTTTGATTAAAGAGCTGTGGGTACAGTATATTTTATAAGCAATTTTCATTAGTTCAAAAATGTTCCTTTAGGCTAGATTAAGCAG
CCATTCATTGTTAGAGCCTGGAGACCTTATTCGAAGGTGTTCATCGTATTCACAGTGCACTATTACTTAGAACTAAAGCCAATTGAACCT
ACTTAGCAATAGCGTTATGCCTTTCACCCTTGATGATTATGGAGCTTATAGCTCTCAGAAACAATACACCTGTCAGTTTCCATCAACTAT
AGCAATCCATGCAGAAGACAAGAGGCCCCCTCAAAGCAGGAGGGGTATTGTTTTAGGTCCAATTTTTCTTATTGTTCTCAAAATCATTAT
AAGGTGGACAGTGTTTTGTGAAGATTTTCTTTTCCCCAGCTCTAAGAAACCATGTGGAAAGAATTCATTGATAACTGTTTTGATTTTTTT
CTTTTTTTAAGTACAGGTTTTGCTAAGTAATCACCCTTAGTGAGCCTGTGTAGTTCAGCTGCCTGTGAGATGTTTGGTGACCAGCTCAGT
GTATTCTTGTATTCTTGATAGAGAATATTTCAGGAGACAAAAGTGCTTCTTCAGACCAGACCTCAAATAACAATTTTATTCTTTTTAATA
AATAAGACCTCAGTAGGCGGACCTGATAACAGTGACAATGAAAGGAAAATAGTGGCAAAATGTGAGTTTCCAGCATGATGTTTCTCATTT
TATTTTCTTCTGTATGAATCAAAAGAATGCTTTACAAAACCATGTTCCCTTAATCACAGGGTTCTCTGGCTTTTATAGGATTGTCATAGC
CAGGACCACACTATTGCTTTTTCATAACATTTTCTTTTTGTTTCTTTCTTTTGAATTTCTTACAGGGCTGCAAAGTATGCCAGGGGAGTA
TGTAGCCCGGGGTGGTCCAATGGGTGTGAGTATGGGACAGCCAAGTTATACCCAACCCCAGATGCCCCCCCATCCTGCTCAGCTGCGTCA
TGGGCCCCCCATGCATACGTACATTCCTGGACACCCTCACCACCCAACAGTGATGATGCATGGAGGACCGCCCCACCCTGGAATGCCAAT
GTCAGCATCAAGCCCCACAGTTCTTAATACAGGAGACCCAACAATGAGTGGACAAGTCATGGACATTCATGCTCAGTAGCTTAAGGGAAT
ATGCATTGTCTGCAATGGTGACTGATTTCAAATCATGTTTTTTCTGCAATGACTGTGGAGTTCCATTCTTGGCATCTACTCTGGACCAAG
GAGCATCCCTAATTCTTCATAGGGACCTTTAAAAAGCAGGAAATACCAACTGAAGTCAATTTGGGGGACATGCTAAATAACTATATAAGA
CATTAAGAGAACAAAGAGTGAAATATTGTAAATGCTATTATACTGTTATCCATATTACGTTGTTTCTTATAGATTTTTTAAAAAAAATGT
GAAATTTTTCCACACTATGTGTGTTGTTTCCATAGCTCTTCACTTCCTCCAGAAGCCTCCTTACATTAAAAAGCCTTACAGTTATCCTGC
AAGGGACAGGAAGGTCTGATTTGCAGGATTTTTAGAGCATTAAAATAACTATCAGGCAGAAGAATCTTTCTTCTCGCCTAGGATTTCAGC
CATGCGCGCGCTCTCTCTCTTTCTCTCTCTTTTCCTCTCTCTCCCTCTTTCTAGCCTGGGGCTTGAATTTGCATGTCTAATTCATTTACT
CACCATATTTGAATTGGCCTGAACAGATGTAAATCGGGAAGGATGGGAAAAACTGCAGTCATCAACAATGATTAATCAGCTGTTGCAGGC
AGTGTCTTAAGGAGACTGGTAGGAGGAGGCATGGAAACCAAAAGGCCGTGTGTTTAGAAGCCTAATTGTCACATCAAGCATCATTGTCCC
CATGCAACAACCACCACCTTATACATCACTTCCTGTTTTAAGCAGCTCTAAAACATAGACTGAAGATTTATTTTTAATATGTTGACTTTA
TTTCTGAGCAAAGCATCGGTCATGTGTGTATTTTTTCATAGTCCCACCTTGGAGCATTTATGTAGACATTGTAAATAAATTTTGTGCAAA

>In-frame_ROCK2_ENST00000315872_chr2_11484122_-_MEIS1_ENST00000398506_chr2_66775075_+_2029nt
CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG
GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC
GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG
GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG
CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA
TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG
AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGCACCCTTACCCTTCTGAAGAACAGAAAAAGCAGTTGGCAC
AAGACACGGGACTCACCATCCTTCAAGTGAACAATTGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAACC
GAGCAGTAAGTCAAGGAACACCTTATAATCCTGATGGACAGCCCATGGGAGGTTTCGTAATGGACGGTCAGCAACATATGGGAATTAGAG
CACCAGGGCTGCAAAGTATGCCAGGGGAGTATGTAGCCCGGGGTGGTCCAATGGGTGTGAGTATGGGACAGCCAAGTTATACCCAACCCC
AGATGCCCCCCCATCCTGCTCAGCTGCGTCATGGGCCCCCCATGCATACGTACATTCCTGGACACCCTCACCACCCAACAGTGATGATGC
ATGGAGGACCGCCCCACCCTGGAATGCCAATGTCAGCATCAAGCCCCACAGTTCTTAATACAGGAGACCCAACAATGAGTGGACAAGTCA
TGGACATTCATGCTCAGTAGCTTAAGGGAATATGCATTGTCTGCAATGGTGACTGATTTCAAATCATGTTTTTTCTGCAATGACTGTGGA
GTTCCATTCTTGGCATCTACTCTGGACCAAGGAGCATCCCTAATTCTTCATAGGGACCTTTAAAAAGCAGGAAATACCAACTGAAGTCAA
TTTGGGGGACATGCTAAATAACTATATAAGACATTAAGAGAACAAAGAGTGAAATATTGTAAATGCTATTATACTGTTATCCATATTACG
TTGTTTCTTATAGATTTTTTAAAAAAAATGTGAAATTTTTCCACACTATGTGTGTTGTTTCCATAGCTCTTCACTTCCTCCAGAAGCCTC
CTTACATTAAAAAGCCTTACAGTTATCCTGCAAGGGACAGGAAGGTCTGATTTGCAGGATTTTTAGAGCATTAAAATAACTATCAGGCAG
AAGAATCTTTCTTCTCGCCTAGGATTTCAGCCATGCGCGCGCTCTCTCTCTTTCTCTCTCTTTTCCTCTCTCTCCCTCTTTCTAGCCTGG
GGCTTGAATTTGCATGTCTAATTCATTTACTCACCATATTTGAATTGGCCTGAACAGATGTAAATCGGGAAGGATGGGAAAAACTGCAGT
CATCAACAATGATTAATCAGCTGTTGCAGGCAGTGTCTTAAGGAGACTGGTAGGAGGAGGCATGGAAACCAAAAGGCCGTGTGTTTAGAA
GCCTAATTGTCACATCAAGCATCATTGTCCCCATGCAACAACCACCACCTTATACATCACTTCCTGTTTTAAGCAGCTCTAAAACATAGA
CTGAAGATTTATTTTTAATATGTTGACTTTATTTCTGAGCAAAGCATCGGTCATGTGTGTATTTTTTCATAGTCCCACCTTGGAGCATTT

>In-frame_ROCK2_ENST00000315872_chr2_11484122_-_MEIS1_ENST00000444274_chr2_66775075_+_1429nt
CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG
GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC
GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG
GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG
CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA
TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG
AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGCACCCTTACCCTTCTGAAGAACAGAAAAAGCAGTTGGCAC
AAGACACGGGACTCACCATCCTTCAAGTGAACAATTGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAACC
GAGCAGTAAGTCAAGGAACACCTTATAATCCTGATGGACAGCCCATGGGAGGTTTCGTAATGGACGGTCAGCAACATATGGGAATTAGAG
CACCAGGGCTGCAAAGTATGCCAGGGGAGTATGTAGCCCGGGGTGGTCCAATGGGTGTGAGTATGGGACAGCCAAGTTATACCCAACCCC
AGATGCCCCCCCATCCTGCTCAGCTGCGTCATGGGCCCCCCATGCATACGTACATTCCTGGACACCCTCACCACCCAACAGTGATGATGC
ATGGAGGACCGCCCCACCCTGGAATGCCAATGTCAGCATCAAGCCCCACAGTTCTTAATACAGGAGACCCAACAATGAGTGGACAAGTCA
TGGACATTCATGCTCAGTAGCTTAAGGGAATATGCATTGTCTGCAATGGTGACTGATTTCAAATCATGTTTTTTCTGCAATGACTGTGGA
GTTCCATTCTTGGCATCTACTCTGGACCAAGGAGCATCCCTAATTCTTCATAGGGACCTTTAAAAAGCAGGAAATACCAACTGAAGTCAA
TTTGGGGGACATGCTAAATAACTATATAAGACATTAAGAGAACAAAGAGTGAAATATTGTAAATGCTATTATACTGTTATCCATATTACG

>In-frame_ROCK2_ENST00000315872_chr2_11484122_-_MEIS1_ENST00000495021_chr2_66775075_+_1503nt
CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG
GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC
GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG
GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG
CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA
TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG
AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGCACCCTTACCCTTCTGAAGAACAGAAAAAGCAGTTGGCAC
AAGACACGGGACTCACCATCCTTCAAGTGAACAATTGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAACC
GAGCAGTAAGTCAAGGAACACCTTATAATCCTGATGGACAGCCCATGGGAGGTTTCGTAATGGACGGTCAGCAACATATGGGAATTAGAG
CACCAGGACCTATGAGTGGAATGGGCATGAATATGGGCATGGAGGGGCAGTGGCACTACATGTAACCTTCATCTAGTTAACCAATCGCAA
AGCAAGGGGGAAGGCTGCAAAGTATGCCAGGGGAGTATGTAGCCCGGGGTGGTCCAATGGGTGTGAGTATGGGACAGCCAAGTTATACCC
AACCCCAGATGCCCCCCCATCCTGCTCAGCTGCGTCATGGGCCCCCCATGCATACGTACATTCCTGGACACCCTCACCACCCAACAGTGA
TGATGCATGGAGGACCGCCCCACCCTGGAATGCCAATGTCAGCATCAAGCCCCACAGTTCTTAATACAGGAGACCCAACAATGAGTGGAC
AAGTCATGGACATTCATGCTCAGTAGCTTAAGGGAATATGCATTGTCTGCAATGGTGACTGATTTCAAATCATGTTTTTTCTGCAATGAC
TGTGGAGTTCCATTCTTGGCATCTACTCTGGACCAAGGAGCATCCCTAATTCTTCATAGGGACCTTTAAAAAGCAGGAAATACCAACTGA
AGTCAATTTGGGGGACATGCTAAATAACTATATAAGACATTAAGAGAACAAAGAGTGAAATATTGTAAATGCTATTATACTGTTATCCAT


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FusionGenePPI for ROCK2_MEIS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ROCK2IKBKE, STK16, RHOA, ELAVL1, MAGEC1, KIAA0196, RABGEF1, FAM21A, GPHN, LMNA, MTA2, NHP2L1, ZW10, DNAJB11, RACGAP1, NTRK1, SNW1, CDC5L, CDKN3, POLR1C, ROCK1, FBXO42, LRPAP1, ADD2, MYL2, LZTFL1, CYLDMEIS1HOXA9, PBX1, HOXD9, EMX2, TLX2, HOXC11, CREB1, CRTC1, CREBBP, ETS1, TRMT10B, SHMT2, LMX1B, MAB21L1, MEIS2, MAB21L2, FOXC1, FAM222A, C16orf71, CCDC120, C5orf24, COL20A1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneMEIS1chr2:11484122chr2:66775075ENST00000272369+713299_3292961109DNA
TgeneMEIS1chr2:11484122chr2:66775075ENST00000398506+611299_329294464DNA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneROCK2chr2:11484122chr2:66775075ENST00000315872-133373_420471389NPM1
HgeneROCK2chr2:11484122chr2:66775075ENST00000315872-133363_784471389PPP1R12A


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ROCK2_MEIS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ROCK2_MEIS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMEIS1C0035258Restless Legs Syndrome1CTD_human
TgeneMEIS1C1458155Mammary Neoplasms1CTD_human