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Fusion gene ID: 31698 |
FusionGeneSummary for ROCK2_DTNB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ROCK2_DTNB | Fusion gene ID: 31698 | Hgene | Tgene | Gene symbol | ROCK2 | DTNB | Gene ID | 9475 | 1838 |
| Gene name | Rho associated coiled-coil containing protein kinase 2 | dystrobrevin beta | |
| Synonyms | ROCK-II | - | |
| Cytomap | 2p25.1 | 2p23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho-associated protein kinase 2p164 ROCK-2rho-associated, coiled-coil-containing protein kinase II | dystrobrevin betaDTN-Bbeta-dystrobrevin | |
| Modification date | 20180527 | 20180522 | |
| UniProtAcc | O75116 | O60941 | |
| Ensembl transtripts involved in fusion gene | ENST00000315872, ENST00000462366, ENST00000401753, | ENST00000496972, ENST00000405222, ENST00000407661, ENST00000406818, ENST00000407038, ENST00000404103, ENST00000407186, ENST00000288642, ENST00000545439, ENST00000472690, | |
| Fusion gene scores | * DoF score | 10 X 6 X 8=480 | 8 X 7 X 7=392 |
| # samples | 10 | 9 | |
| ** MAII score | log2(10/480*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/392*10)=-2.12285674778553 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ROCK2 [Title/Abstract] AND DTNB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ROCK2 | GO:0006468 | protein phosphorylation | 18559669 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-67-3770-01A | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000315872 | ENST00000496972 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| In-frame | ENST00000315872 | ENST00000405222 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| In-frame | ENST00000315872 | ENST00000407661 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| In-frame | ENST00000315872 | ENST00000406818 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| In-frame | ENST00000315872 | ENST00000407038 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| In-frame | ENST00000315872 | ENST00000404103 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| In-frame | ENST00000315872 | ENST00000407186 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| In-frame | ENST00000315872 | ENST00000288642 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| In-frame | ENST00000315872 | ENST00000545439 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| 5CDS-intron | ENST00000315872 | ENST00000472690 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| intron-3CDS | ENST00000462366 | ENST00000496972 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| intron-3CDS | ENST00000462366 | ENST00000405222 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| intron-3CDS | ENST00000462366 | ENST00000407661 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| intron-3CDS | ENST00000462366 | ENST00000406818 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| intron-3CDS | ENST00000462366 | ENST00000407038 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| intron-3CDS | ENST00000462366 | ENST00000404103 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| intron-3CDS | ENST00000462366 | ENST00000407186 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| intron-3CDS | ENST00000462366 | ENST00000288642 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| intron-3CDS | ENST00000462366 | ENST00000545439 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| intron-intron | ENST00000462366 | ENST00000472690 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| intron-3CDS | ENST00000401753 | ENST00000496972 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| intron-3CDS | ENST00000401753 | ENST00000405222 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| intron-3CDS | ENST00000401753 | ENST00000407661 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| intron-3CDS | ENST00000401753 | ENST00000406818 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| intron-3CDS | ENST00000401753 | ENST00000407038 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| intron-3CDS | ENST00000401753 | ENST00000404103 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| intron-3CDS | ENST00000401753 | ENST00000407186 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| intron-3CDS | ENST00000401753 | ENST00000288642 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| intron-3CDS | ENST00000401753 | ENST00000545439 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
| intron-intron | ENST00000401753 | ENST00000472690 | ROCK2 | chr2 | 11484122 | - | DTNB | chr2 | 25656864 | - |
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FusionProtFeatures for ROCK2_DTNB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ROCK2 | DTNB |
| Protein kinase which is a key regulator of actincytoskeleton and cell polarity. Involved in regulation of smoothmuscle contraction, actin cytoskeleton organization, stress fiberand focal adhesion formation, neurite retraction, cell adhesionand motility via phosphorylation of ADD1, BRCA2, CNN1, EZR,DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM.Phosphorylates SORL1 and IRF4. Acts as a negative regulator ofVEGF-induced angiogenic endothelial cell activation. Positivelyregulates the activation of p42/MAPK1-p44/MAPK3 and ofp90RSK/RPS6KA1 during myogenic differentiation. Plays an importantrole in the timely initiation of centrosome duplication. Inhibitskeratinocyte terminal differentiation. May regulate closure of theeyelids and ventral body wall through organization of actomyosinbundles. Plays a critical role in the regulation of spine andsynaptic properties in the hippocampus. Plays an important role ingenerating the circadian rhythm of the aortic myofilament Ca(2+)sensitivity and vascular contractility by modulating the myosinlight chain phosphorylation. {ECO:0000269|PubMed:10579722,ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662,ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646,ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279,ECO:0000269|PubMed:21147781}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >DTNB | chr2:11484122 | chr2:25656864 | ENST00000404103 | - | 11 | 20 | 428_529 | 419 | 607 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >DTNB | chr2:11484122 | chr2:25656864 | ENST00000405222 | - | 10 | 18 | 428_529 | 389 | 570 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >DTNB | chr2:11484122 | chr2:25656864 | ENST00000406818 | - | 11 | 21 | 428_529 | 419 | 637 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >DTNB | chr2:11484122 | chr2:25656864 | ENST00000407038 | - | 10 | 19 | 428_529 | 389 | 577 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >DTNB | chr2:11484122 | chr2:25656864 | ENST00000407661 | - | 11 | 20 | 428_529 | 419 | 619 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >DTNB | chr2:11484122 | chr2:25656864 | ENST00000496972 | - | 10 | 18 | 428_529 | 362 | 581 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >DTNB | chr2:11484122 | chr2:25656864 | ENST00000405222 | - | 10 | 18 | 399_448 | 389 | 570 | Region | Note=Syntrophin-binding region |
| Tgene | >DTNB | chr2:11484122 | chr2:25656864 | ENST00000407038 | - | 10 | 19 | 399_448 | 389 | 577 | Region | Note=Syntrophin-binding region |
| Tgene | >DTNB | chr2:11484122 | chr2:25656864 | ENST00000496972 | - | 10 | 18 | 399_448 | 362 | 581 | Region | Note=Syntrophin-binding region |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ROCK2 | chr2:11484122 | chr2:25656864 | ENST00000315872 | - | 1 | 33 | 1053_1131 | 47 | 1389 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >ROCK2 | chr2:11484122 | chr2:25656864 | ENST00000315872 | - | 1 | 33 | 429_1024 | 47 | 1389 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >ROCK2 | chr2:11484122 | chr2:25656864 | ENST00000315872 | - | 1 | 33 | 1150_1349 | 47 | 1389 | Domain | PH |
| Hgene | >ROCK2 | chr2:11484122 | chr2:25656864 | ENST00000315872 | - | 1 | 33 | 357_425 | 47 | 1389 | Domain | Note=AGC-kinase C-terminal |
| Hgene | >ROCK2 | chr2:11484122 | chr2:25656864 | ENST00000315872 | - | 1 | 33 | 497_573 | 47 | 1389 | Domain | REM-1 |
| Hgene | >ROCK2 | chr2:11484122 | chr2:25656864 | ENST00000315872 | - | 1 | 33 | 92_354 | 47 | 1389 | Domain | Protein kinase |
| Hgene | >ROCK2 | chr2:11484122 | chr2:25656864 | ENST00000315872 | - | 1 | 33 | 98_106 | 47 | 1389 | Nucleotide binding | ATP |
| Hgene | >ROCK2 | chr2:11484122 | chr2:25656864 | ENST00000315872 | - | 1 | 33 | 979_1047 | 47 | 1389 | Region | RHOA binding |
| Hgene | >ROCK2 | chr2:11484122 | chr2:25656864 | ENST00000315872 | - | 1 | 33 | 1260_1315 | 47 | 1389 | Zinc finger | Phorbol-ester/DAG-type |
| Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000404103 | - | 11 | 20 | 399_448 | 419 | 607 | Region | Note=Syntrophin-binding region |
| Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000406818 | - | 11 | 21 | 399_448 | 419 | 637 | Region | Note=Syntrophin-binding region |
| Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000407661 | - | 11 | 20 | 399_448 | 419 | 619 | Region | Note=Syntrophin-binding region |
| Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000404103 | - | 11 | 20 | 237_284 | 419 | 607 | Zinc finger | ZZ-type |
| Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000405222 | - | 10 | 18 | 237_284 | 389 | 570 | Zinc finger | ZZ-type |
| Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000406818 | - | 11 | 21 | 237_284 | 419 | 637 | Zinc finger | ZZ-type |
| Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000407038 | - | 10 | 19 | 237_284 | 389 | 577 | Zinc finger | ZZ-type |
| Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000407661 | - | 11 | 20 | 237_284 | 419 | 619 | Zinc finger | ZZ-type |
| Tgene | DTNB | chr2:11484122 | chr2:25656864 | ENST00000496972 | - | 10 | 18 | 237_284 | 362 | 581 | Zinc finger | ZZ-type |
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FusionGeneSequence for ROCK2_DTNB |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000496972_chr2_25656864_-_231aa MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHE QASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTH >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000405222_chr2_25656864_-_219aa MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHE QASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTH >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000407661_chr2_25656864_-_238aa MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHE QASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEEEQKQAAQATGSPHTSPTHGGGRPMPMPVRSTS >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000406818_chr2_25656864_-_256aa MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHE QASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEEEQKQAAQATGSPHTSPTHGGGRPMPMPVRSTS >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000407038_chr2_25656864_-_226aa MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHE QASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEEEQKQAAQATGSPHTSPTHGGGRPMPMPVRSTS >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000404103_chr2_25656864_-_226aa MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHE QASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEEEQKQAAQATGSPHTSPTHGGGRPMPMPVRSTS >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000407186_chr2_25656864_-_249aa MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHE QASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTH >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000288642_chr2_25656864_-_226aa MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHE QASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEAEARESAQATGSPHTSPTHGGGRPMPMPVRSTS >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000545439_chr2_25656864_-_249aa MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHE QASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTH |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000496972_chr2_25656864_-_693nt ATGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTG GAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCC AACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAG CAGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTG GAGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGCTCAGGCCACA GGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTGCCGGCTCCACCCCCACCCAC TGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGGTACGAGGAGAAACCTCCGCAATGACCTGCTG >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000405222_chr2_25656864_-_657nt ATGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTG GAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCC AACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAG CAGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTG GAGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGCTCAGGCCACA GGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTGCCGGCTCCACCCCCACCCAC TGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGCAGAGGAAGGTGCAGAGGAAGAAGAAGAGAAG >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000407661_chr2_25656864_-_714nt ATGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTG GAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCC AACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAG CAGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTG GAGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGAGGAAGAGCAA AAGCAGGCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCT GCCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGGTACGAGGAGA >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000406818_chr2_25656864_-_768nt ATGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTG GAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCC AACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAG CAGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTG GAGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGAGGAAGAGCAA AAGCAGGCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCT GCCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGGTACGAGGAGA AACCTCCGCAATGACCTGCTGGTGGCAGCTGACTCCATCACCAACACCATGTCATCCCTGGTGAAGGAGCTCCATTCAGCAGAGGAAGGT >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000407038_chr2_25656864_-_678nt ATGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTG GAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCC AACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAG CAGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTG GAGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGAGGAAGAGCAA AAGCAGGCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCT GCCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGCAGAGGAAGGT >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000404103_chr2_25656864_-_678nt ATGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTG GAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCC AACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAG CAGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTG GAGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGAGGAAGAGCAA AAGCAGGCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCT GCCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGCAGAGGAAGGT >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000407186_chr2_25656864_-_747nt ATGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTG GAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCC AACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAG CAGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTG GAGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGCTCAGGCCACA GGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTGCCGGCTCCACCCCCACCCAC TGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGGTACGAGGAGAAACCTCCGCAATGACCTGCTG GTGGCAGCTGACTCCATCACCAACACCATGTCATCCCTGGTGAAGGAGCTCCATTCAGCAGAGGAAGGTGCAGAGGAAGAAGAAGAGAAG >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000288642_chr2_25656864_-_678nt ATGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTG GAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCC AACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAG CAGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTG GAGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGAAGCTGAGGCA CGAGAATCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCT GCCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGCAGAGGAAGGT >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000545439_chr2_25656864_-_747nt ATGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTG GAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCC AACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAG CAGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTG GAGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGCTCAGGCCACA GGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTGCCGGCTCCACCCCCACCCAC TGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGGTACGAGGAGAAACCTCCGCAATGACCTGCTG GTGGCAGCTGACTCCATCACCAACACCATGTCATCCCTGGTGAAGGAGCTCCATTCAGCAGAGGAAGGTGCAGAGGAAGAAGAAGAGAAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000496972_chr2_25656864_-_1527nt CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCA ACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGC AGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTGG AGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGCTCAGGCCACAG GGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTGCCGGCTCCACCCCCACCCACT GTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGGTACGAGGAGAAACCTCCGCAATGACCTGCTGG TGGCAGCTGACTCCATCACCAACACCATGTCATCCCTGGTGAAGGAGCTCCATTCAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCA GGCACAGAGGACGAGGAGCAAGCTGGCGCCGACATGGCGAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCAC ACCTGGACCAGGCTTGCAGGCTGCCAGACGTCACTCCACCCGCCAGGGAGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCGT GGCACAGCTAGTGGGCCTCCCCCTGCACAGCCCTGCATGTACTAGCACCTTCATCACTCCCCTCAGGGCATGGTCTCATCTCCGCATCAG >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000405222_chr2_25656864_-_1446nt CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCA ACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGC AGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTGG AGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGCTCAGGCCACAG GGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTGCCGGCTCCACCCCCACCCACT GTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGCAGAGGAAGGTGCAGAGGAAGAAGAAGAGAAGA TGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAGGAGCAAGCTGGCGCCGACATG GCGAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCACACCTGGACCAGGCTTGCAGGCTGCCAGACGTCACTC CACCCGCCAGGGAGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCGTGGCACAGCTAGTGGGCCTCCCCCTGCACAGCCCTGC ATGTACTAGCACCTTCATCACTCCCCTCAGGGCATGGTCTCATCTCCGCATCAGGAATTCACCTGGAGGTTGAAAAGAGAAAAGAAAAAG >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000407661_chr2_25656864_-_1503nt CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCA ACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGC AGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTGG AGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGAGGAAGAGCAAA AGCAGGCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTG CCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGGTACGAGGAGAA ACCTCCGCAATGACCTGCTGGTGGCAGCTGACTCCATCACCAACACCATGTCATCCCTGGTGAAGGAGCTCCATTCAGGTTAGCAGAGGA GCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAGGAGCAAGCTGGCGCCGACATGGCGAAGGCAAGGTCTTCCCCCAGAGGCACATTC CTCTCCATCTTTCCACCGCACACCTGGACCAGGCTTGCAGGCTGCCAGACGTCACTCCACCCGCCAGGGAGAGGGGAGCCAGAGCCGGTG GGAAGCGGGGAGGGGCTGCGTGGCACAGCTAGTGGGCCTCCCCCTGCACAGCCCTGCATGTACTAGCACCTTCATCACTCCCCTCAGGGC >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000406818_chr2_25656864_-_1557nt CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCA ACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGC AGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTGG AGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGAGGAAGAGCAAA AGCAGGCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTG CCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGGTACGAGGAGAA ACCTCCGCAATGACCTGCTGGTGGCAGCTGACTCCATCACCAACACCATGTCATCCCTGGTGAAGGAGCTCCATTCAGCAGAGGAAGGTG CAGAGGAAGAAGAAGAGAAGATGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAG GAGCAAGCTGGCGCCGACATGGCGAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCACACCTGGACCAGGCTT GCAGGCTGCCAGACGTCACTCCACCCGCCAGGGAGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCGTGGCACAGCTAGTGGG CCTCCCCCTGCACAGCCCTGCATGTACTAGCACCTTCATCACTCCCCTCAGGGCATGGTCTCATCTCCGCATCAGGAATTCACCTGGAGG >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000407038_chr2_25656864_-_1467nt CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCA ACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGC AGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTGG AGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGAGGAAGAGCAAA AGCAGGCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTG CCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGCAGAGGAAGGTG CAGAGGAAGAAGAAGAGAAGATGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAG GAGCAAGCTGGCGCCGACATGGCGAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCACACCTGGACCAGGCTT GCAGGCTGCCAGACGTCACTCCACCCGCCAGGGAGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCGTGGCACAGCTAGTGGG CCTCCCCCTGCACAGCCCTGCATGTACTAGCACCTTCATCACTCCCCTCAGGGCATGGTCTCATCTCCGCATCAGGAATTCACCTGGAGG >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000404103_chr2_25656864_-_1467nt CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCA ACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGC AGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTGG AGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGAGGAAGAGCAAA AGCAGGCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTG CCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGCAGAGGAAGGTG CAGAGGAAGAAGAAGAGAAGATGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAG GAGCAAGCTGGCGCCGACATGGCGAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCACACCTGGACCAGGCTT GCAGGCTGCCAGACGTCACTCCACCCGCCAGGGAGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCGTGGCACAGCTAGTGGG CCTCCCCCTGCACAGCCCTGCATGTACTAGCACCTTCATCACTCCCCTCAGGGCATGGTCTCATCTCCGCATCAGGAATTCACCTGGAGG >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000407186_chr2_25656864_-_1521nt CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCA ACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGC AGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTGG AGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGCTCAGGCCACAG GGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTGCCGGCTCCACCCCCACCCACT GTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGGTACGAGGAGAAACCTCCGCAATGACCTGCTGG TGGCAGCTGACTCCATCACCAACACCATGTCATCCCTGGTGAAGGAGCTCCATTCAGCAGAGGAAGGTGCAGAGGAAGAAGAAGAGAAGA TGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAGGAGCAAGCTGGCGCCGACATG GCGAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCACACCTGGACCAGGCTTGCAGGCTGCCAGACGTCACTC CACCCGCCAGGGAGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCGTGGCACAGCTAGTGGGCCTCCCCCTGCACAGCCCTGC >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000288642_chr2_25656864_-_1448nt CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCA ACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGC AGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTGG AGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGAAGCTGAGGCAC GAGAATCAGCTCAGGCCACAGGGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTG CCGGCTCCACCCCCACCCACTGTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGCAGAGGAAGGTG CAGAGGAAGAAGAAGAGAAGATGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAG GAGCAAGCTGGCGCCGACATGGCGAAGGCAAGGTCTTCCCCCAGAGGCACATTCCTCTCCATCTTTCCACCGCACACCTGGACCAGGCTT GCAGGCTGCCAGACGTCACTCCACCCGCCAGGGAGAGGGGAGCCAGAGCCGGTGGGAAGCGGGGAGGGGCTGCGTGGCACAGCTAGTGGG CCTCCCCCTGCACAGCCCTGCATGTACTAGCACCTTCATCACTCCCCTCAGGGCATGGTCTCATCTCCGCATCAGGAATTCACCTGGAGG >In-frame_ROCK2_ENST00000315872_chr2_11484122_-_DTNB_ENST00000545439_chr2_25656864_-_1263nt CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCG GGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTGCGGGCACTCGCTGAGGACCAGCGGACCGGC GGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCG GGCCCCTGGGAGCAGCCCCCAGGCGGGGGACCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGG CCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGG AGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGACTCGTCCTCCCACTGACTTGAGCTTTAACTTTGATGCCA ACAAACAACAAAGACAGCTTATTGCAGAACTGGAAAACAAAAACAGAGAGATCCTGCAGGAGATTCAGCGTCTCCGCCTGGAACACGAGC AGGCCTCCCAGCCCACCCCTGAGAAGGCACAGCAGAACCCCACGCTGCTGGCAGAGCTGCGGCTGCTGAGGCAAAGGAAGGATGAACTGG AGCAGAGGATGTCGGCCCTGCAGGAGAGCAGGCGGGAGCTGATGGTCCAGCTGGAAGAGCTGATGAAGTTGCTGAAGGCTCAGGCCACAG GGTCACCACATACATCGCCCACCCATGGAGGCGGCCGGCCAATGCCCATGCCAGTGCGCTCCACGTCTGCCGGCTCCACCCCCACCCACT GTCCGCAGGACTCGCTGAGCGGAGTCGGGGGAGACGTGCAGGAGGCCTTCGCACAAGGTACGAGGAGAAACCTCCGCAATGACCTGCTGG TGGCAGCTGACTCCATCACCAACACCATGTCATCCCTGGTGAAGGAGCTCCATTCAGCAGAGGAAGGTGCAGAGGAAGAAGAAGAGAAGA TGCAGAATGGGAAAGACAGAGGTTAGCAGAGGAGCCGGACACAGAGGAAGCTCAGGCACAGAGGACGAGGAGCAAGCTGGCGCCGACATG |
Top |
FusionGenePPI for ROCK2_DTNB |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ROCK2 | IKBKE, STK16, RHOA, ELAVL1, MAGEC1, KIAA0196, RABGEF1, FAM21A, GPHN, LMNA, MTA2, NHP2L1, ZW10, DNAJB11, RACGAP1, NTRK1, SNW1, CDC5L, CDKN3, POLR1C, ROCK1, FBXO42, LRPAP1, ADD2, MYL2, LZTFL1, CYLD | DTNB | KIF5A, TSACC, NUP62, TRAF2, CCDC85B, PRTFDC1, BEGAIN, HMG20A, PPFIBP2, KIF5B, MLC1, DMD, DTNB, KRT31, VCP, PPFIA1, ABI2, MTUS2, GGA1, ABI3, CEP55, CEP63, NDEL1, USHBP1, DTNBP1, SPZ1, KRT40, TXLNA, ZBTB9, CASK, CCDC101, GAPDH, CEP128, TNS1, TNS3, SNTG2, CPNE5, RHPN1, COG6, OLFM2, TENC1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | ROCK2 | chr2:11484122 | chr2:25656864 | ENST00000315872 | - | 1 | 33 | 373_420 | 47 | 1389 | NPM1 |
| Hgene | ROCK2 | chr2:11484122 | chr2:25656864 | ENST00000315872 | - | 1 | 33 | 363_784 | 47 | 1389 | PPP1R12A |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ROCK2_DTNB |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ROCK2_DTNB |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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